Lexicon Pharmaceuticals, Inc.
LXRX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001062822
No open-market purchases or sales by Lexicon Pharmaceuticals, Inc. insiders were filed in the last 90 days; 149 institutions reported holding it in 13F filings for Q2 2026, worth $875.1M in total; no superinvestor holds it.
13F holders, Q2 2026
Institutional positions in Lexicon Pharmaceuticals, Inc. as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 149
- +13 vs. Q1 2026
- Shares held
- 364.6M
- +41.2M (+12.8%) vs. Q1 2026
- Total value
- $875.1M
- +$370.5M (+73.4%) vs. Q1 2026
- New holders
- 43
- 37 more added
- Sold out
- 30
- 36 more reduced
1 institution that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting LXRX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 149 | $875.1M |
| Q1 2026 | 137 | $504.5M |
| Q4 2025 | 126 | $299.5M |
| Q3 2025 | 124 | $344.5M |
| Q2 2025 | 123 | $243.7M |
| Q1 2025 | 127 | $122.5M |
| Q4 2024 | 127 | $220.1M |
| Q3 2024 | 137 | $453.2M |
| Q2 2024 | 127 | $475.0M |
| Q1 2024 | 118 | $419.2M |
| Q4 2023 | 106 | $285.9M |
| Q3 2023 | 112 | $205.8M |
| Q2 2023 | 123 | $438.2M |
| Q1 2023 | 104 | $366.6M |
| Q4 2022 | 105 | $280.5M |
| Q3 2022 | 98 | $357.6M |
| Q2 2022 | 86 | $221.4M |
| Q1 2022 | 101 | $251.3M |
| Q4 2021 | 110 | $479.8M |
| Q3 2021 | 96 | $583.0M |
| Q2 2021 | 107 | $541.5M |
| Q1 2021 | 107 | $711.5M |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Lexicon Pharmaceuticals, Inc.; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Artal Group S.A. | 175,156,062 | $420.4M | 45.15% | +20,421,735+13.2% | Added |
| FMR LLC | 51,782,045 | $124.3M | 0.01% | +6,725,707+14.9% | Added |
| Siren, L.L.C. | 44,303,518 | $106.3M | 2.16% | 00.0% | Unchanged |
| Sessa Capital IM, L.P. | 18,960,836 | $45.5M | 0.79% | +1,047,875+5.8% | Added |
| BlackRock, Inc. | 17,348,741 | $41.6M | 0.00% | +14,026,522+422.2% | Added |
| Vanguard Capital Management LLC | 9,901,208 | $23.8M | 0.00% | +382,041+4.0% | Added |
| Point72 Asset Management, L.P. | 8,251,325 | $19.8M | 0.03% | +436,719+5.6% | Added |
| Geode Capital Management, LLC | 6,244,372 | $15.0M | 0.00% | +3,075,261+97.0% | Added |
| State Street Corp | 4,917,769 | $11.8M | 0.00% | +3,953,731+410.1% | Added |
| Vanguard Portfolio Management LLC | 2,357,749 | $5.66M | 0.00% | +1,811,149+331.3% | Added |
| Northern Trust Corp | 1,968,619 | $4.72M | 0.00% | +1,473,953+298.0% | Added |
| Charles Schwab Investment Management Inc | 1,956,775 | $4.70M | 0.00% | +645,477+49.2% | Added |
| Vanguard Fiduciary Trust Co | 1,634,571 | $3.92M | 0.00% | +302,287+22.7% | Added |
| Citadel Advisors LLC | 1,601,182 | $3.84M | 0.00% | +506,281+46.2% | Added |
| Ishara Investments LP | 1,271,000 | $3.05M | 2.24% | +369,000+40.9% | Added |
| Millennium Management LLC | 1,134,229 | $2.72M | 0.00% | −3,810,502−77.1% | Reduced |
| Renaissance Technologies LLC | 1,127,000 | $2.70M | 0.00% | −473,500−29.6% | Reduced |
| Mackenzie Financial Corp | 963,354 | $2.31M | 0.00% | +190,677+24.7% | Added |
| ADAR1 Capital Management, LLC | 750,000 | $1.80M | 0.08% | 00.0% | Unchanged |
