Lexicon Pharmaceuticals, Inc.
LXRX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001062822
No open-market purchases or sales by Lexicon Pharmaceuticals, Inc. insiders were filed in the last 90 days; 149 institutions reported holding it in 13F filings for Q2 2026, worth $875.1M in total; no superinvestor holds it.
13F holders, Q2 2025
Institutional positions in Lexicon Pharmaceuticals, Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 123
- −4 vs. Q1 2025
- Shares held
- 256.3M
- −9.49M (−3.6%) vs. Q1 2025
- Total value
- $242.9M
- +$120.5M (+98.4%) vs. Q1 2025
- New holders
- 29
- 31 more added
- Sold out
- 33
- 36 more reduced
Compare with Q1 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting LXRX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 149 | $875.1M |
| Q1 2026 | 137 | $504.5M |
| Q4 2025 | 126 | $299.5M |
| Q3 2025 | 124 | $344.4M |
| Q2 2025 | 123 | $242.9M |
| Q1 2025 | 127 | $122.5M |
| Q4 2024 | 127 | $220.1M |
| Q3 2024 | 137 | $453.1M |
| Q2 2024 | 127 | $471.0M |
| Q1 2024 | 118 | $417.8M |
| Q4 2023 | 106 | $279.8M |
| Q3 2023 | 112 | $205.8M |
| Q2 2023 | 123 | $438.2M |
| Q1 2023 | 104 | $353.8M |
| Q4 2022 | 105 | $280.5M |
| Q3 2022 | 98 | $357.3M |
| Q2 2022 | 86 | $221.0M |
| Q1 2022 | 101 | $251.3M |
| Q4 2021 | 110 | $478.9M |
| Q3 2021 | 96 | $583.0M |
| Q2 2021 | 107 | $540.2M |
| Q1 2021 | 107 | $711.5M |
Institutions, Q2 2025
Shares, value and share of portfolio for each institution holding Lexicon Pharmaceuticals, Inc.; share changes are against Q1 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Artal Group S.A. | 136,180,481 | $129.4M | 13.91% | 00.0% | Unchanged |
| Siren, L.L.C. | 38,918,903 | $36.8M | 1.90% | 00.0% | Unchanged |
| FMR LLC | 38,137,535 | $36.1M | 0.00% | +3,594,338+10.4% | Added |
| Vanguard Group Inc | 8,851,036 | $8.37M | 0.00% | −706,139−7.4% | Reduced |
| Schonfeld Strategic Advisors LLC | 4,576,152 | $4.33M | 0.03% | −3,636,841−44.3% | Reduced |
| BlackRock, Inc. | 3,354,669 | $3.17M | 0.00% | −6,658,338−66.5% | Reduced |
| Sessa Capital IM, L.P. | 3,000,000 | $2.84M | 0.09% | +3,000,000 | New |
| Gsa Capital Partners LLP | 2,830,659 | $2.68M | 0.19% | +2,023,167+250.5% | Added |
| CIBC Private Wealth Group, LLC | 2,450,400 | $2.32M | 0.00% | +210,400+9.4% | Added |
| Geode Capital Management, LLC | 2,377,694 | $2.25M | 0.00% | −1,311,577−35.6% | Reduced |
| Millennium Management LLC | 1,643,264 | $1.55M | 0.00% | +1,643,264 | New |
| AQR Capital Management LLC | 1,402,210 | $1.33M | 0.00% | +228,985+19.5% | Added |
| Charles Schwab Investment Management Inc | 883,227 | $835.3K | 0.00% | −267,544−23.2% | Reduced |
| State Street Corp | 818,621 | $774.2K | 0.00% | −1,788,953−68.6% | Reduced |
| Jane Street Group, LLC | 804,667 | $761.0K | 0.00% | +804,667 | New |
| Hennion & Walsh Asset Management, Inc. | 793,400 | $750.3K | 0.03% | −36,654−4.4% | Reduced |
| Royal Bank of Canada | 774,474 | $732.0K | 0.00% | +771,315+24,416.4% | Added |
| Susquehanna International Group, LLP | 755,652 | $714.6K | 0.00% | −195,483−20.6% | Reduced |
| Monaco Asset Management SAM | 531,600 | $502.7K | 0.19% | −202,548−27.6% | Reduced |
