Lexicon Pharmaceuticals, Inc.
LXRX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001062822
No open-market purchases or sales by Lexicon Pharmaceuticals, Inc. insiders were filed in the last 90 days; 149 institutions reported holding it in 13F filings for Q2 2026, worth $875.1M in total; no superinvestor holds it.
13F holders, Q1 2026
Institutional positions in Lexicon Pharmaceuticals, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 137
- +16 vs. Q4 2025
- Shares held
- 323.4M
- +74.5M (+29.9%) vs. Q4 2025
- Total value
- $504.5M
- +$218.3M (+76.3%) vs. Q4 2025
- New holders
- 31
- 41 more added
- Sold out
- 15
- 26 more reduced
5 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting LXRX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 149 | $875.1M |
| Q1 2026 | 137 | $504.5M |
| Q4 2025 | 126 | $299.5M |
| Q3 2025 | 124 | $344.4M |
| Q2 2025 | 123 | $242.9M |
| Q1 2025 | 127 | $122.5M |
| Q4 2024 | 127 | $220.1M |
| Q3 2024 | 137 | $453.1M |
| Q2 2024 | 127 | $471.0M |
| Q1 2024 | 118 | $417.8M |
| Q4 2023 | 106 | $279.8M |
| Q3 2023 | 112 | $205.8M |
| Q2 2023 | 123 | $438.2M |
| Q1 2023 | 104 | $353.8M |
| Q4 2022 | 105 | $280.5M |
| Q3 2022 | 98 | $357.3M |
| Q2 2022 | 86 | $221.0M |
| Q1 2022 | 101 | $251.3M |
| Q4 2021 | 110 | $478.9M |
| Q3 2021 | 96 | $583.0M |
| Q2 2021 | 107 | $540.2M |
| Q1 2021 | 107 | $711.5M |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Lexicon Pharmaceuticals, Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Artal Group S.A. | 154,734,327 | $241.4M | 23.89% | +18,553,846+13.6% | Added |
| FMR LLC | 45,056,338 | $70.3M | 0.00% | +7,222,131+19.1% | Added |
| Siren, L.L.C. | 44,303,518 | $69.1M | 1.92% | +5,384,615+13.8% | Added |
| Sessa Capital IM, L.P. | 17,912,961 | $27.9M | 0.53% | +14,912,961+497.1% | Added |
| Vanguard Capital Management LLC | 9,519,167 | $14.8M | 0.00% | +9,519,167 | New |
| Point72 Asset Management, L.P. | 7,814,606 | $12.2M | 0.02% | +7,530,581+2,651.4% | Added |
| Millennium Management LLC | 4,944,731 | $7.71M | 0.01% | +122,998+2.6% | Added |
| BlackRock, Inc. | 3,322,219 | $5.18M | 0.00% | +129,771+4.1% | Added |
| Geode Capital Management, LLC | 3,169,111 | $4.95M | 0.00% | +669,089+26.8% | Added |
| Jane Street Group, LLC | 2,665,938 | $4.16M | 0.00% | +941,634+54.6% | Added |
| UBS Group AG | 2,483,182 | $3.87M | 0.00% | −524,055−17.4% | Reduced |
| Marshall Wace, LLP | 2,376,304 | $3.71M | 0.00% | +1,113,937+88.2% | Added |
| Susquehanna International Group, LLP | 2,121,164 | $3.31M | 0.00% | +913,922+75.7% | Added |
| CIBC Bancorp USA Inc. | 1,800,000 | $2.81M | 0.00% | +1,800,000 | New |
| Renaissance Technologies LLC | 1,600,500 | $2.50M | 0.00% | +1,337,246+508.0% | Added |
| Vanguard Fiduciary Trust Co | 1,332,284 | $2.08M | 0.00% | +1,332,284 | New |
| Charles Schwab Investment Management Inc | 1,311,298 | $2.05M | 0.00% | +256,175+24.3% | Added |
| Two Sigma Investments, LP | 1,199,632 | $1.87M | 0.00% | +562,324+88.2% | Added |
| Citadel Advisors LLC | 1,094,901 | $1.71M | 0.00% | −616,074−36.0% | Reduced |
| Goldman Sachs Group Inc | 1,070,517 | $1.67M | 0.00% | +149,313+16.2% | Added |
