Lexicon Pharmaceuticals, Inc.
LXRX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001062822
No open-market purchases or sales by Lexicon Pharmaceuticals, Inc. insiders were filed in the last 90 days; 149 institutions reported holding it in 13F filings for Q2 2026, worth $875.1M in total; no superinvestor holds it.
13F holders, Q1 2026
Institutional positions in Lexicon Pharmaceuticals, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 137
- +16 vs. Q4 2025
- Shares held
- 323.4M
- +74.5M (+29.9%) vs. Q4 2025
- Total value
- $504.5M
- +$218.3M (+76.3%) vs. Q4 2025
- New holders
- 31
- 41 more added
- Sold out
- 15
- 26 more reduced
5 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting LXRX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 149 | $875.1M |
| Q1 2026 | 137 | $504.5M |
| Q4 2025 | 126 | $299.5M |
| Q3 2025 | 124 | $344.4M |
| Q2 2025 | 123 | $242.9M |
| Q1 2025 | 127 | $122.5M |
| Q4 2024 | 127 | $220.1M |
| Q3 2024 | 137 | $453.1M |
| Q2 2024 | 127 | $471.0M |
| Q1 2024 | 118 | $417.8M |
| Q4 2023 | 106 | $279.8M |
| Q3 2023 | 112 | $205.8M |
| Q2 2023 | 123 | $438.2M |
| Q1 2023 | 104 | $353.8M |
| Q4 2022 | 105 | $280.5M |
| Q3 2022 | 98 | $357.3M |
| Q2 2022 | 86 | $221.0M |
| Q1 2022 | 101 | $251.3M |
| Q4 2021 | 110 | $478.9M |
| Q3 2021 | 96 | $583.0M |
| Q2 2021 | 107 | $540.2M |
| Q1 2021 | 107 | $711.5M |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Lexicon Pharmaceuticals, Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Covestor Ltd | 81 | $0 | 0.00% | 00.0% | Unchanged |
| Rhumbline Advisers | 0 | $2 | 0.00% | 0 | Unchanged |
| True Wealth Design, LLC | 2 | $4 | 0.00% | −47−95.9% | Reduced |
| HM Payson & Co | 37 | $58 | 0.00% | +37 | New |
| SRS Capital Advisors, Inc. | 41 | $64 | 0.00% | 00.0% | Unchanged |
| EverSource Wealth Advisors, LLC | 48 | $75 | 0.00% | −110−69.6% | Reduced |
| Larson Financial Group LLC | 100 | $156 | 0.00% | 00.0% | Unchanged |
| Syntax Research, Inc. | 142 | $222 | 0.00% | 00.0% | Unchanged |
| Parallel Advisors, LLC | 247 | $385 | 0.00% | +247 | New |
| Farther Finance Advisors, LLC | 255 | $418 | 0.00% | −2,500−90.7% | Reduced |
| Rockefeller Capital Management L.P. | 335 | $523 | 0.00% | 00.0% | Unchanged |
| Caitong International Asset Management Co., Ltd | 353 | $551 | 0.00% | +206+140.1% | Added |
| Jones Financial Companies LLLP | 356 | $587 | 0.00% | −750−67.8% | Reduced |
| Steward Partners Investment Advisory, LLC | 500 | $780 | 0.00% | 00.0% | Unchanged |
| Northwestern Mutual Wealth Management Co | 503 | $785 | 0.00% | +3+0.6% | Added |
| Advisor Group Holdings, Inc. | 663 | $1.03K | 0.00% | +21+3.3% | Added |
| Basecamp Wealth Advisors LLC | 691 | $1.08K | 0.00% | 00.0% | Unchanged |
| Fortitude Family Office, LLC | 706 | $1.10K | 0.00% | 00.0% | Unchanged |
| Cassaday & Co Wealth Management LLC | 1,000 | $1.56K | 0.00% | +1,000 | New |
| Royal Bank of Canada | 1,551 | $2.00K | 0.00% | −5,217−77.1% | Reduced |
| Avion Wealth | 1,333 | $2.00K | 0.00% | 00.0% | Unchanged |
