Denali Therapeutics Inc.
DNLI- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001714899
In the last 90 days, Denali Therapeutics Inc. insiders filed 0 open-market purchases and 4 sales; 294 institutions reported holding it in 13F filings for Q2 2026, worth $4.00B in total; no superinvestor holds it.
13F holders, Q4 2024
Institutional positions in Denali Therapeutics Inc. as of Dec 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 224
- +9 vs. Q3 2024
- Shares held
- 127.9M
- +1.24M (+1.0%) vs. Q3 2024
- Total value
- $2.61B
- −$1.08B (−29.3%) vs. Q3 2024
- New holders
- 41
- 87 more added
- Sold out
- 32
- 59 more reduced
2 institutions that held it in Q3 2024 haven't filed for Q4 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DNLI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 294 | $4.00B |
| Q1 2026 | 269 | $2.82B |
| Q4 2025 | 250 | $2.50B |
| Q3 2025 | 240 | $1.97B |
| Q2 2025 | 231 | $1.93B |
| Q1 2025 | 222 | $1.85B |
| Q4 2024 | 224 | $2.61B |
| Q3 2024 | 217 | $3.69B |
| Q2 2024 | 203 | $2.88B |
| Q1 2024 | 211 | $2.51B |
| Q4 2023 | 209 | $2.47B |
| Q3 2023 | 195 | $2.24B |
| Q2 2023 | 203 | $3.18B |
| Q1 2023 | 202 | $2.49B |
| Q4 2022 | 199 | $2.94B |
| Q3 2022 | 200 | $2.84B |
| Q2 2022 | 188 | $2.73B |
| Q1 2022 | 190 | $2.79B |
| Q4 2021 | 213 | $3.80B |
| Q3 2021 | 214 | $4.28B |
| Q2 2021 | 210 | $6.32B |
| Q1 2021 | 218 | $4.60B |
Institutions, Q4 2024
Shares, value and share of portfolio for each institution holding Denali Therapeutics Inc.; share changes are against Q3 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| HighTower Advisors, LLC | 26,138 | $532.7K | 0.00% | −11,189−30.0% | Reduced |
| Raymond James Financial Inc | 26,143 | $532.8K | 0.00% | +26,143 | New |
| Police & Firemen's Retirement System of New Jersey | 26,479 | $539.6K | 0.01% | +26,479 | New |
| Erste Asset Management GmbH | 26,900 | $554.4K | 0.01% | 00.0% | Unchanged |
| Profund Advisors LLC | 28,735 | $585.6K | 0.02% | +3,877+15.6% | Added |
| China Universal Asset Management Co., Ltd. | 30,517 | $621.9K | 0.06% | +2,982+10.8% | Added |
| HSBC Holdings PLC | 33,390 | $680.5K | 0.00% | +6,507+24.2% | Added |
| State Board of Administration of Florida Retirement System | 34,168 | $696.3K | 0.00% | 00.0% | Unchanged |
| Dana Investment Advisors, Inc. | 34,302 | $699.1K | 0.02% | −550−1.6% | Reduced |
| Y-Intercept (Hong Kong) Ltd | 36,006 | $733.8K | 0.05% | +22,183+160.5% | Added |
| Ironwood Investment Management LLC | 36,546 | $744.8K | 0.37% | −38−0.1% | Reduced |
| Arizona State Retirement System | 37,395 | $762.1K | 0.00% | +438+1.2% | Added |
| Envestnet Asset Management Inc | 37,622 | $766.7K | 0.00% | +9,643+34.5% | Added |
| Campbell & CO Investment Adviser LLC | 37,685 | $768.0K | 0.06% | +37,685 | New |
| Teacher Retirement System of Texas | 38,178 | $778.0K | 0.00% | +5,987+18.6% | Added |
| Handelsbanken Fonder AB | 38,300 | $781.0K | 0.00% | −1,200−3.0% | Reduced |
| Victory Capital Management Inc | 38,508 | $784.8K | 0.00% | −1,392−3.5% | Reduced |
| Fox Run Management, L.L.C. | 38,668 | $788.1K | 0.14% | +38,668 | New |
| Algert Global LLC | 39,015 | $795.1K | 0.02% | −9,615−19.8% | Reduced |
