Lexicon Pharmaceuticals, Inc.
LXRX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001062822
No open-market purchases or sales by Lexicon Pharmaceuticals, Inc. insiders were filed in the last 90 days; 149 institutions reported holding it in 13F filings for Q2 2026, worth $875.1M in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Lexicon Pharmaceuticals, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 126
- +6 vs. Q3 2025
- Shares held
- 260.4M
- +5.41M (+2.1%) vs. Q3 2025
- Total value
- $299.5M
- −$44.8M (−13.0%) vs. Q3 2025
- New holders
- 23
- 28 more added
- Sold out
- 17
- 41 more reduced
4 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting LXRX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 149 | $875.1M |
| Q1 2026 | 137 | $504.5M |
| Q4 2025 | 126 | $299.5M |
| Q3 2025 | 124 | $344.4M |
| Q2 2025 | 123 | $242.9M |
| Q1 2025 | 127 | $122.5M |
| Q4 2024 | 127 | $220.1M |
| Q3 2024 | 137 | $453.1M |
| Q2 2024 | 127 | $471.0M |
| Q1 2024 | 118 | $417.8M |
| Q4 2023 | 106 | $279.8M |
| Q3 2023 | 112 | $205.8M |
| Q2 2023 | 123 | $438.2M |
| Q1 2023 | 104 | $353.8M |
| Q4 2022 | 105 | $280.5M |
| Q3 2022 | 98 | $357.3M |
| Q2 2022 | 86 | $221.0M |
| Q1 2022 | 101 | $251.3M |
| Q4 2021 | 110 | $478.9M |
| Q3 2021 | 96 | $583.0M |
| Q2 2021 | 107 | $540.2M |
| Q1 2021 | 107 | $711.5M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Lexicon Pharmaceuticals, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Artal Group S.A. | 136,180,481 | $156.6M | 21.91% | 00.0% | Unchanged |
| Siren, L.L.C. | 38,918,903 | $44.8M | 1.34% | 00.0% | Unchanged |
| FMR LLC | 37,834,207 | $43.5M | 0.00% | −845,541−2.2% | Reduced |
| Vanguard Group Inc | 9,606,549 | $11.0M | 0.00% | +84,675+0.9% | Added |
| Millennium Management LLC | 4,821,733 | $5.54M | 0.00% | +991,073+25.9% | Added |
| BlackRock, Inc. | 3,192,448 | $3.67M | 0.00% | −202,524−6.0% | Reduced |
| UBS Group AG | 3,007,237 | $3.46M | 0.00% | +2,654,315+752.1% | Added |
| Sessa Capital IM, L.P. | 3,000,000 | $3.45M | 0.07% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 2,500,022 | $2.88M | 0.00% | +102,099+4.3% | Added |
| CIBC Private Wealth Group, LLC | 1,950,000 | $2.24M | 0.00% | −450,257−18.8% | Reduced |
| Jane Street Group, LLC | 1,724,304 | $1.98M | 0.00% | +1,267,774+277.7% | Added |
| Citadel Advisors LLC | 1,710,975 | $1.97M | 0.00% | −923,052−35.0% | Reduced |
| Marshall Wace, LLP | 1,262,367 | $1.45M | 0.00% | +1,262,367 | New |
| Susquehanna International Group, LLP | 1,207,242 | $1.39M | 0.00% | +245,182+25.5% | Added |
| Charles Schwab Investment Management Inc | 1,055,123 | $1.21M | 0.00% | −89,509−7.8% | Reduced |
| Gsa Capital Partners LLP | 996,235 | $1.15M | 0.10% | −206,671−17.2% | Reduced |
| Goldman Sachs Group Inc | 921,204 | $1.06M | 0.00% | +861,857+1,452.2% | Added |
| Hennion & Walsh Asset Management, Inc. | 901,222 | $1.04M | 0.04% | +122,010+15.7% | Added |
| State Street Corp | 884,738 | $1.02M | 0.00% | +4,617+0.5% | Added |
| Ishara Investments LP | 880,000 | $1.01M | 1.18% | +880,000 | New |
