Fulcrum Therapeutics, Inc.
FULC- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001680581
In the last 90 days, Fulcrum Therapeutics, Inc. insiders filed 2 open-market purchases and 0 sales; 154 institutions reported holding it in 13F filings for Q2 2026, worth $291.3M in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Fulcrum Therapeutics, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 172
- +43 vs. Q3 2025
- Shares held
- 67.4M
- +13.7M (+25.4%) vs. Q3 2025
- Total value
- $762.7M
- +$267.8M (+54.1%) vs. Q3 2025
- New holders
- 59
- 43 more added
- Sold out
- 16
- 49 more reduced
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting FULC on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 154 | $291.3M |
| Q1 2026 | 169 | $550.1M |
| Q4 2025 | 172 | $762.7M |
| Q3 2025 | 129 | $494.9M |
| Q2 2025 | 122 | $374.5M |
| Q1 2025 | 117 | $147.8M |
| Q4 2024 | 119 | $243.4M |
| Q3 2024 | 130 | $196.4M |
| Q2 2024 | 121 | $402.0M |
| Q1 2024 | 126 | $569.7M |
| Q4 2023 | 101 | $412.3M |
| Q3 2023 | 81 | $250.4M |
| Q2 2023 | 88 | $183.2M |
| Q1 2023 | 116 | $172.2M |
| Q4 2022 | 110 | $368.5M |
| Q3 2022 | 105 | $422.1M |
| Q2 2022 | 102 | $196.6M |
| Q1 2022 | 108 | $929.9M |
| Q4 2021 | 110 | $657.3M |
| Q3 2021 | 101 | $1.03B |
| Q2 2021 | 67 | $280.8M |
| Q1 2021 | 68 | $317.0M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Fulcrum Therapeutics, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| EAM Investors, LLC | 61,620 | $696.9K | 0.08% | +61,620 | New |
| Integrated Quantitative Investments LLC | 62,522 | $707.1K | 0.15% | +62,522 | New |
| Price T Rowe Associates Inc | 63,760 | $722.0K | 0.00% | −2,132−3.2% | Reduced |
| Squarepoint Ops LLC | 65,852 | $744.8K | 0.00% | +48,026+269.4% | Added |
| Legato Capital Management LLC | 66,347 | $750.4K | 0.06% | +66,347 | New |
| Y-Intercept (Hong Kong) Ltd | 66,716 | $754.6K | 0.02% | +55,444+491.9% | Added |
| Citigroup Inc | 67,102 | $758.9K | 0.00% | +66,384+9,245.7% | Added |
| Superstring Capital Management LP | 72,060 | $815.0K | 0.44% | +72,060 | New |
| Verition Fund Management LLC | 74,691 | $844.8K | 0.00% | +74,691 | New |
| RBF Capital, LLC | 80,506 | $910.5K | 0.04% | 00.0% | Unchanged |
| State of Wisconsin Investment Board | 86,499 | $978.3K | 0.00% | +72,833+533.0% | Added |
| Susquehanna International Group, LLP | 87,930 | $994.5K | 0.00% | +34,359+64.1% | Added |
| Exome Asset Management LLC | 92,055 | $1.04M | 0.51% | −6,744−6.8% | Reduced |
| Jump Financial, LLC | 92,200 | $1.04M | 0.01% | +92,200 | New |
| Principal Financial Group Inc | 97,688 | $1.10M | 0.00% | +31,138+46.8% | Added |
| Gsa Capital Partners LLP | 99,709 | $1.13M | 0.10% | −16,359−14.1% | Reduced |
| Maven Securities LTD | 100,000 | $1.13M | 0.14% | +100,000 | New |
