Lexicon Pharmaceuticals, Inc.
LXRX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001062822
No open-market purchases or sales by Lexicon Pharmaceuticals, Inc. insiders were filed in the last 90 days; 149 institutions reported holding it in 13F filings for Q2 2026, worth $875.1M in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Lexicon Pharmaceuticals, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 124
- +2 vs. Q2 2025
- Shares held
- 255.1M
- −1.13M (−0.4%) vs. Q2 2025
- Total value
- $344.4M
- +$101.5M (+41.8%) vs. Q2 2025
- New holders
- 19
- 26 more added
- Sold out
- 17
- 42 more reduced
1 institution that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting LXRX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 149 | $875.1M |
| Q1 2026 | 137 | $504.5M |
| Q4 2025 | 126 | $299.5M |
| Q3 2025 | 124 | $344.4M |
| Q2 2025 | 123 | $242.9M |
| Q1 2025 | 127 | $122.5M |
| Q4 2024 | 127 | $220.1M |
| Q3 2024 | 137 | $453.1M |
| Q2 2024 | 127 | $471.0M |
| Q1 2024 | 118 | $417.8M |
| Q4 2023 | 106 | $279.8M |
| Q3 2023 | 112 | $205.8M |
| Q2 2023 | 123 | $438.2M |
| Q1 2023 | 104 | $353.8M |
| Q4 2022 | 105 | $280.5M |
| Q3 2022 | 98 | $357.3M |
| Q2 2022 | 86 | $221.0M |
| Q1 2022 | 101 | $251.3M |
| Q4 2021 | 110 | $478.9M |
| Q3 2021 | 96 | $583.0M |
| Q2 2021 | 107 | $540.2M |
| Q1 2021 | 107 | $711.5M |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Lexicon Pharmaceuticals, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Covestor Ltd | 81 | $0 | 0.00% | 00.0% | Unchanged |
| IFP Advisors, Inc | 1 | $1 | 0.00% | 00.0% | Unchanged |
| Rhumbline Advisers | 0 | $2 | 0.00% | 0 | New |
| Point72 (DIFC) Ltd | 15 | $20 | 0.00% | −6,967−99.8% | Reduced |
| True Wealth Design, LLC | 85 | $115 | 0.00% | −658−88.6% | Reduced |
| Larson Financial Group LLC | 100 | $135 | 0.00% | 00.0% | Unchanged |
| Comerica Bank | 122 | $165 | 0.00% | 00.0% | Unchanged |
| Syntax Research, Inc. | 142 | $192 | 0.00% | 00.0% | Unchanged |
| Wells Fargo & Company | 301 | $406 | 0.00% | −26,122−98.9% | Reduced |
| Rockefeller Capital Management L.P. | 335 | $452 | 0.00% | +335 | New |
| EverSource Wealth Advisors, LLC | 455 | $615 | 0.00% | −708−60.9% | Reduced |
| TFC Financial Management | 500 | $675 | 0.00% | +500 | New |
| Essential Partners LLC | 511 | $690 | 0.00% | −1,623−76.1% | Reduced |
| Northwestern Mutual Wealth Management Co | 514 | $694 | 0.00% | +14+2.8% | Added |
| Federation des caisses Desjardins du Quebec | 571 | $771 | 0.00% | +571 | New |
| Advisor Group Holdings, Inc. | 742 | $816 | 0.00% | 00.0% | Unchanged |
| Fortitude Family Office, LLC | 706 | $953 | 0.00% | 00.0% | Unchanged |
| Avion Wealth | 1,333 | $1.00K | 0.00% | 00.0% | Unchanged |
| Jones Financial Companies LLLP | 892 | $1.25K | 0.00% | −1,150−56.3% | Reduced |
| Caitong International Asset Management Co., Ltd | 959 | $1.29K | 0.00% | +959 | New |
| Global Retirement Partners, LLC | 1,000 | $1.35K | 0.00% | 00.0% | Unchanged |
| Farther Finance Advisors, LLC | 1,255 | $1.69K | 0.00% | +253+25.2% | Added |
