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Lexicon Pharmaceuticals, Inc.

LXRX
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001062822

No open-market purchases or sales by Lexicon Pharmaceuticals, Inc. insiders were filed in the last 90 days; 149 institutions reported holding it in 13F filings for Q2 2026, worth $875.1M in total; no superinvestor holds it.

13F holders, Q4 2023

Institutional positions in Lexicon Pharmaceuticals, Inc. as of Dec 31, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
106
−6 vs. Q3 2023
Shares held
182.9M
−5.94M (−3.1%) vs. Q3 2023
Total value
$279.8M
+$74.0M (+36.0%) vs. Q3 2023
New holders
25
30 more added
Sold out
31
24 more reduced

Compare with Q3 2023: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting LXRX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2023: 106 institutions
Q1 2021: 107 institutionsQ2 2021: 107 institutionsQ3 2021: 96 institutionsQ4 2021: 110 institutionsQ1 2022: 101 institutionsQ2 2022: 86 institutionsQ3 2022: 98 institutionsQ4 2022: 105 institutionsQ1 2023: 104 institutionsQ2 2023: 123 institutionsQ3 2023: 112 institutionsQ4 2023: 106 institutionsQ1 2024: 118 institutionsQ2 2024: 127 institutionsQ3 2024: 137 institutionsQ4 2024: 127 institutionsQ1 2025: 127 institutionsQ2 2025: 123 institutionsQ3 2025: 124 institutionsQ4 2025: 126 institutionsQ1 2026: 137 institutionsQ2 2026: 149 institutions
Value heldQ4 2023: $279.8M
Q1 2021: $711.5MQ2 2021: $540.2MQ3 2021: $583.0MQ4 2021: $478.9MQ1 2022: $251.3MQ2 2022: $221.0MQ3 2022: $357.3MQ4 2022: $280.5MQ1 2023: $353.8MQ2 2023: $438.2MQ3 2023: $205.8MQ4 2023: $279.8MQ1 2024: $417.8MQ2 2024: $471.0MQ3 2024: $453.1MQ4 2024: $220.1MQ1 2025: $122.5MQ2 2025: $242.9MQ3 2025: $344.4MQ4 2025: $299.5MQ1 2026: $504.5MQ2 2026: $875.1M
Institutions holding LXRX and their total value by quarter
QuarterHoldersValue
Q2 2026149$875.1M
Q1 2026137$504.5M
Q4 2025126$299.5M
Q3 2025124$344.4M
Q2 2025123$242.9M
Q1 2025127$122.5M
Q4 2024127$220.1M
Q3 2024137$453.1M
Q2 2024127$471.0M
Q1 2024118$417.8M
Q4 2023106$279.8M
Q3 2023112$205.8M
Q2 2023123$438.2M
Q1 2023104$353.8M
Q4 2022105$280.5M
Q3 202298$357.3M
Q2 202286$221.0M
Q1 2022101$251.3M
Q4 2021110$478.9M
Q3 202196$583.0M
Q2 2021107$540.2M
Q1 2021107$711.5M

Institutions, Q4 2023

Shares, value and share of portfolio for each institution holding Lexicon Pharmaceuticals, Inc.; share changes are against Q3 2023.

