Denali Therapeutics Inc.
DNLI- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001714899
In the last 90 days, Denali Therapeutics Inc. insiders filed 0 open-market purchases and 4 sales; 294 institutions reported holding it in 13F filings for Q2 2026, worth $4.00B in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Denali Therapeutics Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 240
- +13 vs. Q2 2025
- Shares held
- 135.5M
- +2.28M (+1.7%) vs. Q2 2025
- Total value
- $1.97B
- +$103.6M (+5.6%) vs. Q2 2025
- New holders
- 35
- 91 more added
- Sold out
- 22
- 67 more reduced
4 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DNLI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 294 | $4.00B |
| Q1 2026 | 269 | $2.82B |
| Q4 2025 | 250 | $2.50B |
| Q3 2025 | 240 | $1.97B |
| Q2 2025 | 231 | $1.93B |
| Q1 2025 | 222 | $1.85B |
| Q4 2024 | 224 | $2.61B |
| Q3 2024 | 217 | $3.69B |
| Q2 2024 | 203 | $2.88B |
| Q1 2024 | 211 | $2.51B |
| Q4 2023 | 209 | $2.47B |
| Q3 2023 | 195 | $2.24B |
| Q2 2023 | 203 | $3.18B |
| Q1 2023 | 202 | $2.49B |
| Q4 2022 | 199 | $2.94B |
| Q3 2022 | 200 | $2.84B |
| Q2 2022 | 188 | $2.73B |
| Q1 2022 | 190 | $2.79B |
| Q4 2021 | 213 | $3.80B |
| Q3 2021 | 214 | $4.28B |
| Q2 2021 | 210 | $6.32B |
| Q1 2021 | 218 | $4.60B |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Denali Therapeutics Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Segall Bryant & Hamill, LLC | 512,958 | $7.45M | 0.10% | +12,399+2.5% | Added |
| Ensign Peak Advisors, Inc | 534,071 | $7.75M | 0.01% | +60,376+12.7% | Added |
| Cercano Management LLC | 625,000 | $9.07M | 0.35% | 00.0% | Unchanged |
| Citadel Advisors LLC | 688,224 | $9.99M | 0.01% | −560,729−44.9% | Reduced |
| Masters Capital Management LLC | 750,000 | $10.9M | 1.75% | +150,000+25.0% | Added |
| Marshall Wace, LLP | 787,029 | $11.4M | 0.01% | −618,221−44.0% | Reduced |
| Bank of New York Mellon Corp | 800,747 | $11.6M | 0.00% | +9,991+1.3% | Added |
| Siren, L.L.C. | 821,513 | $11.9M | 0.47% | 00.0% | Unchanged |
| Candriam Luxembourg S.C.A. | 833,582 | $12.1M | 0.06% | −10,667−1.3% | Reduced |
| Casdin Capital, LLC | 890,000 | $12.9M | 1.08% | 00.0% | Unchanged |
| Voloridge Investment Management, LLC | 936,230 | $13.6M | 0.05% | +165,703+21.5% | Added |
| Bank of America Corp | 961,138 | $14.0M | 0.00% | +310,916+47.8% | Added |
| Foresite Capital Management VI LLC | 1,000,000 | $14.5M | 5.61% | +1,000,000 | New |
| Standard Life Aberdeen plc | 1,113,586 | $16.2M | 0.03% | +210,835+23.4% | Added |
| Charles Schwab Investment Management Inc | 1,151,384 | $16.7M | 0.00% | +95,365+9.0% | Added |
| Northern Trust Corp | 1,234,179 | $17.9M | 0.00% | +32,470+2.7% | Added |
| Principal Financial Group Inc | 1,271,190 | $18.5M | 0.01% | +198,207+18.5% | Added |
| Millennium Management LLC | 1,307,171 | $19.0M | 0.01% | +406,670+45.2% | Added |
| Fisher Asset Management, LLC | 1,631,496 | $23.7M | 0.01% | +115,505+7.6% | Added |
| Morgan Stanley | 1,689,492 | $24.5M | 0.00% | +377,476+28.8% | Added |
| StemPoint Capital LP | 1,734,659 | $25.2M | 5.08% | +1,026,744+145.0% | Added |
| UBS Group AG | 2,012,353 | $29.2M | 0.01% | +1,061,589+111.7% | Added |
| Goldman Sachs Group Inc | 2,163,705 | $31.4M | 0.00% | +298,381+16.0% | Added |
