Denali Therapeutics Inc.
DNLI- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001714899
In the last 90 days, Denali Therapeutics Inc. insiders filed 0 open-market purchases and 4 sales; 294 institutions reported holding it in 13F filings for Q2 2026, worth $4.00B in total; no superinvestor holds it.
13F holders, Q1 2025
Institutional positions in Denali Therapeutics Inc. as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 222
- +1 vs. Q4 2024
- Shares held
- 135.9M
- +8.35M (+6.5%) vs. Q4 2024
- Total value
- $1.85B
- −$751.0M (−28.9%) vs. Q4 2024
- New holders
- 36
- 74 more added
- Sold out
- 35
- 80 more reduced
3 institutions that held it in Q4 2024 haven't filed for Q1 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DNLI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 294 | $4.00B |
| Q1 2026 | 269 | $2.82B |
| Q4 2025 | 250 | $2.50B |
| Q3 2025 | 240 | $1.97B |
| Q2 2025 | 231 | $1.93B |
| Q1 2025 | 222 | $1.85B |
| Q4 2024 | 224 | $2.61B |
| Q3 2024 | 217 | $3.69B |
| Q2 2024 | 203 | $2.88B |
| Q1 2024 | 211 | $2.51B |
| Q4 2023 | 209 | $2.47B |
| Q3 2023 | 195 | $2.24B |
| Q2 2023 | 203 | $3.18B |
| Q1 2023 | 202 | $2.49B |
| Q4 2022 | 199 | $2.94B |
| Q3 2022 | 200 | $2.84B |
| Q2 2022 | 188 | $2.73B |
| Q1 2022 | 190 | $2.79B |
| Q4 2021 | 213 | $3.80B |
| Q3 2021 | 214 | $4.28B |
| Q2 2021 | 210 | $6.32B |
| Q1 2021 | 218 | $4.60B |
Institutions, Q1 2025
Shares, value and share of portfolio for each institution holding Denali Therapeutics Inc.; share changes are against Q4 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Erste Asset Management GmbH | 26,900 | $397.6K | 0.01% | 00.0% | Unchanged |
| Creative Planning | 30,564 | $415.5K | 0.00% | −17,386−36.3% | Reduced |
| Envestnet Asset Management Inc | 31,430 | $427.3K | 0.00% | −6,192−16.5% | Reduced |
| Dana Investment Advisors, Inc. | 32,155 | $437.1K | 0.02% | −2,147−6.3% | Reduced |
| ProShare Advisors LLC | 33,461 | $454.9K | 0.00% | −8,364−20.0% | Reduced |
| State Board of Administration of Florida Retirement System | 34,168 | $464.5K | 0.00% | 00.0% | Unchanged |
| Teacher Retirement System of Texas | 34,857 | $473.9K | 0.00% | −3,321−8.7% | Reduced |
| Two Sigma Advisers, LP | 35,300 | $479.9K | 0.00% | +20,200+133.8% | Added |
| Arizona State Retirement System | 37,112 | $504.5K | 0.00% | −283−0.8% | Reduced |
| Pathstone Holdings, LLC | 38,305 | $520.7K | 0.00% | +17,081+80.5% | Added |
| Handelsbanken Fonder AB | 38,300 | $521.0K | 0.00% | 00.0% | Unchanged |
| Prudential Financial Inc | 38,643 | $525.2K | 0.00% | −71,950−65.1% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 39,757 | $540.5K | 0.00% | 00.0% | Unchanged |
| Knights of Columbus Asset Advisors LLC | 40,275 | $547.5K | 0.04% | +1,058+2.7% | Added |
| Victory Capital Management Inc | 41,627 | $565.9K | 0.00% | +3,119+8.1% | Added |
| Graham Capital Management, L.P. | 43,005 | $584.7K | 0.02% | +22,299+107.7% | Added |
| Skandinaviska Enskilda Banken AB (publ) | 43,245 | $587.9K | 0.00% | 00.0% | Unchanged |
| Employees Retirement System of Texas | 43,769 | $595.0K | 0.01% | 00.0% | Unchanged |
| Walleye Capital LLC | 44,138 | $600.1K | 0.01% | +19,318+77.8% | Added |
| Pier 88 Investment Partners LLC | 44,910 | $610.6K | 0.12% | −500−1.1% | Reduced |
