Denali Therapeutics Inc.
DNLI- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001714899
In the last 90 days, Denali Therapeutics Inc. insiders filed 0 open-market purchases and 4 sales; 294 institutions reported holding it in 13F filings for Q2 2026, worth $4.00B in total; no superinvestor holds it.
13F holders, Q2 2025
Institutional positions in Denali Therapeutics Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 231
- +10 vs. Q1 2025
- Shares held
- 137.6M
- +1.67M (+1.2%) vs. Q1 2025
- Total value
- $1.93B
- +$76.1M (+4.1%) vs. Q1 2025
- New holders
- 46
- 84 more added
- Sold out
- 36
- 64 more reduced
1 institution that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DNLI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 294 | $4.00B |
| Q1 2026 | 269 | $2.82B |
| Q4 2025 | 250 | $2.50B |
| Q3 2025 | 240 | $1.97B |
| Q2 2025 | 231 | $1.93B |
| Q1 2025 | 222 | $1.85B |
| Q4 2024 | 224 | $2.61B |
| Q3 2024 | 217 | $3.69B |
| Q2 2024 | 203 | $2.88B |
| Q1 2024 | 211 | $2.51B |
| Q4 2023 | 209 | $2.47B |
| Q3 2023 | 195 | $2.24B |
| Q2 2023 | 203 | $3.18B |
| Q1 2023 | 202 | $2.49B |
| Q4 2022 | 199 | $2.94B |
| Q3 2022 | 200 | $2.84B |
| Q2 2022 | 188 | $2.73B |
| Q1 2022 | 190 | $2.79B |
| Q4 2021 | 213 | $3.80B |
| Q3 2021 | 214 | $4.28B |
| Q2 2021 | 210 | $6.32B |
| Q1 2021 | 218 | $4.60B |
Institutions, Q2 2025
Shares, value and share of portfolio for each institution holding Denali Therapeutics Inc.; share changes are against Q1 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Candriam Luxembourg S.C.A. | 844,249 | $11.8M | 0.07% | −13,913−1.6% | Reduced |
| Casdin Capital, LLC | 890,000 | $12.5M | 1.13% | −100,000−10.1% | Reduced |
| Millennium Management LLC | 900,501 | $12.6M | 0.01% | −592,567−39.7% | Reduced |
| Standard Life Aberdeen plc | 902,751 | $12.6M | 0.02% | +142,936+18.8% | Added |
| UBS Group AG | 950,764 | $13.3M | 0.00% | +162,335+20.6% | Added |
| Charles Schwab Investment Management Inc | 1,056,019 | $14.8M | 0.00% | +46,123+4.6% | Added |
| Principal Financial Group Inc | 1,072,983 | $15.0M | 0.01% | −8,595−0.8% | Reduced |
| Northern Trust Corp | 1,201,709 | $16.8M | 0.00% | +69,536+6.1% | Added |
| Citadel Advisors LLC | 1,248,953 | $17.5M | 0.02% | +79,270+6.8% | Added |
| Morgan Stanley | 1,312,016 | $18.4M | 0.00% | +58,413+4.7% | Added |
| Marshall Wace, LLP | 1,405,250 | $19.7M | 0.02% | −783,172−35.8% | Reduced |
| Fisher Asset Management, LLC | 1,515,991 | $21.2M | 0.01% | +151,032+11.1% | Added |
| Goldman Sachs Group Inc | 1,865,324 | $26.1M | 0.00% | +193,246+11.6% | Added |
| Point72 Asset Management, L.P. | 2,213,947 | $31.0M | 0.07% | +2,213,947 | New |
| Dimensional Fund Advisors LP | 2,412,928 | $33.8M | 0.01% | +312,072+14.9% | Added |
| Alliancebernstein L.P. | 3,137,140 | $43.9M | 0.01% | −17,247−0.5% | Reduced |
| Geode Capital Management, LLC | 3,172,305 | $44.4M | 0.00% | +135,129+4.4% | Added |
| T. Rowe Price Investment Management, Inc. | 3,246,934 | $45.4M | 0.03% | +3,246,934 | New |
| Baker Bros. Advisors LP | 3,731,695 | $52.2M | 0.51% | 00.0% | Unchanged |
| Crestline Management, LP | 3,860,732 | $54.0M | 86.33% | −300,000−7.2% | Reduced |
| Norges Bank | 3,947,387 | $55.2M | 0.01% | +899,781+29.5% | Added |
| State Street Corp | 4,517,994 | $63.2M | 0.00% | +57,237+1.3% | Added |
| Capital Research Global Investors | 4,750,579 | $66.5M | 0.01% | −14,558−0.3% | Reduced |
