Lyra Therapeutics, Inc.
LYRADelisted Apr 20, 2026- Industry
- Surgical & Medical Instruments & Apparatus
- SEC CIK
- 0001327273
Lyra Therapeutics, Inc. was delisted on Apr 20, 2026; its insiders filed their last Form 4 on May 15, 2026; 23 institutions reported holding it in 13F filings for Q4 2025, worth $747.3K in total; no superinvestor held it.
13F holders, Q4 2023
Institutional positions in Lyra Therapeutics, Inc. as of Dec 31, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 60
- +15 vs. Q3 2023
- Shares held
- 42.4M
- +10.4M (+32.7%) vs. Q3 2023
- Total value
- $222.0M
- +$97.1M (+77.8%) vs. Q3 2023
- New holders
- 22
- 22 more added
- Sold out
- 7
- 3 more reduced
Compare with Q3 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting LYRA on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 0 | $0 |
| Q1 2026 | 1 | $51.1K |
| Q4 2025 | 23 | $747.3K |
| Q3 2025 | 26 | $2.93M |
| Q2 2025 | 30 | $4.42M |
| Q1 2025 | 57 | $3.23M |
| Q4 2024 | 54 | $5.54M |
| Q3 2024 | 62 | $8.36M |
| Q2 2024 | 51 | $9.06M |
| Q1 2024 | 79 | $283.4M |
| Q4 2023 | 60 | $222.0M |
| Q3 2023 | 45 | $124.8M |
| Q2 2023 | 39 | $138.4M |
| Q1 2023 | 31 | $38.1M |
| Q4 2022 | 37 | $59.9M |
| Q3 2022 | 38 | $96.0M |
| Q2 2022 | 38 | $108.9M |
| Q1 2022 | 28 | $20.2M |
| Q4 2021 | 34 | $22.4M |
| Q3 2021 | 37 | $60.8M |
| Q2 2021 | 46 | $56.0M |
| Q1 2021 | 50 | $87.6M |
Institutions, Q4 2023
Shares, value and share of portfolio for each institution holding Lyra Therapeutics, Inc.; share changes are against Q3 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Group One Trading, L.P. | 200 | $1.05K | 0.00% | 00.0% | Unchanged |
| Wells Fargo & Company | 247 | $1.29K | 0.00% | +26+11.8% | Added |
| Rhumbline Advisers | 296 | $1.55K | 0.00% | 00.0% | Unchanged |
| Point72 Asia (Singapore) Pte. Ltd. | 653 | $3.42K | 0.00% | +653 | New |
| Simplex Trading, LLC | 1,169 | $6.00K | 0.00% | +1,085+1,291.7% | Added |
| Comerica Bank | 1,159 | $6.07K | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 2,000 | $10.5K | 0.00% | +500+33.3% | Added |
| Tower Research Capital LLC (TRC) | 2,362 | $12.4K | 0.00% | −4,400−65.1% | Reduced |
| Royal Bank of Canada | 3,286 | $17.0K | 0.00% | +15+0.5% | Added |
| UBS Group AG | 4,800 | $25.2K | 0.00% | +4,782+26,566.7% | Added |
| Heritage Wealth Management, Inc./Texas | 10,000 | $52.4K | 0.04% | +10,000 | New |
| DLK Investment Management, LLC | 12,000 | $62.9K | 0.03% | +12,000 | New |
| Y-Intercept (Hong Kong) Ltd | 12,279 | $64.3K | 0.01% | +12,279 | New |
| Two Sigma Securities, LLC | 12,765 | $66.9K | 0.00% | +12,765 | New |
| Goldman Sachs Group Inc | 13,063 | $68.5K | 0.00% | +13,063 | New |
| Walleye Capital LLC | 15,006 | $78.6K | 0.00% | +15,006 | New |
| Jump Financial, LLC | 16,737 | $87.7K | 0.00% | +16,737 | New |
| Bank of New York Mellon Corp | 18,621 | $97.6K | 0.00% | 00.0% | Unchanged |
| Balyasny Asset Management LLC | 28,795 | $150.9K | 0.00% | +28,795 | New |
| ExodusPoint Capital Management, LP | 29,045 | $152.0K | 0.00% | +29,045 | New |
| Cubist Systematic Strategies, LLC | 29,630 | $155.3K | 0.00% | +29,630 | New |
| Letko, Brosseau & Associates Inc | 31,900 | $167.2K | 0.00% | 00.0% | Unchanged |
| Barclays PLC | 32,817 | $172.0K | 0.00% | +32,817 | New |
| JPMorgan Chase & Co | 33,170 | $173.8K | 0.00% | +33,136+97,458.8% | Added |