| Two Sigma Investments, LP | 637,308 | $732.9K | 0.00% | +78,300+14.0% | Added |
| Acadian Asset Management LLC | 640,130 | $732.0K | 0.00% | +603,225+1,634.5% | Added |
| Invesco Ltd. | 594,883 | $684.1K | 0.00% | +73,480+14.1% | Added |
| Northern Trust Corp | 412,164 | $474.0K | 0.00% | +42,370+11.5% | Added |
| Compagnie Lombard Odier SCmA | 410,000 | $471.5K | 0.01% | 00.0% | Unchanged |
| Point72 Asset Management, L.P. | 284,025 | $326.6K | 0.00% | +284,025 | New |
| Omers Administration Corp | 273,800 | $314.9K | 0.00% | +273,800 | New |
| ExodusPoint Capital Management, LP | 268,433 | $308.7K | 0.00% | +268,433 | New |
| Renaissance Technologies LLC | 263,254 | $302.7K | 0.00% | −29,146−10.0% | Reduced |
| Group One Trading, L.P. | 224,308 | $258.0K | 0.01% | +8,064+3.7% | Added |
| Barclays PLC | 194,743 | $224.0K | 0.00% | +162,881+511.2% | Added |
| Morgan Stanley | 193,035 | $222.0K | 0.00% | +24,017+14.2% | Added |
| Two Sigma Advisers, LP | 180,977 | $208.1K | 0.00% | +180,977 | New |
| Ikarian Capital, LLC | 164,674 | $189.4K | 0.02% | −11,805−6.7% | Reduced |
| Cerity Partners LLC | 144,944 | $166.7K | 0.00% | −13,096−8.3% | Reduced |
| AQR Capital Management LLC | 144,800 | $166.5K | 0.00% | −158,131−52.2% | Reduced |
| Headlands Technologies LLC | 136,113 | $156.5K | 0.01% | +86,466+174.2% | Added |
| Lighthouse Investment Partners, LLC | 126,600 | $145.6K | 0.00% | +126,600 | New |
| HRT Financial LP | 117,549 | $135.0K | 0.00% | +71,102+153.1% | Added |
| Monaco Asset Management SAM | 117,188 | $134.8K | 0.04% | −232,812−66.5% | Reduced |
| Two Sigma Securities, LLC | 114,632 | $131.8K | 0.02% | +98,751+621.8% | Added |
| Graham Capital Management, L.P. | 109,900 | $126.4K | 0.00% | +109,900 | New |
| Bank of America Corp | 102,097 | $117.4K | 0.00% | +44,293+76.6% | Added |
| Hudson Bay Capital Management LP | 100,532 | $115.6K | 0.00% | +100,532 | New |
| XTX Topco Ltd | 96,090 | $110.5K | 0.00% | −233,446−70.8% | Reduced |
| Jefferies Financial Group Inc. | 92,530 | $106.4K | 0.00% | −4,870−5.0% | Reduced |
| Citigroup Inc | 91,670 | $105.4K | 0.00% | +73,551+405.9% | Added |
| Quarry LP | 88,000 | $101.2K | 0.02% | +88,000 | New |
| LPL Financial LLC | 87,057 | $100.1K | 0.00% | −4,201−4.6% | Reduced |
| Caxton Associates LLP | 71,027 | $81.7K | 0.00% | +71,027 | New |
| Bank of Montreal | 70,000 | $80.5K | 0.00% | 00.0% | Unchanged |
| JustInvest LLC | 66,567 | $76.6K | 0.00% | 00.0% | Unchanged |
| Straight Path Wealth Management | 62,666 | $72.1K | 0.02% | 00.0% | Unchanged |
| State of Wyoming | 60,571 | $69.7K | 0.01% | +52,045+610.4% | Added |
| Squarepoint Ops LLC | 60,472 | $69.5K | 0.00% | +1,796+3.1% | Added |
| Optiver Holding B.V. | 52,595 | $60.5K | 0.00% | −23,298−30.7% | Reduced |
| Fortis Group Advisors, LLC | 50,000 | $58.0K | 0.01% | −7,800−13.5% | Reduced |
| R Squared Ltd | 46,579 | $53.6K | 0.03% | +14,530+45.3% | Added |
| Boothbay Fund Management, LLC | 44,315 | $51.0K | 0.00% | −11,805−21.0% | Reduced |
| Wedbush Securities Inc | 40,850 | $47.0K | 0.00% | 00.0% | Unchanged |
| KWB Wealth | 40,640 | $46.7K | 0.00% | 00.0% | Unchanged |