| Ameriprise Financial Inc | 100,675 | $1.14M | 0.00% | −23,991−19.2% | Reduced |
| Marshall Wace, LLP | 102,921 | $1.16M | 0.00% | +102,921 | New |
| UBS Group AG | 102,967 | $1.16M | 0.00% | −198,190−65.8% | Reduced |
| Walleye Capital LLC | 108,434 | $1.23M | 0.01% | +108,434 | New |
| Nuveen, LLC | 112,203 | $1.27M | 0.00% | 00.0% | Unchanged |
| Bank of New York Mellon Corp | 116,906 | $1.32M | 0.00% | −2,252−1.9% | Reduced |
| Barclays PLC | 132,541 | $1.50M | 0.00% | +42,925+47.9% | Added |
| Fiduciary Trust Co | 136,555 | $1.54M | 0.02% | 00.0% | Unchanged |
| SummitTX Capital, L.P. | 138,143 | $1.56M | 0.05% | +138,143 | New |
| Wellington Management Group LLP | 146,427 | $1.66M | 0.00% | −32,931−18.4% | Reduced |
| American Century Companies Inc | 157,672 | $1.78M | 0.00% | +5,428+3.6% | Added |
| Simplify Asset Management Inc. | 159,674 | $1.81M | 0.03% | +76,440+91.8% | Added |
| Morgan Stanley | 165,623 | $1.87M | 0.00% | −78,212−32.1% | Reduced |
| Wells Fargo & Company | 166,395 | $1.88M | 0.00% | +133,888+411.9% | Added |
| Nicholas Investment Partners, LP | 182,961 | $2.07M | 0.15% | +182,961 | New |
| Catalio Capital Management, LP | 201,301 | $2.28M | 0.40% | +201,301 | New |
| Bank of America Corp | 231,177 | $2.61M | 0.00% | +83,966+57.0% | Added |
| Driehaus Capital Management LLC | 243,388 | $2.75M | 0.02% | +243,388 | New |
| Bessemer Group Inc | 286,988 | $3.25M | 0.00% | 00.0% | Unchanged |
| Deutsche Bank AG | 287,096 | $3.25M | 0.00% | +1,767+0.6% | Added |
| Goldman Sachs Group Inc | 323,879 | $3.66M | 0.00% | −262,472−44.8% | Reduced |
| Trexquant Investment LP | 355,547 | $4.02M | 0.04% | +334,532+1,591.9% | Added |
| Sio Capital Management, LLC | 382,000 | $4.32M | 0.72% | +382,000 | New |
| Charles Schwab Investment Management Inc | 388,896 | $4.40M | 0.00% | +55,413+16.6% | Added |
| Qube Research & Technologies Ltd | 392,489 | $4.44M | 0.01% | +392,489 | New |
| Silverarc Capital Management, LLC | 394,650 | $4.46M | 0.65% | +394,650 | New |
| Invesco Ltd. | 417,189 | $4.72M | 0.00% | +293,317+236.8% | Added |
| Jane Street Group, LLC | 493,750 | $5.58M | 0.01% | +172,230+53.6% | Added |
| Boothbay Fund Management, LLC | 517,526 | $5.85M | 0.15% | −160,888−23.7% | Reduced |
| Northern Trust Corp | 552,220 | $6.25M | 0.00% | −16,102−2.8% | Reduced |
| Connor, Clark & Lunn Investment Management Ltd. | 582,377 | $6.59M | 0.02% | +198,239+51.6% | Added |
| Acadian Asset Management LLC | 736,740 | $8.33M | 0.01% | +196,099+36.3% | Added |
| Great Point Partners LLC | 800,000 | $9.05M | 2.93% | +800,000 | New |
| Vestal Point Capital, LP | 950,000 | $10.7M | 0.39% | +950,000 | New |
| Balyasny Asset Management LLC | 970,439 | $11.0M | 0.02% | −480,041−33.1% | Reduced |
