Definium Therapeutics, Inc.
DFTX- Exchange
- Nasdaq
- Industry
- Medicinal Chemicals & Botanical Products
- SEC CIK
- 0001813814
In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 1 sale; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q1 2026
Institutional positions in Definium Therapeutics, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 248
- +42 vs. Q4 2025
- Shares held
- 78.1M
- +12.8M (+19.6%) vs. Q4 2025
- Total value
- $1.47B
- +$600.8M (+68.7%) vs. Q4 2025
- New holders
- 69
- 82 more added
- Sold out
- 27
- 53 more reduced
3 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DFTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 362 | $5.35B |
| Q1 2026 | 248 | $1.47B |
| Q4 2025 | 209 | $908.7M |
| Q3 2025 | 196 | $468.6M |
| Q2 2025 | 183 | $271.0M |
| Q1 2025 | 191 | $240.5M |
| Q4 2024 | 174 | $288.9M |
| Q3 2024 | 158 | $281.6M |
| Q2 2024 | 152 | $299.3M |
| Q1 2024 | 135 | $327.2M |
| Q4 2023 | 104 | $17.9M |
| Q3 2023 | 93 | $12.1M |
| Q2 2023 | 84 | $13.9M |
| Q1 2023 | 89 | $12.6M |
| Q4 2022 | 104 | $11.1M |
| Q3 2022 | 101 | $20.5M |
| Q2 2022 | 156 | $15.1M |
| Q1 2022 | 159 | $53.6M |
| Q4 2021 | 176 | $72.0M |
| Q3 2021 | 175 | $104.8M |
| Q2 2021 | 156 | $131.0M |
| Q1 2021 | 8 | $932.0K |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Definium Therapeutics, Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Fox Run Management, L.L.C. | 14,557 | $254.7K | 0.04% | −16,151−52.6% | Reduced |
| Boothbay Fund Management, LLC | 14,096 | $266.4K | 0.01% | +14,096 | New |
| Amundi | 14,136 | $267.2K | 0.00% | +14,136 | New |
| Profund Advisors LLC | 14,196 | $268.3K | 0.01% | −7,793−35.4% | Reduced |
| Heritage Wealth Management, Inc. | 14,375 | $271.7K | 0.15% | +14,375 | New |
| Virtu Financial LLC | 14,460 | $273.0K | 0.01% | +14,460 | New |
| Persistent Asset Partners Ltd | 15,861 | $299.8K | 0.12% | +15,861 | New |
| Voya Investment Management LLC | 16,384 | $309.7K | 0.00% | +392+2.5% | Added |
| KLP Kapitalforvaltning AS | 17,000 | $321.3K | 0.00% | 00.0% | Unchanged |
| Sequoia Financial Advisors, LLC | 17,245 | $325.9K | 0.00% | +72+0.4% | Added |
| Gsa Capital Partners LLP | 18,155 | $343.0K | 0.02% | −34,100−65.3% | Reduced |
| HighTower Advisors, LLC | 18,559 | $350.8K | 0.00% | +18,559 | New |
| ProShare Advisors LLC | 18,731 | $354.0K | 0.00% | −2,808−13.0% | Reduced |
| STRS Ohio | 19,300 | $364.8K | 0.00% | +19,300 | New |
| Marex Group plc | 20,000 | $378.0K | 0.00% | 00.0% | Unchanged |
| China Universal Asset Management Co., Ltd. | 20,192 | $381.6K | 0.03% | +4,140+25.8% | Added |
| Vanguard Investments Australia, Ltd. | 20,467 | $386.8K | 0.00% | +20,467 | New |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 20,868 | $394.4K | 0.00% | +5,751+38.0% | Added |
| Concurrent Investment Advisors, LLC | 21,285 | $402.3K | 0.00% | +888+4.4% | Added |
| Virtus Investment Advisers, Inc. | 21,727 | $410.6K | 0.11% | +529+2.5% | Added |
| Arizona State Retirement System | 22,054 | $416.8K | 0.00% | −188−0.8% | Reduced |
| BNP Paribas Arbitrage, SA | 23,356 | $441.4K | 0.00% | +973+4.3% | Added |
