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Fulcrum Therapeutics, Inc.

FULC
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001680581

In the last 90 days, Fulcrum Therapeutics, Inc. insiders filed 2 open-market purchases and 0 sales; 154 institutions reported holding it in 13F filings for Q2 2026, worth $291.3M in total; no superinvestor holds it.

13F holders, Q3 2021

Institutional positions in Fulcrum Therapeutics, Inc. as of Sep 30, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
101
+35 vs. Q2 2021
Shares held
36.6M
+9.75M (+36.4%) vs. Q2 2021
Total value
$1.03B
+$750.7M (+267.3%) vs. Q2 2021
New holders
43
35 more added
Sold out
8
16 more reduced

1 institution that held it in Q2 2021 haven't filed for Q3 2021 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q2 2021: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting FULC on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ3 2021: 101 institutions
Q1 2021: 68 institutionsQ2 2021: 67 institutionsQ3 2021: 101 institutionsQ4 2021: 110 institutionsQ1 2022: 108 institutionsQ2 2022: 102 institutionsQ3 2022: 105 institutionsQ4 2022: 110 institutionsQ1 2023: 116 institutionsQ2 2023: 88 institutionsQ3 2023: 81 institutionsQ4 2023: 101 institutionsQ1 2024: 126 institutionsQ2 2024: 121 institutionsQ3 2024: 130 institutionsQ4 2024: 119 institutionsQ1 2025: 117 institutionsQ2 2025: 122 institutionsQ3 2025: 129 institutionsQ4 2025: 172 institutionsQ1 2026: 169 institutionsQ2 2026: 154 institutions
Value heldQ3 2021: $1.03B
Q1 2021: $317.0MQ2 2021: $280.8MQ3 2021: $1.03BQ4 2021: $657.3MQ1 2022: $929.9MQ2 2022: $196.6MQ3 2022: $422.1MQ4 2022: $368.5MQ1 2023: $172.2MQ2 2023: $183.2MQ3 2023: $250.4MQ4 2023: $412.3MQ1 2024: $569.7MQ2 2024: $402.0MQ3 2024: $196.4MQ4 2024: $243.4MQ1 2025: $147.8MQ2 2025: $374.5MQ3 2025: $494.9MQ4 2025: $762.7MQ1 2026: $550.1MQ2 2026: $291.3M
Institutions holding FULC and their total value by quarter
QuarterHoldersValue
Q2 2026154$291.3M
Q1 2026169$550.1M
Q4 2025172$762.7M
Q3 2025129$494.9M
Q2 2025122$374.5M
Q1 2025117$147.8M
Q4 2024119$243.4M
Q3 2024130$196.4M
Q2 2024121$402.0M
Q1 2024126$569.7M
Q4 2023101$412.3M
Q3 202381$250.4M
Q2 202388$183.2M
Q1 2023116$172.2M
Q4 2022110$368.5M
Q3 2022105$422.1M
Q2 2022102$196.6M
Q1 2022108$929.9M
Q4 2021110$657.3M
Q3 2021101$1.03B
Q2 202167$280.8M
Q1 202168$317.0M

Institutions, Q3 2021

Shares, value and share of portfolio for each institution holding Fulcrum Therapeutics, Inc.; share changes are against Q2 2021.

