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Fulcrum Therapeutics, Inc.

FULC
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001680581

In the last 90 days, Fulcrum Therapeutics, Inc. insiders filed 2 open-market purchases and 1 sale; 154 institutions reported holding it in 13F filings for Q2 2026, worth $291.3M in total; no superinvestor holds it.

13F holders, Q2 2026

Institutional positions in Fulcrum Therapeutics, Inc. as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
154
−14 vs. Q1 2026
Shares held
79.5M
+7.79M (+10.9%) vs. Q1 2026
Total value
$291.3M
−$258.8M (−47.0%) vs. Q1 2026
New holders
28
72 more added
Sold out
42
35 more reduced

1 institution that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q1 2026: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting FULC on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ2 2026: 154 institutions
Q1 2021: 68 institutionsQ2 2021: 67 institutionsQ3 2021: 101 institutionsQ4 2021: 110 institutionsQ1 2022: 108 institutionsQ2 2022: 102 institutionsQ3 2022: 105 institutionsQ4 2022: 110 institutionsQ1 2023: 116 institutionsQ2 2023: 88 institutionsQ3 2023: 81 institutionsQ4 2023: 101 institutionsQ1 2024: 126 institutionsQ2 2024: 121 institutionsQ3 2024: 130 institutionsQ4 2024: 119 institutionsQ1 2025: 117 institutionsQ2 2025: 122 institutionsQ3 2025: 129 institutionsQ4 2025: 172 institutionsQ1 2026: 169 institutionsQ2 2026: 154 institutions
Value heldQ2 2026: $291.3M
Q1 2021: $317.0MQ2 2021: $280.8MQ3 2021: $1.03BQ4 2021: $657.3MQ1 2022: $929.9MQ2 2022: $196.6MQ3 2022: $422.1MQ4 2022: $368.5MQ1 2023: $172.2MQ2 2023: $183.2MQ3 2023: $250.4MQ4 2023: $412.3MQ1 2024: $569.7MQ2 2024: $402.0MQ3 2024: $196.4MQ4 2024: $243.4MQ1 2025: $147.8MQ2 2025: $374.5MQ3 2025: $494.9MQ4 2025: $762.7MQ1 2026: $550.1MQ2 2026: $291.3M
Institutions holding FULC and their total value by quarter
QuarterHoldersValue
Q2 2026154$291.3M
Q1 2026169$550.1M
Q4 2025172$762.7M
Q3 2025129$494.9M
Q2 2025122$374.5M
Q1 2025117$147.8M
Q4 2024119$243.4M
Q3 2024130$196.4M
Q2 2024121$402.0M
Q1 2024126$569.7M
Q4 2023101$412.3M
Q3 202381$250.4M
Q2 202388$183.2M
Q1 2023116$172.2M
Q4 2022110$368.5M
Q3 2022105$422.1M
Q2 2022102$196.6M
Q1 2022108$929.9M
Q4 2021110$657.3M
Q3 2021101$1.03B
Q2 202167$280.8M
Q1 202168$317.0M

Institutions, Q2 2026

Shares, value and share of portfolio for each institution holding Fulcrum Therapeutics, Inc.; share changes are against Q1 2026.