| Raymond James Financial Inc | 23,713 | $448.2K | 0.00% | +2,592+12.3% | Added |
| Campbell & CO Investment Adviser LLC | 24,755 | $467.9K | 0.03% | +24,755 | New |
| Intech Investment Management LLC | 24,990 | $472.3K | 0.00% | −4,665−15.7% | Reduced |
| Bay Rivers Group | 26,346 | $497.9K | 0.21% | +10,345+64.7% | Added |
| Manufacturers Life Insurance Company, The | 26,404 | $499.0K | 0.00% | −1,918−6.8% | Reduced |
| Citigroup Inc | 26,486 | $500.6K | 0.00% | −14,977−36.1% | Reduced |
| Kingswood Wealth Advisors, LLC | 26,591 | $502.6K | 0.02% | +26,591 | New |
| Police & Firemen's Retirement System of New Jersey | 27,361 | $517.1K | 0.00% | +2,154+8.5% | Added |
| State of New Jersey Common Pension Fund D | 27,441 | $518.6K | 0.00% | +27,441 | New |
| SEI Investments Co | 28,117 | $531.4K | 0.00% | +16,281+137.6% | Added |
| New York State Common Retirement Fund | 29,600 | $559.4K | 0.00% | 00.0% | Unchanged |
| Engineers Gate Manager LP | 29,767 | $562.6K | 0.01% | +29,767 | New |
| Rathbone Brothers plc | 30,200 | $570.8K | 0.00% | 00.0% | Unchanged |
| Cetera Investment Advisers | 31,824 | $601.5K | 0.00% | +15,224+91.7% | Added |
| Caption Management, LLC | 33,758 | $638.0K | 0.03% | +33,758 | New |
| PSP Research LLC | 34,800 | $657.7K | 0.47% | −41−0.1% | Reduced |
| Mariner, LLC | 34,851 | $658.6K | 0.00% | +14,685+72.8% | Added |
| Walleye Capital LLC | 35,485 | $670.7K | 0.00% | +35,485 | New |
| Caxton Associates LLP | 37,255 | $704.1K | 0.02% | +21,564+137.4% | Added |
| Palumbo Wealth Management LLC | 37,966 | $717.6K | 0.18% | −1,036−2.7% | Reduced |
| Barclays PLC | 39,683 | $750.0K | 0.00% | −143,940−78.4% | Reduced |
| Jennison Associates LLC | 39,957 | $755.2K | 0.00% | −13,828−25.7% | Reduced |
| Quantinno Capital Management LP | 39,958 | $755.2K | 0.00% | +634+1.6% | Added |
| Wells Fargo & Company | 39,973 | $755.5K | 0.00% | −67,084−62.7% | Reduced |
| Scotia Capital Inc. | 40,548 | $766.4K | 0.00% | −9,129−18.4% | Reduced |
| Simplex Trading, LLC | 41,156 | $777.8K | 0.02% | −7,070−14.7% | Reduced |
| Twinbeech Capital LP | 42,100 | $795.7K | 0.08% | +42,100 | New |
| CenterBook Partners LP | 42,829 | $809.5K | 0.04% | −95,986−69.1% | Reduced |
| Allstate Corp | 45,366 | $857.4K | 0.01% | +45,366 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 46,193 | $873.0K | 0.00% | +2,457+5.6% | Added |
| Vanguard Global Advisers, LLC | 48,044 | $908.0K | 0.00% | +48,044 | New |
| Nisa Investment Advisors, LLC | 48,903 | $924.3K | 0.00% | +525+1.1% | Added |
| State of Wisconsin Investment Board | 50,420 | $952.9K | 0.00% | −8,182−14.0% | Reduced |
| Kestra Private Wealth Services, LLC | 50,588 | $956.1K | 0.01% | +448+0.9% | Added |
| Blair William & Co | 53,695 | $1.01M | 0.00% | +53,695 | New |
| Vanguard Asset Management, Ltd | 54,018 | $1.02M | 0.00% | +54,018 | New |
| MetLife Investment Management | 54,261 | $1.03M | 0.01% | +1,681+3.2% | Added |
| Rockefeller Capital Management L.P. | 55,206 | $1.04M | 0.00% | +54,855+15,628.2% | Added |
