Lyra Therapeutics, Inc.
LYRADelisted Apr 20, 2026- Industry
- Surgical & Medical Instruments & Apparatus
- SEC CIK
- 0001327273
Lyra Therapeutics, Inc. was delisted on Apr 20, 2026; its insiders filed their last Form 4 on May 15, 2026; 23 institutions reported holding it in 13F filings for Q4 2025, worth $747.3K in total; no superinvestor held it.
13F holders, Q1 2024
Institutional positions in Lyra Therapeutics, Inc. as of Mar 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 79
- +19 vs. Q4 2023
- Shares held
- 45.6M
- +3.21M (+7.6%) vs. Q4 2023
- Total value
- $283.4M
- +$61.4M (+27.7%) vs. Q4 2023
- New holders
- 25
- 30 more added
- Sold out
- 6
- 13 more reduced
Compare with Q4 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting LYRA on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 0 | $0 |
| Q1 2026 | 1 | $51.1K |
| Q4 2025 | 23 | $747.3K |
| Q3 2025 | 26 | $2.93M |
| Q2 2025 | 30 | $4.42M |
| Q1 2025 | 57 | $3.23M |
| Q4 2024 | 54 | $5.54M |
| Q3 2024 | 62 | $8.36M |
| Q2 2024 | 51 | $9.06M |
| Q1 2024 | 79 | $283.4M |
| Q4 2023 | 60 | $222.0M |
| Q3 2023 | 45 | $124.8M |
| Q2 2023 | 39 | $138.4M |
| Q1 2023 | 31 | $38.1M |
| Q4 2022 | 37 | $59.9M |
| Q3 2022 | 38 | $96.0M |
| Q2 2022 | 38 | $108.9M |
| Q1 2022 | 28 | $20.2M |
| Q4 2021 | 34 | $22.4M |
| Q3 2021 | 37 | $60.8M |
| Q2 2021 | 46 | $56.0M |
| Q1 2021 | 50 | $87.6M |
Institutions, Q1 2024
Shares, value and share of portfolio for each institution holding Lyra Therapeutics, Inc.; share changes are against Q4 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Macquarie Group Ltd | 1,375 | $9 | 0.00% | +1,375 | New |
| UBS Group AG | 18 | $112 | 0.00% | −4,782−99.6% | Reduced |
| Northwestern Mutual Wealth Management Co | 100 | $622 | 0.00% | +100 | New |
| National Bank of Canada | 3,700 | $1.39K | 0.00% | +3,700 | New |
| Wells Fargo & Company | 251 | $1.56K | 0.00% | +4+1.6% | Added |
| Rhumbline Advisers | 296 | $1.84K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 654 | $4.00K | 0.00% | −2,632−80.1% | Reduced |
| Comerica Bank | 1,159 | $7.21K | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 2,000 | $12.4K | 0.00% | 00.0% | Unchanged |
| Point72 Asia (Singapore) Pte. Ltd. | 5,710 | $35.5K | 0.01% | +5,057+774.4% | Added |
| Catalyst Funds Management Pty Ltd | 8,200 | $51.0K | 0.01% | +8,200 | New |
| Tower Research Capital LLC (TRC) | 8,921 | $55.5K | 0.00% | +6,559+277.7% | Added |
| Heritage Wealth Management, Inc./Texas | 10,000 | $62.2K | 0.04% | 00.0% | Unchanged |
| Engineers Gate Manager LP | 10,718 | $66.7K | 0.00% | +10,718 | New |
| Jefferies Financial Group Inc. | 11,400 | $70.9K | 0.00% | +11,400 | New |
| Squarepoint Ops LLC | 11,670 | $72.6K | 0.00% | +11,670 | New |
| Virtu Financial LLC | 11,928 | $74.0K | 0.01% | +11,928 | New |
| DLK Investment Management, LLC | 12,000 | $74.6K | 0.03% | 00.0% | Unchanged |
| Bank of Montreal | 13,900 | $82.3K | 0.00% | +13,900 | New |
| Brevan Howard Capital Management LP | 14,042 | $87.3K | 0.01% | +14,042 | New |
| Prelude Capital Management, LLC | 15,400 | $95.8K | 0.01% | +15,400 | New |
| Jump Financial, LLC | 20,187 | $125.6K | 0.00% | +3,450+20.6% | Added |
| Y-Intercept (Hong Kong) Ltd | 20,531 | $127.7K | 0.01% | +8,252+67.2% | Added |
| Cubist Systematic Strategies, LLC | 21,160 | $131.6K | 0.00% | −8,470−28.6% | Reduced |
| Omers Administration Corp | 22,200 | $138.1K | 0.00% | +22,200 | New |
| Occudo Quantitative Strategies LP | 22,820 | $141.9K | 0.02% | +22,820 | New |
| American Century Companies Inc | 25,778 | $160.3K | 0.00% | +25,778 | New |
| Balyasny Asset Management LLC | 31,459 | $195.7K | 0.00% | +2,664+9.3% | Added |
| Letko, Brosseau & Associates Inc | 31,900 | $198.4K | 0.00% | 00.0% | Unchanged |
| ExodusPoint Capital Management, LP | 32,118 | $200.0K | 0.00% | +3,073+10.6% | Added |
| Barclays PLC | 32,817 | $204.1K | 0.00% | 00.0% | Unchanged |
| Cambridge Investment Research Advisors, Inc. | 41,563 | $259.0K | 0.00% | +41,563 | New |
| Renaissance Technologies LLC | 50,900 | $317.0K | 0.00% | +7,000+15.9% | Added |
