Denali Therapeutics Inc.
DNLI- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001714899
In the last 90 days, Denali Therapeutics Inc. insiders filed 0 open-market purchases and 4 sales; 294 institutions reported holding it in 13F filings for Q2 2026, worth $4.00B in total; no superinvestor holds it.
13F holders, Q2 2026
Institutional positions in Denali Therapeutics Inc. as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 294
- +28 vs. Q1 2026
- Shares held
- 156.2M
- +8.88M (+6.0%) vs. Q1 2026
- Total value
- $4.00B
- +$1.18B (+41.8%) vs. Q1 2026
- New holders
- 56
- 120 more added
- Sold out
- 28
- 68 more reduced
3 institutions that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DNLI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 294 | $4.00B |
| Q1 2026 | 269 | $2.82B |
| Q4 2025 | 250 | $2.50B |
| Q3 2025 | 240 | $1.97B |
| Q2 2025 | 231 | $1.93B |
| Q1 2025 | 222 | $1.85B |
| Q4 2024 | 224 | $2.61B |
| Q3 2024 | 217 | $3.69B |
| Q2 2024 | 203 | $2.88B |
| Q1 2024 | 211 | $2.51B |
| Q4 2023 | 209 | $2.47B |
| Q3 2023 | 195 | $2.24B |
| Q2 2023 | 203 | $3.18B |
| Q1 2023 | 202 | $2.49B |
| Q4 2022 | 199 | $2.94B |
| Q3 2022 | 200 | $2.84B |
| Q2 2022 | 188 | $2.73B |
| Q1 2022 | 190 | $2.79B |
| Q4 2021 | 213 | $3.80B |
| Q3 2021 | 214 | $4.28B |
| Q2 2021 | 210 | $6.32B |
| Q1 2021 | 218 | $4.60B |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Denali Therapeutics Inc.; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| MetLife Investment Management | 85,621 | $2.20M | 0.01% | +8,063+10.4% | Added |
| Russell Investments Group, Ltd. | 86,032 | $2.21M | 0.00% | +71,974+512.0% | Added |
| D.A. Davidson & Co. | 87,741 | $2.26M | 0.01% | −22,494−20.4% | Reduced |
| Rafferty Asset Management, LLC | 96,342 | $2.48M | 0.01% | −54,345−36.1% | Reduced |
| Lumbard & Kellner, LLC | 98,282 | $2.53M | 0.77% | +3,500+3.7% | Added |
| Ghisallo Capital Management LLC | 100,000 | $2.57M | 0.05% | 00.0% | Unchanged |
| Integral Health Asset Management, LLC | 100,000 | $2.57M | 0.11% | +100,000 | New |
| PFM Health Sciences, LP | 100,966 | $2.60M | 0.23% | +100,966 | New |
| Integrated Wealth Concepts LLC | 102,241 | $2.63M | 0.02% | +2,687+2.7% | Added |
| Legal & General Group Plc | 111,953 | $2.88M | 0.00% | +1,703+1.5% | Added |
| B. Metzler seel. Sohn & Co. AG | 112,300 | $2.89M | 0.02% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 115,775 | $2.98M | 0.01% | +4,081+3.7% | Added |
| Manufacturers Life Insurance Company, The | 117,348 | $3.02M | 0.00% | −8,094−6.5% | Reduced |
| Susquehanna International Group, LLP | 123,258 | $3.17M | 0.00% | +72,783+144.2% | Added |
| Odyssean, LLC | 125,062 | $3.22M | 0.52% | +125,062 | New |
| Hudson Bay Capital Management LP | 130,000 | $3.34M | 0.02% | −216,360−62.5% | Reduced |
| Man Group plc | 139,065 | $3.58M | 0.01% | +200.0% | Added |
| Vanguard Asset Management, Ltd | 141,153 | $3.63M | 0.00% | +15,910+12.7% | Added |
| Great Lakes Advisors, LLC | 145,045 | $3.73M | 0.03% | −82,065−36.1% | Reduced |
| Deutsche Bank AG | 149,804 | $3.85M | 0.00% | +29,436+24.5% | Added |
| California State Teachers Retirement System | 152,086 | $3.91M | 0.00% | −10,490−6.5% | Reduced |
| E. Ohman J:or Asset Management AB | 160,000 | $4.12M | 0.10% | +160,000 | New |