| Susquehanna International Group, LLP | 696,776 | $1.67M | 0.00% | −1,424,388−67.2% | Reduced |
| Acadian Asset Management LLC | 696,617 | $1.67M | 0.00% | +251,329+56.4% | Added |
| UBS Group AG | 684,713 | $1.64M | 0.00% | −1,798,469−72.4% | Reduced |
| Two Sigma Investments, LP | 643,444 | $1.54M | 0.00% | −556,188−46.4% | Reduced |
| Nuveen, LLC | 586,664 | $1.41M | 0.00% | +586,664 | New |
| Bank of New York Mellon Corp | 568,706 | $1.36M | 0.00% | +541,247+1,971.1% | Added |
| Invesco Ltd. | 508,071 | $1.22M | 0.00% | −4,355−0.8% | Reduced |
| Goldman Sachs Group Inc | 485,546 | $1.17M | 0.00% | −584,971−54.6% | Reduced |
| Compagnie Lombard Odier SCmA | 480,000 | $1.15M | 0.01% | −30,000−5.9% | Reduced |
| Bank of America Corp | 421,299 | $1.01M | 0.00% | −104,804−19.9% | Reduced |
| Gsa Capital Partners LLP | 397,219 | $953.0K | 0.06% | −532,870−57.3% | Reduced |
| Barclays PLC | 387,483 | $930.0K | 0.00% | +281,996+267.3% | Added |
| XTX Topco Ltd | 357,877 | $858.9K | 0.01% | +43,263+13.8% | Added |
| Janney Montgomery Scott LLC | 295,548 | $709.0K | 0.00% | +295,548 | New |
| Canada Pension Plan Investment Board | 257,900 | $619.0K | 0.00% | +257,900 | New |
| Rhumbline Advisers | 256,885 | $616.5K | 0.00% | +256,885 | Added |
| Deutsche Bank AG | 247,528 | $594.1K | 0.00% | +247,528 | New |
| Wells Fargo & Company | 230,470 | $553.1K | 0.00% | +222,710+2,870.0% | Added |
| Price T Rowe Associates Inc | 204,391 | $491.0K | 0.00% | +204,391 | New |
| Wellington Management Group LLP | 179,700 | $431.3K | 0.00% | +179,700 | New |
| Citigroup Inc | 175,205 | $420.5K | 0.00% | +8,807+5.3% | Added |
| Group One Trading, L.P. | 175,013 | $420.0K | 0.01% | −9,993−5.4% | Reduced |
| Virtus Investment Advisers, Inc. | 170,415 | $409.0K | 0.10% | +170,415 | New |
| Headlands Technologies LLC | 167,198 | $401.3K | 0.04% | −24,124−12.6% | Reduced |
| Ikarian Capital, LLC | 164,674 | $395.2K | 0.06% | 00.0% | Unchanged |
| Quarry LP | 156,186 | $374.8K | 0.06% | +46,186+42.0% | Added |
| MetLife Investment Management | 146,410 | $351.4K | 0.00% | +146,410 | New |
| Morgan Stanley | 132,902 | $319.0K | 0.00% | −86,960−39.6% | Reduced |
| Panagora Asset Management Inc | 132,042 | $316.9K | 0.00% | +132,042 | New |
| JPMorgan Chase & Co | 109,839 | $290.0K | 0.00% | +109,839 | New |
| State of Wyoming | 119,090 | $285.8K | 0.03% | +108,311+1,004.8% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 114,114 | $273.9K | 0.00% | +114,114 | New |
| Cornerstone Investment Partners, LLC | 113,739 | $273.0K | 0.01% | +113,739 | New |
| Cerity Partners LLC | 98,400 | $236.2K | 0.00% | −12,058−10.9% | Reduced |
| Algert Global LLC | 92,150 | $221.2K | 0.00% | +92,150 | New |
| Bank of Nova Scotia | 86,607 | $207.9K | 0.00% | +12,900+17.5% | Added |
| LPL Financial LLC | 84,916 | $203.8K | 0.00% | +15,133+21.7% | Added |
| Vanguard Global Advisers, LLC | 77,946 | $187.1K | 0.00% | −15,695−16.8% | Reduced |
| AQR Capital Management LLC | 75,230 | $180.6K | 0.00% | −21,004−21.8% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 73,402 | $176.2K | 0.00% | +73,402 | New |
