Fulcrum Therapeutics, Inc.
FULC- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001680581
In the last 90 days, Fulcrum Therapeutics, Inc. insiders filed 2 open-market purchases and 0 sales; 154 institutions reported holding it in 13F filings for Q2 2026, worth $291.3M in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Fulcrum Therapeutics, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 172
- +43 vs. Q3 2025
- Shares held
- 67.4M
- +13.7M (+25.4%) vs. Q3 2025
- Total value
- $762.7M
- +$267.8M (+54.1%) vs. Q3 2025
- New holders
- 59
- 43 more added
- Sold out
- 16
- 49 more reduced
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting FULC on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 154 | $291.3M |
| Q1 2026 | 169 | $550.1M |
| Q4 2025 | 172 | $762.7M |
| Q3 2025 | 129 | $494.9M |
| Q2 2025 | 122 | $374.5M |
| Q1 2025 | 117 | $147.8M |
| Q4 2024 | 119 | $243.4M |
| Q3 2024 | 130 | $196.4M |
| Q2 2024 | 121 | $402.0M |
| Q1 2024 | 126 | $569.7M |
| Q4 2023 | 101 | $412.3M |
| Q3 2023 | 81 | $250.4M |
| Q2 2023 | 88 | $183.2M |
| Q1 2023 | 116 | $172.2M |
| Q4 2022 | 110 | $368.5M |
| Q3 2022 | 105 | $422.1M |
| Q2 2022 | 102 | $196.6M |
| Q1 2022 | 108 | $929.9M |
| Q4 2021 | 110 | $657.3M |
| Q3 2021 | 101 | $1.03B |
| Q2 2021 | 67 | $280.8M |
| Q1 2021 | 68 | $317.0M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Fulcrum Therapeutics, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Suvretta Capital Management, LLC | 6,561,111 | $74.2M | 1.85% | +1,180,111+21.9% | Added |
| Ra Capital Management, L.P. | 6,053,960 | $68.5M | 0.70% | −4,175,139−40.8% | Reduced |
| TCG Crossover Management, LLC | 5,250,000 | $59.4M | 1.97% | 00.0% | Unchanged |
| Nantahala Capital Management, LLC | 4,293,346 | $48.6M | 2.89% | −377,438−8.1% | Reduced |
| BlackRock, Inc. | 4,263,761 | $48.2M | 0.00% | +557,011+15.0% | Added |
| Vanguard Group Inc | 3,559,552 | $40.3M | 0.00% | +560,088+18.7% | Added |
| Braidwell LP | 3,061,222 | $34.6M | 1.11% | +2,841,734+1,294.7% | Added |
| Point72 Asset Management, L.P. | 2,398,232 | $27.1M | 0.04% | +2,398,232 | New |
| Siren, L.L.C. | 1,950,000 | $22.1M | 0.66% | +1,950,000 | New |
| D. E. Shaw & Co., Inc. | 1,913,755 | $21.6M | 0.02% | +464,332+32.0% | Added |
| First Turn Management, LLC | 1,892,683 | $21.4M | 2.45% | +1,892,683 | New |
| GSK plc | 1,785,714 | $20.2M | 2.53% | +1,785,714 | New |
| Adage Capital Partners GP, L.L.C. | 1,700,000 | $19.2M | 0.03% | −732,000−30.1% | Reduced |
| Ikarian Capital, LLC | 1,375,472 | $15.6M | 2.01% | +86,247+6.7% | Added |
| Standard Life Aberdeen plc | 1,254,027 | $14.2M | 0.02% | +1,116,066+809.0% | Added |
| ADAR1 Capital Management, LLC | 1,253,749 | $14.2M | 1.06% | +912,137+267.0% | Added |
| Citadel Advisors LLC | 1,207,004 | $13.7M | 0.01% | +352,448+41.2% | Added |
| Geode Capital Management, LLC | 1,105,813 | $12.5M | 0.00% | +101,762+10.1% | Added |
| Dimensional Fund Advisors LP | 1,051,124 | $11.9M | 0.00% | −248,184−19.1% | Reduced |
| State Street Corp | 1,005,345 | $11.4M | 0.00% | −57,862−5.4% | Reduced |