| Alps Advisors Inc | 160,378 | $4.12M | 0.02% | +31,273+24.2% | Added |
| Edmond de Rothschild Holding S.A. | 165,080 | $4.25M | 0.06% | −60,600−26.9% | Reduced |
| Teachers Retirement System of the State of Kentucky | 166,181 | $4.27M | 0.03% | 00.0% | Unchanged |
| New York State Common Retirement Fund | 171,712 | $4.42M | 0.01% | +43,593+34.0% | Added |
| Rhenman & Partners Asset Management AB | 179,000 | $4.60M | 0.43% | −20,000−10.1% | Reduced |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 179,195 | $4.61M | 0.01% | +79,692+80.1% | Added |
| Wells Fargo & Company | 189,865 | $4.88M | 0.00% | +82,208+76.4% | Added |
| Rhumbline Advisers | 194,787 | $5.01M | 0.00% | +10,539+5.7% | Added |
| SCS Capital Management LLC | 197,998 | $5.09M | 0.05% | 00.0% | Unchanged |
| Masters Capital Management LLC | 200,000 | $5.14M | 0.72% | −400,000−66.7% | Reduced |
| Burkehill Global Management, LP | 200,000 | $5.14M | 0.19% | 00.0% | Unchanged |
| Susquehanna Portfolio Strategies, LLC | 211,474 | $5.44M | 0.09% | +53,578+33.9% | Added |
| Alyeska Investment Group, L.P. | 219,334 | $5.64M | 0.01% | −1,721,789−88.7% | Reduced |
| XTX Topco Ltd | 226,953 | $5.84M | 0.08% | +148,386+188.9% | Added |
| Privium Fund Management B.V. | 229,857 | $5.91M | 1.09% | −25,000−9.8% | Reduced |
| Groupama Asset Managment | 229,939 | $5.91M | 0.07% | +22,809+11.0% | Added |
| TD Asset Management Inc | 231,644 | $5.96M | 0.01% | −24,122−9.4% | Reduced |
| Swiss National Bank | 270,500 | $6.96M | 0.00% | −3,300−1.2% | Reduced |
| JPMorgan Chase & Co | 287,019 | $7.59M | 0.00% | −36,970−11.4% | Reduced |
| Marex Group plc | 295,631 | $7.60M | 0.06% | +8,631+3.0% | Added |
| ExodusPoint Capital Management, LP | 336,567 | $8.66M | 0.08% | +336,567 | New |
| Invesco Ltd. | 343,898 | $8.85M | 0.00% | +33,702+10.9% | Added |
| Woodline Partners LP | 364,082 | $9.36M | 0.03% | 00.0% | Unchanged |
| AQR Capital Management LLC | 388,469 | $9.99M | 0.00% | +285,890+278.7% | Added |
| Defilade Capital Management, L.P. | 391,866 | $10.1M | 1.35% | −968,103−71.2% | Reduced |
| Citigroup Inc | 487,278 | $12.5M | 0.01% | +448,000+1,140.6% | Added |
| Segall Bryant & Hamill, LLC | 519,483 | $13.4M | 0.16% | +8,940+1.8% | Added |
| Marshall Wace, LLP | 549,830 | $14.1M | 0.01% | −441,438−44.5% | Reduced |
| Ensign Peak Advisors, Inc | 582,669 | $15.0M | 0.02% | +66,948+13.0% | Added |
| Nuveen, LLC | 608,967 | $15.7M | 0.00% | +313,381+106.0% | Added |
| Cercano Management LLC | 625,000 | $16.1M | 2.14% | 00.0% | Unchanged |
| American Century Companies Inc | 712,526 | $18.3M | 0.01% | −223,166−23.9% | Reduced |
| DAFNA Capital Management LLC | 739,014 | $19.0M | 3.62% | +420,514+132.0% | Added |
| Bank of New York Mellon Corp | 800,283 | $20.6M | 0.00% | +32,244+4.2% | Added |
| Morgan Stanley | 961,050 | $24.7M | 0.00% | −143,707−13.0% | Reduced |
| Vanguard Fiduciary Trust Co | 991,904 | $25.5M | 0.01% | +42,209+4.4% | Added |
| ADAR1 Capital Management, LLC | 1,029,080 | $26.5M | 1.24% | −842,375−45.0% | Reduced |
| Millennium Management LLC | 1,125,748 | $29.0M | 0.02% | −132,202−10.5% | Reduced |
| Candriam Luxembourg S.C.A. | 1,189,886 | $30.6M | 0.14% | +90,041+8.2% | Added |