| University of Texas/Texas Am Investment Managment Co | 71,427 | $171.4K | 0.02% | +35,713+100.0% | Added |
| Prudential Financial Inc | 71,345 | $171.2K | 0.00% | +37,545+111.1% | Added |
| Manufacturers Life Insurance Company, The | 69,747 | $167.4K | 0.00% | +69,747 | New |
| New York State Common Retirement Fund | 68,400 | $164.2K | 0.00% | +68,400 | New |
| Two Sigma Securities, LLC | 66,375 | $159.3K | 0.01% | +66,375 | New |
| SEI Investments Co | 63,937 | $153.4K | 0.00% | +63,937 | New |
| Straight Path Wealth Management | 62,666 | $150.4K | 0.04% | 00.0% | Unchanged |
| R Squared Ltd | 54,985 | $132.0K | 0.07% | −12,541−18.6% | Reduced |
| JustInvest LLC | 54,334 | $130.4K | 0.00% | −631−1.1% | Reduced |
| Fortis Group Advisors, LLC | 50,000 | $120.0K | 0.02% | 00.0% | Unchanged |
| Schonfeld Strategic Advisors LLC | 49,435 | $118.6K | 0.00% | −25,675−34.2% | Reduced |
| Scotia Capital Inc. | 48,871 | $117.3K | 0.00% | −110,960−69.4% | Reduced |
| Profund Advisors LLC | 48,586 | $116.6K | 0.00% | +48,586 | New |
| Voya Investment Management LLC | 47,771 | $114.7K | 0.00% | +47,771 | New |
| Axq Capital, LP | 45,727 | $109.7K | 0.01% | +25,577+126.9% | Added |
| Boothbay Fund Management, LLC | 44,315 | $106.4K | 0.00% | 00.0% | Unchanged |
| Alliancebernstein L.P. | 67,800 | $105.8K | 0.00% | +67,800 | New |
| Winton Group Ltd | 43,200 | $103.7K | 0.00% | +17,700+69.4% | Added |
| Intech Investment Management LLC | 42,491 | $102.0K | 0.00% | +42,491 | New |
| LMR Partners LLP | 41,091 | $98.6K | 0.00% | +17,786+76.3% | Added |
| Bank of Montreal | 40,000 | $96.0K | 0.00% | −30,000−42.9% | Reduced |
| BNP Paribas Arbitrage, SA | 37,780 | $90.7K | 0.00% | +20,230+115.3% | Added |
| Rafferty Asset Management, LLC | 34,090 | $81.8K | 0.00% | +34,090 | New |
| ProShare Advisors LLC | 32,588 | $78.2K | 0.00% | +32,588 | New |
| Leonteq Securities AG | 30,000 | $72.0K | 0.00% | 00.0% | Unchanged |
| Pathstone Holdings, LLC | 29,969 | $71.9K | 0.00% | +195+0.7% | Added |
| Pinnacle Associates Ltd | 29,015 | $69.6K | 0.00% | 00.0% | Unchanged |
| Security National Bank of Sioux City Iowa | 26,650 | $64.0K | 0.03% | 00.0% | Unchanged |
| Victory Capital Management Inc | 24,223 | $58.1K | 0.00% | +1,544+6.8% | Added |
| Legal & General Group Plc | 24,185 | $58.0K | 0.00% | +24,185 | New |
| Xponance, Inc. | 23,763 | $57.0K | 0.00% | +23,763 | New |
| Graham Capital Management, L.P. | 23,541 | $56.5K | 0.00% | −10,486−30.8% | Reduced |
| Ameritas Investment Partners, Inc. | 22,986 | $55.2K | 0.00% | +22,986 | New |
| D. E. Shaw & Co., Inc. | 22,200 | $53.3K | 0.00% | +22,200 | New |
| Quadrature Capital Ltd | 21,998 | $52.8K | 0.00% | −88,381−80.1% | Reduced |
| Wedbush Securities Inc | 20,000 | $48.0K | 0.00% | −20,850−51.0% | Reduced |
| Tiaa-Cref Individual & Institutional Services, LLC | 20,000 | $48.0K | 0.00% | 00.0% | Unchanged |
| Diker Management LLC | 20,000 | $48.0K | 0.04% | 00.0% | Unchanged |
| Invera Wealth Advisors, LLC | 20,000 | $48.0K | 0.03% | 00.0% | Unchanged |
| Russell Investments Group, Ltd. | 19,902 | $47.8K | 0.00% | +19,902 | New |
| Tower Research Capital LLC (TRC) | 19,486 | $46.8K | 0.00% | +19,486 | New |