Lexicon Pharmaceuticals, Inc.
LXRX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001062822
No open-market purchases or sales by Lexicon Pharmaceuticals, Inc. insiders were filed in the last 90 days; 149 institutions reported holding it in 13F filings for Q2 2026, worth $875.1M in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Lexicon Pharmaceuticals, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 124
- +2 vs. Q2 2025
- Shares held
- 255.1M
- −1.13M (−0.4%) vs. Q2 2025
- Total value
- $344.4M
- +$101.5M (+41.8%) vs. Q2 2025
- New holders
- 19
- 26 more added
- Sold out
- 17
- 42 more reduced
1 institution that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting LXRX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 149 | $875.1M |
| Q1 2026 | 137 | $504.5M |
| Q4 2025 | 126 | $299.5M |
| Q3 2025 | 124 | $344.4M |
| Q2 2025 | 123 | $242.9M |
| Q1 2025 | 127 | $122.5M |
| Q4 2024 | 127 | $220.1M |
| Q3 2024 | 137 | $453.1M |
| Q2 2024 | 127 | $471.0M |
| Q1 2024 | 118 | $417.8M |
| Q4 2023 | 106 | $279.8M |
| Q3 2023 | 112 | $205.8M |
| Q2 2023 | 123 | $438.2M |
| Q1 2023 | 104 | $353.8M |
| Q4 2022 | 105 | $280.5M |
| Q3 2022 | 98 | $357.3M |
| Q2 2022 | 86 | $221.0M |
| Q1 2022 | 101 | $251.3M |
| Q4 2021 | 110 | $478.9M |
| Q3 2021 | 96 | $583.0M |
| Q2 2021 | 107 | $540.2M |
| Q1 2021 | 107 | $711.5M |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Lexicon Pharmaceuticals, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Artal Group S.A. | 136,180,481 | $183.8M | 24.25% | 00.0% | Unchanged |
| Siren, L.L.C. | 38,918,903 | $52.5M | 2.06% | 00.0% | Unchanged |
| FMR LLC | 38,679,748 | $52.2M | 0.00% | +542,213+1.4% | Added |
| Vanguard Group Inc | 9,521,874 | $12.9M | 0.00% | +670,838+7.6% | Added |
| Millennium Management LLC | 3,830,660 | $5.17M | 0.00% | +2,187,396+133.1% | Added |
| BlackRock, Inc. | 3,394,972 | $4.58M | 0.00% | +40,303+1.2% | Added |
| Sessa Capital IM, L.P. | 3,000,000 | $4.05M | 0.10% | 00.0% | Unchanged |
| Citadel Advisors LLC | 2,634,027 | $3.56M | 0.00% | +2,634,027 | New |
| CIBC Private Wealth Group, LLC | 2,400,257 | $3.24M | 0.01% | −50,143−2.0% | Reduced |
| Geode Capital Management, LLC | 2,397,923 | $3.24M | 0.00% | +20,229+0.9% | Added |
| Gsa Capital Partners LLP | 1,202,906 | $1.62M | 0.14% | −1,627,753−57.5% | Reduced |
| Charles Schwab Investment Management Inc | 1,144,632 | $1.55M | 0.00% | +261,405+29.6% | Added |
| Susquehanna International Group, LLP | 962,060 | $1.30M | 0.00% | +206,408+27.3% | Added |
| State Street Corp | 880,121 | $1.19M | 0.00% | +61,500+7.5% | Added |
| Schonfeld Strategic Advisors LLC | 825,633 | $1.11M | 0.01% | −3,750,519−82.0% | Reduced |
| Hennion & Walsh Asset Management, Inc. | 779,212 | $1.05M | 0.04% | −14,188−1.8% | Reduced |
| Royal Bank of Canada | 722,435 | $975.0K | 0.00% | −52,039−6.7% | Reduced |
| Jacobs Levy Equity Management, Inc | 692,727 | $935.2K | 0.00% | +692,727 | New |
| Two Sigma Investments, LP | 559,008 | $754.7K | 0.00% | +155,086+38.4% | Added |
| Invesco Ltd. | 521,403 | $703.9K | 0.00% | +100,703+23.9% | Added |
