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Definium Therapeutics, Inc.

DFTX
Exchange
Nasdaq
Industry
Medicinal Chemicals & Botanical Products
SEC CIK
0001813814

In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 1 sale; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.

13F holders, Q2 2026

Institutional positions in Definium Therapeutics, Inc. as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
362
+119 vs. Q1 2026
Shares held
114.8M
+40.3M (+54.1%) vs. Q1 2026
Total value
$5.35B
+$3.94B (+280.1%) vs. Q1 2026
New holders
148
117 more added
Sold out
29
64 more reduced

5 institutions that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q1 2026: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting DFTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ2 2026: 362 institutions
Q1 2021: 8 institutionsQ2 2021: 156 institutionsQ3 2021: 175 institutionsQ4 2021: 176 institutionsQ1 2022: 159 institutionsQ2 2022: 156 institutionsQ3 2022: 101 institutionsQ4 2022: 104 institutionsQ1 2023: 89 institutionsQ2 2023: 84 institutionsQ3 2023: 93 institutionsQ4 2023: 104 institutionsQ1 2024: 135 institutionsQ2 2024: 152 institutionsQ3 2024: 158 institutionsQ4 2024: 174 institutionsQ1 2025: 191 institutionsQ2 2025: 183 institutionsQ3 2025: 196 institutionsQ4 2025: 209 institutionsQ1 2026: 248 institutionsQ2 2026: 362 institutions
Value heldQ2 2026: $5.35B
Q1 2021: $932.0KQ2 2021: $131.0MQ3 2021: $104.8MQ4 2021: $72.0MQ1 2022: $53.6MQ2 2022: $15.1MQ3 2022: $20.5MQ4 2022: $11.1MQ1 2023: $12.6MQ2 2023: $13.9MQ3 2023: $12.1MQ4 2023: $17.9MQ1 2024: $327.2MQ2 2024: $299.3MQ3 2024: $281.6MQ4 2024: $288.9MQ1 2025: $240.5MQ2 2025: $271.0MQ3 2025: $468.6MQ4 2025: $908.7MQ1 2026: $1.47BQ2 2026: $5.35B
Institutions holding DFTX and their total value by quarter
QuarterHoldersValue
Q2 2026362$5.35B
Q1 2026248$1.47B
Q4 2025209$908.7M
Q3 2025196$468.6M
Q2 2025183$271.0M
Q1 2025191$240.5M
Q4 2024174$288.9M
Q3 2024158$281.6M
Q2 2024152$299.3M
Q1 2024135$327.2M
Q4 2023104$17.9M
Q3 202393$12.1M
Q2 202384$13.9M
Q1 202389$12.6M
Q4 2022104$11.1M
Q3 2022101$20.5M
Q2 2022156$15.1M
Q1 2022159$53.6M
Q4 2021176$72.0M
Q3 2021175$104.8M
Q2 2021156$131.0M
Q1 20218$932.0K

Institutions, Q2 2026

Shares, value and share of portfolio for each institution holding Definium Therapeutics, Inc.; share changes are against Q1 2026.