Institutions holding FULC in Q3 2021
InstitutionSharesValue% of portfolioChange in sharesAction
FMR LLC6,044,763$170.5M0.01%+3,665,282+154.0%Added
TRV GP III, LLC4,962,202$140.0M26.57%−1,000,000−16.8%Reduced
RTW Investments, LP3,855,291$108.8M1.64%+650,000+20.3%Added
TRV GP IV, LLC2,343,154$66.1M15.00%00.0%Unchanged
BlackRock Inc.2,030,873$57.3M0.00%+733,428+56.5%Added
Suvretta Capital Management, LLC1,941,969$54.8M0.93%+314,525+19.3%Added
Cowen and Company, LLC1,560,563$44.0M2.12%+240,676+18.2%Added
Vanguard Group Inc1,253,426$35.4M0.00%+346,391+38.2%Added
Boxer Capital, LLC1,250,000$35.3M1.23%+1,250,000New
Adage Capital Partners GP, L.L.C.1,180,000$33.3M0.07%+1,180,000New
D. E. Shaw & Co., Inc.798,101$22.5M0.03%+798,101New
Polar Capital Holdings Plc750,000$21.2M0.12%+750,000New
Two Sigma Investments, LP632,539$17.8M0.05%+616,928+3,951.9%Added
Invesco Ltd.596,057$16.8M0.00%+596,057New
Geode Capital Management, LLC458,442$12.9M0.00%+101,850+28.6%Added
Rock Springs Capital Management LP455,290$12.8M0.27%+455,290New
State Street Corp452,312$12.8M0.00%+140,087+44.9%Added
Harvard Management Co Inc410,714$11.6M0.68%00.0%Unchanged
Parkman Healthcare Partners LLC338,796$9.56M2.42%+192,407+131.4%Added
Acuta Capital Partners, LLC322,500$9.10M3.24%−281,574−46.6%Reduced
Citadel Advisors LLC313,910$8.86M0.01%−96,615−23.5%Reduced
Bessemer Group Inc310,618$8.76M0.02%+24,904+8.7%Added
Perceptive Advisors LLC294,118$8.30M0.12%00.0%Unchanged
Northern Trust Corp257,872$7.28M0.00%+40,161+18.4%Added
Alphabet Inc.255,452$7.21M0.17%−422,689−62.3%Reduced
Natixis250,000$7.11M0.02%+250,000New
Lord, Abbett & Co. LLC187,043$5.28M0.01%+187,043New
Silverarc Capital Management, LLC185,691$5.24M3.03%+185,691New
JPMorgan Chase & Co173,727$4.90M0.00%−10,845−5.9%Reduced
Platinum Investment Management Ltd152,186$4.29M0.12%00.0%Unchanged
Marshall Wace, LLP151,689$4.28M0.02%+151,689New
Nuveen Asset Management, LLC131,878$4.07M0.00%+15,847+13.7%Added
Two Sigma Advisers, LP142,200$4.01M0.01%+142,200New
Point72 Asset Management, L.P.140,000$3.95M0.02%−412,885−74.7%Reduced
Renaissance Technologies LLC133,900$3.78M0.00%+133,900New
Fiduciary Trust Co129,215$3.65M0.06%+3,216+2.6%Added
Millennium Management LLC99,707$2.81M0.00%−525,928−84.1%Reduced
Marshall Wace North America L.P.95,104$2.68M0.01%+95,104New
Bank of New York Mellon Corp95,031$2.68M0.00%+31,059+48.6%Added
Morgan Stanley85,011$2.40M0.00%+12,715+17.6%Added
Schonfeld Strategic Advisors LLC82,100$2.32M0.03%+82,100New
EAM Global Investors LLC78,384$2.21M0.52%+78,384New
Charles Schwab Investment Management Inc67,348$1.90M0.00%+13,064+24.1%Added
Goldman Sachs Group Inc62,502$1.76M0.00%+35,036+127.6%Added
Susquehanna Fundamental Investments, LLC57,726$1.63M0.03%+57,726New
EAM Investors, LLC55,383$1.56M0.26%+55,383New
Sofinnova Investments, Inc.51,006$1.44M0.09%+51,006New
Dimensional Fund Advisors LP50,748$1.43M0.00%−24,835−32.9%Reduced
Ghost Tree Capital, LLC50,000$1.41M0.47%+50,000New
