Definium Therapeutics, Inc.
DFTX- Exchange
- Nasdaq
- Industry
- Medicinal Chemicals & Botanical Products
- SEC CIK
- 0001813814
In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 1 sale; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q3 2025
Institutional positions in Definium Therapeutics, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 196
- +15 vs. Q2 2025
- Shares held
- 39.7M
- −2.05M (−4.9%) vs. Q2 2025
- Total value
- $468.6M
- +$197.6M (+72.9%) vs. Q2 2025
- New holders
- 39
- 56 more added
- Sold out
- 24
- 48 more reduced
2 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DFTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 362 | $5.35B |
| Q1 2026 | 248 | $1.47B |
| Q4 2025 | 209 | $908.7M |
| Q3 2025 | 196 | $468.6M |
| Q2 2025 | 183 | $271.0M |
| Q1 2025 | 191 | $240.5M |
| Q4 2024 | 174 | $288.9M |
| Q3 2024 | 158 | $281.6M |
| Q2 2024 | 152 | $299.3M |
| Q1 2024 | 135 | $327.2M |
| Q4 2023 | 104 | $17.9M |
| Q3 2023 | 93 | $12.1M |
| Q2 2023 | 84 | $13.9M |
| Q1 2023 | 89 | $12.6M |
| Q4 2022 | 104 | $11.1M |
| Q3 2022 | 101 | $20.5M |
| Q2 2022 | 156 | $15.1M |
| Q1 2022 | 159 | $53.6M |
| Q4 2021 | 176 | $72.0M |
| Q3 2021 | 175 | $104.8M |
| Q2 2021 | 156 | $131.0M |
| Q1 2021 | 8 | $932.0K |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Definium Therapeutics, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| New York State Common Retirement Fund | 17,100 | $201.6K | 0.00% | 00.0% | Unchanged |
| Sequoia Financial Advisors, LLC | 17,132 | $202.0K | 0.00% | +553+3.3% | Added |
| Susquehanna International Group, LLP | 17,273 | $203.6K | 0.00% | −152,052−89.8% | Reduced |
| Raymond James Financial Inc | 17,792 | $209.8K | 0.00% | +763+4.5% | Added |
| Arizona State Retirement System | 17,867 | $210.7K | 0.00% | +286+1.6% | Added |
| Mariner, LLC | 18,084 | $213.2K | 0.00% | +6,041+50.2% | Added |
| Profund Advisors LLC | 18,666 | $220.1K | 0.01% | +4,959+36.2% | Added |
| Police & Firemen's Retirement System of New Jersey | 21,033 | $248.0K | 0.00% | +2,479+13.4% | Added |
| AQR Capital Management LLC | 21,596 | $254.6K | 0.00% | +1,838+9.3% | Added |
| Mercer Global Advisors Inc | 21,931 | $258.6K | 0.00% | +2,079+10.5% | Added |
| Federation des caisses Desjardins du Quebec | 21,992 | $259.3K | 0.00% | +570+2.7% | Added |
| Citigroup Inc | 23,463 | $276.6K | 0.00% | −13,870−37.2% | Reduced |
| Moloney Securities Asset Management, LLC | 23,511 | $277.2K | 0.03% | −8,000−25.4% | Reduced |
| Scientech Research LLC | 24,239 | $285.8K | 0.10% | +24,239 | New |
| Persistent Asset Partners Ltd | 24,282 | $286.3K | 0.21% | −12,360−33.7% | Reduced |
| Manufacturers Life Insurance Company, The | 25,318 | $298.5K | 0.00% | −2,250−8.2% | Reduced |
| Sender Co & Partners, Inc. | 25,906 | $305.4K | 0.12% | +25,906 | New |
| Caxton Corp | 27,011 | $318.5K | 1.39% | −7,062−20.7% | Reduced |
| Intech Investment Management LLC | 27,134 | $319.9K | 0.00% | −10,552−28.0% | Reduced |
| Janus Henderson Group PLC | 28,000 | $329.8K | 0.00% | 00.0% | Unchanged |
| Rathbone Brothers plc | 30,200 | $356.1K | 0.00% | +2,000+7.1% | Added |