| Rialto Wealth Management, LLC | 1,313 | $2.05K | 0.00% | 00.0% | Unchanged |
| UMA Financial Services, Inc. | 1,412 | $2.20K | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 1,461 | $2.28K | 0.00% | 00.0% | Unchanged |
| Nisa Investment Advisors, LLC | 2,592 | $4.04K | 0.00% | 00.0% | Unchanged |
| Advisory Services Network, LLC | 3,242 | $5.06K | 0.00% | +3,242 | New |
| SBI Securities Co., Ltd. | 4,081 | $6.37K | 0.00% | +1,063+35.2% | Added |
| Wells Fargo & Company | 7,760 | $12.1K | 0.00% | +7,759+775,900.0% | Added |
| NBT Bank N A | 10,000 | $15.6K | 0.00% | 00.0% | Unchanged |
| Berger Financial Group, Inc | 10,000 | $15.6K | 0.00% | 00.0% | Unchanged |
| Talisman Wealth Advisors LLC | 10,000 | $15.6K | 0.01% | +10,000 | New |
| CWM, LLC | 10,402 | $16.2K | 0.00% | −2,777−21.1% | Reduced |
| State of Wyoming | 10,779 | $16.8K | 0.00% | −49,792−82.2% | Reduced |
| Perennial Investment Advisors, LLC | 10,990 | $17.1K | 0.00% | 00.0% | Unchanged |
| Mariner, LLC | 11,072 | $17.3K | 0.00% | +11,072 | New |
| Fortress Wealth Group, LLC | 11,350 | $18.0K | 0.01% | 00.0% | Unchanged |
| Chemistry Wealth Management LLC | 12,000 | $18.7K | 0.00% | 00.0% | Unchanged |
| Wealth Enhancement Advisory Services, LLC | 12,388 | $19.7K | 0.00% | −1,132−8.4% | Reduced |
| Cetera Investment Advisers | 12,633 | $19.7K | 0.00% | −1,555−11.0% | Reduced |
| Truist Financial Corp | 14,000 | $21.8K | 0.00% | 00.0% | Unchanged |
| Callan Family Office, LLC | 14,090 | $22.0K | 0.00% | 00.0% | Unchanged |
| HBK Sorce Advisory LLC | 11,786 | $23.6K | 0.00% | 00.0% | Unchanged |
| Captrust Financial Advisors | 15,450 | $24.1K | 0.00% | +3,715+31.7% | Added |
| Prelude Capital Management, LLC | 17,173 | $26.8K | 0.00% | +17,173 | New |
| CTC Alternative Strategies, Ltd. | 17,544 | $27.4K | 0.06% | +17,544 | New |
| BNP Paribas Arbitrage, SA | 17,550 | $27.4K | 0.00% | +17,539+159,445.5% | Added |
| Quantessence Capital LLC | 18,581 | $29.0K | 0.14% | +18,581 | New |
| Credit Agricole S A | 18,975 | $29.6K | 0.00% | 00.0% | Unchanged |
| Invera Wealth Advisors, LLC | 20,000 | $31.2K | 0.02% | 00.0% | Unchanged |
| Tiaa-Cref Individual & Institutional Services, LLC | 20,000 | $31.2K | 0.00% | +20,000 | New |
| Diker Management LLC | 20,000 | $31.2K | 0.03% | +20,000 | New |
| Axq Capital, LP | 20,150 | $31.4K | 0.00% | +20,150 | New |
| Cambridge Investment Research Advisors, Inc. | 21,505 | $34.0K | 0.00% | 00.0% | Unchanged |
| Victory Capital Management Inc | 22,679 | $35.4K | 0.00% | +1,488+7.0% | Added |
| LMR Partners LLP | 23,305 | $36.4K | 0.00% | +23,305 | New |
| Oppenheimer & Co Inc | 23,500 | $36.7K | 0.00% | 00.0% | Unchanged |
| Winton Group Ltd | 25,500 | $39.8K | 0.00% | +25,500 | New |
| Security National Bank of Sioux City Iowa | 26,650 | $41.6K | 0.02% | 00.0% | Unchanged |
| Bank of New York Mellon Corp | 27,459 | $42.8K | 0.00% | +8,335+43.6% | Added |
| Pinnacle Associates Ltd | 29,015 | $45.3K | 0.00% | 00.0% | Unchanged |
| Pathstone Holdings, LLC | 29,774 | $46.4K | 0.00% | −195−0.7% | Reduced |