Jane Street Group, LLC49,942$1.41M0.00%+49,942New
Price T Rowe Associates Inc44,400$1.25M0.00%+44,400New
Tekla Capital Management LLC43,898$1.24M0.04%+43,898New
Allianz Asset Management GmbH41,080$1.16M0.00%+41,080New
Country Trust Bank37,341$1.05M0.03%00.0%Unchanged
Deutsche Bank AG36,595$1.03M0.00%+23,445+178.3%Added
Darwin Global Management, Ltd.33,997$959.0K0.18%+33,997New
Voloridge Investment Management, LLC30,533$861.0K0.01%+30,533New
Cubist Systematic Strategies, LLC30,498$860.0K0.01%+27,703+991.2%Added
Rhumbline Advisers30,199$852.0K0.00%+7,724+34.4%Added
LMR Partners LLP30,000$846.0K0.01%+30,000New
Panagora Asset Management Inc28,407$801.0K0.00%+27,579+3,330.8%Added
Brandywine Managers, LLC20,388$575.0K0.60%00.0%Unchanged
Verition Fund Management LLC20,000$564.0K0.01%+20,000New
ClariVest Asset Management LLC19,700$556.0K0.02%+19,700New
SG Americas Securities, LLC19,228$542.0K0.00%+19,228New
New York State Common Retirement Fund18,598$525.0K0.00%+6,188+49.9%Added
Alliancebernstein L.P.16,600$468.0K0.00%00.0%Unchanged
Mass General Brigham, Inc15,860$447.0K0.12%+15,860New
American International Group, Inc.14,583$411.0K0.00%+2,172+17.5%Added
California State Teachers Retirement System14,396$406.0K0.00%−16,163−52.9%Reduced
Manufacturers Life Insurance Company, The14,007$395.0K0.00%+14,007New
State of Wisconsin Investment Board13,600$384.0K0.00%+13,600New
PDT Partners, LLC13,523$381.0K0.03%−4,477−24.9%Reduced
ProShare Advisors LLC12,023$339.0K0.00%+404+3.5%Added
Bank of Montreal11,501$325.0K0.00%−12,600−52.3%Reduced
Voya Investment Management LLC10,551$298.0K0.00%+10,551New
MetLife Investment Management9,555$269.5K0.00%+9,555New
Bank Julius Baer & Co. Ltd, Zurich8,500$240.0K0.00%+8+0.1%Added
Hershey Trust Co7,929$224.0K0.00%+7,929New
STRS Ohio7,800$220.0K0.00%+4,600+143.8%Added
Jacobs Levy Equity Management, Inc7,487$211.0K0.00%−6,302−45.7%Reduced
Bank of America Corp7,468$211.0K0.00%−2,809−27.3%Reduced
Paradigm Financial Advisors, LLC7,375$208.0K0.05%+7,375New
Citigroup Inc7,315$206.0K0.00%+396+5.7%Added
Metropolitan Life Insurance Co7,229$203.9K0.00%+7,229New
Nisa Investment Advisors, LLC5,950$168.0K0.00%+900+17.8%Added
Wells Fargo & Company5,859$165.0K0.00%−2,073−26.1%Reduced
Group One Trading, L.P.4,973$140.0K0.00%+4,973New
Blackstone Group Inc.4,758$134.0K0.00%+4,758New
Royal Bank of Canada3,240$91.0K0.00%+1,722+113.4%Added
Legal & General Group Plc2,129$60.0K0.00%+364+20.6%Added
Ameritas Investment Partners, Inc.2,042$58.0K0.00%+942+85.6%Added
UBS Group AG1,305$37.0K0.00%+363+38.5%Added
Penserra Capital Management LLC925$26.0K0.00%+180+24.2%Added
Cutler Group LP900$25.0K0.00%+900New
Tower Research Capital LLC (TRC)534$15.0K0.00%−1,119−67.7%Reduced
Smith Group Asset Management, LLC520$15.0K0.00%+520New
Advisor Group Holdings, Inc.300$8.00K0.00%+300New
Daiwa Securities Group Inc.138$4.00K0.00%+86+165.4%Added
Federated Hermes, Inc.71$2.00K0.00%−587−89.2%Reduced