Institutions holding FULC in Q2 2026
InstitutionSharesValue% of portfolioChange in sharesAction
BlackRock, Inc.8,824,259$32.3M0.00%+3,433,666+63.7%Added
EcoR1 Capital, LLC6,549,866$24.0M1.19%+6,549,866New
Tang Capital Management LLC6,521,412$23.9M1.08%+6,521,412New
Nantahala Capital Management, LLC5,475,040$20.0M1.21%+2,425,000+79.5%Added
Suvretta Capital Management, LLC3,680,921$13.5M0.28%−2,880,190−43.9%Reduced
D. E. Shaw & Co., Inc.3,044,385$11.1M0.01%+1,421,104+87.5%Added
Citadel Advisors LLC2,704,505$9.90M0.01%+1,412,019+109.2%Added
Vanguard Capital Management LLC2,697,216$9.87M0.00%+4,268+0.2%Added
Jane Street Group, LLC2,217,498$8.12M0.01%+1,907,081+614.4%Added
State Street Corp2,037,025$7.46M0.00%+487,174+31.4%Added
Adage Capital Partners GP, L.L.C.2,000,000$7.32M0.01%+1,600,000+400.0%Added
GSK plc1,785,714$6.54M1.09%00.0%Unchanged
Qube Research & Technologies Ltd1,748,467$6.40M0.01%+773,728+79.4%Added
Renaissance Technologies LLC1,647,800$6.03M0.01%+1,634,200+12,016.2%Added
ADAR1 Capital Management, LLC1,565,029$5.73M0.27%+1,434,469+1,098.7%Added
Millennium Management LLC1,485,803$5.44M0.00%+1,129,332+316.8%Added
Geode Capital Management, LLC1,432,133$5.24M0.00%−54,409−3.7%Reduced
Marshall Wace, LLP1,358,423$4.97M0.00%+1,358,423New
UBS Group AG1,253,909$4.59M0.00%+938,724+297.8%Added
Susquehanna International Group, LLP1,180,946$4.32M0.00%+1,079,610+1,065.4%Added
AQR Capital Management LLC1,103,261$4.04M0.00%+560,096+103.1%Added
Goldman Sachs Group Inc1,094,425$4.01M0.00%+522,516+91.4%Added
Ikarian Capital, LLC1,049,161$3.84M0.63%00.0%Unchanged
Bank of America Corp1,043,029$3.82M0.00%+916,470+724.1%Added
Acadian Asset Management LLC1,038,797$3.79M0.00%+311,482+42.8%Added
Jump Financial, LLC1,005,000$3.68M0.03%+635,195+171.8%Added
Dimensional Fund Advisors LP960,547$3.52M0.00%−169,734−15.0%Reduced
Assenagon Asset Management S.A.835,204$3.06M0.00%−358,669−30.0%Reduced
Two Sigma Investments, LP812,766$2.97M0.00%+673,766+484.7%Added
Vanguard Portfolio Management LLC782,144$2.86M0.00%+182,765+30.5%Added
Connor, Clark & Lunn Investment Management Ltd.745,317$2.73M0.01%+8,633+1.2%Added
Balyasny Asset Management LLC692,372$2.53M0.00%−1,087,574−61.1%Reduced
Y-Intercept (Hong Kong) Ltd681,832$2.50M0.05%+528,488+344.6%Added
Point72 Asset Management, L.P.651,427$2.38M0.00%−1,423,428−68.6%Reduced
Northern Trust Corp487,869$1.79M0.00%+14,884+3.1%Added
Charles Schwab Investment Management Inc433,220$1.59M0.00%+6,351+1.5%Added
Vanguard Fiduciary Trust Co345,648$1.27M0.00%+15,764+4.8%Added
Boothbay Fund Management, LLC303,988$1.11M0.02%00.0%Unchanged
Bessemer Group Inc286,988$1.05M0.00%00.0%Unchanged
Peapod Lane Capital LLC285,798$1.05M0.71%+285,798New
Wellington Management Group LLP285,084$1.04M0.00%+166,484+140.4%Added
Engineers Gate Manager LP242,000$885.7K0.01%+115,891+91.9%Added
Hennion & Walsh Asset Management, Inc.233,851$855.9K0.02%+233,851New
EntryPoint Capital, LLC217,199$794.9K0.19%+171,951+380.0%Added
XTX Topco Ltd209,247$765.8K0.01%+137,644+192.2%Added
Quadrature Capital Ltd189,119$692.2K0.01%+189,119New
Morgan Stanley184,192$674.1K0.00%+10,855+6.3%Added