| Knights of Columbus Asset Advisors LLC | 39,217 | $799.2K | 0.05% | +98+0.3% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 39,757 | $810.2K | 0.00% | +10,038+33.8% | Added |
| ProShare Advisors LLC | 41,825 | $852.4K | 0.00% | +9,877+30.9% | Added |
| Skandinaviska Enskilda Banken AB (publ) | 43,245 | $875.3K | 0.00% | 00.0% | Unchanged |
| Employees Retirement System of Texas | 43,769 | $892.0K | 0.01% | 00.0% | Unchanged |
| ADAR1 Capital Management, LLC | 44,826 | $913.6K | 0.19% | −57,000−56.0% | Reduced |
| Pier 88 Investment Partners LLC | 45,410 | $925.5K | 0.18% | −13,760−23.3% | Reduced |
| MAI Capital Management | 46,526 | $948.2K | 0.01% | +46,526 | New |
| Intech Investment Management LLC | 47,401 | $966.0K | 0.01% | +17,858+60.4% | Added |
| Creative Planning | 47,950 | $977.2K | 0.00% | −12,304−20.4% | Reduced |
| Guggenheim Capital LLC | 48,131 | $980.9K | 0.01% | +27,518+133.5% | Added |
| Squarepoint Ops LLC | 48,619 | $990.9K | 0.00% | +14,896+44.2% | Added |
| Engineers Gate Manager LP | 53,358 | $1.09M | 0.02% | +53,358 | New |
| Voya Investment Management LLC | 54,813 | $1.12M | 0.00% | −2,991−5.2% | Reduced |
| DekaBank Deutsche Girozentrale | 59,800 | $1.22M | 0.00% | 00.0% | Unchanged |
| Diadema Partners LP | 60,000 | $1.22M | 1.38% | +60,000 | New |
| Janus Henderson Group PLC | 60,028 | $1.22M | 0.00% | +7,900+15.2% | Added |
| Trexquant Investment LP | 60,656 | $1.24M | 0.01% | +36,122+147.2% | Added |
| Corebridge Financial, Inc. | 61,800 | $1.26M | 0.01% | −4,665−7.0% | Reduced |
| First Trust Advisors LP | 65,442 | $1.33M | 0.00% | +47,308+260.9% | Added |
| Nisa Investment Advisors, LLC | 66,621 | $1.36M | 0.01% | +139+0.2% | Added |
| Susquehanna International Group, LLP | 71,240 | $1.45M | 0.00% | +21,070+42.0% | Added |
| Franklin Resources Inc | 74,862 | $1.53M | 0.00% | −5,179−6.5% | Reduced |
| MetLife Investment Management | 76,050 | $1.55M | 0.01% | +4,240+5.9% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 85,075 | $1.73M | 0.00% | +3,411+4.2% | Added |
| State of New Jersey Common Pension Fund D | 86,243 | $1.76M | 0.01% | +8,760+11.3% | Added |
| Wells Fargo & Company | 88,933 | $1.81M | 0.00% | −4,764−5.1% | Reduced |
| Fred Alger Management, LLC | 91,807 | $1.87M | 0.01% | −29,509−24.3% | Reduced |
| Hudson Bay Capital Management LP | 92,500 | $1.89M | 0.01% | +58,000+168.1% | Added |
| Thrivent Financial for Lutherans | 92,972 | $1.90M | 0.00% | −45,890−33.0% | Reduced |
| State of Wisconsin Investment Board | 93,094 | $1.90M | 0.00% | +11,643+14.3% | Added |
| Woodline Partners LP | 100,000 | $2.04M | 0.01% | +100,000 | New |
| Groupama Asset Managment | 110,207 | $2.23M | 0.05% | +32,162+41.2% | Added |
| Prudential Financial Inc | 110,593 | $2.25M | 0.00% | −6,800−5.8% | Reduced |
| Alps Advisors Inc | 116,377 | $2.37M | 0.01% | +10,130+9.5% | Added |
| California State Teachers Retirement System | 120,174 | $2.45M | 0.00% | −938−0.8% | Reduced |
| Invesco Ltd. | 121,478 | $2.48M | 0.00% | −84,885−41.1% | Reduced |
| Cinctive Capital Management LP | 130,445 | $2.66M | 0.14% | −18,649−12.5% | Reduced |
| Rafferty Asset Management, LLC | 141,310 | $2.88M | 0.01% | +23,629+20.1% | Added |
| New York State Common Retirement Fund | 144,724 | $2.95M | 0.00% | −5,184−3.5% | Reduced |
