Definium Therapeutics, Inc.
DFTX- Exchange
- Nasdaq
- Industry
- Medicinal Chemicals & Botanical Products
- SEC CIK
- 0001813814
In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 1 sale; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q1 2026
Institutional positions in Definium Therapeutics, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 248
- +42 vs. Q4 2025
- Shares held
- 78.1M
- +12.8M (+19.6%) vs. Q4 2025
- Total value
- $1.47B
- +$600.8M (+68.7%) vs. Q4 2025
- New holders
- 69
- 82 more added
- Sold out
- 27
- 53 more reduced
3 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DFTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 362 | $5.35B |
| Q1 2026 | 248 | $1.47B |
| Q4 2025 | 209 | $908.7M |
| Q3 2025 | 196 | $468.6M |
| Q2 2025 | 183 | $271.0M |
| Q1 2025 | 191 | $240.5M |
| Q4 2024 | 174 | $288.9M |
| Q3 2024 | 158 | $281.6M |
| Q2 2024 | 152 | $299.3M |
| Q1 2024 | 135 | $327.2M |
| Q4 2023 | 104 | $17.9M |
| Q3 2023 | 93 | $12.1M |
| Q2 2023 | 84 | $13.9M |
| Q1 2023 | 89 | $12.6M |
| Q4 2022 | 104 | $11.1M |
| Q3 2022 | 101 | $20.5M |
| Q2 2022 | 156 | $15.1M |
| Q1 2022 | 159 | $53.6M |
| Q4 2021 | 176 | $72.0M |
| Q3 2021 | 175 | $104.8M |
| Q2 2021 | 156 | $131.0M |
| Q1 2021 | 8 | $932.0K |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Definium Therapeutics, Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Patient Square Capital LP | 331,000 | $6.26M | 1.11% | +331,000 | New |
| Sofinnova Investments, Inc. | 344,166 | $6.50M | 0.33% | +344,166 | New |
| Superstring Capital Management LP | 351,461 | $6.64M | 4.75% | −73,741−17.3% | Reduced |
| Tri Locum Partners LP | 369,588 | $6.99M | 0.98% | +369,588 | New |
| Integral Health Asset Management, LLC | 400,000 | $7.56M | 0.40% | +50,000+14.3% | Added |
| Deutsche Bank AG | 411,834 | $7.78M | 0.00% | +13,565+3.4% | Added |
| Qube Research & Technologies Ltd | 426,055 | $8.05M | 0.01% | +426,055 | New |
| Morgan Stanley | 438,573 | $8.29M | 0.00% | +71,878+19.6% | Added |
| UBS Group AG | 493,977 | $9.34M | 0.00% | −189,825−27.8% | Reduced |
| Blackstone Group Inc. | 508,668 | $9.61M | 0.04% | −1,551,137−75.3% | Reduced |
| Ensign Peak Advisors, Inc | 546,783 | $10.3M | 0.02% | +284,783+108.7% | Added |
| Vanguard Fiduciary Trust Co | 575,937 | $10.9M | 0.00% | +575,937 | New |
| Boxer Capital Management, LLC | 598,500 | $11.3M | 1.49% | 00.0% | Unchanged |
| Eventide Asset Management, LLC | 686,162 | $13.0M | 0.21% | +686,162 | New |
| Nuveen, LLC | 698,130 | $13.2M | 0.00% | +421,676+152.5% | Added |
| Woodline Partners LP | 752,792 | $14.2M | 0.05% | +602,222+400.0% | Added |
| Bank of New York Mellon Corp | 752,922 | $14.2M | 0.00% | +454,262+152.1% | Added |
| Northern Trust Corp | 798,987 | $15.1M | 0.00% | +64,327+8.8% | Added |
| OrbiMed Advisors LLC | 804,000 | $15.2M | 0.35% | −422,700−34.5% | Reduced |
| Charles Schwab Investment Management Inc | 808,715 | $15.3M | 0.00% | +1,466+0.2% | Added |
| Millennium Management LLC | 846,896 | $16.0M | 0.01% | −536,279−38.8% | Reduced |
| Vanguard Portfolio Management LLC | 872,665 | $16.5M | 0.00% | +872,665 | New |
| Siren, L.L.C. | 919,493 | $17.4M | 0.48% | +119,493+14.9% | Added |
| Ameriprise Financial Inc | 966,608 | $18.3M | 0.00% | +462,367+91.7% | Added |
| Catalio Capital Management, LP | 1,037,984 | $19.6M | 4.10% | +1,037,984 | New |
| AWM Investment Company, Inc. | 1,076,893 | $20.4M | 2.25% | −313,769−22.6% | Reduced |
| Holocene Advisors, LP | 1,091,967 | $20.6M | 0.05% | +1,091,967 | New |
| Vanguard Capital Management LLC | 1,096,978 | $20.7M | 0.00% | +1,096,978 | New |
| Adage Capital Partners GP, L.L.C. | 1,150,000 | $21.7M | 0.03% | 00.0% | Unchanged |