| KWB Wealth | 40,640 | $46.7K | 0.00% | 00.0% | Unchanged |
| Leonteq Securities AG | 30,000 | $46.8K | 0.00% | 00.0% | Unchanged |
| Prudential Financial Inc | 33,800 | $52.7K | 0.00% | 00.0% | Unchanged |
| Graham Capital Management, L.P. | 34,027 | $53.1K | 0.00% | −75,873−69.0% | Reduced |
| University of Texas/Texas Am Investment Managment Co | 35,714 | $55.7K | 0.01% | 00.0% | Unchanged |
| ExodusPoint Capital Management, LP | 37,430 | $58.4K | 0.00% | −231,003−86.1% | Reduced |
| CIBC Asset Management Inc | 39,520 | $61.7K | 0.00% | 00.0% | Unchanged |
| Jump Financial, LLC | 40,246 | $62.8K | 0.00% | +40,246 | New |
| Wedbush Securities Inc | 40,850 | $64.0K | 0.00% | 00.0% | Unchanged |
| Boothbay Fund Management, LLC | 44,315 | $69.1K | 0.00% | 00.0% | Unchanged |
| EntryPoint Capital, LLC | 48,498 | $75.7K | 0.02% | +14,880+44.3% | Added |
| Fortis Group Advisors, LLC | 50,000 | $80.5K | 0.01% | 00.0% | Unchanged |
| JustInvest LLC | 54,965 | $85.7K | 0.00% | −11,602−17.4% | Reduced |
| Straight Path Wealth Management | 62,666 | $97.8K | 0.03% | 00.0% | Unchanged |
| R Squared Ltd | 67,526 | $105.3K | 0.06% | +20,947+45.0% | Added |
| Diametric Capital, LP | 67,841 | $105.8K | 0.03% | +67,841 | New |
| Jefferies Financial Group Inc. | 68,734 | $107.2K | 0.00% | −23,796−25.7% | Reduced |
| LPL Financial LLC | 69,783 | $108.9K | 0.00% | −17,274−19.8% | Reduced |
| Bank of Montreal | 70,000 | $109.2K | 0.00% | 00.0% | Unchanged |
| Bank of Nova Scotia | 73,707 | $115.0K | 0.00% | +73,707 | New |
| Schonfeld Strategic Advisors LLC | 75,110 | $117.2K | 0.00% | +62,002+473.0% | Added |
| Vanguard Global Advisers, LLC | 93,641 | $146.1K | 0.00% | +93,641 | New |
| AQR Capital Management LLC | 96,234 | $150.1K | 0.00% | −48,566−33.5% | Reduced |
| Barclays PLC | 105,487 | $164.6K | 0.00% | −89,256−45.8% | Reduced |
| Omers Administration Corp | 106,800 | $166.6K | 0.00% | −167,000−61.0% | Reduced |
| Man Group plc | 108,806 | $169.7K | 0.00% | +108,806 | New |
| Quarry LP | 110,000 | $171.6K | 0.03% | +22,000+25.0% | Added |
| Quadrature Capital Ltd | 110,379 | $172.2K | 0.00% | +91,965+499.4% | Added |
| Cerity Partners LLC | 110,458 | $172.3K | 0.00% | −34,486−23.8% | Reduced |
| HRT Financial LP | 122,780 | $191.0K | 0.00% | +5,231+4.5% | Added |
| Bridgewater Advisors Inc. | 82,209 | $200.6K | 0.01% | +82,209 | New |
| Jacobs Levy Equity Management, Inc | 130,020 | $202.8K | 0.00% | +130,020 | New |
| Hudson Bay Capital Management LP | 152,616 | $238.1K | 0.00% | +52,084+51.8% | Added |
| Jain Global LLC | 154,800 | $241.5K | 0.00% | +154,800 | New |
| Scotia Capital Inc. | 159,831 | $249.3K | 0.00% | +159,831 | New |
| Brevan Howard Capital Management LP | 160,499 | $250.4K | 0.00% | +160,499 | New |
| Ikarian Capital, LLC | 164,674 | $256.9K | 0.04% | 00.0% | Unchanged |
| Citigroup Inc | 166,398 | $259.6K | 0.00% | +74,728+81.5% | Added |
| Group One Trading, L.P. | 185,006 | $288.6K | 0.01% | −39,302−17.5% | Reduced |