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Ionis Pharmaceuticals Inc

IONS
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0000874015

In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.

13F holders, Q2 2024

Institutional positions in Ionis Pharmaceuticals Inc as of Jun 30, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
357
−1 vs. Q1 2024
Shares held
143.3M
+1.29M (+0.9%) vs. Q1 2024
Total value
$6.83B
+$666.0M (+10.8%) vs. Q1 2024
New holders
52
120 more added
Sold out
53
132 more reduced

3 institutions that held it in Q1 2024 haven't filed for Q2 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q1 2024: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ2 2024: 357 institutions
Q1 2021: 365 institutionsQ2 2021: 338 institutionsQ3 2021: 326 institutionsQ4 2021: 341 institutionsQ1 2022: 333 institutionsQ2 2022: 351 institutionsQ3 2022: 350 institutionsQ4 2022: 339 institutionsQ1 2023: 315 institutionsQ2 2023: 305 institutionsQ3 2023: 312 institutionsQ4 2023: 365 institutionsQ1 2024: 361 institutionsQ2 2024: 357 institutionsQ3 2024: 354 institutionsQ4 2024: 356 institutionsQ1 2025: 344 institutionsQ2 2025: 363 institutionsQ3 2025: 437 institutionsQ4 2025: 494 institutionsQ1 2026: 497 institutionsQ2 2026: 515 institutions
Value heldQ2 2024: $6.83B
Q1 2021: $5.55BQ2 2021: $4.96BQ3 2021: $4.08BQ4 2021: $3.75BQ1 2022: $4.63BQ2 2022: $4.61BQ3 2022: $5.59BQ4 2022: $4.93BQ1 2023: $4.69BQ2 2023: $5.60BQ3 2023: $6.35BQ4 2023: $7.21BQ1 2024: $6.17BQ2 2024: $6.83BQ3 2024: $6.31BQ4 2024: $5.61BQ1 2025: $5.03BQ2 2025: $6.67BQ3 2025: $11.0BQ4 2025: $13.5BQ1 2026: $13.0BQ2 2026: $14.3B
Institutions holding IONS and their total value by quarter
QuarterHoldersValue
Q2 2026515$14.3B
Q1 2026497$13.0B
Q4 2025494$13.5B
Q3 2025437$11.0B
Q2 2025363$6.67B
Q1 2025344$5.03B
Q4 2024356$5.61B
Q3 2024354$6.31B
Q2 2024357$6.83B
Q1 2024361$6.17B
Q4 2023365$7.21B
Q3 2023312$6.35B
Q2 2023305$5.60B
Q1 2023315$4.69B
Q4 2022339$4.93B
Q3 2022350$5.59B
Q2 2022351$4.61B
Q1 2022333$4.63B
Q4 2021341$3.75B
Q3 2021326$4.08B
Q2 2021338$4.96B
Q1 2021365$5.55B

Institutions, Q2 2024

Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q1 2024.

