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Lyra Therapeutics, Inc.

LYRADelisted Apr 20, 2026
Industry
Surgical & Medical Instruments & Apparatus
SEC CIK
0001327273

Lyra Therapeutics, Inc. was delisted on Apr 20, 2026; its insiders filed their last Form 4 on May 15, 2026; 23 institutions reported holding it in 13F filings for Q4 2025, worth $747.3K in total; no superinvestor held it.

13F holders, Q1 2025

Institutional positions in Lyra Therapeutics, Inc. as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
57
+3 vs. Q4 2024
Shares held
25.6M
−1.29M (−4.8%) vs. Q4 2024
Total value
$3.23M
−$2.32M (−41.8%) vs. Q4 2024
New holders
6
14 more added
Sold out
3
19 more reduced

Compare with Q4 2024: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting LYRA on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ1 2025: 57 institutions
Q1 2021: 50 institutionsQ2 2021: 46 institutionsQ3 2021: 37 institutionsQ4 2021: 34 institutionsQ1 2022: 28 institutionsQ2 2022: 38 institutionsQ3 2022: 38 institutionsQ4 2022: 37 institutionsQ1 2023: 31 institutionsQ2 2023: 39 institutionsQ3 2023: 45 institutionsQ4 2023: 60 institutionsQ1 2024: 79 institutionsQ2 2024: 51 institutionsQ3 2024: 62 institutionsQ4 2024: 54 institutionsQ1 2025: 57 institutionsQ2 2025: 30 institutionsQ3 2025: 26 institutionsQ4 2025: 23 institutionsQ1 2026: 1 institutionQ2 2026: 0 institutions
Value heldQ1 2025: $3.23M
Q1 2021: $87.6MQ2 2021: $56.0MQ3 2021: $60.8MQ4 2021: $22.4MQ1 2022: $20.2MQ2 2022: $108.9MQ3 2022: $96.0MQ4 2022: $59.9MQ1 2023: $38.1MQ2 2023: $138.4MQ3 2023: $124.8MQ4 2023: $222.0MQ1 2024: $283.4MQ2 2024: $9.06MQ3 2024: $8.36MQ4 2024: $5.54MQ1 2025: $3.23MQ2 2025: $4.42MQ3 2025: $2.93MQ4 2025: $747.3KQ1 2026: $51.1KQ2 2026: $0
Institutions holding LYRA and their total value by quarter
QuarterHoldersValue
Q2 20260$0
Q1 20261$51.1K
Q4 202523$747.3K
Q3 202526$2.93M
Q2 202530$4.42M
Q1 202557$3.23M
Q4 202454$5.54M
Q3 202462$8.36M
Q2 202451$9.06M
Q1 202479$283.4M
Q4 202360$222.0M
Q3 202345$124.8M
Q2 202339$138.4M
Q1 202331$38.1M
Q4 202237$59.9M
Q3 202238$96.0M
Q2 202238$108.9M
Q1 202228$20.2M
Q4 202134$22.4M
Q3 202137$60.8M
Q2 202146$56.0M
Q1 202150$87.6M

Institutions, Q1 2025

Shares, value and share of portfolio for each institution holding Lyra Therapeutics, Inc.; share changes are against Q4 2024.