| Marshall Wace, LLP | 1,200,825 | $22.7M | 0.02% | −1,774,877−59.6% | Reduced |
| Two Sigma Investments, LP | 1,201,610 | $22.7M | 0.02% | +776,403+182.6% | Added |
| Balyasny Asset Management LLC | 1,274,221 | $24.1M | 0.05% | −33,894−2.6% | Reduced |
| Candriam Luxembourg S.C.A. | 1,293,629 | $24.4M | 0.13% | +322,411+33.2% | Added |
| Wellington Management Group LLP | 1,304,749 | $24.7M | 0.00% | +84,082+6.9% | Added |
| Citadel Advisors LLC | 1,333,442 | $25.2M | 0.02% | +1,123,498+535.1% | Added |
| ArrowMark Colorado Holdings LLC | 1,594,717 | $30.1M | 0.80% | +1,594,717 | New |
| Goldman Sachs Group Inc | 1,675,411 | $31.7M | 0.00% | +750,079+81.1% | Added |
| Trails Edge Capital Partners, LP | 1,738,110 | $32.9M | 7.73% | −830,000−32.3% | Reduced |
| FMR LLC | 1,809,610 | $34.2M | 0.00% | +1,647,557+1,016.7% | Added |
| Commodore Capital LP | 2,000,000 | $37.8M | 2.19% | 00.0% | Unchanged |
| Octagon Capital Advisors LP | 2,440,000 | $46.1M | 5.10% | +210,000+9.4% | Added |
| State Street Corp | 2,471,873 | $46.7M | 0.00% | +103,807+4.4% | Added |
| Geode Capital Management, LLC | 2,495,399 | $47.2M | 0.00% | +162,461+7.0% | Added |
| Deep Track Capital, LP | 3,000,000 | $56.7M | 1.17% | +1,323,460+78.9% | Added |
| Janus Henderson Group PLC | 3,556,041 | $67.2M | 0.03% | +1,144,345+47.4% | Added |
| Avoro Capital Advisors LLC | 5,000,000 | $94.5M | 0.93% | 00.0% | Unchanged |
| Driehaus Capital Management LLC | 5,911,889 | $111.7M | 0.82% | −625,313−9.6% | Reduced |
| BlackRock, Inc. | 8,480,230 | $160.3M | 0.00% | +206,954+2.5% | Added |
| Vestal Point Capital, LP | 0 | $0 | 0.00% | −637,000−100.0% | Sold out |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | $0 | 0.00% | −278,720−100.0% | Sold out |
| Two Sigma Advisers, LP | 0 | $0 | 0.00% | −65,281−100.0% | Sold out |
| California State Teachers Retirement System | 0 | $0 | 0.00% | −58,383−100.0% | Sold out |
| Scientech Research LLC | 0 | $0 | 0.00% | −31,699−100.0% | Sold out |
| Dark Forest Capital Management LP | 0 | $0 | 0.00% | −30,661−100.0% | Sold out |
| Mercer Global Advisors Inc | 0 | $0 | 0.00% | −20,392−100.0% | Sold out |
| EntryPoint Capital, LLC | 0 | $0 | 0.00% | −20,219−100.0% | Sold out |
| Rafferty Asset Management, LLC | 0 | $0 | 0.00% | −18,885−100.0% | Sold out |
| Gotham Asset Management, LLC | 0 | $0 | 0.00% | −17,825−100.0% | Sold out |
| Caxton Corp | 0 | $0 | 0.00% | −15,688−100.0% | Sold out |
| Fore Capital, LLC | 0 | $0 | 0.00% | −15,000−100.0% | Sold out |
| Wealth Enhancement Advisory Services, LLC | 0 | $0 | 0.00% | −13,718−100.0% | Sold out |
| XTX Topco Ltd | 0 | $0 | 0.00% | −10,994−100.0% | Sold out |
| Flagship Harbor Advisors, LLC | 0 | $0 | 0.00% | −8,721−100.0% | Sold out |
| Amalgamated Bank | 0 | $0 | 0.00% | −2,957−100.0% | Sold out |
| Quantbot Technologies LP | 0 | $0 | 0.00% | −1,649−100.0% | Sold out |
| Atlantic Union Bankshares Corp | 0 | $0 | 0.00% | −500−100.0% | Sold out |
| Daiwa Securities Group Inc. | 0 | $0 | 0.00% | −242−100.0% | Sold out |
| Reflection Asset Management | 0 | $0 | 0.00% | −66−100.0% | Sold out |
| Kohmann Bosshard Financial Services, LLC | 0 | $0 | 0.00% | −66−100.0% | Sold out |
| Tradewinds Capital Management, LLC | 0 | $0 | 0.00% | −53−100.0% | Sold out |
| CNB Bank | 0 | $0 | 0.00% | −10−100.0% | Sold out |
| SageView Advisory Group, LLC | 0 | $0 | 0.00% | −6−100.0% | Sold out |
| NBT Bank N A | 0 | $0 | 0.00% | −6−100.0% | Sold out |
| Signaturefd, LLC | 0 | $0 | 0.00% | −2−100.0% | Sold out |
| Navalign, LLC | 0 | $0 | 0.00% | −2−100.0% | Sold out |
| Vanguard Group Inc | – | – | – | – | Not filed |
| Global Retirement Partners, LLC | – | – | – | – | Not filed |
| CIBC Private Wealth Group, LLC | – | – | – | – | Not filed |