| Temasek Holdings (Private) Ltd | 5,355,832 | $74.9M | 0.29% | 00.0% | Unchanged |
| Wellington Management Group LLP | 5,664,733 | $79.2M | 0.01% | −5,744,865−50.4% | Reduced |
| UBS Asset Management Americas Inc | 6,262,277 | $87.6M | 0.02% | −504,639−7.5% | Reduced |
| Price T Rowe Associates Inc | 6,582,295 | $92.1M | 0.01% | +2,215,061+50.7% | Added |
| FMR LLC | 7,538,468 | $105.5M | 0.01% | +125,114+1.7% | Added |
| Vanguard Group Inc | 11,810,735 | $165.2M | 0.00% | +10,978+0.1% | Added |
| Baillie Gifford & Co | 11,955,323 | $167.3M | 0.12% | −134,717−1.1% | Reduced |
| BlackRock, Inc. | 12,053,345 | $168.6M | 0.00% | −1,781,611−12.9% | Reduced |
| Squarepoint Ops LLC | 0 | $0 | 0.00% | −687,151−100.0% | Sold out |
| Artisan Partners Limited Partnership | 0 | $0 | 0.00% | −612,438−100.0% | Sold out |
| Qube Research & Technologies Ltd | 0 | $0 | 0.00% | −288,221−100.0% | Sold out |
| Boxer Capital Management, LLC | 0 | $0 | 0.00% | −250,000−100.0% | Sold out |
| D. E. Shaw & Co., Inc. | 0 | $0 | 0.00% | −78,218−100.0% | Sold out |
| Corebridge Financial, Inc. | 0 | $0 | 0.00% | −60,898−100.0% | Sold out |
| Y-Intercept (Hong Kong) Ltd | 0 | $0 | 0.00% | −54,813−100.0% | Sold out |
| SG Americas Securities, LLC | 0 | $0 | 0.00% | −48,365−100.0% | Sold out |
| Walleye Capital LLC | 0 | $0 | 0.00% | −44,138−100.0% | Sold out |
| VELA Investment Management, LLC | 0 | $0 | 0.00% | −27,771−100.0% | Sold out |
| Cetera Investment Advisers | 0 | $0 | 0.00% | −19,993−100.0% | Sold out |
| SEI Investments Co | 0 | $0 | 0.00% | −17,276−100.0% | Sold out |
| Balyasny Asset Management LLC | 0 | $0 | 0.00% | −16,595−100.0% | Sold out |
| Oxford Asset Management LLP | 0 | $0 | 0.00% | −14,249−100.0% | Sold out |
| XTX Topco Ltd | 0 | $0 | 0.00% | −13,485−100.0% | Sold out |
| Bridgefront Capital, LLC | 0 | $0 | 0.00% | −13,084−100.0% | Sold out |
| Pitcairn Co | 0 | $0 | 0.00% | −12,423−100.0% | Sold out |
| Entropy Technologies, LP | 0 | $0 | 0.00% | −11,215−100.0% | Sold out |
| Bayesian Capital Management, LP | 0 | $0 | 0.00% | −10,130−100.0% | Sold out |
| BI Asset Management Fondsmaeglerselskab A/S | 0 | $0 | 0.00% | −2,988−100.0% | Sold out |
| Riverview Trust Co | 0 | $0 | 0.00% | −1,171−100.0% | Sold out |
| Quadrant Capital Group LLC | 0 | $0 | 0.00% | −515−100.0% | Sold out |
| Umb Bank N A | 0 | $0 | 0.00% | −416−100.0% | Sold out |
| Coldstream Capital Management Inc | 0 | $0 | 0.00% | −145−100.0% | Sold out |
| Sherman Asset Management, Inc. | 0 | $0 | 0.00% | −94−100.0% | Sold out |
| Amundi | 0 | $0 | 0.00% | −88−100.0% | Sold out |
| Sierra Ocean, LLC | 0 | $0 | 0.00% | −66−100.0% | Sold out |
| South State Corp. | 0 | $0 | 0.00% | −30−100.0% | Sold out |
| Stephens Consulting, LLC | 0 | $0 | 0.00% | −30−100.0% | Sold out |
| Steward Partners Investment Advisory, LLC | 0 | $0 | 0.00% | −25−100.0% | Sold out |
| First Horizon Advisors, Inc. | 0 | $0 | 0.00% | −25−100.0% | Sold out |
| Principal Securities, Inc. | 0 | $0 | 0.00% | −14−100.0% | Sold out |
| Hexagon Capital Partners LLC | 0 | $0 | 0.00% | −15−100.0% | Sold out |
| Boston Private Wealth LLC | 0 | $0 | 0.00% | −11−100.0% | Sold out |
| Global Financial Private Client, LLC | 0 | $0 | 0.00% | −5−100.0% | Sold out |
| DiNuzzo Private Wealth, Inc. | 0 | $0 | 0.00% | −2−100.0% | Sold out |
| Lindbrook Capital, LLC | – | – | – | – | Not filed |