Institutions holding LXRX in Q4 2023
InstitutionSharesValue% of portfolioChange in sharesAction
Artal Group S.A.117,553,284$179.9M6.13%00.0%Unchanged
BVF Inc24,435,632$37.4M0.94%+4,440,300+22.2%Added
BlackRock Inc.7,005,153$10.7M0.00%+350,187+5.3%Added
Vanguard Group Inc5,980,371$9.15M0.00%−419,840−6.6%Reduced
JPMorgan Chase & Co3,043,291$4.66M0.00%+228,257+8.1%Added
NEA Management Company, LLC2,382,286$3.64M0.24%00.0%Unchanged
Geode Capital Management, LLC2,348,916$3.59M0.00%+222,779+10.5%Added
FMR LLC2,276,468$3.48M0.00%−5,286,608−69.9%Reduced
State Street Corp1,892,319$2.90M0.00%+16,180+0.9%Added
Ameriprise Financial Inc1,890,200$2.89M0.00%+675,522+55.6%Added
Pinnacle Associates Ltd1,730,821$2.65M0.04%−182,048−9.5%Reduced
Millennium Management LLC1,633,176$2.50M0.00%−2,252,577−58.0%Reduced
Morgan Stanley917,688$1.40M0.00%+678,068+283.0%Added
Charles Schwab Investment Management Inc864,175$1.32M0.00%+12,254+1.4%Added
Northern Trust Corp859,588$1.32M0.00%−291,229−25.3%Reduced
Citadel Advisors LLC786,160$1.20M0.00%+784,249+41,038.7%Added
Gsa Capital Partners LLP780,077$1.19M0.10%+780,077New
Susquehanna International Group, LLP417,813$639.3K0.00%+89,307+27.2%Added
Renaissance Technologies LLC412,175$631.0K0.00%+139,920+51.4%Added
Nuveen Asset Management, LLC411,046$628.9K0.00%+1,867+0.5%Added
D. E. Shaw & Co., Inc.359,210$549.6K0.00%−424,912−54.2%Reduced
Bank of New York Mellon Corp341,077$521.8K0.00%+9,754+2.9%Added
EntryPoint Capital, LLC323,968$495.7K0.48%+323,968New
Connor, Clark & Lunn Investment Management Ltd.282,467$432.2K0.00%−54,597−16.2%Reduced
Jane Street Group, LLC272,367$416.7K0.00%+190,437+232.4%Added
Virtus ETF Advisers LLC250,923$383.9K0.24%+129,212+106.2%Added
Alliancebernstein L.P.245,301$375.3K0.00%00.0%Unchanged
Goldman Sachs Group Inc235,339$360.1K0.00%−124,372−34.6%Reduced
Citigroup Inc224,998$344.2K0.00%+188,983+524.7%Added
Bank of America Corp210,725$322.4K0.00%+46,249+28.1%Added
Two Sigma Investments, LP202,887$310.4K0.00%−442,481−68.6%Reduced
UBS Group AG169,616$259.5K0.00%+44,254+35.3%Added
CIBC Private Wealth Group, LLC150,100$229.7K0.00%+150,100New
Rhumbline Advisers130,291$199.3K0.00%00.0%Unchanged
Barclays PLC127,016$194.3K0.00%+87,827+224.1%Added
Deerfield Management Company, L.P. (Series C)103,144$157.8K0.00%+103,144New
Price T Rowe Associates Inc100,691$155.0K0.00%00.0%Unchanged
Compagnie Lombard Odier SCmA94,000$143.8K0.00%00.0%Unchanged
Invesco Ltd.61,182$93.6K0.00%+9,245+17.8%Added
Simplex Trading, LLC54,248$82.0K0.00%+54,248New
Amundi54,532$80.7K0.00%+54,532New
Russell Investments Group, Ltd.49,100$75.1K0.00%00.0%Unchanged
Tudor Investment Corp Et Al47,101$72.1K0.00%00.0%Unchanged
American International Group, Inc.46,049$70.5K0.00%−186−0.4%Reduced
Captrust Financial Advisors44,636$68.3K0.00%+180.0%Added
LPL Financial LLC43,994$67.3K0.00%+17,000+63.0%Added
SG Americas Securities, LLC43,793$67.0K0.00%−14,914−25.4%Reduced
KWB Wealth40,640$62.2K0.01%+40,640New
Deutsche Bank AG40,289$61.6K0.00%00.0%Unchanged
