Lexicon Pharmaceuticals, Inc.
LXRX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001062822
No open-market purchases or sales by Lexicon Pharmaceuticals, Inc. insiders were filed in the last 90 days; 149 institutions reported holding it in 13F filings for Q2 2026, worth $875.1M in total; no superinvestor holds it.
Holders of 5% or more of LXRX
Holders whose latest Schedule 13D or 13G filing reports 5% or more of Lexicon Pharmaceuticals, Inc., largest stake first. The change is against the holder's previous filing.
| Holder | Latest form | Stake | Change | First filed | Latest filing | Filing |
|---|---|---|---|---|---|---|
| Invus Global Management, LLC | 13D/A | 39.40%175.2M shares | +3.20 ppfrom 36.20% | Feb 2, 20262 filings | May 8, 2026 | SEC |
| FMR LLC | 13G/A | 11.70%51.8M shares | +1.20 ppfrom 10.50% | Jan 11, 20215 filings | Aug 6, 2026 | SEC |
Stakes are as of each holder's latest filing. Holders whose last filing was in the old format (before December 18, 2024) have no stake on record and are not listed, and after an acquisition or delisting holders usually stop filing.
13D and 13G filings
13 Schedule 13D and 13G filings on Lexicon Pharmaceuticals, Inc., newest first, including old-format filings without a stake.
| Filed (ET) | Filer | Form | Stake | Change | Event date | Filing |
|---|---|---|---|---|---|---|
| Aug 6, 202610:31 AM ET | FMR LLCand 1 other | 13G/A | 11.70%51.8M shares | +1.20 ppfrom 10.50% | Jun 30, 2026 | SEC |
| May 8, 20269:42 PM ET | Invus Global Management, LLCand 17 others | 13D/A | 39.40%175.2M shares | +3.20 ppfrom 36.20% | Apr 30, 2026 | SEC |
| Feb 2, 20269:54 PM ET | Invus Global Management, LLCand 17 others | 13D/A | 36.20%154.7M shares | – | Jan 29, 2026 | SEC |
| Jul 8, 20259:07 AM ET | FMR LLCand 1 other | 13G/A | 10.50%38.1M shares | +0.90 ppfrom 9.60% | Jun 30, 2025 | SEC |
| May 12, 202510:36 AM ET | FMR LLCand 1 other | 13G/A | 9.60%34.5M shares | – | Mar 31, 2025 | SEC |
| Feb 14, 2023 | Biotechnology Value Fund L P | 13G/AOld format | – | – | – | SEC |
| Aug 9, 2022 | Invus, L.P. | 13D/AOld format | – | – | – | SEC |
| Aug 1, 2022 | Invus, L.P. | 13D/AOld format | – | – | – | SEC |
| Feb 14, 2022 | Biotechnology Value Fund L P | 13G/AOld format | – | – | – | SEC |
| Feb 9, 2022 | FMR LLC | 13G/AOld format | – | – | – | SEC |
| Jan 21, 2021 | Invus, L.P. | 13D/AOld format | – | – | – | SEC |
| Jan 11, 2021 | FMR LLC | 13G/AOld format | – | – | – | SEC |
| Jan 5, 2021 | Invus, L.P. | 13D/AOld format | – | – | – | SEC |
Form 144: proposed insider sales
Notices from officers, directors and other affiliates planning to sell Lexicon Pharmaceuticals, Inc. shares.
No Form 144 notices for Lexicon Pharmaceuticals, Inc. are on file.