| Balyasny Asset Management LLC | 970,439 | $11.0M | 0.02% | −480,041−33.1% | Reduced |
| Vestal Point Capital, LP | 950,000 | $10.7M | 0.39% | +950,000 | New |
| Great Point Partners LLC | 800,000 | $9.05M | 2.93% | +800,000 | New |
| Acadian Asset Management LLC | 736,740 | $8.33M | 0.01% | +196,099+36.3% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 582,377 | $6.59M | 0.02% | +198,239+51.6% | Added |
| Northern Trust Corp | 552,220 | $6.25M | 0.00% | −16,102−2.8% | Reduced |
| Boothbay Fund Management, LLC | 517,526 | $5.85M | 0.15% | −160,888−23.7% | Reduced |
| Jane Street Group, LLC | 493,750 | $5.58M | 0.01% | +172,230+53.6% | Added |
| Invesco Ltd. | 417,189 | $4.72M | 0.00% | +293,317+236.8% | Added |
| Silverarc Capital Management, LLC | 394,650 | $4.46M | 0.65% | +394,650 | New |
| Qube Research & Technologies Ltd | 392,489 | $4.44M | 0.01% | +392,489 | New |
| Charles Schwab Investment Management Inc | 388,896 | $4.40M | 0.00% | +55,413+16.6% | Added |
| Sio Capital Management, LLC | 382,000 | $4.32M | 0.72% | +382,000 | New |
| Trexquant Investment LP | 355,547 | $4.02M | 0.04% | +334,532+1,591.9% | Added |
| Goldman Sachs Group Inc | 323,879 | $3.66M | 0.00% | −262,472−44.8% | Reduced |
| Deutsche Bank AG | 287,096 | $3.25M | 0.00% | +1,767+0.6% | Added |
| Bessemer Group Inc | 286,988 | $3.25M | 0.00% | 00.0% | Unchanged |
| Driehaus Capital Management LLC | 243,388 | $2.75M | 0.02% | +243,388 | New |
| Bank of America Corp | 231,177 | $2.61M | 0.00% | +83,966+57.0% | Added |
| Catalio Capital Management, LP | 201,301 | $2.28M | 0.40% | +201,301 | New |
| Nicholas Investment Partners, LP | 182,961 | $2.07M | 0.15% | +182,961 | New |
| Wells Fargo & Company | 166,395 | $1.88M | 0.00% | +133,888+411.9% | Added |
| Morgan Stanley | 165,623 | $1.87M | 0.00% | −78,212−32.1% | Reduced |
| Simplify Asset Management Inc. | 159,674 | $1.81M | 0.03% | +76,440+91.8% | Added |
| American Century Companies Inc | 157,672 | $1.78M | 0.00% | +5,428+3.6% | Added |
| Wellington Management Group LLP | 146,427 | $1.66M | 0.00% | −32,931−18.4% | Reduced |
| SummitTX Capital, L.P. | 138,143 | $1.56M | 0.05% | +138,143 | New |
| Fiduciary Trust Co | 136,555 | $1.54M | 0.02% | 00.0% | Unchanged |
| Barclays PLC | 132,541 | $1.50M | 0.00% | +42,925+47.9% | Added |
| Bank of New York Mellon Corp | 116,906 | $1.32M | 0.00% | −2,252−1.9% | Reduced |
| Nuveen, LLC | 112,203 | $1.27M | 0.00% | 00.0% | Unchanged |
| Walleye Capital LLC | 108,434 | $1.23M | 0.01% | +108,434 | New |
| UBS Group AG | 102,967 | $1.16M | 0.00% | −198,190−65.8% | Reduced |
| Marshall Wace, LLP | 102,921 | $1.16M | 0.00% | +102,921 | New |
| Ameriprise Financial Inc | 100,675 | $1.14M | 0.00% | −23,991−19.2% | Reduced |
| Maven Securities LTD | 100,000 | $1.13M | 0.14% | +100,000 | New |
| Gsa Capital Partners LLP | 99,709 | $1.13M | 0.10% | −16,359−14.1% | Reduced |
| Principal Financial Group Inc | 97,688 | $1.10M | 0.00% | +31,138+46.8% | Added |
| Jump Financial, LLC | 92,200 | $1.04M | 0.01% | +92,200 | New |
| Exome Asset Management LLC | 92,055 | $1.04M | 0.51% | −6,744−6.8% | Reduced |