| State Street Corp | 1,005,345 | $11.4M | 0.00% | −57,862−5.4% | Reduced |
| Dimensional Fund Advisors LP | 1,051,124 | $11.9M | 0.00% | −248,184−19.1% | Reduced |
| Geode Capital Management, LLC | 1,105,813 | $12.5M | 0.00% | +101,762+10.1% | Added |
| Citadel Advisors LLC | 1,207,004 | $13.7M | 0.01% | +352,448+41.2% | Added |
| ADAR1 Capital Management, LLC | 1,253,749 | $14.2M | 1.06% | +912,137+267.0% | Added |
| Standard Life Aberdeen plc | 1,254,027 | $14.2M | 0.02% | +1,116,066+809.0% | Added |
| Ikarian Capital, LLC | 1,375,472 | $15.6M | 2.01% | +86,247+6.7% | Added |
| Adage Capital Partners GP, L.L.C. | 1,700,000 | $19.2M | 0.03% | −732,000−30.1% | Reduced |
| GSK plc | 1,785,714 | $20.2M | 2.53% | +1,785,714 | New |
| First Turn Management, LLC | 1,892,683 | $21.4M | 2.45% | +1,892,683 | New |
| D. E. Shaw & Co., Inc. | 1,913,755 | $21.6M | 0.02% | +464,332+32.0% | Added |
| Siren, L.L.C. | 1,950,000 | $22.1M | 0.66% | +1,950,000 | New |
| Point72 Asset Management, L.P. | 2,398,232 | $27.1M | 0.04% | +2,398,232 | New |
| Braidwell LP | 3,061,222 | $34.6M | 1.11% | +2,841,734+1,294.7% | Added |
| Vanguard Group Inc | 3,559,552 | $40.3M | 0.00% | +560,088+18.7% | Added |
| BlackRock, Inc. | 4,263,761 | $48.2M | 0.00% | +557,011+15.0% | Added |
| Nantahala Capital Management, LLC | 4,293,346 | $48.6M | 2.89% | −377,438−8.1% | Reduced |
| TCG Crossover Management, LLC | 5,250,000 | $59.4M | 1.97% | 00.0% | Unchanged |
| Ra Capital Management, L.P. | 6,053,960 | $68.5M | 0.70% | −4,175,139−40.8% | Reduced |
| Suvretta Capital Management, LLC | 6,561,111 | $74.2M | 1.85% | +1,180,111+21.9% | Added |
| J. Goldman & Co LP | 0 | $0 | 0.00% | −135,000−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −124,924−100.0% | Sold out |
| Susquehanna Fundamental Investments, LLC | 0 | $0 | 0.00% | −111,582−100.0% | Sold out |
| Bridgeway Capital Management, LLC | 0 | $0 | 0.00% | −95,400−100.0% | Sold out |
| Jacobs Levy Equity Management, Inc | 0 | $0 | 0.00% | −70,015−100.0% | Sold out |
| Acuta Capital Partners, LLC | 0 | $0 | 0.00% | −57,141−100.0% | Sold out |
| PharVision Advisers, LLC | 0 | $0 | 0.00% | −23,868−100.0% | Sold out |
| Algert Global LLC | 0 | $0 | 0.00% | −16,550−100.0% | Sold out |
| Sanctuary Advisors, LLC | 0 | $0 | 0.00% | −13,154−100.0% | Sold out |
| Martingale Asset Management L P | 0 | $0 | 0.00% | −10,563−100.0% | Sold out |
| BIT Capital GmbH | 0 | $0 | 0.00% | −6,090−100.0% | Sold out |
| Clear Street Markets LLC | 0 | $0 | 0.00% | −2,917−100.0% | Sold out |
| Macquarie Group Ltd | 0 | $0 | 0.00% | −2,495−100.0% | Sold out |
| Rise Advisors, LLC | 0 | $0 | 0.00% | −348−100.0% | Sold out |
| Clearstead Advisors, LLC | 0 | $0 | 0.00% | −4−100.0% | Sold out |
| Summit Wealth Group LLC | 0 | $0 | 0.00% | −533−100.0% | Sold out |