| Legal & General Group Plc | 149,513 | $3.05M | 0.00% | +8,108+5.7% | Added |
| Citigroup Inc | 166,706 | $3.40M | 0.00% | +71,992+76.0% | Added |
| Two Sigma Investments, LP | 179,884 | $3.67M | 0.01% | +80,417+80.8% | Added |
| Rhumbline Advisers | 190,390 | $3.88M | 0.00% | +497+0.3% | Added |
| Susquehanna Fundamental Investments, LLC | 192,563 | $3.92M | 0.07% | +192,563 | New |
| Holocene Advisors, LP | 199,072 | $4.06M | 0.01% | +101,625+104.3% | Added |
| Edmond de Rothschild Holding S.A. | 205,680 | $4.19M | 0.07% | 00.0% | Unchanged |
| Teachers Retirement System of the State of Kentucky | 207,124 | $4.22M | 0.04% | 00.0% | Unchanged |
| Manufacturers Life Insurance Company, The | 208,521 | $4.25M | 0.00% | +1,702+0.8% | Added |
| JPMorgan Chase & Co | 222,983 | $4.54M | 0.00% | −12,403−5.3% | Reduced |
| Jane Street Group, LLC | 229,165 | $4.67M | 0.01% | −140,506−38.0% | Reduced |
| Schroder Investment Management Group | 247,800 | $5.02M | 0.00% | +120,494+94.6% | Added |
| Swiss National Bank | 253,500 | $5.17M | 0.00% | +2,800+1.1% | Added |
| Twinbeech Capital LP | 254,586 | $5.19M | 0.09% | +254,586 | New |
| TD Asset Management Inc | 265,752 | $5.42M | 0.00% | +21,200+8.7% | Added |
| Bank of America Corp | 270,333 | $5.51M | 0.00% | −77,831−22.4% | Reduced |
| Deutsche Bank AG | 277,853 | $5.66M | 0.00% | +37,907+15.8% | Added |
| Barclays PLC | 278,067 | $5.67M | 0.00% | +22,184+8.7% | Added |
| Segall Bryant & Hamill, LLC | 289,075 | $5.89M | 0.08% | +289,075 | New |
| AXA S.A. | 293,755 | $5.99M | 0.02% | −51,128−14.8% | Reduced |
| Qube Research & Technologies Ltd | 311,507 | $6.35M | 0.01% | +311,507 | New |
| Pier Capital, LLC | 332,319 | $6.77M | 0.97% | +164,237+97.7% | Added |
| Ensign Peak Advisors, Inc | 346,304 | $7.06M | 0.01% | 00.0% | Unchanged |
| Nuveen Asset Management, LLC | 355,057 | $7.24M | 0.00% | −360,243−50.4% | Reduced |
| Standard Life Aberdeen plc | 402,282 | $8.20M | 0.02% | +38,603+10.6% | Added |
| Millennium Management LLC | 404,224 | $8.24M | 0.01% | +344,056+571.8% | Added |
| Clarius Group, LLC | 409,995 | $8.36M | 0.57% | 00.0% | Unchanged |
| Balyasny Asset Management LLC | 416,074 | $8.48M | 0.02% | +370,966+822.4% | Added |
| American Century Companies Inc | 480,529 | $9.79M | 0.01% | +29,155+6.5% | Added |
| Point72 Asset Management, L.P. | 548,739 | $11.2M | 0.03% | +215,209+64.5% | Added |
| Polar Asset Management Partners Inc. | 551,092 | $11.2M | 0.17% | +509,992+1,240.9% | Added |
| StemPoint Capital LP | 584,328 | $11.9M | 2.99% | +302,278+107.2% | Added |
| Cercano Management LLC | 625,000 | $12.7M | 0.32% | 00.0% | Unchanged |
| Yiheng Capital Management, L.P. | 700,098 | $14.3M | 3.16% | +100,000+16.7% | Added |
| Fisher Asset Management, LLC | 792,499 | $16.2M | 0.01% | +245,168+44.8% | Added |
| Citadel Advisors LLC | 829,911 | $16.9M | 0.02% | +52,631+6.8% | Added |
| Candriam Luxembourg S.C.A. | 832,977 | $17.0M | 0.10% | −109,181−11.6% | Reduced |
| Siren, L.L.C. | 834,028 | $17.0M | 0.75% | 00.0% | Unchanged |
| UBS Group AG | 852,861 | $17.4M | 0.00% | +711,458+503.1% | Added |
| Casdin Capital, LLC | 990,000 | $20.2M | 1.35% | 00.0% | Unchanged |
| Charles Schwab Investment Management Inc | 1,028,462 | $21.0M | 0.00% | +12,652+1.2% | Added |