Lexicon Pharmaceuticals, Inc.
LXRX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001062822
No open-market purchases or sales by Lexicon Pharmaceuticals, Inc. insiders were filed in the last 90 days; 149 institutions reported holding it in 13F filings for Q2 2026, worth $875.1M in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Lexicon Pharmaceuticals, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 126
- +6 vs. Q3 2025
- Shares held
- 260.4M
- +5.41M (+2.1%) vs. Q3 2025
- Total value
- $299.5M
- −$44.8M (−13.0%) vs. Q3 2025
- New holders
- 23
- 28 more added
- Sold out
- 17
- 41 more reduced
4 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting LXRX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 149 | $875.1M |
| Q1 2026 | 137 | $504.5M |
| Q4 2025 | 126 | $299.5M |
| Q3 2025 | 124 | $344.4M |
| Q2 2025 | 123 | $242.9M |
| Q1 2025 | 127 | $122.5M |
| Q4 2024 | 127 | $220.1M |
| Q3 2024 | 137 | $453.1M |
| Q2 2024 | 127 | $471.0M |
| Q1 2024 | 118 | $417.8M |
| Q4 2023 | 106 | $279.8M |
| Q3 2023 | 112 | $205.8M |
| Q2 2023 | 123 | $438.2M |
| Q1 2023 | 104 | $353.8M |
| Q4 2022 | 105 | $280.5M |
| Q3 2022 | 98 | $357.3M |
| Q2 2022 | 86 | $221.0M |
| Q1 2022 | 101 | $251.3M |
| Q4 2021 | 110 | $478.9M |
| Q3 2021 | 96 | $583.0M |
| Q2 2021 | 107 | $540.2M |
| Q1 2021 | 107 | $711.5M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Lexicon Pharmaceuticals, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Covestor Ltd | 81 | $0 | 0.00% | 00.0% | Unchanged |
| Motiv8 Investments LLC | 200 | $0 | 0.00% | +200 | New |
| Wells Fargo & Company | 1 | $1 | 0.00% | −300−99.7% | Reduced |
| Rhumbline Advisers | 0 | $2 | 0.00% | 0 | Unchanged |
| BNP Paribas Arbitrage, SA | 11 | $13 | 0.00% | −4,977−99.8% | Reduced |
| SRS Capital Advisors, Inc. | 41 | $47 | 0.00% | −5,056−99.2% | Reduced |
| True Wealth Design, LLC | 49 | $57 | 0.00% | −36−42.4% | Reduced |
| Larson Financial Group LLC | 100 | $115 | 0.00% | 00.0% | Unchanged |
| Comerica Bank | 122 | $140 | 0.00% | 00.0% | Unchanged |
| Syntax Research, Inc. | 142 | $164 | 0.00% | 00.0% | Unchanged |
| Caitong International Asset Management Co., Ltd | 147 | $169 | 0.00% | −812−84.7% | Reduced |
| EverSource Wealth Advisors, LLC | 158 | $182 | 0.00% | −297−65.3% | Reduced |
| Rockefeller Capital Management L.P. | 335 | $385 | 0.00% | 00.0% | Unchanged |
| Steward Partners Investment Advisory, LLC | 500 | $575 | 0.00% | −10,285−95.4% | Reduced |
| Northwestern Mutual Wealth Management Co | 500 | $575 | 0.00% | −14−2.7% | Reduced |
| Advisor Group Holdings, Inc. | 642 | $738 | 0.00% | −100−13.5% | Reduced |
| Basecamp Wealth Advisors LLC | 691 | $795 | 0.00% | +691 | New |
| Fortitude Family Office, LLC | 706 | $812 | 0.00% | 00.0% | Unchanged |
| Avion Wealth | 1,333 | $1.00K | 0.00% | 00.0% | Unchanged |
| Global Retirement Partners, LLC | 1,000 | $1.15K | 0.00% | 00.0% | Unchanged |
| Jones Financial Companies LLLP | 1,106 | $1.27K | 0.00% | +214+24.0% | Added |
| Rialto Wealth Management, LLC | 1,313 | $1.51K | 0.00% | 00.0% | Unchanged |