| Rialto Wealth Management, LLC | 1,313 | $1.77K | 0.00% | 00.0% | Unchanged |
| UMA Financial Services, Inc. | 1,412 | $1.91K | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 1,461 | $1.97K | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 1,369 | $2.00K | 0.00% | 00.0% | Unchanged |
| Nisa Investment Advisors, LLC | 2,592 | $3.50K | 0.00% | 00.0% | Unchanged |
| Advisory Services Network, LLC | 3,242 | $4.38K | 0.00% | +3,242 | New |
| Golden State Wealth Management, LLC | 3,700 | $5.00K | 0.00% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 4,988 | $6.73K | 0.00% | −3,715−42.7% | Reduced |
| SRS Capital Advisors, Inc. | 5,097 | $6.88K | 0.00% | +5,097 | New |
| GF Fund Management Co. Ltd. | 7,818 | $10.6K | 0.00% | +7,818 | New |
| State of Wyoming | 8,526 | $11.5K | 0.00% | +8,526 | New |
| NBT Bank N A | 10,000 | $13.5K | 0.00% | 00.0% | Unchanged |
| Steward Partners Investment Advisory, LLC | 10,785 | $14.6K | 0.00% | −10,638−49.7% | Reduced |
| Berger Financial Group, Inc | 10,929 | $14.8K | 0.00% | 00.0% | Unchanged |
| Perennial Investment Advisors, LLC | 10,990 | $14.8K | 0.00% | 00.0% | Unchanged |
| SG Americas Securities, LLC | 10,830 | $15.0K | 0.00% | −2,984−21.6% | Reduced |
| North Star Asset Management Inc | 11,500 | $15.5K | 0.00% | 00.0% | Unchanged |
| Chemistry Wealth Management LLC | 12,000 | $16.2K | 0.00% | 00.0% | Unchanged |
| ProShare Advisors LLC | 12,946 | $17.5K | 0.00% | −615−4.5% | Reduced |
| HBK Sorce Advisory LLC | 11,786 | $18.0K | 0.00% | 00.0% | Unchanged |
| Truist Financial Corp | 14,000 | $18.9K | 0.00% | 00.0% | Unchanged |
| Mirae Asset Global Investments Co., Ltd. | 14,049 | $19.0K | 0.00% | +20+0.1% | Added |
| Captrust Financial Advisors | 14,069 | $19.0K | 0.00% | −21,513−60.5% | Reduced |
| SBI Securities Co., Ltd. | 15,047 | $20.3K | 0.00% | −4,190−21.8% | Reduced |
| Two Sigma Securities, LLC | 15,881 | $21.4K | 0.00% | −26,524−62.5% | Reduced |
| Ieq Capital, LLC | 16,266 | $22.0K | 0.00% | −175,835−91.5% | Reduced |
| Cetera Investment Advisers | 17,524 | $23.7K | 0.00% | +17,524 | New |
| Citigroup Inc | 18,119 | $24.5K | 0.00% | −30,425−62.7% | Reduced |
| Bank of New York Mellon Corp | 19,124 | $25.8K | 0.00% | 00.0% | Unchanged |
| Invera Wealth Advisors, LLC | 20,000 | $27.0K | 0.02% | 00.0% | Unchanged |
| Tiaa Trust, National Association | 20,000 | $27.0K | 0.00% | 00.0% | Unchanged |
| Victory Capital Management Inc | 21,023 | $28.4K | 0.00% | −92−0.4% | Reduced |
| Wealth Enhancement Advisory Services, LLC | 18,877 | $28.7K | 0.00% | −55,577−74.6% | Reduced |
| Wolverine Trading, LLC | 21,191 | $29.5K | 0.00% | +21,191 | New |
| Oppenheimer & Co Inc | 23,500 | $31.7K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 23,679 | $32.0K | 0.00% | +10,989+86.6% | Added |
| Cambridge Investment Research Advisors, Inc. | 23,400 | $32.0K | 0.00% | +1,900+8.8% | Added |
| Scientech Research LLC | 24,884 | $33.6K | 0.01% | −32,978−57.0% | Reduced |
| CWM, LLC | 26,744 | $36.0K | 0.00% | −82,586−75.5% | Reduced |