| Dimensional Fund Advisors LP | 2,357,214 | $34.2M | 0.01% | −55,714−2.3% | Reduced |
| Point72 Asset Management, L.P. | 2,519,535 | $36.6M | 0.08% | +305,588+13.8% | Added |
| Holocene Advisors, LP | 3,135,712 | $45.5M | 0.10% | +2,732,540+677.8% | Added |
| Crestline Management, LP | 3,410,732 | $49.5M | 85.26% | −450,000−11.7% | Reduced |
| Geode Capital Management, LLC | 3,466,057 | $50.3M | 0.00% | +293,752+9.3% | Added |
| Alliancebernstein L.P. | 3,520,414 | $51.1M | 0.02% | +383,274+12.2% | Added |
| Baker Bros. Advisors LP | 3,731,695 | $54.2M | 0.39% | 00.0% | Unchanged |
| Price T Rowe Associates Inc | 4,568,368 | $66.3M | 0.01% | −2,013,927−30.6% | Reduced |
| Capital Research Global Investors | 4,760,858 | $69.1M | 0.01% | +10,279+0.2% | Added |
| Temasek Holdings (Private) Ltd | 5,355,832 | $77.8M | 0.27% | 00.0% | Unchanged |
| State Street Corp | 5,464,261 | $79.3M | 0.00% | +946,267+20.9% | Added |
| UBS Asset Management Americas Inc | 5,465,037 | $79.4M | 0.02% | −797,240−12.7% | Reduced |
| T. Rowe Price Investment Management, Inc. | 5,638,567 | $81.9M | 0.05% | +2,391,633+73.7% | Added |
| FMR LLC | 6,340,316 | $92.1M | 0.00% | −1,198,152−15.9% | Reduced |
| Baillie Gifford & Co | 11,591,585 | $168.3M | 0.12% | −363,738−3.0% | Reduced |
| Vanguard Group Inc | 11,992,918 | $174.1M | 0.00% | +182,183+1.5% | Added |
| BlackRock, Inc. | 12,289,626 | $178.4M | 0.00% | +236,281+2.0% | Added |
| AXA S.A. | 0 | $0 | 0.00% | −293,853−100.0% | Sold out |
| Twinbeech Capital LP | 0 | $0 | 0.00% | −210,370−100.0% | Sold out |
| Soleus Capital Management, L.P. | 0 | $0 | 0.00% | −182,110−100.0% | Sold out |
| Polar Asset Management Partners Inc. | 0 | $0 | 0.00% | −91,600−100.0% | Sold out |
| Man Group plc | 0 | $0 | 0.00% | −70,028−100.0% | Sold out |
| Skandinaviska Enskilda Banken AB (publ) | 0 | $0 | 0.00% | −43,245−100.0% | Sold out |
| Dark Forest Capital Management LP | 0 | $0 | 0.00% | −28,433−100.0% | Sold out |
| Capital Fund Management S.A. | 0 | $0 | 0.00% | −21,871−100.0% | Sold out |
| Virtu Financial LLC | 0 | $0 | 0.00% | −18,438−100.0% | Sold out |
| Prelude Capital Management, LLC | 0 | $0 | 0.00% | −15,940−100.0% | Sold out |
| NEOS Investment Management LLC | 0 | $0 | 0.00% | −15,174−100.0% | Sold out |
| Tema ETFs LLC | 0 | $0 | 0.00% | −15,174−100.0% | Sold out |
| STRS Ohio | 0 | $0 | 0.00% | −14,300−100.0% | Sold out |
| Caxton Associates LLP | 0 | $0 | 0.00% | −14,229−100.0% | Sold out |
| Headlands Technologies LLC | 0 | $0 | 0.00% | −1,847−100.0% | Sold out |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | $0 | 0.00% | −1,369−100.0% | Sold out |
| Mount Yale Investment Advisors, LLC | 0 | $0 | 0.00% | −201−100.0% | Sold out |
| SRS Capital Advisors, Inc. | 0 | $0 | 0.00% | −52−100.0% | Sold out |
| Bare Financial Services, Inc | 0 | $0 | 0.00% | −36−100.0% | Sold out |
| CIBC Private Wealth Group, LLC | 0 | $0 | 0.00% | −35−100.0% | Sold out |
| Skopos Labs, Inc. | 0 | $0 | 0.00% | −31−100.0% | Sold out |
| WealthTrak Capital Management LLC | 0 | $0 | 0.00% | −10−100.0% | Sold out |
| Norges Bank | – | – | – | – | Not filed |
| Camber Capital Management LP | – | – | – | – | Not filed |
| CIBC World Markets Corp | – | – | – | – | Not filed |
| E Fund Management Co., Ltd. | – | – | – | – | Not filed |