| UMA Financial Services, Inc. | 1,412 | $1.62K | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 1,461 | $1.68K | 0.00% | 00.0% | Unchanged |
| Nisa Investment Advisors, LLC | 2,592 | $2.98K | 0.00% | 00.0% | Unchanged |
| Farther Finance Advisors, LLC | 2,755 | $3.17K | 0.00% | +1,500+119.5% | Added |
| SBI Securities Co., Ltd. | 3,018 | $3.47K | 0.00% | −12,029−79.9% | Reduced |
| Golden State Wealth Management, LLC | 3,700 | $4.25K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 6,768 | $7.00K | 0.00% | −715,667−99.1% | Reduced |
| Berger Financial Group, Inc | 10,000 | $11.5K | 0.00% | −929−8.5% | Reduced |
| NBT Bank N A | 10,000 | $11.5K | 0.00% | 00.0% | Unchanged |
| Perennial Investment Advisors, LLC | 10,990 | $12.6K | 0.00% | 00.0% | Unchanged |
| Fortress Wealth Group, LLC | 11,350 | $13.2K | 0.00% | +11,350 | New |
| Captrust Financial Advisors | 11,735 | $13.5K | 0.00% | −2,334−16.6% | Reduced |
| Chemistry Wealth Management LLC | 12,000 | $13.8K | 0.00% | 00.0% | Unchanged |
| HBK Sorce Advisory LLC | 11,786 | $14.5K | 0.00% | 00.0% | Unchanged |
| CWM, LLC | 13,179 | $15.0K | 0.00% | −13,565−50.7% | Reduced |
| Schonfeld Strategic Advisors LLC | 13,108 | $15.1K | 0.00% | −812,525−98.4% | Reduced |
| Wealth Enhancement Advisory Services, LLC | 13,520 | $15.4K | 0.00% | −5,357−28.4% | Reduced |
| Truist Financial Corp | 14,000 | $16.1K | 0.00% | 00.0% | Unchanged |
| Lazard Asset Management LLC | 14,090 | $16.2K | 0.00% | +14,090 | New |
| Callan Family Office, LLC | 14,090 | $16.2K | 0.00% | +14,090 | New |
| Cetera Investment Advisers | 14,188 | $16.3K | 0.00% | −3,336−19.0% | Reduced |
| Simplex Trading, LLC | 14,758 | $17.0K | 0.00% | −58,529−79.9% | Reduced |
| StoneX Group Inc. | 16,234 | $18.7K | 0.00% | +16,234 | New |
| Quadrature Capital Ltd | 18,414 | $21.2K | 0.00% | −209,795−91.9% | Reduced |
| Credit Agricole S A | 18,975 | $21.8K | 0.00% | +18,975 | New |
| Bank of New York Mellon Corp | 19,124 | $22.0K | 0.00% | 00.0% | Unchanged |
| Invera Wealth Advisors, LLC | 20,000 | $23.0K | 0.01% | 00.0% | Unchanged |
| Tiaa Trust, National Association | 20,000 | $23.0K | 0.00% | 00.0% | Unchanged |
| Victory Capital Management Inc | 21,191 | $24.4K | 0.00% | +168+0.8% | Added |
| Cambridge Investment Research Advisors, Inc. | 21,505 | $25.0K | 0.00% | −1,895−8.1% | Reduced |
| Oppenheimer & Co Inc | 23,500 | $27.0K | 0.00% | 00.0% | Unchanged |
| Security National Bank of Sioux City Iowa | 26,650 | $30.6K | 0.02% | +26,650 | New |
| Pinnacle Associates Ltd | 29,015 | $33.4K | 0.00% | −21,800−42.9% | Reduced |
| Tower Research Capital LLC (TRC) | 29,093 | $33.5K | 0.00% | +5,414+22.9% | Added |
| Pathstone Holdings, LLC | 29,969 | $34.5K | 0.00% | −239−0.8% | Reduced |
| Leonteq Securities AG | 30,000 | $34.5K | 0.00% | +30,000 | New |
| Vermillion & White Wealth Management Group, LLC | 32,000 | $36.8K | 0.02% | −500−1.5% | Reduced |
| EntryPoint Capital, LLC | 33,618 | $38.7K | 0.02% | +33,618 | New |