| MAI Capital Management | 46,526 | $632.5K | 0.00% | 00.0% | Unchanged |
| SG Americas Securities, LLC | 48,365 | $658.0K | 0.00% | +37,362+339.6% | Added |
| Ironwood Investment Management LLC | 49,305 | $670.3K | 0.37% | +12,759+34.9% | Added |
| Voya Investment Management LLC | 51,011 | $693.5K | 0.00% | −3,802−6.9% | Reduced |
| Y-Intercept (Hong Kong) Ltd | 54,813 | $745.2K | 0.05% | +18,807+52.2% | Added |
| Guggenheim Capital LLC | 56,012 | $761.5K | 0.01% | +7,881+16.4% | Added |
| HSBC Holdings PLC | 58,003 | $778.5K | 0.00% | +24,613+73.7% | Added |
| Corebridge Financial, Inc. | 60,898 | $827.9K | 0.00% | −902−1.5% | Reduced |
| Janus Henderson Group PLC | 60,028 | $887.5K | 0.00% | 00.0% | Unchanged |
| Thrivent Financial for Lutherans | 67,917 | $924.0K | 0.00% | −25,055−26.9% | Reduced |
| Campbell & CO Investment Adviser LLC | 68,185 | $927.0K | 0.07% | +30,500+80.9% | Added |
| DekaBank Deutsche Girozentrale | 64,210 | $935.0K | 0.00% | +4,410+7.4% | Added |
| New York State Common Retirement Fund | 70,240 | $954.9K | 0.00% | −74,484−51.5% | Reduced |
| Twinbeech Capital LP | 72,022 | $979.1K | 0.02% | −182,564−71.7% | Reduced |
| Tudor Investment Corp Et Al | 72,597 | $987.0K | 0.01% | +72,597 | New |
| MetLife Investment Management | 74,765 | $1.02M | 0.01% | −1,285−1.7% | Reduced |
| Wells Fargo & Company | 77,282 | $1.05M | 0.00% | −11,651−13.1% | Reduced |
| Intech Investment Management LLC | 77,590 | $1.05M | 0.01% | +30,189+63.7% | Added |
| D. E. Shaw & Co., Inc. | 78,218 | $1.06M | 0.00% | +78,218 | New |
| State of Wisconsin Investment Board | 79,891 | $1.09M | 0.00% | −13,203−14.2% | Reduced |
| Dark Forest Capital Management LP | 80,820 | $1.10M | 0.05% | +67,932+527.1% | Added |
| Franklin Resources Inc | 83,248 | $1.13M | 0.00% | +8,386+11.2% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 88,507 | $1.21M | 0.00% | +3,432+4.0% | Added |
| State of New Jersey Common Pension Fund D | 93,590 | $1.27M | 0.01% | +7,347+8.5% | Added |
| Rhenman & Partners Asset Management AB | 100,000 | $1.36M | 0.16% | +100,000 | New |
| Two Sigma Investments, LP | 102,403 | $1.39M | 0.00% | −77,481−43.1% | Reduced |
| Alps Advisors Inc | 111,375 | $1.51M | 0.01% | −5,002−4.3% | Reduced |
| Trexquant Investment LP | 113,224 | $1.54M | 0.02% | +52,568+86.7% | Added |
| Woodline Partners LP | 113,517 | $1.54M | 0.01% | +13,517+13.5% | Added |
| California State Teachers Retirement System | 117,535 | $1.60M | 0.00% | −2,639−2.2% | Reduced |
| DAFNA Capital Management LLC | 127,900 | $1.74M | 0.49% | +127,900 | New |
| Rafferty Asset Management, LLC | 129,135 | $1.76M | 0.01% | −12,175−8.6% | Reduced |
| Soleus Capital Management, L.P. | 135,000 | $1.84M | 0.14% | +135,000 | New |
| Legal & General Group Plc | 151,962 | $2.07M | 0.00% | +2,449+1.6% | Added |
| Deutsche Bank AG | 156,252 | $2.13M | 0.00% | −121,601−43.8% | Reduced |
| Groupama Asset Managment | 144,488 | $2.14M | 0.04% | +34,281+31.1% | Added |
| Susquehanna International Group, LLP | 167,197 | $2.27M | 0.00% | +95,957+134.7% | Added |
| Man Group plc | 169,385 | $2.30M | 0.01% | +146,950+655.0% | Added |
| Renaissance Technologies LLC | 173,100 | $2.35M | 0.00% | +173,100 | New |
