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Lexicon Pharmaceuticals, Inc.

LXRX
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001062822

No open-market purchases or sales by Lexicon Pharmaceuticals, Inc. insiders were filed in the last 90 days; 149 institutions reported holding it in 13F filings for Q2 2026, worth $875.1M in total; no superinvestor holds it.

13F holders, Q1 2026

Institutional positions in Lexicon Pharmaceuticals, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
137
+16 vs. Q4 2025
Shares held
323.4M
+74.5M (+29.9%) vs. Q4 2025
Total value
$504.5M
+$218.3M (+76.3%) vs. Q4 2025
New holders
31
41 more added
Sold out
15
26 more reduced

5 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q4 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting LXRX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ1 2026: 137 institutions
Q1 2021: 107 institutionsQ2 2021: 107 institutionsQ3 2021: 96 institutionsQ4 2021: 110 institutionsQ1 2022: 101 institutionsQ2 2022: 86 institutionsQ3 2022: 98 institutionsQ4 2022: 105 institutionsQ1 2023: 104 institutionsQ2 2023: 123 institutionsQ3 2023: 112 institutionsQ4 2023: 106 institutionsQ1 2024: 118 institutionsQ2 2024: 127 institutionsQ3 2024: 137 institutionsQ4 2024: 127 institutionsQ1 2025: 127 institutionsQ2 2025: 123 institutionsQ3 2025: 124 institutionsQ4 2025: 126 institutionsQ1 2026: 137 institutionsQ2 2026: 149 institutions
Value heldQ1 2026: $504.5M
Q1 2021: $711.5MQ2 2021: $540.2MQ3 2021: $583.0MQ4 2021: $478.9MQ1 2022: $251.3MQ2 2022: $221.0MQ3 2022: $357.3MQ4 2022: $280.5MQ1 2023: $353.8MQ2 2023: $438.2MQ3 2023: $205.8MQ4 2023: $279.8MQ1 2024: $417.8MQ2 2024: $471.0MQ3 2024: $453.1MQ4 2024: $220.1MQ1 2025: $122.5MQ2 2025: $242.9MQ3 2025: $344.4MQ4 2025: $299.5MQ1 2026: $504.5MQ2 2026: $875.1M
Institutions holding LXRX and their total value by quarter
QuarterHoldersValue
Q2 2026149$875.1M
Q1 2026137$504.5M
Q4 2025126$299.5M
Q3 2025124$344.4M
Q2 2025123$242.9M
Q1 2025127$122.5M
Q4 2024127$220.1M
Q3 2024137$453.1M
Q2 2024127$471.0M
Q1 2024118$417.8M
Q4 2023106$279.8M
Q3 2023112$205.8M
Q2 2023123$438.2M
Q1 2023104$353.8M
Q4 2022105$280.5M
Q3 202298$357.3M
Q2 202286$221.0M
Q1 2022101$251.3M
Q4 2021110$478.9M
Q3 202196$583.0M
Q2 2021107$540.2M
Q1 2021107$711.5M

Institutions, Q1 2026

Shares, value and share of portfolio for each institution holding Lexicon Pharmaceuticals, Inc.; share changes are against Q4 2025.

Institutions holding LXRX in Q1 2026
InstitutionSharesValue% of portfolioChange in sharesAction
Chemistry Wealth Management LLC12,000$18.7K0.00%00.0%Unchanged
Fortress Wealth Group, LLC11,350$18.0K0.01%00.0%Unchanged
Mariner, LLC11,072$17.3K0.00%+11,072New
Perennial Investment Advisors, LLC10,990$17.1K0.00%00.0%Unchanged
State of Wyoming10,779$16.8K0.00%−49,792−82.2%Reduced
CWM, LLC10,402$16.2K0.00%−2,777−21.1%Reduced
NBT Bank N A10,000$15.6K0.00%00.0%Unchanged
Berger Financial Group, Inc10,000$15.6K0.00%00.0%Unchanged
Talisman Wealth Advisors LLC10,000$15.6K0.01%+10,000New
Wells Fargo & Company7,760$12.1K0.00%+7,759+775,900.0%Added
SBI Securities Co., Ltd.4,081$6.37K0.00%+1,063+35.2%Added
Advisory Services Network, LLC3,242$5.06K0.00%+3,242New
Nisa Investment Advisors, LLC2,592$4.04K0.00%00.0%Unchanged
The PNC Financial Services Group, Inc.1,461$2.28K0.00%00.0%Unchanged
UMA Financial Services, Inc.1,412$2.20K0.00%00.0%Unchanged
Rialto Wealth Management, LLC1,313$2.05K0.00%00.0%Unchanged
Royal Bank of Canada1,551$2.00K0.00%−5,217−77.1%Reduced
Avion Wealth1,333$2.00K0.00%00.0%Unchanged
Cassaday & Co Wealth Management LLC1,000$1.56K0.00%+1,000New
Fortitude Family Office, LLC706$1.10K0.00%00.0%Unchanged
Basecamp Wealth Advisors LLC691$1.08K0.00%00.0%Unchanged
Advisor Group Holdings, Inc.663$1.03K0.00%+21+3.3%Added
Northwestern Mutual Wealth Management Co503$7850.00%+3+0.6%Added
Steward Partners Investment Advisory, LLC500$7800.00%00.0%Unchanged
Jones Financial Companies LLLP356$5870.00%−750−67.8%Reduced
Caitong International Asset Management Co., Ltd353$5510.00%+206+140.1%Added
Rockefeller Capital Management L.P.335$5230.00%00.0%Unchanged
Farther Finance Advisors, LLC255$4180.00%−2,500−90.7%Reduced
Parallel Advisors, LLC247$3850.00%+247New
Syntax Research, Inc.142$2220.00%00.0%Unchanged
Larson Financial Group LLC100$1560.00%00.0%Unchanged
EverSource Wealth Advisors, LLC48$750.00%−110−69.6%Reduced
SRS Capital Advisors, Inc.41$640.00%00.0%Unchanged
HM Payson & Co37$580.00%+37New
True Wealth Design, LLC2$40.00%−47−95.9%Reduced
Rhumbline Advisers0$20.00%0Unchanged
Covestor Ltd81$00.00%00.0%Unchanged
Two Sigma Advisers, LP0$00.00%−180,977−100.0%Sold out
Lighthouse Investment Partners, LLC0$00.00%−126,600−100.0%Sold out
Monaco Asset Management SAM0$00.00%−117,188−100.0%Sold out
Two Sigma Securities, LLC0$00.00%−114,632−100.0%Sold out
Caxton Associates LLP0$00.00%−71,027−100.0%Sold out
Squarepoint Ops LLC0$00.00%−60,472−100.0%Sold out
Optiver Holding B.V.0$00.00%−52,595−100.0%Sold out
Virtu Financial LLC0$00.00%−36,468−100.0%Sold out
Vermillion & White Wealth Management Group, LLC0$00.00%−32,000−100.0%Sold out
Tower Research Capital LLC (TRC)0$00.00%−29,093−100.0%Sold out
Tiaa Trust, National Association0$00.00%−20,000−100.0%Sold out
StoneX Group Inc.0$00.00%−16,234−100.0%Sold out
Simplex Trading, LLC0$00.00%−14,758−100.0%Sold out
Lazard Asset Management LLC0$00.00%−14,090−100.0%Sold out
Golden State Wealth Management, LLC0$00.00%−3,700−100.0%Sold out
Vanguard Group Inc––––Not filed
CIBC Private Wealth Group, LLC––––Not filed
Global Retirement Partners, LLC––––Not filed
Comerica Bank––––Not filed
Motiv8 Investments LLC––––Not filed