| State Street Corp | 964,038 | $1.50M | 0.00% | +79,300+9.0% | Added |
| Gsa Capital Partners LLP | 930,089 | $1.45M | 0.09% | −66,146−6.6% | Reduced |
| Ishara Investments LP | 902,000 | $1.41M | 1.42% | +22,000+2.5% | Added |
| Hennion & Walsh Asset Management, Inc. | 848,138 | $1.32M | 0.04% | −53,084−5.9% | Reduced |
| Mackenzie Financial Corp | 772,677 | $1.21M | 0.00% | +772,677 | New |
| ADAR1 Capital Management, LLC | 750,000 | $1.17M | 0.07% | +750,000 | New |
| Vanguard Portfolio Management LLC | 546,600 | $852.7K | 0.00% | +546,600 | New |
| Bank of America Corp | 526,103 | $820.7K | 0.00% | +424,006+415.3% | Added |
| Invesco Ltd. | 512,426 | $799.4K | 0.00% | −82,457−13.9% | Reduced |
| Compagnie Lombard Odier SCmA | 510,000 | $795.6K | 0.01% | +100,000+24.4% | Added |
| Northern Trust Corp | 494,666 | $771.7K | 0.00% | +82,502+20.0% | Added |
| Acadian Asset Management LLC | 445,288 | $693.0K | 0.00% | −194,842−30.4% | Reduced |
| Tang Capital Management LLC | 399,700 | $623.5K | 0.03% | +399,700 | New |
| XTX Topco Ltd | 314,614 | $490.8K | 0.01% | +218,524+227.4% | Added |
| Morgan Stanley | 219,862 | $343.0K | 0.00% | +26,827+13.9% | Added |
| Catalyst Funds Management Pty Ltd | 207,900 | $324.3K | 0.05% | +167,600+415.9% | Added |
| Headlands Technologies LLC | 191,322 | $298.5K | 0.03% | +55,209+40.6% | Added |
| Group One Trading, L.P. | 185,006 | $288.6K | 0.01% | −39,302−17.5% | Reduced |
| Citigroup Inc | 166,398 | $259.6K | 0.00% | +74,728+81.5% | Added |
| Ikarian Capital, LLC | 164,674 | $256.9K | 0.04% | 00.0% | Unchanged |
| Brevan Howard Capital Management LP | 160,499 | $250.4K | 0.00% | +160,499 | New |
| Scotia Capital Inc. | 159,831 | $249.3K | 0.00% | +159,831 | New |
| Jain Global LLC | 154,800 | $241.5K | 0.00% | +154,800 | New |
| Hudson Bay Capital Management LP | 152,616 | $238.1K | 0.00% | +52,084+51.8% | Added |
| Jacobs Levy Equity Management, Inc | 130,020 | $202.8K | 0.00% | +130,020 | New |
| Bridgewater Advisors Inc. | 82,209 | $200.6K | 0.01% | +82,209 | New |
| HRT Financial LP | 122,780 | $191.0K | 0.00% | +5,231+4.5% | Added |
| Cerity Partners LLC | 110,458 | $172.3K | 0.00% | −34,486−23.8% | Reduced |
| Quadrature Capital Ltd | 110,379 | $172.2K | 0.00% | +91,965+499.4% | Added |
| Quarry LP | 110,000 | $171.6K | 0.03% | +22,000+25.0% | Added |
| Man Group plc | 108,806 | $169.7K | 0.00% | +108,806 | New |
| Omers Administration Corp | 106,800 | $166.6K | 0.00% | −167,000−61.0% | Reduced |
| Barclays PLC | 105,487 | $164.6K | 0.00% | −89,256−45.8% | Reduced |
| AQR Capital Management LLC | 96,234 | $150.1K | 0.00% | −48,566−33.5% | Reduced |
| Vanguard Global Advisers, LLC | 93,641 | $146.1K | 0.00% | +93,641 | New |
| Schonfeld Strategic Advisors LLC | 75,110 | $117.2K | 0.00% | +62,002+473.0% | Added |
| Bank of Nova Scotia | 73,707 | $115.0K | 0.00% | +73,707 | New |
| Bank of Montreal | 70,000 | $109.2K | 0.00% | 00.0% | Unchanged |
| LPL Financial LLC | 69,783 | $108.9K | 0.00% | −17,274−19.8% | Reduced |
| Jefferies Financial Group Inc. | 68,734 | $107.2K | 0.00% | −23,796−25.7% | Reduced |