| HRT Financial LP | 488,468 | $461.0K | 0.00% | +488,468 | New |
| Wellington Management Group LLP | 486,674 | $460.2K | 0.00% | +486,674 | New |
| Invesco Ltd. | 420,700 | $397.9K | 0.00% | +134,941+47.2% | Added |
| Northern Trust Corp | 416,372 | $393.8K | 0.00% | −693,515−62.5% | Reduced |
| Two Sigma Investments, LP | 403,922 | $382.0K | 0.00% | +403,922 | New |
| UBS Group AG | 400,732 | $379.1K | 0.00% | −1,694,608−80.9% | Reduced |
| Group One Trading, L.P. | 346,752 | $327.9K | 0.01% | −19,054−5.2% | Reduced |
| Compagnie Lombard Odier SCmA | 330,000 | $312.1K | 0.00% | +220,000+200.0% | Added |
| Goldman Sachs Group Inc | 325,746 | $308.1K | 0.00% | −29,406−8.3% | Reduced |
| Cerity Partners LLC | 206,279 | $195.1K | 0.00% | +35,892+21.1% | Added |
| Ieq Capital, LLC | 192,101 | $181.7K | 0.00% | +14,799+8.3% | Added |
| Ikarian Capital, LLC | 176,479 | $166.9K | 0.06% | −1,241,473−87.6% | Reduced |
| Cubist Systematic Strategies, LLC | 158,204 | $149.6K | 0.00% | +144,407+1,046.7% | Added |
| Jain Global LLC | 151,813 | $143.6K | 0.00% | +151,813 | New |
| Virtu Financial LLC | 146,805 | $139.0K | 0.01% | +146,805 | New |
| Morgan Stanley | 131,393 | $124.3K | 0.00% | −510,236−79.5% | Reduced |
| Aster Capital Management (DIFC) Ltd | 130,452 | $123.4K | 0.03% | +130,452 | New |
| CWM, LLC | 109,330 | $103.0K | 0.00% | +3,826+3.6% | Added |
| LPL Financial LLC | 104,433 | $98.8K | 0.00% | +33,476+47.2% | Added |
| Bank of Montreal | 100,000 | $94.6K | 0.00% | 00.0% | Unchanged |
| Squarepoint Ops LLC | 95,617 | $90.4K | 0.00% | −99,792−51.1% | Reduced |
| Commonwealth Equity Services, LLC | 90,864 | $86.0K | 0.00% | 00.0% | Unchanged |
| Quantessence Capital LLC | 84,098 | $79.5K | 0.02% | +84,098 | New |
| China Universal Asset Management Co., Ltd. | 72,943 | $69.0K | 0.01% | +434+0.6% | Added |
| Wealth Enhancement Advisory Services, LLC | 74,454 | $67.1K | 0.00% | +5,247+7.6% | Added |
| Point72 Asia (Singapore) Pte. Ltd. | 70,045 | $66.2K | 0.01% | −101,102−59.1% | Reduced |
| XTX Topco Ltd | 66,276 | $62.7K | 0.00% | +53,805+431.4% | Added |
| Fortis Group Advisors, LLC | 57,800 | $61.8K | 0.01% | +20,000+52.9% | Added |
| JustInvest LLC | 65,330 | $61.8K | 0.00% | +28,594+77.8% | Added |
| Straight Path Wealth Management | 62,666 | $59.3K | 0.02% | 00.0% | Unchanged |
| Scientech Research LLC | 57,862 | $54.7K | 0.01% | +57,862 | New |
| Boothbay Fund Management, LLC | 56,120 | $53.1K | 0.00% | −398,771−87.7% | Reduced |
| Catalyst Funds Management Pty Ltd | 53,700 | $50.8K | 0.01% | +53,700 | New |
| Simplex Trading, LLC | 52,680 | $49.0K | 0.00% | −122,302−69.9% | Reduced |
| Pinnacle Associates Ltd | 50,815 | $48.1K | 0.00% | −3,365−6.2% | Reduced |
| Citigroup Inc | 48,544 | $45.9K | 0.00% | −48,424−49.9% | Reduced |
| Two Sigma Securities, LLC | 42,405 | $40.1K | 0.00% | +42,405 | New |
| Wedbush Securities Inc | 40,850 | $39.0K | 0.00% | 00.0% | Unchanged |
| Pallas Capital Advisors LLC | 36,765 | $34.8K | 0.00% | +557+1.5% | Added |
| University of Texas/Texas Am Investment Managment Co | 35,714 | $33.8K | 0.01% | 00.0% | Unchanged |
| Captrust Financial Advisors | 35,582 | $33.6K | 0.00% | +2,398+7.2% | Added |