| Prudential Financial Inc | 33,800 | $38.9K | 0.00% | −1,200−3.4% | Reduced |
| University of Texas/Texas Am Investment Managment Co | 35,714 | $41.1K | 0.01% | 00.0% | Unchanged |
| Virtu Financial LLC | 36,468 | $42.0K | 0.00% | +36,468 | New |
| CIBC Asset Management Inc | 39,520 | $45.4K | 0.00% | +39,520 | New |
| Catalyst Funds Management Pty Ltd | 40,300 | $46.3K | 0.01% | 00.0% | Unchanged |
| KWB Wealth | 40,640 | $46.7K | 0.00% | 00.0% | Unchanged |
| Wedbush Securities Inc | 40,850 | $47.0K | 0.00% | 00.0% | Unchanged |
| Boothbay Fund Management, LLC | 44,315 | $51.0K | 0.00% | −11,805−21.0% | Reduced |
| R Squared Ltd | 46,579 | $53.6K | 0.03% | +14,530+45.3% | Added |
| Fortis Group Advisors, LLC | 50,000 | $58.0K | 0.01% | −7,800−13.5% | Reduced |
| Optiver Holding B.V. | 52,595 | $60.5K | 0.00% | −23,298−30.7% | Reduced |
| Squarepoint Ops LLC | 60,472 | $69.5K | 0.00% | +1,796+3.1% | Added |
| State of Wyoming | 60,571 | $69.7K | 0.01% | +52,045+610.4% | Added |
| Straight Path Wealth Management | 62,666 | $72.1K | 0.02% | 00.0% | Unchanged |
| JustInvest LLC | 66,567 | $76.6K | 0.00% | 00.0% | Unchanged |
| Bank of Montreal | 70,000 | $80.5K | 0.00% | 00.0% | Unchanged |
| Caxton Associates LLP | 71,027 | $81.7K | 0.00% | +71,027 | New |
| LPL Financial LLC | 87,057 | $100.1K | 0.00% | −4,201−4.6% | Reduced |
| Quarry LP | 88,000 | $101.2K | 0.02% | +88,000 | New |
| Citigroup Inc | 91,670 | $105.4K | 0.00% | +73,551+405.9% | Added |
| Jefferies Financial Group Inc. | 92,530 | $106.4K | 0.00% | −4,870−5.0% | Reduced |
| XTX Topco Ltd | 96,090 | $110.5K | 0.00% | −233,446−70.8% | Reduced |
| Hudson Bay Capital Management LP | 100,532 | $115.6K | 0.00% | +100,532 | New |
| Bank of America Corp | 102,097 | $117.4K | 0.00% | +44,293+76.6% | Added |
| Graham Capital Management, L.P. | 109,900 | $126.4K | 0.00% | +109,900 | New |
| Two Sigma Securities, LLC | 114,632 | $131.8K | 0.02% | +98,751+621.8% | Added |
| Monaco Asset Management SAM | 117,188 | $134.8K | 0.04% | −232,812−66.5% | Reduced |
| HRT Financial LP | 117,549 | $135.0K | 0.00% | +71,102+153.1% | Added |
| Lighthouse Investment Partners, LLC | 126,600 | $145.6K | 0.00% | +126,600 | New |
| Headlands Technologies LLC | 136,113 | $156.5K | 0.01% | +86,466+174.2% | Added |
| AQR Capital Management LLC | 144,800 | $166.5K | 0.00% | −158,131−52.2% | Reduced |
| Cerity Partners LLC | 144,944 | $166.7K | 0.00% | −13,096−8.3% | Reduced |
| Ikarian Capital, LLC | 164,674 | $189.4K | 0.02% | −11,805−6.7% | Reduced |
| Two Sigma Advisers, LP | 180,977 | $208.1K | 0.00% | +180,977 | New |
| Morgan Stanley | 193,035 | $222.0K | 0.00% | +24,017+14.2% | Added |
| Barclays PLC | 194,743 | $224.0K | 0.00% | +162,881+511.2% | Added |
| Group One Trading, L.P. | 224,308 | $258.0K | 0.01% | +8,064+3.7% | Added |
| Renaissance Technologies LLC | 263,254 | $302.7K | 0.00% | −29,146−10.0% | Reduced |
| ExodusPoint Capital Management, LP | 268,433 | $308.7K | 0.00% | +268,433 | New |
| Omers Administration Corp | 273,800 | $314.9K | 0.00% | +273,800 | New |