Institutions holding LYRA in Q1 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Perceptive Advisors LLC12,757,562$1.61M0.06%00.0%Unchanged
BlackRock, Inc.3,018,986$381.3K0.00%−90,812−2.9%Reduced
Vanguard Group Inc1,765,585$222.5K0.00%−21,837−1.2%Reduced
Samsara BioCapital, LLC1,390,130$175.6K0.03%−575,559−29.3%Reduced
Ikarian Capital, LLC1,058,148$133.6K0.04%00.0%Unchanged
Geode Capital Management, LLC1,016,004$128.3K0.00%+130,038+14.7%Added
ADAR1 Capital Management, LLC533,200$67.3K0.01%00.0%Unchanged
State Street Corp488,720$61.7K0.00%00.0%Unchanged
UBS Group AG434,226$54.7K0.00%+9,261+2.2%Added
Goldman Sachs Group Inc370,194$46.8K0.00%−185,314−33.4%Reduced
Two Sigma Advisers, LP364,478$46.0K0.00%−21,022−5.5%Reduced
Northern Trust Corp332,639$42.0K0.00%+46,329+16.2%Added
BNP Paribas Arbitrage, SA242,546$30.6K0.00%−2,374−1.0%Reduced
Boothbay Fund Management, LLC233,989$29.6K0.00%00.0%Unchanged
Susquehanna International Group, LLP217,567$27.5K0.00%+114,137+110.4%Added
Two Sigma Investments, LP193,145$24.4K0.00%−16,852−8.0%Reduced
New York State Common Retirement Fund154,800$19.6K0.00%00.0%Unchanged
Charles Schwab Investment Management Inc111,609$14.1K0.00%00.0%Unchanged
Rhumbline Advisers87,710$11.0K0.00%+46,452+112.6%Added
Bank of New York Mellon Corp71,585$9.04K0.00%−4,381−5.8%Reduced
Morgan Stanley65,619$8.29K0.00%−150,866−69.7%Reduced
FMR LLC58,213$7.35K0.00%−41,578−41.7%Reduced
AQR Capital Management LLC58,041$7.33K0.00%+29,328+102.1%Added
JPMorgan Chase & Co56,277$7.11K0.00%−100,165−64.0%Reduced
Tower Research Capital LLC (TRC)52,736$6.66K0.00%+12,951+32.6%Added
Barclays PLC50,038$6.32K0.00%−25,216−33.5%Reduced
Jane Street Group, LLC43,997$5.56K0.00%+43,997New
Citigroup Inc35,177$4.44K0.00%−2,925−7.7%Reduced
Alliancebernstein L.P.33,120$4.18K0.00%00.0%Unchanged
SEI Investments Co30,067$3.83K0.00%−54,008−64.2%Reduced
Mirae Asset Global ETFs Holdings Ltd.29,018$3.67K0.00%+1,248+4.5%Added
Wells Fargo & Company25,305$3.20K0.00%+561+2.3%Added
Price T Rowe Associates Inc17,541$3.00K0.00%00.0%Unchanged
Corebridge Financial, Inc.23,709$2.99K0.00%−352−1.5%Reduced
Invesco Ltd.23,626$2.98K0.00%00.0%Unchanged
Bank of America Corp21,352$2.69K0.00%−31,312−59.5%Reduced
Intech Investment Management LLC16,560$2.09K0.00%+16,560New
SG Americas Securities, LLC14,620$2.00K0.00%−17,287−54.2%Reduced
Squarepoint Ops LLC15,283$1.93K0.00%+15,283New
Abel Hall, LLC12,214$1.54K0.00%−5,433−30.8%Reduced
CIBC World Markets Corp10,739$1.36K0.00%+10,739New
ProShare Advisors LLC10,477$1.32K0.00%−3,154−23.1%Reduced
Sassicaia Capital Advisers LLC10,000$1.26K0.00%+10,000New
Royal Bank of Canada8,019$1.00K0.00%+2,725+51.5%Added
CWM, LLC6,677$1.00K0.00%+1,306+24.3%Added
Northwestern Mutual Wealth Management Co6,000$7580.00%+6,000New
Ameritas Investment Partners, Inc.4,741$5990.00%00.0%Unchanged
SBI Securities Co., Ltd.4,272$5400.00%+3+0.1%Added
California State Teachers Retirement System3,507$4430.00%00.0%Unchanged
Comerica Bank1,159$1460.00%00.0%Unchanged
Bryn Mawr Trust Co1,025$1290.00%00.0%Unchanged
Jones Financial Companies LLLP500$690.00%00.0%Unchanged
Nisa Investment Advisors, LLC500$630.00%00.0%Unchanged
EverSource Wealth Advisors, LLC343$430.00%+224+188.2%Added
Sterling Capital Management LLC88$110.00%00.0%Unchanged
Amalgamated Bank1,674$00.00%00.0%Unchanged
Simplex Trading, LLC1,317$00.00%+954+262.8%Added
Qube Research & Technologies Ltd0$00.00%−342,159−100.0%Sold out
Bank of Montreal0$00.00%−54,130−100.0%Sold out
Virtu Financial LLC0$00.00%−42,069−100.0%Sold out