Alliancebernstein L.P.83,370$639.4K0.00%+48,800+141.2%Added
American Century Companies Inc155,868$570.5K0.00%−374−0.2%Reduced
Nuveen, LLC154,871$566.8K0.00%+25,253+19.5%Added
Bank of New York Mellon Corp154,513$565.5K0.00%+4,571+3.0%Added
Simplify Asset Management Inc.153,794$562.9K0.01%+37,800+32.6%Added
Gsa Capital Partners LLP143,911$527.0K0.03%+7,247+5.3%Added
Fiduciary Trust Co136,555$499.8K0.01%00.0%Unchanged
Squarepoint Ops LLC126,558$463.2K0.00%−49,386−28.1%Reduced
Verdad Advisers, LP125,224$458.3K0.44%+125,224New
BNP Paribas Arbitrage, SA119,038$435.7K0.00%+104,891+741.4%Added
HSBC Holdings PLC109,353$426.5K0.00%+50,717+86.5%Added
Rangeley Capital, LLC114,890$420.5K0.41%+114,890New
Invesco Ltd.113,319$414.7K0.00%+2,194+2.0%Added
Russell Investments Group, Ltd.104,199$381.4K0.00%+25,042+31.6%Added
Canada Pension Plan Investment Board102,400$374.8K0.00%+84,000+456.5%Added
Algert Global LLC101,360$371.0K0.00%+68,310+206.7%Added
Panagora Asset Management Inc95,521$349.6K0.00%−148,044−60.8%Reduced
Price T Rowe Associates Inc94,235$345.0K0.00%+14,066+17.5%Added
FMR LLC92,327$337.9K0.00%+31,286+51.3%Added
Headlands Technologies LLC89,723$328.4K0.03%+89,723New
Susquehanna Portfolio Strategies, LLC85,580$313.2K0.00%+66,259+342.9%Added
Barclays PLC83,373$305.1K0.00%−5,085−5.7%Reduced
Axq Capital, LP81,483$298.2K0.03%+59,440+269.7%Added
Rhumbline Advisers73,443$268.8K0.00%+7,268+11.0%Added
RBF Capital, LLC70,000$256.2K0.01%00.0%Unchanged
Prelude Capital Management, LLC67,857$248.4K0.02%+67,857New
Alps Advisors Inc67,632$247.5K0.00%+67,632New
Citigroup Inc62,774$229.8K0.00%+39,339+167.9%Added
Fox Run Management, L.L.C.56,446$206.6K0.03%+56,446New
Deutsche Bank AG52,381$191.7K0.00%+3,553+7.3%Added
Wells Fargo & Company49,696$181.9K0.00%+27,145+120.4%Added
STRS Ohio46,200$169.1K0.00%−3,100−6.3%Reduced
JPMorgan Chase & Co41,371$154.3K0.00%+11,579+38.9%Added
Commonwealth Equity Services, LLC40,000$146.4K0.00%−290−0.7%Reduced
Marquette Asset Management, LLC38,552$141.1K0.02%+38,552New
MetLife Investment Management34,079$124.7K0.00%+915+2.8%Added
Franklin Resources Inc34,063$124.7K0.00%−20,603−37.7%Reduced
Profund Advisors LLC32,514$119.0K0.00%+17,013+109.8%Added
State of Alaska, Department of Revenue31,000$113.0K0.00%+31,000New
SEI Investments Co30,681$112.3K0.00%+30,681New
Country Trust Bank30,041$110.0K0.00%00.0%Unchanged
LMR Partners LLP30,000$109.8K0.00%00.0%Unchanged
Aigen Investment Management, LP29,512$108.0K0.03%+29,512New
Scientech Research LLC28,584$104.6K0.08%+28,584New
Mariner, LLC28,104$102.9K0.00%+4,844+20.8%Added
Mirae Asset Global ETFs Holdings Ltd.27,325$100.0K0.00%−755−2.7%Reduced
Graham Capital Management, L.P.25,067$91.7K0.00%−17,674−41.4%Reduced
State Board of Administration of Florida Retirement System25,052$91.7K0.00%+25,052New
Rafferty Asset Management, LLC24,538$89.8K0.00%+24,538New
Creative Planning21,373$78.2K0.00%−42,716−66.7%Reduced
Mercer Global Advisors Inc21,370$78.2K0.00%+10,504+96.7%Added
Castleview Partners, LLC19,100$69.9K0.03%+19,100New
Vanguard Global Advisers, LLC18,858$69.0K0.00%−19,661−51.0%Reduced