| Susquehanna International Group, LLP | 87,930 | $994.5K | 0.00% | +34,359+64.1% | Added |
| State of Wisconsin Investment Board | 86,499 | $978.3K | 0.00% | +72,833+533.0% | Added |
| RBF Capital, LLC | 80,506 | $910.5K | 0.04% | 00.0% | Unchanged |
| Verition Fund Management LLC | 74,691 | $844.8K | 0.00% | +74,691 | New |
| Superstring Capital Management LP | 72,060 | $815.0K | 0.44% | +72,060 | New |
| Citigroup Inc | 67,102 | $758.9K | 0.00% | +66,384+9,245.7% | Added |
| Y-Intercept (Hong Kong) Ltd | 66,716 | $754.6K | 0.02% | +55,444+491.9% | Added |
| Legato Capital Management LLC | 66,347 | $750.4K | 0.06% | +66,347 | New |
| Squarepoint Ops LLC | 65,852 | $744.8K | 0.00% | +48,026+269.4% | Added |
| Price T Rowe Associates Inc | 63,760 | $722.0K | 0.00% | −2,132−3.2% | Reduced |
| Integrated Quantitative Investments LLC | 62,522 | $707.1K | 0.15% | +62,522 | New |
| EAM Investors, LLC | 61,620 | $696.9K | 0.08% | +61,620 | New |
| Atom Investors LP | 60,595 | $685.3K | 0.05% | +60,595 | New |
| New York State Common Retirement Fund | 57,725 | $652.9K | 0.00% | +44,625+340.6% | Added |
| Rhumbline Advisers | 55,713 | $630.1K | 0.00% | −13,659−19.7% | Reduced |
| DekaBank Deutsche Girozentrale | 60,000 | $617.0K | 0.00% | 00.0% | Unchanged |
| Millennium Management LLC | 54,431 | $615.6K | 0.00% | −96,436−63.9% | Reduced |
| XTX Topco Ltd | 51,802 | $585.9K | 0.02% | +51,802 | New |
| KVP Capital Advisors, LP | 50,000 | $565.5K | 0.58% | +50,000 | New |
| Burkehill Global Management, LP | 50,000 | $565.5K | 0.04% | +50,000 | New |
| Seven Grand Managers, LLC | 50,000 | $565.5K | 0.04% | +50,000 | New |
| Brevan Howard Capital Management LP | 48,900 | $559.4K | 0.01% | +33,597+219.5% | Added |
| STRS Ohio | 49,300 | $557.6K | 0.00% | −28,600−36.7% | Reduced |
| Graham Capital Management, L.P. | 48,464 | $548.1K | 0.02% | +17,978+59.0% | Added |
| Franklin Resources Inc | 44,249 | $500.5K | 0.00% | −15,773−26.3% | Reduced |
| HSBC Holdings PLC | 43,262 | $497.9K | 0.00% | −10,544−19.6% | Reduced |
| Jain Global LLC | 41,260 | $466.7K | 0.00% | +41,260 | New |
| Commonwealth Equity Services, LLC | 40,000 | $452.4K | 0.00% | −43,428−52.1% | Reduced |
| SEI Investments Co | 37,511 | $424.2K | 0.00% | +37,511 | New |
| Campbell & CO Investment Adviser LLC | 35,601 | $402.6K | 0.02% | −66,869−65.3% | Reduced |
| Group One Trading, L.P. | 34,750 | $393.0K | 0.01% | +28,990+503.3% | Added |
| Axq Capital, LP | 31,545 | $356.8K | 0.08% | +31,545 | New |
| Woodline Partners LP | 30,793 | $348.3K | 0.00% | +30,793 | New |
| Two Sigma Advisers, LP | 30,500 | $345.0K | 0.00% | −1,000−3.2% | Reduced |
| Country Trust Bank | 30,041 | $339.8K | 0.01% | 00.0% | Unchanged |
| LMR Partners LLP | 30,000 | $339.3K | 0.00% | 00.0% | Unchanged |
| Quantinno Capital Management LP | 29,264 | $331.0K | 0.00% | +4,615+18.7% | Added |
| Prelude Capital Management, LLC | 28,832 | $326.1K | 0.02% | 00.0% | Unchanged |
| Fox Run Management, L.L.C. | 25,568 | $289.2K | 0.04% | −25,223−49.7% | Reduced |
| MetLife Investment Management | 22,714 | $256.9K | 0.00% | −3,181−12.3% | Reduced |