| DRW Securities, LLC | 30,727 | $360.9K | 0.02% | −38,699−55.7% | Reduced |
| Blair William & Co | 31,905 | $376.2K | 0.00% | +9,687+43.6% | Added |
| Virtu Financial LLC | 32,184 | $379.0K | 0.02% | +32,184 | New |
| Palumbo Wealth Management LLC | 32,929 | $388.2K | 0.12% | +8,886+37.0% | Added |
| Fore Capital, LLC | 35,000 | $412.6K | 0.52% | 00.0% | Unchanged |
| Mirae Asset Global ETFs Holdings Ltd. | 35,397 | $417.3K | 0.00% | −5,864−14.2% | Reduced |
| Schonfeld Strategic Advisors LLC | 35,510 | $418.7K | 0.00% | +35,510 | New |
| Quantinno Capital Management LP | 35,742 | $421.4K | 0.00% | +18,588+108.4% | Added |
| Invesco Ltd. | 40,129 | $473.1K | 0.00% | +1,666+4.3% | Added |
| Simplex Trading, LLC | 41,165 | $485.0K | 0.01% | −46,786−53.2% | Reduced |
| Price T Rowe Associates Inc | 41,205 | $486.0K | 0.00% | +4,874+13.4% | Added |
| JPMorgan Chase & Co | 43,182 | $509.1K | 0.00% | −5,305−10.9% | Reduced |
| Nisa Investment Advisors, LLC | 48,378 | $570.4K | 0.00% | +45,000+1,332.1% | Added |
| MetLife Investment Management | 49,196 | $580.0K | 0.00% | 00.0% | Unchanged |
| Cerity Partners LLC | 49,650 | $585.4K | 0.00% | 00.0% | Unchanged |
| Kestra Private Wealth Services, LLC | 50,140 | $591.2K | 0.01% | 00.0% | Unchanged |
| Fox Run Management, L.L.C. | 51,692 | $609.4K | 0.10% | +51,692 | New |
| Royal Bank of Canada | 51,759 | $611.0K | 0.00% | −45,370−46.7% | Reduced |
| Scotia Capital Inc. | 53,931 | $636.1K | 0.00% | 00.0% | Unchanged |
| Legal & General Group Plc | 55,019 | $648.7K | 0.00% | −1,684−3.0% | Reduced |
| Deutsche Bank AG | 55,160 | $650.3K | 0.00% | +7,171+14.9% | Added |
| Gsa Capital Partners LLP | 55,489 | $654.0K | 0.05% | +55,489 | New |
| Wells Fargo & Company | 56,495 | $666.1K | 0.00% | +8,778+18.4% | Added |
| California State Teachers Retirement System | 57,291 | $675.5K | 0.00% | +30.0% | Added |
| HRT Financial LP | 57,565 | $678.0K | 0.00% | +57,565 | New |
| Wolverine Trading, LLC | 60,250 | $725.4K | 0.01% | +60,250 | New |
| Ikarian Capital, LLC | 62,691 | $739.1K | 0.17% | 00.0% | Unchanged |
| Boothbay Fund Management, LLC | 67,984 | $801.5K | 0.02% | +50,000+278.0% | Added |
| Alliancebernstein L.P. | 74,830 | $882.2K | 0.00% | 00.0% | Unchanged |
| PFM Health Sciences, LP | 75,138 | $885.9K | 0.08% | +75,138 | New |
| LPL Financial LLC | 75,947 | $895.4K | 0.00% | +7,458+10.9% | Added |
| StemPoint Capital LP | 76,875 | $906.4K | 0.18% | −13,977−15.4% | Reduced |
| Royce & Associates LP | 81,024 | $955.3K | 0.01% | +81,024 | New |
| Two Sigma Advisers, LP | 81,483 | $960.7K | 0.00% | +81,483 | New |
| Bank of America Corp | 84,011 | $990.5K | 0.00% | −35,203−29.5% | Reduced |
| Data Collective IV GP, LLC | 100,350 | $1.18M | 1.74% | 00.0% | Unchanged |
| Diadema Partners LP | 105,891 | $1.25M | 0.87% | −52,645−33.2% | Reduced |
| Cubist Systematic Strategies, LLC | 108,214 | $1.28M | 0.02% | +108,214 | New |
| Rhumbline Advisers | 112,118 | $1.32M | 0.00% | −3,178−2.8% | Reduced |
| Swiss National Bank | 117,100 | $1.38M | 0.00% | +2,000+1.7% | Added |