Institutions holding IONS in Q2 2024
InstitutionSharesValue% of portfolioChange in sharesAction
Baillie Gifford & Co260,254$12.4M0.01%−35,429−12.0%Reduced
CI Private Wealth, LLC268,037$12.8M0.02%+746+0.3%Added
Manufacturers Life Insurance Company, The274,850$13.1M0.01%+29,783+12.2%Added
C WorldWide Group Holding A/S300,000$14.3M0.15%00.0%Unchanged
Logos Global Management LP300,000$14.3M1.65%+300,000New
UBS Asset Management Americas Inc320,290$15.3M0.00%+133,963+71.9%Added
Goldman Sachs Group Inc328,305$15.6M0.00%+127,925+63.8%Added
Great Point Partners LLC330,000$15.7M3.01%+330,000New
Hudson Bay Capital Management LP366,000$17.4M0.13%+30,500+9.1%Added
Wells Fargo & Company366,561$17.5M0.00%−217,597−37.2%Reduced
Groupama Asset Managment379,976$18.1M0.37%+122,108+47.4%Added
Nuveen Asset Management, LLC410,404$19.6M0.01%−12,626−3.0%Reduced
Squarepoint Ops LLC436,818$20.8M0.08%−308,355−41.4%Reduced
Pinnacle Associates Ltd453,379$21.6M0.34%−6,379−1.4%Reduced
Eversept Partners, LP456,881$21.8M1.67%+80,443+21.4%Added
AXA S.A.464,963$22.2M0.07%+1480.0%Added
Nomura Holdings Inc501,188$23.9M0.15%+30,351+6.4%Added
Bank of America Corp514,543$24.5M0.00%−91,755−15.1%Reduced
Jacobs Levy Equity Management, Inc572,870$27.3M0.11%+1,107+0.2%Added
JPMorgan Chase & Co594,091$28.3M0.00%−36,888−5.8%Reduced
Bank of New York Mellon Corp597,479$28.5M0.01%+13,890+2.4%Added
Barclays PLC615,674$29.3M0.01%+38,287+6.6%Added
Citadel Advisors LLC627,033$29.9M0.03%+549,003+703.6%Added
Man Group plc633,409$30.2M0.08%+380,188+150.1%Added
Royal Bank of Canada678,360$32.3M0.01%−53,877−7.4%Reduced
Northern Trust Corp717,975$34.2M0.01%+25,728+3.7%Added
Schonfeld Strategic Advisors LLC723,618$34.5M0.27%+552,758+323.5%Added
BNP PARIBAS ASSET MANAGEMENT Holding S.A.780,753$37.2M0.10%+2,160+0.3%Added
Adage Capital Partners GP, L.L.C.800,000$38.1M0.07%−200,000−20.0%Reduced
Candriam Luxembourg S.C.A.948,266$45.2M0.27%+36,369+4.0%Added
TD Asset Management Inc952,762$45.4M0.04%+54,400+6.1%Added
Invesco Ltd.968,917$46.2M0.01%+526,030+118.8%Added
Morgan Stanley1,012,805$48.3M0.00%−150,793−13.0%Reduced
Norges Bank1,019,341$48.6M0.01%−217,657−17.6%Reduced
Two Sigma Investments, LP1,028,142$49.0M0.12%−55,737−5.1%Reduced
Balyasny Asset Management LLC1,077,321$51.3M0.13%+1,077,321New
Two Sigma Advisers, LP1,287,111$61.3M0.14%+247,000+23.7%Added
Charles Schwab Investment Management Inc1,328,106$63.3M0.01%+26,738+2.1%Added
ARK Investment Management LLCSuperinvestorARK Invest1,361,025$64.9M0.58%−38,827−2.8%Reduced
Artisan Partners Limited Partnership1,671,036$79.6M0.12%+1,254,307+301.0%Added
Macquarie Group Ltd1,873,668$89.3M0.10%−1,326,910−41.5%Reduced
Deep Track Capital, LP2,000,000$95.3M2.85%+626,525+45.6%Added
Clearbridge Investments, LLC2,160,270$103.0M0.08%−2,305,921−51.6%Reduced
Capital World Investors2,252,089$107.3M0.02%+1,412,626+168.3%Added
OrbiMed Advisors LLC2,372,333$113.1M2.41%+359,300+17.8%Added
Pictet Asset Management Holding SA2,409,954$114.9M0.13%−1,329,803−35.6%Reduced
Geode Capital Management, LLC2,484,544$118.4M0.01%+120,288+5.1%Added