| Diametric Capital, LP | 67,841 | $105.8K | 0.03% | +67,841 | New |
| R Squared Ltd | 67,526 | $105.3K | 0.06% | +20,947+45.0% | Added |
| Straight Path Wealth Management | 62,666 | $97.8K | 0.03% | 00.0% | Unchanged |
| JustInvest LLC | 54,965 | $85.7K | 0.00% | −11,602−17.4% | Reduced |
| Fortis Group Advisors, LLC | 50,000 | $80.5K | 0.01% | 00.0% | Unchanged |
| EntryPoint Capital, LLC | 48,498 | $75.7K | 0.02% | +14,880+44.3% | Added |
| Boothbay Fund Management, LLC | 44,315 | $69.1K | 0.00% | 00.0% | Unchanged |
| Wedbush Securities Inc | 40,850 | $64.0K | 0.00% | 00.0% | Unchanged |
| Jump Financial, LLC | 40,246 | $62.8K | 0.00% | +40,246 | New |
| CIBC Asset Management Inc | 39,520 | $61.7K | 0.00% | 00.0% | Unchanged |
| ExodusPoint Capital Management, LP | 37,430 | $58.4K | 0.00% | −231,003−86.1% | Reduced |
| University of Texas/Texas Am Investment Managment Co | 35,714 | $55.7K | 0.01% | 00.0% | Unchanged |
| Graham Capital Management, L.P. | 34,027 | $53.1K | 0.00% | −75,873−69.0% | Reduced |
| Prudential Financial Inc | 33,800 | $52.7K | 0.00% | 00.0% | Unchanged |
| Leonteq Securities AG | 30,000 | $46.8K | 0.00% | 00.0% | Unchanged |
| KWB Wealth | 40,640 | $46.7K | 0.00% | 00.0% | Unchanged |
| Pathstone Holdings, LLC | 29,774 | $46.4K | 0.00% | −195−0.7% | Reduced |
| Pinnacle Associates Ltd | 29,015 | $45.3K | 0.00% | 00.0% | Unchanged |
| Bank of New York Mellon Corp | 27,459 | $42.8K | 0.00% | +8,335+43.6% | Added |
| Security National Bank of Sioux City Iowa | 26,650 | $41.6K | 0.02% | 00.0% | Unchanged |
| Winton Group Ltd | 25,500 | $39.8K | 0.00% | +25,500 | New |
| Oppenheimer & Co Inc | 23,500 | $36.7K | 0.00% | 00.0% | Unchanged |
| LMR Partners LLP | 23,305 | $36.4K | 0.00% | +23,305 | New |
| Victory Capital Management Inc | 22,679 | $35.4K | 0.00% | +1,488+7.0% | Added |
| Cambridge Investment Research Advisors, Inc. | 21,505 | $34.0K | 0.00% | 00.0% | Unchanged |
| Axq Capital, LP | 20,150 | $31.4K | 0.00% | +20,150 | New |
| Invera Wealth Advisors, LLC | 20,000 | $31.2K | 0.02% | 00.0% | Unchanged |
| Tiaa-Cref Individual & Institutional Services, LLC | 20,000 | $31.2K | 0.00% | +20,000 | New |
| Diker Management LLC | 20,000 | $31.2K | 0.03% | +20,000 | New |
| Credit Agricole S A | 18,975 | $29.6K | 0.00% | 00.0% | Unchanged |
| Quantessence Capital LLC | 18,581 | $29.0K | 0.14% | +18,581 | New |
| BNP Paribas Arbitrage, SA | 17,550 | $27.4K | 0.00% | +17,539+159,445.5% | Added |
| CTC Alternative Strategies, Ltd. | 17,544 | $27.4K | 0.06% | +17,544 | New |
| Prelude Capital Management, LLC | 17,173 | $26.8K | 0.00% | +17,173 | New |
| Captrust Financial Advisors | 15,450 | $24.1K | 0.00% | +3,715+31.7% | Added |
| HBK Sorce Advisory LLC | 11,786 | $23.6K | 0.00% | 00.0% | Unchanged |
| Callan Family Office, LLC | 14,090 | $22.0K | 0.00% | 00.0% | Unchanged |
| Truist Financial Corp | 14,000 | $21.8K | 0.00% | 00.0% | Unchanged |
| Cetera Investment Advisers | 12,633 | $19.7K | 0.00% | −1,555−11.0% | Reduced |
| Wealth Enhancement Advisory Services, LLC | 12,388 | $19.7K | 0.00% | −1,132−8.4% | Reduced |