Stifel Financial Corp39,652$60.7K0.00%−42,315−51.6%Reduced
Two Sigma Securities, LLC38,268$58.5K0.00%+38,268New
Voya Investment Management LLC37,359$57.2K0.00%00.0%Unchanged
University of Texas/Texas Am Investment Managment Co35,714$54.6K0.01%00.0%Unchanged
Pathstone Holdings, LLC34,445$52.7K0.00%+34,445New
Commonwealth Equity Services, LLC34,184$52.0K0.00%−5,385−13.6%Reduced
New York State Common Retirement Fund33,670$51.5K0.00%−206−0.6%Reduced
BNP Paribas Arbitrage, SA32,519$49.8K0.00%−88,053−73.0%Reduced
Victory Capital Management Inc32,187$49.2K0.00%+5,813+22.0%Added
Bayesian Capital Management, LP32,119$49.1K0.01%+32,119New
Rpo LLC32,000$49.0K0.08%+32,000New
Prosperity Financial Group, Inc.31,500$48.2K0.03%00.0%Unchanged
ProShare Advisors LLC30,982$47.4K0.00%+2,933+10.5%Added
Royal Bank of Canada29,085$44.0K0.00%+15,307+111.1%Added
China Universal Asset Management Co., Ltd.28,329$43.3K0.01%+22,043+350.7%Added
Tiaa Trust, National Association27,000$41.3K0.00%00.0%Unchanged
Wells Fargo & Company26,735$40.9K0.00%+5,571+26.3%Added
Oppenheimer & Co Inc24,500$37.5K0.00%+24,500New
State Board of Administration of Florida Retirement System24,062$36.8K0.00%+24,062New
Principal Securities, Inc.21,500$32.9K0.00%+21,500New
Manufacturers Life Insurance Company, The18,220$27.9K0.00%−24,267−57.1%Reduced
Cantor Fitzgerald, L. P.16,522$25.3K0.01%+16,522New
Group One Trading, L.P.16,054$24.6K0.00%+16,054New
Tower Research Capital LLC (TRC)15,921$24.4K0.00%−1,009−6.0%Reduced
California State Teachers Retirement System15,249$23.3K0.00%−102,634−87.1%Reduced
JustInvest LLC15,173$23.2K0.00%+15,173New
Boothbay Fund Management, LLC14,400$22.0K0.00%+14,400New
Wolverine Trading, LLC14,018$21.4K0.00%−3,396−19.5%Reduced
Truist Financial Corp12,500$19.1K0.00%+500+4.2%Added
Pinnacle Wealth Management Advisory Group, LLC12,445$19.0K0.00%+310+2.6%Added
Chemistry Wealth Management LLC12,000$18.4K0.01%00.0%Unchanged
Legal & General Group Plc11,158$17.1K0.00%−72,477−86.7%Reduced
Berger Financial Group, Inc10,929$16.7K0.00%00.0%Unchanged
Raymond James & Associates10,841$16.6K0.00%00.0%Unchanged
Principal Financial Group Inc10,534$16.1K0.00%+201+1.9%Added
Estabrook Capital Management10,000$15.3K0.00%00.0%Unchanged
LifeSteps Financial, Inc.10,000$15.3K0.01%00.0%Unchanged
Assetmark, Inc10,000$15.3K0.00%+10,000New
Amalgamated Bank9,947$15.0K0.00%−717−6.7%Reduced
Ameritas Investment Partners, Inc.5,367$8.21K0.00%00.0%Unchanged
National Bank of Canada2,200$3.50K0.00%00.0%Unchanged
Quintet Private Bank (Europe) S.A.1,928$2.95K0.00%00.0%Unchanged
Signaturefd, LLC1,611$2.46K0.00%+1,611New
Advisor Group Holdings, Inc.1,394$2.13K0.00%−5,850−80.8%Reduced
Quadrant Capital Group LLC1,371$2.10K0.00%+1,371New
Global Retirement Partners, LLC1,000$1.32K0.00%00.0%Unchanged
Daiwa Securities Group Inc.434$1.00K0.00%00.0%Unchanged
Avion Wealth407$1.00K0.00%00.0%Unchanged
Northwestern Mutual Wealth Management Co500$7650.00%00.0%Unchanged
Advisory Services Network, LLC242$3700.00%+242New
Headlands Technologies LLC204$3120.00%+204New