| Jane Street Group, LLC | 456,530 | $616.3K | 0.00% | −348,137−43.3% | Reduced |
| Compagnie Lombard Odier SCmA | 410,000 | $553.5K | 0.01% | +80,000+24.2% | Added |
| Northern Trust Corp | 369,794 | $499.2K | 0.00% | −46,578−11.2% | Reduced |
| UBS Group AG | 352,922 | $476.4K | 0.00% | −47,810−11.9% | Reduced |
| Monaco Asset Management SAM | 350,000 | $472.5K | 0.18% | −181,600−34.2% | Reduced |
| XTX Topco Ltd | 329,536 | $444.9K | 0.02% | +263,260+397.2% | Added |
| AQR Capital Management LLC | 302,931 | $409.0K | 0.00% | −1,099,279−78.4% | Reduced |
| Renaissance Technologies LLC | 292,400 | $394.7K | 0.00% | +292,400 | New |
| Quadrature Capital Ltd | 228,209 | $309.2K | 0.00% | +228,209 | New |
| Group One Trading, L.P. | 216,244 | $291.9K | 0.01% | −130,508−37.6% | Reduced |
| Ikarian Capital, LLC | 176,479 | $238.2K | 0.05% | 00.0% | Unchanged |
| Morgan Stanley | 169,018 | $228.2K | 0.00% | +37,625+28.6% | Added |
| Cerity Partners LLC | 158,040 | $213.4K | 0.00% | −48,239−23.4% | Reduced |
| Jefferies Financial Group Inc. | 97,400 | $131.5K | 0.00% | +97,400 | New |
| LPL Financial LLC | 91,258 | $123.2K | 0.00% | −13,175−12.6% | Reduced |
| Optiver Holding B.V. | 75,893 | $102.5K | 0.00% | +72,858+2,400.6% | Added |
| Simplex Trading, LLC | 73,287 | $98.0K | 0.00% | +20,607+39.1% | Added |
| Bank of Montreal | 70,000 | $94.5K | 0.00% | −30,000−30.0% | Reduced |
| JustInvest LLC | 66,567 | $89.9K | 0.00% | +1,237+1.9% | Added |
| China Universal Asset Management Co., Ltd. | 63,698 | $86.0K | 0.01% | −9,245−12.7% | Reduced |
| Cubist Systematic Strategies, LLC | 63,484 | $85.7K | 0.00% | −94,720−59.9% | Reduced |
| Straight Path Wealth Management | 62,666 | $84.6K | 0.02% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 59,347 | $80.1K | 0.00% | −266,399−81.8% | Reduced |
| Fortis Group Advisors, LLC | 57,800 | $79.8K | 0.01% | 00.0% | Unchanged |
| Squarepoint Ops LLC | 58,676 | $79.2K | 0.00% | −36,941−38.6% | Reduced |
| Bank of America Corp | 57,804 | $78.0K | 0.00% | +25,707+80.1% | Added |
| Boothbay Fund Management, LLC | 56,120 | $75.8K | 0.00% | 00.0% | Unchanged |
| Pinnacle Associates Ltd | 50,815 | $68.6K | 0.00% | 00.0% | Unchanged |
| Headlands Technologies LLC | 49,647 | $67.0K | 0.01% | +49,647 | New |
| HRT Financial LP | 46,447 | $62.0K | 0.00% | −442,021−90.5% | Reduced |
| Wedbush Securities Inc | 40,850 | $55.0K | 0.00% | 00.0% | Unchanged |
| Catalyst Funds Management Pty Ltd | 40,300 | $54.4K | 0.01% | −13,400−25.0% | Reduced |
| Acadian Asset Management LLC | 36,905 | $49.0K | 0.00% | +36,905 | New |
| University of Texas/Texas Am Investment Managment Co | 35,714 | $48.2K | 0.01% | 00.0% | Unchanged |
| Commonwealth Equity Services, LLC | 35,738 | $48.0K | 0.00% | −55,126−60.7% | Reduced |
| Point72 Asia (Singapore) Pte. Ltd. | 35,024 | $47.3K | 0.01% | −35,021−50.0% | Reduced |
| Prudential Financial Inc | 35,000 | $47.2K | 0.00% | +35,000 | New |
| Vermillion & White Wealth Management Group, LLC | 32,500 | $43.9K | 0.02% | +26,000+400.0% | Added |
| R Squared Ltd | 32,049 | $43.3K | 0.02% | +2,490+8.4% | Added |
| Barclays PLC | 31,862 | $43.0K | 0.00% | −408−1.3% | Reduced |