| Artisan Partners Limited Partnership | 1,224,497 | $31.5M | 0.05% | +124,778+11.3% | Added |
| Bank of America Corp | 1,230,957 | $31.7M | 0.00% | +96,774+8.5% | Added |
| Charles Schwab Investment Management Inc | 1,244,955 | $32.0M | 0.00% | +37,556+3.1% | Added |
| Standard Life Aberdeen plc | 1,345,481 | $34.6M | 0.05% | −508,965−27.4% | Reduced |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,355,514 | $34.9M | 0.03% | +1,059,011+357.2% | Added |
| Northern Trust Corp | 1,389,765 | $35.7M | 0.00% | +79,109+6.0% | Added |
| Siren, L.L.C. | 1,396,513 | $35.9M | 0.73% | 00.0% | Unchanged |
| Foresite Capital Management VI LLC | 1,396,771 | $35.9M | 5.59% | +186,800+15.4% | Added |
| Principal Financial Group Inc | 1,420,083 | $36.5M | 0.02% | −58,403−4.0% | Reduced |
| Crestline Management, LP | 1,910,732 | $49.1M | 91.90% | −300,000−13.6% | Reduced |
| Casdin Capital, LLC | 2,045,000 | $52.6M | 2.63% | +205,000+11.1% | Added |
| Nomura Asset Management International Inc. | 2,208,263 | $56.8M | 0.09% | +2,093,739+1,828.2% | Added |
| Alliancebernstein L.P. | 2,984,807 | $57.3M | 0.02% | +91,189+3.2% | Added |
| Fisher Asset Management, LLC | 2,414,162 | $62.1M | 0.02% | −22,733−0.9% | Reduced |
| Capital Research Global Investors | 2,565,817 | $66.0M | 0.01% | +51,229+2.0% | Added |
| Pictet Asset Management Holding SA | 2,791,206 | $71.9M | 0.07% | +232,341+9.1% | Added |
| Norges Bank | 2,824,746 | $72.7M | 0.01% | +2,824,746 | New |
| Dimensional Fund Advisors LP | 2,860,604 | $73.6M | 0.01% | +168,429+6.3% | Added |
| UBS Group AG | 3,120,592 | $80.3M | 0.01% | +549,248+21.4% | Added |
| Price T Rowe Associates Inc | 3,136,149 | $80.7M | 0.01% | +672,003+27.3% | Added |
| UBS Asset Management Americas Inc | 3,161,972 | $81.3M | 0.01% | −1,270,342−28.7% | Reduced |
| Baker Bros. Advisors LP | 3,734,336 | $96.0M | 0.48% | +2,641+0.1% | Added |
| Holocene Advisors, LP | 3,905,225 | $100.4M | 0.23% | +709,796+22.2% | Added |
| Geode Capital Management, LLC | 3,973,342 | $102.2M | 0.01% | +246,228+6.6% | Added |
| Goldman Sachs Group Inc | 4,155,895 | $106.9M | 0.01% | −251,360−5.7% | Reduced |
| FMR LLC | 4,535,836 | $116.7M | 0.01% | −39,538−0.9% | Reduced |
| Vanguard Capital Management LLC | 6,275,729 | $161.4M | 0.00% | +127,772+2.1% | Added |
| Vanguard Portfolio Management LLC | 6,477,057 | $166.6M | 0.01% | +356,897+5.8% | Added |
| Temasek Holdings (Private) Ltd | 7,012,974 | $180.4M | 0.49% | 00.0% | Unchanged |
| State Street Corp | 7,049,304 | $181.3M | 0.01% | +777,303+12.4% | Added |
| Baillie Gifford & Co | 11,960,230 | $307.6M | 0.28% | −106,249−0.9% | Reduced |
| BlackRock, Inc. | 14,026,413 | $360.8M | 0.01% | +991,979+7.6% | Added |
| T. Rowe Price Investment Management, Inc. | 16,178,963 | $416.1M | 0.27% | +7,659,771+89.9% | Added |
| Vestal Point Capital, LP | 0 | $0 | 0.00% | −1,773,326−100.0% | Sold out |
| StemPoint Capital LP | 0 | $0 | 0.00% | −426,561−100.0% | Sold out |
| Braidwell LP | 0 | $0 | 0.00% | −296,324−100.0% | Sold out |
| Schroder Investment Management Group | 0 | $0 | 0.00% | −285,820−100.0% | Sold out |
| Palo Alto Investors LP | 0 | $0 | 0.00% | −234,582−100.0% | Sold out |
| Balyasny Asset Management LLC | 0 | $0 | 0.00% | −195,108−100.0% | Sold out |