| UBS Asset Management Americas Inc | 117,239 | $1.38M | 0.00% | +75,110+178.3% | Added |
| AdvisorShares Investments LLC | 121,664 | $1.43M | 0.23% | +12,071+11.0% | Added |
| Barclays PLC | 150,605 | $1.78M | 0.00% | −24,628−14.1% | Reduced |
| CenterBook Partners LP | 159,421 | $1.88M | 0.09% | +159,421 | New |
| Boxer Capital Management, LLC | 163,500 | $1.93M | 0.61% | +163,500 | New |
| D. E. Shaw & Co., Inc. | 216,334 | $2.55M | 0.00% | +157,570+268.1% | Added |
| Point72 Asset Management, L.P. | 224,300 | $2.64M | 0.01% | +224,300 | New |
| Bank of New York Mellon Corp | 229,031 | $2.70M | 0.00% | −11,708−4.9% | Reduced |
| Nuveen, LLC | 233,504 | $2.75M | 0.00% | −6,338−2.6% | Reduced |
| Wellington Management Group LLP | 256,366 | $3.02M | 0.00% | −5,587−2.1% | Reduced |
| Jane Street Group, LLC | 274,848 | $3.24M | 0.00% | +146,533+114.2% | Added |
| Two Sigma Investments, LP | 296,443 | $3.50M | 0.01% | +239,965+424.9% | Added |
| Millennium Management LLC | 298,205 | $3.52M | 0.00% | +114,805+62.6% | Added |
| Adage Capital Partners GP, L.L.C. | 300,000 | $3.54M | 0.01% | +300,000 | New |
| Citadel Advisors LLC | 339,438 | $4.00M | 0.00% | +160,834+90.1% | Added |
| Ally Bridge Group (NY) LLC | 361,444 | $4.26M | 3.57% | −364,728−50.2% | Reduced |
| OrbiMed Advisors LLC | 367,824 | $4.34M | 0.10% | +367,824 | New |
| Morgan Stanley | 495,618 | $5.84M | 0.00% | −192,913−28.0% | Reduced |
| Goldman Sachs Group Inc | 550,630 | $6.49M | 0.00% | +447,783+435.4% | Added |
| UBS Group AG | 551,809 | $6.51M | 0.00% | +37,364+7.3% | Added |
| Tang Capital Management LLC | 600,200 | $7.08M | 0.27% | 00.0% | Unchanged |
| Northern Trust Corp | 628,538 | $7.41M | 0.00% | +29,296+4.9% | Added |
| Charles Schwab Investment Management Inc | 633,702 | $7.47M | 0.00% | +35,490+5.9% | Added |
| Rosalind Advisors, Inc. | 750,000 | $8.84M | 3.21% | +330,000+78.6% | Added |
| AWM Investment Company, Inc. | 1,215,662 | $14.3M | 1.34% | 00.0% | Unchanged |
| Deep Track Capital, LP | 1,500,000 | $17.7M | 0.49% | −1,000,000−40.0% | Reduced |
| Geode Capital Management, LLC | 1,824,701 | $21.5M | 0.00% | +91,247+5.3% | Added |
| State Street Corp | 1,924,893 | $22.7M | 0.00% | +119,000+6.6% | Added |
| Vanguard Group Inc | 2,012,874 | $23.7M | 0.00% | +198,878+11.0% | Added |
| Octagon Capital Advisors LP | 2,130,000 | $25.1M | 3.92% | 00.0% | Unchanged |
| Marshall Wace, LLP | 2,381,980 | $28.1M | 0.03% | −1,039,244−30.4% | Reduced |
| Blackstone Group Inc. | 2,776,561 | $32.7M | 0.14% | −810,918−22.6% | Reduced |
| Driehaus Capital Management LLC | 3,109,911 | $36.7M | 0.26% | +17,253+0.6% | Added |
| Commodore Capital LP | 3,225,000 | $38.0M | 1.86% | −1,775,000−35.5% | Reduced |
| BlackRock, Inc. | 5,935,557 | $70.0M | 0.00% | +133,418+2.3% | Added |
| Woodline Partners LP | 0 | $0 | 0.00% | −502,198−100.0% | Sold out |
| Oppenheimer & Co Inc | 0 | $0 | 0.00% | −98,336−100.0% | Sold out |
| Balyasny Asset Management LLC | 0 | $0 | 0.00% | −38,937−100.0% | Sold out |
| XTX Topco Ltd | 0 | $0 | 0.00% | −32,402−100.0% | Sold out |