| Man Group plc | 38,003 | $199.1K | 0.00% | +38,003 | New |
| Schonfeld Strategic Advisors LLC | 41,713 | $218.6K | 0.00% | +41,713 | New |
| Laurion Capital Management LP | 42,424 | $222.3K | 0.01% | +42,424 | New |
| Renaissance Technologies LLC | 43,900 | $230.0K | 0.00% | −5,900−11.8% | Reduced |
| Two Sigma Advisers, LP | 50,700 | $265.7K | 0.00% | +50,700 | New |
| Qube Research & Technologies Ltd | 55,449 | $290.6K | 0.00% | +52,167+1,589.5% | Added |
| Northern Trust Corp | 61,549 | $322.5K | 0.00% | +4,540+8.0% | Added |
| 683 Capital Management, LLC | 69,869 | $366.1K | 0.04% | +69,869 | New |
| Jane Street Group, LLC | 78,251 | $410.0K | 0.00% | +78,251 | New |
| State Street Corp | 109,180 | $572.1K | 0.00% | +14,100+14.8% | Added |
| BlackRock Inc. | 110,797 | $580.6K | 0.00% | +63,315+133.3% | Added |
| Dimensional Fund Advisors LP | 112,634 | $590.2K | 0.00% | +84,380+298.6% | Added |
| Clearline Capital LP | 119,128 | $624.2K | 0.07% | 00.0% | Unchanged |
| Citigroup Inc | 124,443 | $652.1K | 0.00% | +56,766+83.9% | Added |
| Two Sigma Investments, LP | 132,606 | $694.9K | 0.00% | +116,186+707.6% | Added |
| Bridgeway Capital Management, LLC | 141,800 | $743.0K | 0.02% | 00.0% | Unchanged |
| Bank of America Corp | 144,678 | $758.1K | 0.00% | +18,724+14.9% | Added |
| Boothbay Fund Management, LLC | 249,939 | $1.31M | 0.05% | +15,936+6.8% | Added |
| Susquehanna International Group, LLP | 259,416 | $1.36M | 0.00% | +96,556+59.3% | Added |
| Ensign Peak Advisors, Inc | 301,533 | $1.58M | 0.00% | 00.0% | Unchanged |
| Millennium Management LLC | 325,995 | $1.71M | 0.00% | +62,646+23.8% | Added |
| Geode Capital Management, LLC | 336,458 | $1.76M | 0.00% | +27,768+9.0% | Added |
| Woodline Partners LP | 599,975 | $3.14M | 0.03% | +599,975 | New |
| Parkman Healthcare Partners LLC | 754,885 | $3.96M | 0.56% | +129,829+20.8% | Added |
| Vanguard Group Inc | 1,071,460 | $5.61M | 0.00% | +207,128+24.0% | Added |
| Armistice Capital, LLC | 1,088,000 | $5.70M | 0.15% | −462,000−29.8% | Reduced |
| Ikarian Capital, LLC | 1,254,384 | $6.57M | 1.80% | 00.0% | Unchanged |
| Pura Vida Investments, LLC | 1,413,242 | $7.41M | 8.08% | 00.0% | Unchanged |
| Rosalind Advisors, Inc. | 1,888,720 | $9.90M | 8.28% | +1,888,720 | New |
| VR Adviser, LLC | 2,575,593 | $13.5M | 0.93% | +1,651,423+178.7% | Added |
| Samsara BioCapital, LLC | 2,780,261 | $14.6M | 2.27% | 00.0% | Unchanged |
| Citadel Advisors LLC | 2,861,255 | $15.0M | 0.02% | +12,691+0.4% | Added |
| Point72 Asset Management, L.P. | 3,000,000 | $15.7M | 0.05% | +3,000,000 | New |
| Vestal Point Capital, LP | 3,000,000 | $15.7M | 1.67% | +3,000,000 | New |
| Nantahala Capital Management, LLC | 4,050,218 | $21.2M | 2.12% | 00.0% | Unchanged |
| Perceptive Advisors LLC | 12,757,562 | $66.8M | 1.49% | 00.0% | Unchanged |
| Soleus Capital Management, L.P. | 0 | $0 | 0.00% | −592,417−100.0% | Sold out |
| Alyeska Investment Group, L.P. | 0 | $0 | 0.00% | −130,839−100.0% | Sold out |
| Prescott Group Capital Management, L.L.C. | 0 | $0 | 0.00% | −30,000−100.0% | Sold out |
| Virtu Financial LLC | 0 | $0 | 0.00% | −19,618−100.0% | Sold out |
| Ameliora Wealth Management Ltd. | 0 | $0 | 0.00% | −750−100.0% | Sold out |
| US Bancorp | 0 | $0 | 0.00% | −500−100.0% | Sold out |
| Signaturefd, LLC | 0 | $0 | 0.00% | −500−100.0% | Sold out |