Institutions holding DFTX in Q2 2026
InstitutionSharesValue% of portfolioChange in sharesAction
Bullock Wealth Management Group907$39.4K0.02%00.0%Unchanged
SRS Capital Advisors, Inc.793$37.3K0.00%+327+70.2%Added
Atlantic Union Bankshares Corp776$36.5K0.00%+776New
SBI Securities Co., Ltd.701$33.0K0.00%+603+615.3%Added
Jones Financial Companies LLLP677$30.4K0.00%+497+276.1%Added
Optiver Holding B.V.624$29.4K0.00%+575+1,173.5%Added
Los Angeles Capital Management LLC618$29.1K0.00%00.0%Unchanged
Massmutual Trust Co FSB568$26.7K0.00%00.0%Unchanged
Larson Financial Group LLC541$25.4K0.00%+6+1.1%Added
Sterling Capital Management LLC457$21.5K0.00%−1,986−81.3%Reduced
Strategic Wealth Partners, Ltd.429$20.2K0.00%+263+158.4%Added
NVWM, LLC416$19.6K0.00%00.0%Unchanged
Parallel Advisors, LLC333$15.7K0.00%+101+43.5%Added
Western Pacific Wealth Management, LP333$15.7K0.01%00.0%Unchanged
Harbour Investments, Inc.328$15.4K0.00%−228−41.0%Reduced
Aster Capital Management (DIFC) Ltd316$14.9K0.00%+316New
Neo Ivy Capital Management315$14.8K0.00%+315New
EverSource Wealth Advisors, LLC281$13.2K0.00%−14−4.7%Reduced
Ancora Advisors, LLC258$12.1K0.00%+7+2.8%Added
Hollencrest Capital Management236$11.1K0.00%−7,150−96.8%Reduced
Continuum Advisory, LLC213$10.0K0.00%+213New
Smartleaf Asset Management LLC215$10.0K0.00%00.0%Unchanged
Sims Investment Management, LLC199$9.36K0.00%+199New
Atlantic Edge Private Wealth Management, LLC193$9.08K0.00%00.0%Unchanged
Premier Financial Group193$9.08K0.00%+193New
Salem Investment Counselors Inc150$7.06K0.00%00.0%Unchanged
Northwestern Mutual Wealth Management Co142$6.68K0.00%−13−8.4%Reduced
Sankala Group LLC141$6.43K0.00%00.0%Unchanged
Community Bank, N.A.135$6.35K0.00%+135New
NBC Securities, Inc.100$4.70K0.00%00.0%Unchanged
Versant Capital Management, Inc90$4.23K0.00%+90New
MH & Associates Securities Management Corp66$3.10K0.00%00.0%Unchanged
Activest Wealth Management66$3.10K0.00%00.0%Unchanged
McDonald Partners LLC66$3.10K0.00%+66New
Global Retirement Partners, LLC66$3.10K0.00%+66New
Guardian Partners Inc.66$3.10K0.00%+66New
Essential Partners LLC60$2.82K0.00%+39+185.7%Added
HighMark Wealth Management LLC50$2.35K0.00%−50−50.0%Reduced
Institute for Wealth Management, LLC.46$2.16K0.00%+46New
TD Private Client Wealth LLC43$2.02K0.00%+43New
Signaturefd, LLC40$1.88K0.00%+40New
Plante Moran Financial Advisors, LLC36$1.69K0.00%00.0%Unchanged
Financial Gravity Companies, Inc.35$1.65K0.00%+35New
Chesapeake Asset Management LLC33$1.55K0.00%00.0%Unchanged
Benson Wealth Management INC30$1.41K0.00%00.0%Unchanged
Robbins Farley LLC28$1.32K0.00%00.0%Unchanged
Vanguard National Trust Co27$1.27K0.00%00.0%Unchanged
Rachor Investment Advisory Services, LLC25$1.18K0.00%00.0%Unchanged
Pinnacle Wealth Planning Services, Inc.25$1.18K0.00%00.0%Unchanged
Covestor Ltd27$1.00K0.00%+27New
Hilton Head Capital Partners, LLC20$9410.00%+20New
Clearstead Advisors, LLC14$6600.00%+14New
CNB Bank10$4700.00%+10New
Keating Financial Advisory Services, Inc.8$3760.00%+7+700.0%Added
Comprehensive Financial Planning, Inc.8$3760.00%+8New
Ares Financial Consulting, LLC8$3760.00%+8New
Gilpin Wealth Management, LLC6$2830.00%+6New
SJS Investment Consulting Inc.4$1890.00%+4New
Quarry LP1$470.00%+1New
Huntington National Bank1$10.00%00.0%Unchanged
TSFG, LLC6$00.00%00.0%Unchanged
Coppell Advisory Solutions LLC1––+1New
Trails Edge Capital Partners, LP0$00.00%−1,738,110−100.0%Sold out
Patient Square Capital LP0$00.00%−331,000−100.0%Sold out
Jane Street Group, LLC0$00.00%−260,241−100.0%Sold out
Soviero Asset Management, LP0$00.00%−140,000−100.0%Sold out
Squarepoint Ops LLC0$00.00%−125,522−100.0%Sold out
Rosalind Advisors, Inc.0$00.00%−125,000−100.0%Sold out
ExodusPoint Capital Management, LP0$00.00%−104,915−100.0%Sold out
HRT Financial LP0$00.00%−89,141−100.0%Sold out
Ikarian Capital, LLC0$00.00%−58,803−100.0%Sold out
Twinbeech Capital LP0$00.00%−42,100−100.0%Sold out
Caxton Associates LLP0$00.00%−37,255−100.0%Sold out
Campbell & CO Investment Adviser LLC0$00.00%−24,755−100.0%Sold out
Virtu Financial LLC0$00.00%−14,460−100.0%Sold out
Boothbay Fund Management, LLC0$00.00%−14,096−100.0%Sold out
Fox Run Management, L.L.C.0$00.00%−14,557−100.0%Sold out
Magnetar Financial LLC0$00.00%−13,178−100.0%Sold out
Summit Trail Advisors, LLC0$00.00%−13,000−100.0%Sold out
RPS Advisory Solutions LLC0$00.00%−11,355−100.0%Sold out
Dynamic Technology Lab Private Ltd0$00.00%−10,880−100.0%Sold out
Verition Fund Management LLC0$00.00%−10,384−100.0%Sold out
Sound Income Strategies, LLC0$00.00%−3,690−100.0%Sold out
Advisory Services Network, LLC0$00.00%−2,659−100.0%Sold out
Opal Wealth Advisors, LLC0$00.00%−1,101−100.0%Sold out
Private Wealth Management Group, LLC0$00.00%−450−100.0%Sold out
Meeder Asset Management Inc0$00.00%−353−100.0%Sold out
Federated Hermes, Inc.0$00.00%−207−100.0%Sold out
Louisbourg Investments Inc.0$00.00%−52−100.0%Sold out
RMG Wealth Management LLC0$00.00%−30−100.0%Sold out
CoreCap Advisors, LLC0$00.00%−5−100.0%Sold out
Janus Henderson Group PLC––––Not filed
CWM, LLC––––Not filed
Sunbelt Securities, Inc.––––Not filed
Anfield Capital Management, LLC––––Not filed
Sofos Investments, Inc.––––Not filed