| Pathstone Holdings, LLC | 30,208 | $40.8K | 0.00% | +167+0.6% | Added |
| JPMorgan Chase & Co | 30,037 | $40.5K | 0.00% | +5,353+21.7% | Added |
| KWB Wealth | 40,640 | $38.4K | 0.00% | 00.0% | Unchanged |
| CWM, LLC | 26,744 | $36.0K | 0.00% | −82,586−75.5% | Reduced |
| Scientech Research LLC | 24,884 | $33.6K | 0.01% | −32,978−57.0% | Reduced |
| Cambridge Investment Research Advisors, Inc. | 23,400 | $32.0K | 0.00% | +1,900+8.8% | Added |
| Tower Research Capital LLC (TRC) | 23,679 | $32.0K | 0.00% | +10,989+86.6% | Added |
| Oppenheimer & Co Inc | 23,500 | $31.7K | 0.00% | 00.0% | Unchanged |
| Wolverine Trading, LLC | 21,191 | $29.5K | 0.00% | +21,191 | New |
| Wealth Enhancement Advisory Services, LLC | 18,877 | $28.7K | 0.00% | −55,577−74.6% | Reduced |
| Victory Capital Management Inc | 21,023 | $28.4K | 0.00% | −92−0.4% | Reduced |
| Invera Wealth Advisors, LLC | 20,000 | $27.0K | 0.02% | 00.0% | Unchanged |
| Tiaa Trust, National Association | 20,000 | $27.0K | 0.00% | 00.0% | Unchanged |
| Bank of New York Mellon Corp | 19,124 | $25.8K | 0.00% | 00.0% | Unchanged |
| Citigroup Inc | 18,119 | $24.5K | 0.00% | −30,425−62.7% | Reduced |
| Cetera Investment Advisers | 17,524 | $23.7K | 0.00% | +17,524 | New |
| Ieq Capital, LLC | 16,266 | $22.0K | 0.00% | −175,835−91.5% | Reduced |
| Two Sigma Securities, LLC | 15,881 | $21.4K | 0.00% | −26,524−62.5% | Reduced |
| SBI Securities Co., Ltd. | 15,047 | $20.3K | 0.00% | −4,190−21.8% | Reduced |
| Captrust Financial Advisors | 14,069 | $19.0K | 0.00% | −21,513−60.5% | Reduced |
| Mirae Asset Global Investments Co., Ltd. | 14,049 | $19.0K | 0.00% | +20+0.1% | Added |
| Truist Financial Corp | 14,000 | $18.9K | 0.00% | 00.0% | Unchanged |
| HBK Sorce Advisory LLC | 11,786 | $18.0K | 0.00% | 00.0% | Unchanged |
| ProShare Advisors LLC | 12,946 | $17.5K | 0.00% | −615−4.5% | Reduced |
| Chemistry Wealth Management LLC | 12,000 | $16.2K | 0.00% | 00.0% | Unchanged |
| North Star Asset Management Inc | 11,500 | $15.5K | 0.00% | 00.0% | Unchanged |
| SG Americas Securities, LLC | 10,830 | $15.0K | 0.00% | −2,984−21.6% | Reduced |
| Perennial Investment Advisors, LLC | 10,990 | $14.8K | 0.00% | 00.0% | Unchanged |
| Berger Financial Group, Inc | 10,929 | $14.8K | 0.00% | 00.0% | Unchanged |
| Steward Partners Investment Advisory, LLC | 10,785 | $14.6K | 0.00% | −10,638−49.7% | Reduced |
| NBT Bank N A | 10,000 | $13.5K | 0.00% | 00.0% | Unchanged |
| State of Wyoming | 8,526 | $11.5K | 0.00% | +8,526 | New |
| GF Fund Management Co. Ltd. | 7,818 | $10.6K | 0.00% | +7,818 | New |
| SRS Capital Advisors, Inc. | 5,097 | $6.88K | 0.00% | +5,097 | New |
| BNP Paribas Arbitrage, SA | 4,988 | $6.73K | 0.00% | −3,715−42.7% | Reduced |
| Golden State Wealth Management, LLC | 3,700 | $5.00K | 0.00% | 00.0% | Unchanged |
| Advisory Services Network, LLC | 3,242 | $4.38K | 0.00% | +3,242 | New |
| Nisa Investment Advisors, LLC | 2,592 | $3.50K | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 1,369 | $2.00K | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 1,461 | $1.97K | 0.00% | 00.0% | Unchanged |