Lyra Therapeutics, Inc.
LYRADelisted Apr 20, 2026- Industry
- Surgical & Medical Instruments & Apparatus
- SEC CIK
- 0001327273
Lyra Therapeutics, Inc. was delisted on Apr 20, 2026; its insiders filed their last Form 4 on May 15, 2026; 23 institutions reported holding it in 13F filings for Q4 2025, worth $747.3K in total; no superinvestor held it.
13F holders, Q4 2023
Institutional positions in Lyra Therapeutics, Inc. as of Dec 31, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 60
- +15 vs. Q3 2023
- Shares held
- 42.4M
- +10.4M (+32.7%) vs. Q3 2023
- Total value
- $222.0M
- +$97.1M (+77.8%) vs. Q3 2023
- New holders
- 22
- 22 more added
- Sold out
- 7
- 3 more reduced
Compare with Q3 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting LYRA on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 0 | $0 |
| Q1 2026 | 1 | $51.1K |
| Q4 2025 | 23 | $747.3K |
| Q3 2025 | 26 | $2.93M |
| Q2 2025 | 30 | $4.42M |
| Q1 2025 | 57 | $3.23M |
| Q4 2024 | 54 | $5.54M |
| Q3 2024 | 62 | $8.36M |
| Q2 2024 | 51 | $9.06M |
| Q1 2024 | 79 | $283.4M |
| Q4 2023 | 60 | $222.0M |
| Q3 2023 | 45 | $124.8M |
| Q2 2023 | 39 | $138.4M |
| Q1 2023 | 31 | $38.1M |
| Q4 2022 | 37 | $59.9M |
| Q3 2022 | 38 | $96.0M |
| Q2 2022 | 38 | $108.9M |
| Q1 2022 | 28 | $20.2M |
| Q4 2021 | 34 | $22.4M |
| Q3 2021 | 37 | $60.8M |
| Q2 2021 | 46 | $56.0M |
| Q1 2021 | 50 | $87.6M |
Institutions, Q4 2023
Shares, value and share of portfolio for each institution holding Lyra Therapeutics, Inc.; share changes are against Q3 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Perceptive Advisors LLC | 12,757,562 | $66.8M | 1.49% | 00.0% | Unchanged |
| Nantahala Capital Management, LLC | 4,050,218 | $21.2M | 2.12% | 00.0% | Unchanged |
| Point72 Asset Management, L.P. | 3,000,000 | $15.7M | 0.05% | +3,000,000 | New |
| Vestal Point Capital, LP | 3,000,000 | $15.7M | 1.67% | +3,000,000 | New |
| Citadel Advisors LLC | 2,861,255 | $15.0M | 0.02% | +12,691+0.4% | Added |
| Samsara BioCapital, LLC | 2,780,261 | $14.6M | 2.27% | 00.0% | Unchanged |
| VR Adviser, LLC | 2,575,593 | $13.5M | 0.93% | +1,651,423+178.7% | Added |
| Rosalind Advisors, Inc. | 1,888,720 | $9.90M | 8.28% | +1,888,720 | New |
| Pura Vida Investments, LLC | 1,413,242 | $7.41M | 8.08% | 00.0% | Unchanged |
| Ikarian Capital, LLC | 1,254,384 | $6.57M | 1.80% | 00.0% | Unchanged |
| Armistice Capital, LLC | 1,088,000 | $5.70M | 0.15% | −462,000−29.8% | Reduced |
| Vanguard Group Inc | 1,071,460 | $5.61M | 0.00% | +207,128+24.0% | Added |
| Parkman Healthcare Partners LLC | 754,885 | $3.96M | 0.56% | +129,829+20.8% | Added |
| Woodline Partners LP | 599,975 | $3.14M | 0.03% | +599,975 | New |
| Geode Capital Management, LLC | 336,458 | $1.76M | 0.00% | +27,768+9.0% | Added |
| Millennium Management LLC | 325,995 | $1.71M | 0.00% | +62,646+23.8% | Added |
| Ensign Peak Advisors, Inc | 301,533 | $1.58M | 0.00% | 00.0% | Unchanged |
| Susquehanna International Group, LLP | 259,416 | $1.36M | 0.00% | +96,556+59.3% | Added |
| Boothbay Fund Management, LLC | 249,939 | $1.31M | 0.05% | +15,936+6.8% | Added |
| Bank of America Corp | 144,678 | $758.1K | 0.00% | +18,724+14.9% | Added |
| Bridgeway Capital Management, LLC | 141,800 | $743.0K | 0.02% | 00.0% | Unchanged |
| Two Sigma Investments, LP | 132,606 | $694.9K | 0.00% | +116,186+707.6% | Added |