| Northern Trust Corp | 60,495 | $376.3K | 0.00% | −1,054−1.7% | Reduced |
| Morgan Stanley | 64,392 | $400.5K | 0.00% | +64,392 | New |
| Marathon Trading Investment Management LLC | 67,010 | $416.8K | 0.17% | +67,010 | New |
| Bridgeway Capital Management, LLC | 86,800 | $539.9K | 0.01% | −55,000−38.8% | Reduced |
| Man Group plc | 90,283 | $561.6K | 0.00% | +52,280+137.6% | Added |
| HRT Financial LP | 98,525 | $612.0K | 0.00% | +98,525 | New |
| JPMorgan Chase & Co | 109,405 | $680.5K | 0.00% | +76,235+229.8% | Added |
| Citigroup Inc | 118,875 | $739.4K | 0.00% | −5,568−4.5% | Reduced |
| Clearline Capital LP | 119,128 | $741.0K | 0.07% | 00.0% | Unchanged |
| State Street Corp | 126,180 | $784.8K | 0.00% | +17,000+15.6% | Added |
| Qube Research & Technologies Ltd | 131,902 | $820.4K | 0.00% | +76,453+137.9% | Added |
| Two Sigma Advisers, LP | 143,900 | $895.1K | 0.00% | +93,200+183.8% | Added |
| Superstring Capital Management LP | 145,284 | $903.7K | 0.60% | +145,284 | New |
| BlackRock Inc. | 151,919 | $944.9K | 0.00% | +41,122+37.1% | Added |
| Jane Street Group, LLC | 157,703 | $980.9K | 0.00% | +79,452+101.5% | Added |
| Bank of America Corp | 159,597 | $992.7K | 0.00% | +14,919+10.3% | Added |
| Acuta Capital Partners, LLC | 173,320 | $1.08M | 0.70% | +173,320 | New |
| Two Sigma Investments, LP | 183,743 | $1.14M | 0.00% | +51,137+38.6% | Added |
| Dimensional Fund Advisors LP | 190,986 | $1.19M | 0.00% | +78,352+69.6% | Added |
| Boothbay Fund Management, LLC | 232,670 | $1.45M | 0.04% | −17,269−6.9% | Reduced |
| Hudson Bay Capital Management LP | 250,000 | $1.55M | 0.01% | +250,000 | New |
| Goldman Sachs Group Inc | 334,665 | $2.08M | 0.00% | +321,602+2,461.9% | Added |
| Susquehanna International Group, LLP | 343,322 | $2.14M | 0.00% | +83,906+32.3% | Added |
| Schonfeld Strategic Advisors LLC | 357,319 | $2.22M | 0.02% | +315,606+756.6% | Added |
| Geode Capital Management, LLC | 359,431 | $2.24M | 0.00% | +22,973+6.8% | Added |
| Millennium Management LLC | 406,121 | $2.53M | 0.00% | +80,126+24.6% | Added |
| Walleye Capital LLC | 528,118 | $3.28M | 0.04% | +513,112+3,419.4% | Added |
| Invesco Ltd. | 555,233 | $3.45M | 0.00% | +555,233 | New |
| Ensign Peak Advisors, Inc | 591,311 | $3.68M | 0.01% | +289,778+96.1% | Added |
| Parkman Healthcare Partners LLC | 642,245 | $3.99M | 0.49% | −112,640−14.9% | Reduced |
| Woodline Partners LP | 676,554 | $4.21M | 0.04% | +76,579+12.8% | Added |
| Laurion Capital Management LP | 747,827 | $4.65M | 0.13% | +705,403+1,662.7% | Added |
| Verition Fund Management LLC | 768,214 | $4.78M | 0.05% | +768,214 | New |
| Vestal Point Capital, LP | 800,000 | $4.98M | 0.41% | −2,200,000−73.3% | Reduced |
| Tri Locum Partners LP | 978,793 | $6.09M | 2.11% | +978,793 | New |
| Ally Bridge Group (NY) LLC | 1,003,741 | $6.24M | 3.47% | +1,003,741 | New |
| Ikarian Capital, LLC | 1,056,829 | $6.57M | 1.79% | −197,555−15.7% | Reduced |
| Rosalind Advisors, Inc. | 1,144,524 | $7.12M | 6.66% | −744,196−39.4% | Reduced |
| Pura Vida Investments, LLC | 1,413,242 | $8.79M | 5.98% | 00.0% | Unchanged |
| Vanguard Group Inc | 1,481,481 | $9.21M | 0.00% | +410,021+38.3% | Added |
| VR Adviser, LLC | 2,576,093 | $16.0M | 0.76% | +5000.0% | Added |
| Point72 Asset Management, L.P. | 2,742,460 | $17.1M | 0.05% | −257,540−8.6% | Reduced |
| Samsara BioCapital, LLC | 2,780,261 | $17.3M | 2.68% | 00.0% | Unchanged |
| Nantahala Capital Management, LLC | 2,820,982 | $17.5M | 1.72% | −1,229,236−30.3% | Reduced |
| Citadel Advisors LLC | 4,339,101 | $27.0M | 0.03% | +1,477,846+51.7% | Added |
| Perceptive Advisors LLC | 12,757,562 | $79.4M | 1.40% | 00.0% | Unchanged |
| Armistice Capital, LLC | 0 | $0 | 0.00% | −1,088,000−100.0% | Sold out |
| 683 Capital Management, LLC | 0 | $0 | 0.00% | −69,869−100.0% | Sold out |
| Bank of New York Mellon Corp | 0 | $0 | 0.00% | −18,621−100.0% | Sold out |
| Two Sigma Securities, LLC | 0 | $0 | 0.00% | −12,765−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −1,169−100.0% | Sold out |
| Group One Trading, L.P. | 0 | $0 | 0.00% | −200−100.0% | Sold out |