| Teachers Retirement System of the State of Kentucky | 183,392 | $2.49M | 0.02% | −23,732−11.5% | Reduced |
| JPMorgan Chase & Co | 188,403 | $2.56M | 0.00% | −34,580−15.5% | Reduced |
| Invesco Ltd. | 189,427 | $2.58M | 0.00% | +67,949+55.9% | Added |
| Rhumbline Advisers | 190,256 | $2.59M | 0.00% | −134−0.1% | Reduced |
| Citigroup Inc | 194,004 | $2.64M | 0.00% | +27,298+16.4% | Added |
| SCS Capital Management LLC | 197,998 | $2.69M | 0.03% | +197,998 | New |
| Edmond de Rothschild Holding S.A. | 205,680 | $2.80M | 0.05% | 00.0% | Unchanged |
| Jane Street Group, LLC | 213,673 | $2.90M | 0.01% | −15,492−6.8% | Reduced |
| Barclays PLC | 240,648 | $3.27M | 0.00% | −37,419−13.5% | Reduced |
| Hudson Bay Capital Management LP | 250,000 | $3.40M | 0.02% | +157,500+170.3% | Added |
| Boxer Capital Management, LLC | 250,000 | $3.40M | 1.02% | +250,000 | New |
| Swiss National Bank | 250,900 | $3.41M | 0.00% | −2,600−1.0% | Reduced |
| Manufacturers Life Insurance Company, The | 258,132 | $3.51M | 0.00% | +49,611+23.8% | Added |
| Segall Bryant & Hamill, LLC | 281,139 | $3.82M | 0.06% | −7,936−2.7% | Reduced |
| Qube Research & Technologies Ltd | 288,221 | $3.92M | 0.01% | −23,286−7.5% | Reduced |
| AXA S.A. | 293,381 | $3.99M | 0.01% | −374−0.1% | Reduced |
| Voloridge Investment Management, LLC | 301,973 | $4.11M | 0.02% | +301,973 | New |
| TD Asset Management Inc | 308,580 | $4.20M | 0.00% | +42,828+16.1% | Added |
| Schroder Investment Management Group | 291,795 | $4.31M | 0.00% | +43,995+17.8% | Added |
| Nuveen, LLC | 322,945 | $4.39M | 0.00% | +322,945 | New |
| Pier Capital, LLC | 335,504 | $4.56M | 0.76% | +3,185+1.0% | Added |
| American Century Companies Inc | 349,420 | $4.75M | 0.00% | −131,109−27.3% | Reduced |
| Clarius Group, LLC | 368,995 | $5.02M | 0.32% | −41,000−10.0% | Reduced |
| Pictet Asset Management Holding SA | 343,959 | $5.06M | 0.01% | +324,603+1,677.0% | Added |
| Bank of America Corp | 447,757 | $6.09M | 0.00% | +177,424+65.6% | Added |
| Yiheng Capital Management, L.P. | 469,981 | $6.39M | 2.25% | −230,117−32.9% | Reduced |
| Ensign Peak Advisors, Inc | 587,785 | $7.99M | 0.02% | +241,481+69.7% | Added |
| Artisan Partners Limited Partnership | 612,438 | $8.33M | 0.01% | −442,085−41.9% | Reduced |
| Cercano Management LLC | 625,000 | $8.50M | 0.25% | 00.0% | Unchanged |
| StemPoint Capital LP | 667,078 | $9.07M | 2.90% | +82,750+14.2% | Added |
| Squarepoint Ops LLC | 687,151 | $9.34M | 0.02% | +638,532+1,313.3% | Added |
| Standard Life Aberdeen plc | 759,815 | $10.3M | 0.02% | +357,533+88.9% | Added |
| UBS Group AG | 788,429 | $10.7M | 0.00% | −64,432−7.6% | Reduced |
| Siren, L.L.C. | 821,513 | $11.2M | 0.63% | −12,515−1.5% | Reduced |
| Candriam Luxembourg S.C.A. | 858,162 | $11.7M | 0.07% | +25,185+3.0% | Added |
| Casdin Capital, LLC | 990,000 | $13.5M | 1.10% | 00.0% | Unchanged |
| Charles Schwab Investment Management Inc | 1,009,896 | $13.7M | 0.00% | −18,566−1.8% | Reduced |
| Principal Financial Group Inc | 1,081,578 | $14.7M | 0.01% | −49,385−4.4% | Reduced |
| Bank of New York Mellon Corp | 1,103,892 | $15.0M | 0.00% | −139,095−11.2% | Reduced |
| Northern Trust Corp | 1,132,173 | $15.4M | 0.00% | −69,345−5.8% | Reduced |
| Citadel Advisors LLC | 1,169,683 | $15.9M | 0.02% | +339,772+40.9% | Added |