| KWB Wealth | 40,640 | $38.4K | 0.00% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 30,037 | $40.5K | 0.00% | +5,353+21.7% | Added |
| Pathstone Holdings, LLC | 30,208 | $40.8K | 0.00% | +167+0.6% | Added |
| Barclays PLC | 31,862 | $43.0K | 0.00% | −408−1.3% | Reduced |
| R Squared Ltd | 32,049 | $43.3K | 0.02% | +2,490+8.4% | Added |
| Vermillion & White Wealth Management Group, LLC | 32,500 | $43.9K | 0.02% | +26,000+400.0% | Added |
| Prudential Financial Inc | 35,000 | $47.2K | 0.00% | +35,000 | New |
| Point72 Asia (Singapore) Pte. Ltd. | 35,024 | $47.3K | 0.01% | −35,021−50.0% | Reduced |
| Commonwealth Equity Services, LLC | 35,738 | $48.0K | 0.00% | −55,126−60.7% | Reduced |
| University of Texas/Texas Am Investment Managment Co | 35,714 | $48.2K | 0.01% | 00.0% | Unchanged |
| Acadian Asset Management LLC | 36,905 | $49.0K | 0.00% | +36,905 | New |
| Catalyst Funds Management Pty Ltd | 40,300 | $54.4K | 0.01% | −13,400−25.0% | Reduced |
| Wedbush Securities Inc | 40,850 | $55.0K | 0.00% | 00.0% | Unchanged |
| HRT Financial LP | 46,447 | $62.0K | 0.00% | −442,021−90.5% | Reduced |
| Headlands Technologies LLC | 49,647 | $67.0K | 0.01% | +49,647 | New |
| Pinnacle Associates Ltd | 50,815 | $68.6K | 0.00% | 00.0% | Unchanged |
| Boothbay Fund Management, LLC | 56,120 | $75.8K | 0.00% | 00.0% | Unchanged |
| Bank of America Corp | 57,804 | $78.0K | 0.00% | +25,707+80.1% | Added |
| Squarepoint Ops LLC | 58,676 | $79.2K | 0.00% | −36,941−38.6% | Reduced |
| Fortis Group Advisors, LLC | 57,800 | $79.8K | 0.01% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 59,347 | $80.1K | 0.00% | −266,399−81.8% | Reduced |
| Straight Path Wealth Management | 62,666 | $84.6K | 0.02% | 00.0% | Unchanged |
| Cubist Systematic Strategies, LLC | 63,484 | $85.7K | 0.00% | −94,720−59.9% | Reduced |
| China Universal Asset Management Co., Ltd. | 63,698 | $86.0K | 0.01% | −9,245−12.7% | Reduced |
| JustInvest LLC | 66,567 | $89.9K | 0.00% | +1,237+1.9% | Added |
| Bank of Montreal | 70,000 | $94.5K | 0.00% | −30,000−30.0% | Reduced |
| Simplex Trading, LLC | 73,287 | $98.0K | 0.00% | +20,607+39.1% | Added |
| Optiver Holding B.V. | 75,893 | $102.5K | 0.00% | +72,858+2,400.6% | Added |
| LPL Financial LLC | 91,258 | $123.2K | 0.00% | −13,175−12.6% | Reduced |
| Jefferies Financial Group Inc. | 97,400 | $131.5K | 0.00% | +97,400 | New |
| Cerity Partners LLC | 158,040 | $213.4K | 0.00% | −48,239−23.4% | Reduced |
| Morgan Stanley | 169,018 | $228.2K | 0.00% | +37,625+28.6% | Added |
| Ikarian Capital, LLC | 176,479 | $238.2K | 0.05% | 00.0% | Unchanged |
| Group One Trading, L.P. | 216,244 | $291.9K | 0.01% | −130,508−37.6% | Reduced |
| Quadrature Capital Ltd | 228,209 | $309.2K | 0.00% | +228,209 | New |
| Renaissance Technologies LLC | 292,400 | $394.7K | 0.00% | +292,400 | New |
| AQR Capital Management LLC | 302,931 | $409.0K | 0.00% | −1,099,279−78.4% | Reduced |
| XTX Topco Ltd | 329,536 | $444.9K | 0.02% | +263,260+397.2% | Added |
| Monaco Asset Management SAM | 350,000 | $472.5K | 0.18% | −181,600−34.2% | Reduced |