| AQR Capital Management LLC | 57,094 | $1.08M | 0.00% | −1,204−2.1% | Reduced |
| Ikarian Capital, LLC | 58,803 | $1.11M | 0.16% | 00.0% | Unchanged |
| Legal & General Group Plc | 59,799 | $1.13M | 0.00% | −7,176−10.7% | Reduced |
| Platinum Investment Management Ltd | 70,000 | $1.32M | 0.33% | 00.0% | Unchanged |
| Price T Rowe Associates Inc | 70,001 | $1.32M | 0.00% | +17,771+34.0% | Added |
| LPL Financial LLC | 78,271 | $1.48M | 0.00% | +1,035+1.3% | Added |
| Susquehanna International Group, LLP | 81,456 | $1.54M | 0.00% | −395,656−82.9% | Reduced |
| Group One Trading, L.P. | 87,832 | $1.66M | 0.05% | +87,832 | New |
| Invesco Ltd. | 88,121 | $1.67M | 0.00% | +34,739+65.1% | Added |
| HRT Financial LP | 89,141 | $1.68M | 0.00% | +62,859+239.2% | Added |
| AdvisorShares Investments LLC | 91,301 | $1.73M | 0.31% | −11,537−11.2% | Reduced |
| Alliancebernstein L.P. | 91,703 | $1.73M | 0.00% | +16,866+22.5% | Added |
| Fred Alger Management, LLC | 92,165 | $1.74M | 0.01% | +92,165 | New |
| Royal Bank of Canada | 97,192 | $1.84M | 0.00% | +3,566+3.8% | Added |
| Seven Fleet Capital Management LP | 99,887 | $1.89M | 0.59% | +99,887 | New |
| Burkehill Global Management, LP | 100,000 | $1.89M | 0.09% | 00.0% | Unchanged |
| Data Collective IV GP, LLC | 100,350 | $1.90M | 3.39% | 00.0% | Unchanged |
| ExodusPoint Capital Management, LP | 104,915 | $1.98M | 0.02% | +85,967+453.7% | Added |
| Russell Investments Group, Ltd. | 119,464 | $2.26M | 0.00% | +110,599+1,247.6% | Added |
| Rhumbline Advisers | 119,972 | $2.27M | 0.00% | +9,225+8.3% | Added |
| Rosalind Advisors, Inc. | 125,000 | $2.36M | 0.97% | −625,000−83.3% | Reduced |
| Squarepoint Ops LLC | 125,522 | $2.37M | 0.01% | +80,120+176.5% | Added |
| Neuberger Berman Group LLC | 133,369 | $2.52M | 0.00% | +133,369 | New |
| Soviero Asset Management, LP | 140,000 | $2.65M | 1.49% | −10,000−6.7% | Reduced |
| Bank of America Corp | 158,345 | $2.99M | 0.00% | +47,878+43.3% | Added |
| Swiss National Bank | 158,400 | $2.99M | 0.00% | 00.0% | Unchanged |
| Eversept Partners, LP | 160,723 | $3.04M | 0.20% | +160,723 | New |
| Point72 Asset Management, L.P. | 175,490 | $3.32M | 0.01% | −4,951−2.7% | Reduced |
| HighVista Strategies LLC | 185,856 | $3.51M | 0.97% | +185,856 | New |
| Polygon Management Ltd. | 199,994 | $3.78M | 0.74% | +199,994 | New |
| PFM Health Sciences, LP | 205,317 | $3.88M | 0.41% | +205,317 | New |
| Brevan Howard Capital Management LP | 211,488 | $4.00M | 0.04% | +200,374+1,802.9% | Added |
| Seven Grand Managers, LLC | 225,000 | $4.25M | 0.28% | 00.0% | Unchanged |
| Royce & Associates LP | 234,051 | $4.42M | 0.04% | +70,010+42.7% | Added |
| JPMorgan Chase & Co | 264,545 | $4.63M | 0.00% | +110,823+72.1% | Added |
| Jane Street Group, LLC | 260,241 | $4.92M | 0.01% | −275,761−51.4% | Reduced |
| D. E. Shaw & Co., Inc. | 271,717 | $5.14M | 0.00% | −22,005−7.5% | Reduced |
| BIT Capital GmbH | 277,511 | $5.24M | 0.29% | +277,511 | New |
| RTW Investments, LP | 300,000 | $5.67M | 0.06% | 00.0% | Unchanged |
| StemPoint Capital LP | 325,483 | $6.15M | 1.18% | +325,483 | New |