| Barclays PLC | 32,270 | $30.5K | 0.00% | −113,801−77.9% | Reduced |
| Bank of America Corp | 32,097 | $30.3K | 0.00% | −64,290−66.7% | Reduced |
| Pathstone Holdings, LLC | 30,041 | $28.4K | 0.00% | −1,356−4.3% | Reduced |
| R Squared Ltd | 29,559 | $28.0K | 0.02% | +29,559 | New |
| Hudson Bay Capital Management LP | 27,010 | $25.5K | 0.00% | +27,010 | New |
| Wells Fargo & Company | 26,423 | $25.0K | 0.00% | −37,505−58.7% | Reduced |
| JPMorgan Chase & Co | 24,684 | $23.3K | 0.00% | −63,515−72.0% | Reduced |
| D. E. Shaw & Co., Inc. | 23,723 | $22.4K | 0.00% | +23,723 | New |
| Oppenheimer & Co Inc | 23,500 | $22.2K | 0.00% | +3,400+16.9% | Added |
| Steward Partners Investment Advisory, LLC | 21,423 | $20.3K | 0.00% | +100+0.5% | Added |
| Cambridge Investment Research Advisors, Inc. | 21,500 | $20.0K | 0.00% | −575−2.6% | Reduced |
| Victory Capital Management Inc | 21,115 | $20.0K | 0.00% | −518−2.4% | Reduced |
| Invera Wealth Advisors, LLC | 20,000 | $18.9K | 0.01% | 00.0% | Unchanged |
| Tiaa Trust, National Association | 20,000 | $18.9K | 0.00% | 00.0% | Unchanged |
| KWB Wealth | 40,640 | $18.7K | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 19,237 | $18.2K | 0.00% | +15,917+479.4% | Added |
| Bank of New York Mellon Corp | 19,124 | $18.1K | 0.00% | −290,995−93.8% | Reduced |
| Merit Financial Group, LLC | 16,699 | $15.8K | 0.00% | +1,207+7.8% | Added |
| Integrated Wealth Concepts LLC | 16,210 | $15.3K | 0.00% | +16,210 | New |
| Jump Financial, LLC | 15,993 | $15.1K | 0.00% | +15,993 | New |
| HighTower Advisors, LLC | 14,910 | $14.1K | 0.00% | +14,910 | New |
| Mirae Asset Global Investments Co., Ltd. | 14,029 | $13.3K | 0.00% | +1,933+16.0% | Added |
| Truist Financial Corp | 14,000 | $13.2K | 0.00% | 00.0% | Unchanged |
| SG Americas Securities, LLC | 13,814 | $13.0K | 0.00% | −54,198−79.7% | Reduced |
| Buckingham Strategic Partners | 13,746 | $13.0K | 0.00% | +1,650+13.6% | Added |
| ProShare Advisors LLC | 13,561 | $12.8K | 0.00% | −27,601−67.1% | Reduced |
| Tower Research Capital LLC (TRC) | 12,690 | $12.0K | 0.00% | −15,417−54.9% | Reduced |
| ExodusPoint Capital Management, LP | 12,241 | $12.0K | 0.00% | +12,241 | New |
| Chemistry Wealth Management LLC | 12,000 | $11.3K | 0.00% | 00.0% | Unchanged |
| HBK Sorce Advisory LLC | 11,786 | $11.1K | 0.00% | +11,786 | New |
| Avantax Advisory Services, Inc. | 11,724 | $11.1K | 0.00% | 00.0% | Unchanged |
| North Star Asset Management Inc | 11,500 | $10.9K | 0.00% | 00.0% | Unchanged |
| Perennial Investment Advisors, LLC | 10,990 | $10.4K | 0.00% | +10,990 | New |
| Berger Financial Group, Inc | 10,929 | $10.3K | 0.00% | 00.0% | Unchanged |
| NBT Bank N A | 10,000 | $9.46K | 0.00% | +10,000 | New |
| BNP Paribas Arbitrage, SA | 8,703 | $8.23K | 0.00% | −80,411−90.2% | Reduced |
| Point72 (DIFC) Ltd | 6,982 | $6.60K | 0.00% | −6,345−47.6% | Reduced |
| Vermillion & White Wealth Management Group, LLC | 6,500 | $6.15K | 0.00% | +6,500 | New |
| Golden State Wealth Management, LLC | 3,700 | $3.50K | 0.00% | 00.0% | Unchanged |
| Optiver Holding B.V. | 3,035 | $2.87K | 0.00% | +1,192+64.7% | Added |