| Citigroup Inc | 124,443 | $652.1K | 0.00% | +56,766+83.9% | Added |
| Clearline Capital LP | 119,128 | $624.2K | 0.07% | 00.0% | Unchanged |
| Dimensional Fund Advisors LP | 112,634 | $590.2K | 0.00% | +84,380+298.6% | Added |
| BlackRock Inc. | 110,797 | $580.6K | 0.00% | +63,315+133.3% | Added |
| State Street Corp | 109,180 | $572.1K | 0.00% | +14,100+14.8% | Added |
| Jane Street Group, LLC | 78,251 | $410.0K | 0.00% | +78,251 | New |
| 683 Capital Management, LLC | 69,869 | $366.1K | 0.04% | +69,869 | New |
| Northern Trust Corp | 61,549 | $322.5K | 0.00% | +4,540+8.0% | Added |
| Qube Research & Technologies Ltd | 55,449 | $290.6K | 0.00% | +52,167+1,589.5% | Added |
| Two Sigma Advisers, LP | 50,700 | $265.7K | 0.00% | +50,700 | New |
| Renaissance Technologies LLC | 43,900 | $230.0K | 0.00% | −5,900−11.8% | Reduced |
| Laurion Capital Management LP | 42,424 | $222.3K | 0.01% | +42,424 | New |
| Schonfeld Strategic Advisors LLC | 41,713 | $218.6K | 0.00% | +41,713 | New |
| Man Group plc | 38,003 | $199.1K | 0.00% | +38,003 | New |
| JPMorgan Chase & Co | 33,170 | $173.8K | 0.00% | +33,136+97,458.8% | Added |
| Barclays PLC | 32,817 | $172.0K | 0.00% | +32,817 | New |
| Letko, Brosseau & Associates Inc | 31,900 | $167.2K | 0.00% | 00.0% | Unchanged |
| Cubist Systematic Strategies, LLC | 29,630 | $155.3K | 0.00% | +29,630 | New |
| ExodusPoint Capital Management, LP | 29,045 | $152.0K | 0.00% | +29,045 | New |
| Balyasny Asset Management LLC | 28,795 | $150.9K | 0.00% | +28,795 | New |
| Bank of New York Mellon Corp | 18,621 | $97.6K | 0.00% | 00.0% | Unchanged |
| Jump Financial, LLC | 16,737 | $87.7K | 0.00% | +16,737 | New |
| Walleye Capital LLC | 15,006 | $78.6K | 0.00% | +15,006 | New |
| Goldman Sachs Group Inc | 13,063 | $68.5K | 0.00% | +13,063 | New |
| Two Sigma Securities, LLC | 12,765 | $66.9K | 0.00% | +12,765 | New |
| Y-Intercept (Hong Kong) Ltd | 12,279 | $64.3K | 0.01% | +12,279 | New |
| DLK Investment Management, LLC | 12,000 | $62.9K | 0.03% | +12,000 | New |
| Heritage Wealth Management, Inc./Texas | 10,000 | $52.4K | 0.04% | +10,000 | New |
| UBS Group AG | 4,800 | $25.2K | 0.00% | +4,782+26,566.7% | Added |
| Royal Bank of Canada | 3,286 | $17.0K | 0.00% | +15+0.5% | Added |
| Tower Research Capital LLC (TRC) | 2,362 | $12.4K | 0.00% | −4,400−65.1% | Reduced |
| Advisor Group Holdings, Inc. | 2,000 | $10.5K | 0.00% | +500+33.3% | Added |
| Comerica Bank | 1,159 | $6.07K | 0.00% | 00.0% | Unchanged |
| Simplex Trading, LLC | 1,169 | $6.00K | 0.00% | +1,085+1,291.7% | Added |
| Point72 Asia (Singapore) Pte. Ltd. | 653 | $3.42K | 0.00% | +653 | New |
| Rhumbline Advisers | 296 | $1.55K | 0.00% | 00.0% | Unchanged |
| Wells Fargo & Company | 247 | $1.29K | 0.00% | +26+11.8% | Added |
| Group One Trading, L.P. | 200 | $1.05K | 0.00% | 00.0% | Unchanged |
| Soleus Capital Management, L.P. | 0 | $0 | 0.00% | −592,417−100.0% | Sold out |
| Alyeska Investment Group, L.P. | 0 | $0 | 0.00% | −130,839−100.0% | Sold out |
| Prescott Group Capital Management, L.L.C. | 0 | $0 | 0.00% | −30,000−100.0% | Sold out |
| Virtu Financial LLC | 0 | $0 | 0.00% | −19,618−100.0% | Sold out |
| Ameliora Wealth Management Ltd. | 0 | $0 | 0.00% | −750−100.0% | Sold out |
| US Bancorp | 0 | $0 | 0.00% | −500−100.0% | Sold out |
| Signaturefd, LLC | 0 | $0 | 0.00% | −500−100.0% | Sold out |