BVF Inc3,186,376$151.9M4.26%+757,763+31.2%Added
Tweedy, Browne Co LLC3,454,676$164.6M7.57%00.0%Unchanged
Price T Rowe Associates Inc3,934,311$187.5M0.02%+412,108+11.7%Added
State Street Corp4,190,505$199.7M0.01%+34,841+0.8%Added
Wellington Management Group LLP6,568,808$313.1M0.06%+873,109+15.3%Added
Bellevue Group AG8,260,434$393.7M6.40%−39,080−0.5%Reduced
BlackRock Inc.10,321,030$491.9M0.01%+549,139+5.6%Added
T. Rowe Price Investment Management, Inc.12,639,684$602.4M0.38%−677,428−5.1%Reduced
Vanguard Group Inc13,845,712$659.9M0.01%+415,256+3.1%Added
FMR LLC21,894,806$1.04B0.07%+32,071+0.1%Added
First Turn Management, LLC0$00.00%−421,487−100.0%Sold out
Voloridge Investment Management, LLC0$00.00%−191,367−100.0%Sold out
Senator Investment Group LP0$00.00%−135,000−100.0%Sold out
Superstring Capital Management LP0$00.00%−120,896−100.0%Sold out
Campbell & CO Investment Adviser LLC0$00.00%−94,772−100.0%Sold out
Parkwood LLC0$00.00%−71,259−100.0%Sold out
Twinbeech Capital LP0$00.00%−46,364−100.0%Sold out
Nicholas Investment Partners, LP0$00.00%−38,186−100.0%Sold out
Graham Capital Management, L.P.0$00.00%−30,541−100.0%Sold out
Lighthouse Investment Partners, LLC0$00.00%−30,379−100.0%Sold out
STRS Ohio0$00.00%−29,965−100.0%Sold out
Cetera Investment Advisers0$00.00%−21,758−100.0%Sold out
Edgestream Partners, L.P.0$00.00%−17,646−100.0%Sold out
Aigen Investment Management, LP0$00.00%−16,747−100.0%Sold out
Entropy Technologies, LP0$00.00%−14,542−100.0%Sold out
Bank Julius Baer & Co. Ltd, Zurich0$00.00%−14,230−100.0%Sold out
Aquatic Capital Management LLC0$00.00%−11,700−100.0%Sold out
Corton Capital Inc.0$00.00%−10,631−100.0%Sold out
Capula Management Ltd0$00.00%−10,217−100.0%Sold out
Sherbrooke Park Advisers LLC0$00.00%−10,119−100.0%Sold out
Bard Financial Services, Inc.0$00.00%−9,950−100.0%Sold out
Walleye Trading LLC0$00.00%−9,362−100.0%Sold out
XTX Topco Ltd0$00.00%−8,585−100.0%Sold out
Centiva Capital, LP0$00.00%−8,474−100.0%Sold out
Torno Capital, LLC0$00.00%−8,000−100.0%Sold out
SG Americas Securities, LLC0$00.00%−7,582−100.0%Sold out
Point72 Asia (Singapore) Pte. Ltd.0$00.00%−6,986−100.0%Sold out
Regions Financial Corp0$00.00%−6,785−100.0%Sold out
Baird Financial Group, Inc.0$00.00%−6,696−100.0%Sold out
Wrapmanager Inc0$00.00%−6,668−100.0%Sold out
Diversified Trust Co0$00.00%−6,015−100.0%Sold out
Acadian Asset Management LLC0$00.00%−5,891−100.0%Sold out
Massachusetts Financial Services Co0$00.00%−5,580−100.0%Sold out
Level Four Advisory Services, LLC0$00.00%−4,396−100.0%Sold out
Paloma Partners Management Co0$00.00%−4,909−100.0%Sold out
Vident Advisory, LLC0$00.00%−4,796−100.0%Sold out
Quantbot Technologies LP0$00.00%−4,284−100.0%Sold out
Icon Wealth Advisors, LLC0$00.00%−2,391−100.0%Sold out
American International Group, Inc.0$00.00%−2,208−100.0%Sold out
Nelson, Van Denburg & Campbell Wealth Management Group, LLC0$00.00%−1,104−100.0%Sold out
Elequin Capital LP0$00.00%−474−100.0%Sold out
Leonteq Securities AG0$00.00%−212−100.0%Sold out
LifeSteps Financial, Inc.0$00.00%−200−100.0%Sold out