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Lexicon Pharmaceuticals, Inc.

LXRX
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001062822

No open-market purchases or sales by Lexicon Pharmaceuticals, Inc. insiders were filed in the last 90 days; 149 institutions reported holding it in 13F filings for Q2 2026, worth $875.1M in total; no superinvestor holds it.

13F holders, Q2 2025

Institutional positions in Lexicon Pharmaceuticals, Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
123
−4 vs. Q1 2025
Shares held
256.3M
−9.49M (−3.6%) vs. Q1 2025
Total value
$242.9M
+$120.5M (+98.4%) vs. Q1 2025
New holders
29
31 more added
Sold out
33
36 more reduced

Compare with Q1 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting LXRX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ2 2025: 123 institutions
Q1 2021: 107 institutionsQ2 2021: 107 institutionsQ3 2021: 96 institutionsQ4 2021: 110 institutionsQ1 2022: 101 institutionsQ2 2022: 86 institutionsQ3 2022: 98 institutionsQ4 2022: 105 institutionsQ1 2023: 104 institutionsQ2 2023: 123 institutionsQ3 2023: 112 institutionsQ4 2023: 106 institutionsQ1 2024: 118 institutionsQ2 2024: 127 institutionsQ3 2024: 137 institutionsQ4 2024: 127 institutionsQ1 2025: 127 institutionsQ2 2025: 123 institutionsQ3 2025: 124 institutionsQ4 2025: 126 institutionsQ1 2026: 137 institutionsQ2 2026: 149 institutions
Value heldQ2 2025: $242.9M
Q1 2021: $711.5MQ2 2021: $540.2MQ3 2021: $583.0MQ4 2021: $478.9MQ1 2022: $251.3MQ2 2022: $221.0MQ3 2022: $357.3MQ4 2022: $280.5MQ1 2023: $353.8MQ2 2023: $438.2MQ3 2023: $205.8MQ4 2023: $279.8MQ1 2024: $417.8MQ2 2024: $471.0MQ3 2024: $453.1MQ4 2024: $220.1MQ1 2025: $122.5MQ2 2025: $242.9MQ3 2025: $344.4MQ4 2025: $299.5MQ1 2026: $504.5MQ2 2026: $875.1M
Institutions holding LXRX and their total value by quarter
QuarterHoldersValue
Q2 2026149$875.1M
Q1 2026137$504.5M
Q4 2025126$299.5M
Q3 2025124$344.4M
Q2 2025123$242.9M
Q1 2025127$122.5M
Q4 2024127$220.1M
Q3 2024137$453.1M
Q2 2024127$471.0M
Q1 2024118$417.8M
Q4 2023106$279.8M
Q3 2023112$205.8M
Q2 2023123$438.2M
Q1 2023104$353.8M
Q4 2022105$280.5M
Q3 202298$357.3M
Q2 202286$221.0M
Q1 2022101$251.3M
Q4 2021110$478.9M
Q3 202196$583.0M
Q2 2021107$540.2M
Q1 2021107$711.5M

Institutions, Q2 2025

Shares, value and share of portfolio for each institution holding Lexicon Pharmaceuticals, Inc.; share changes are against Q1 2025.

Institutions holding LXRX in Q2 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Nisa Investment Advisors, LLC2,592$2.45K0.00%+1,992+332.0%Added
Essential Partners LLC2,134$2.02K0.00%+2,134New
Raymond James Financial Inc2,076$1.96K0.00%−9,836−82.6%Reduced
Quintet Private Bank (Europe) S.A.1,928$1.82K0.00%00.0%Unchanged
Jones Financial Companies LLLP2,042$1.67K0.00%00.0%Unchanged
The PNC Financial Services Group, Inc.1,461$1.38K0.00%00.0%Unchanged
UMA Financial Services, Inc.1,412$1.34K0.00%+1,412New
Rialto Wealth Management, LLC1,313$1.24K0.00%00.0%Unchanged
EverSource Wealth Advisors, LLC1,163$1.10K0.00%+233+25.1%Added
Daiwa Securities Group Inc.1,369$1.00K0.00%00.0%Unchanged
Avion Wealth1,333$1.00K0.00%+199+17.5%Added
Farther Finance Advisors, LLC1,002$9480.00%+1,000+50,000.0%Added
Global Retirement Partners, LLC1,000$9460.00%+1,000New
True Wealth Design, LLC743$7030.00%+124+20.0%Added
Advisor Group Holdings, Inc.742$6970.00%−200−21.2%Reduced
Fortitude Family Office, LLC706$6680.00%+706New
Northwestern Mutual Wealth Management Co500$4730.00%00.0%Unchanged
Syntax Research, Inc.142$1350.00%00.0%Unchanged
Comerica Bank122$1150.00%00.0%Unchanged
Larson Financial Group LLC100$950.00%00.0%Unchanged
CBIZ Investment Advisory Services, LLC71$670.00%00.0%Unchanged
IFP Advisors, Inc1$10.00%+1New
Covestor Ltd81$00.00%00.0%Unchanged
Rhumbline Advisers0$00.00%−137,230−100.0%Sold out
Tang Capital Management LLC0$00.00%−1,150,268−100.0%Sold out
Acadian Asset Management LLC0$00.00%−573,688−100.0%Sold out
BBR Partners, LLC0$00.00%−570,000−100.0%Sold out
Nantahala Capital Management, LLC0$00.00%−460,850−100.0%Sold out
Virtus Investment Advisers, Inc.0$00.00%−436,672−100.0%Sold out
Alliancebernstein L.P.0$00.00%−246,121−100.0%Sold out
Deutsche Bank AG0$00.00%−94,394−100.0%Sold out
Price T Rowe Associates Inc0$00.00%−92,248−100.0%Sold out
Intech Investment Management LLC0$00.00%−73,853−100.0%Sold out
Mirae Asset Global ETFs Holdings Ltd.0$00.00%−68,683−100.0%Sold out
Corebridge Financial, Inc.0$00.00%−56,248−100.0%Sold out
New York State Common Retirement Fund0$00.00%−33,702−100.0%Sold out
Police & Firemen's Retirement System of New Jersey0$00.00%−29,715−100.0%Sold out
CIBC World Markets Corp0$00.00%−25,477−100.0%Sold out
SIH Partners, LLLP0$00.00%−23,712−100.0%Sold out
Simplicity Wealth,LLC0$00.00%−20,447−100.0%Sold out
Ethic Inc.0$00.00%−17,259−100.0%Sold out
HSBC Holdings PLC0$00.00%−13,415−100.0%Sold out
Voya Investment Management LLC0$00.00%−13,922−100.0%Sold out
Legal & General Group Plc0$00.00%−11,466−100.0%Sold out
Chaney Capital Management, Inc.0$00.00%−11,167−100.0%Sold out
Unique Wealth Strategies, LLC0$00.00%−10,000−100.0%Sold out
Ameritas Investment Partners, Inc.0$00.00%−8,867−100.0%Sold out
California State Teachers Retirement System0$00.00%−8,319−100.0%Sold out
Amalgamated Bank0$00.00%−2,409−100.0%Sold out
Coldstream Capital Management Inc0$00.00%−1,388−100.0%Sold out
Sterling Capital Management LLC0$00.00%−1,280−100.0%Sold out
US Bancorp0$00.00%−1,082−100.0%Sold out
Pinney & Scofield, Inc.0$00.00%−1,000−100.0%Sold out
Citadel Advisors LLC0$00.00%−406−100.0%Sold out
SJS Investment Consulting Inc.0$00.00%−400−100.0%Sold out
GWM Advisors LLC0$00.00%−5−100.0%Sold out