| Catalyst Funds Management Pty Ltd | 40,300 | $46.3K | 0.01% | 00.0% | Unchanged |
| CIBC Asset Management Inc | 39,520 | $45.4K | 0.00% | +39,520 | New |
| Virtu Financial LLC | 36,468 | $42.0K | 0.00% | +36,468 | New |
| University of Texas/Texas Am Investment Managment Co | 35,714 | $41.1K | 0.01% | 00.0% | Unchanged |
| Prudential Financial Inc | 33,800 | $38.9K | 0.00% | −1,200−3.4% | Reduced |
| EntryPoint Capital, LLC | 33,618 | $38.7K | 0.02% | +33,618 | New |
| Vermillion & White Wealth Management Group, LLC | 32,000 | $36.8K | 0.02% | −500−1.5% | Reduced |
| Leonteq Securities AG | 30,000 | $34.5K | 0.00% | +30,000 | New |
| Pathstone Holdings, LLC | 29,969 | $34.5K | 0.00% | −239−0.8% | Reduced |
| Tower Research Capital LLC (TRC) | 29,093 | $33.5K | 0.00% | +5,414+22.9% | Added |
| Pinnacle Associates Ltd | 29,015 | $33.4K | 0.00% | −21,800−42.9% | Reduced |
| Security National Bank of Sioux City Iowa | 26,650 | $30.6K | 0.02% | +26,650 | New |
| Oppenheimer & Co Inc | 23,500 | $27.0K | 0.00% | 00.0% | Unchanged |
| Cambridge Investment Research Advisors, Inc. | 21,505 | $25.0K | 0.00% | −1,895−8.1% | Reduced |
| Victory Capital Management Inc | 21,191 | $24.4K | 0.00% | +168+0.8% | Added |
| Invera Wealth Advisors, LLC | 20,000 | $23.0K | 0.01% | 00.0% | Unchanged |
| Tiaa Trust, National Association | 20,000 | $23.0K | 0.00% | 00.0% | Unchanged |
| Bank of New York Mellon Corp | 19,124 | $22.0K | 0.00% | 00.0% | Unchanged |
| Credit Agricole S A | 18,975 | $21.8K | 0.00% | +18,975 | New |
| Quadrature Capital Ltd | 18,414 | $21.2K | 0.00% | −209,795−91.9% | Reduced |
| StoneX Group Inc. | 16,234 | $18.7K | 0.00% | +16,234 | New |
| Simplex Trading, LLC | 14,758 | $17.0K | 0.00% | −58,529−79.9% | Reduced |
| Cetera Investment Advisers | 14,188 | $16.3K | 0.00% | −3,336−19.0% | Reduced |
| Lazard Asset Management LLC | 14,090 | $16.2K | 0.00% | +14,090 | New |
| Callan Family Office, LLC | 14,090 | $16.2K | 0.00% | +14,090 | New |
| Truist Financial Corp | 14,000 | $16.1K | 0.00% | 00.0% | Unchanged |
| Wealth Enhancement Advisory Services, LLC | 13,520 | $15.4K | 0.00% | −5,357−28.4% | Reduced |
| Schonfeld Strategic Advisors LLC | 13,108 | $15.1K | 0.00% | −812,525−98.4% | Reduced |
| CWM, LLC | 13,179 | $15.0K | 0.00% | −13,565−50.7% | Reduced |
| HBK Sorce Advisory LLC | 11,786 | $14.5K | 0.00% | 00.0% | Unchanged |
| Chemistry Wealth Management LLC | 12,000 | $13.8K | 0.00% | 00.0% | Unchanged |
| Captrust Financial Advisors | 11,735 | $13.5K | 0.00% | −2,334−16.6% | Reduced |
| Fortress Wealth Group, LLC | 11,350 | $13.2K | 0.00% | +11,350 | New |
| Perennial Investment Advisors, LLC | 10,990 | $12.6K | 0.00% | 00.0% | Unchanged |
| Berger Financial Group, Inc | 10,000 | $11.5K | 0.00% | −929−8.5% | Reduced |
| NBT Bank N A | 10,000 | $11.5K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 6,768 | $7.00K | 0.00% | −715,667−99.1% | Reduced |
| Golden State Wealth Management, LLC | 3,700 | $4.25K | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 3,018 | $3.47K | 0.00% | −12,029−79.9% | Reduced |