Definium Therapeutics, Inc.
DFTX- Exchange
- Nasdaq
- Industry
- Medicinal Chemicals & Botanical Products
- SEC CIK
- 0001813814
In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 1 sale; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q3 2025
Institutional positions in Definium Therapeutics, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 196
- +15 vs. Q2 2025
- Shares held
- 39.7M
- −2.05M (−4.9%) vs. Q2 2025
- Total value
- $468.6M
- +$197.6M (+72.9%) vs. Q2 2025
- New holders
- 39
- 56 more added
- Sold out
- 24
- 48 more reduced
2 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DFTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 362 | $5.35B |
| Q1 2026 | 248 | $1.47B |
| Q4 2025 | 209 | $908.7M |
| Q3 2025 | 196 | $468.6M |
| Q2 2025 | 183 | $271.0M |
| Q1 2025 | 191 | $240.5M |
| Q4 2024 | 174 | $288.9M |
| Q3 2024 | 158 | $281.6M |
| Q2 2024 | 152 | $299.3M |
| Q1 2024 | 135 | $327.2M |
| Q4 2023 | 104 | $17.9M |
| Q3 2023 | 93 | $12.1M |
| Q2 2023 | 84 | $13.9M |
| Q1 2023 | 89 | $12.6M |
| Q4 2022 | 104 | $11.1M |
| Q3 2022 | 101 | $20.5M |
| Q2 2022 | 156 | $15.1M |
| Q1 2022 | 159 | $53.6M |
| Q4 2021 | 176 | $72.0M |
| Q3 2021 | 175 | $104.8M |
| Q2 2021 | 156 | $131.0M |
| Q1 2021 | 8 | $932.0K |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Definium Therapeutics, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| TSFG, LLC | 6 | $0 | 0.00% | 00.0% | Unchanged |
| Huntington National Bank | 1 | $1 | 0.00% | 00.0% | Unchanged |
| Signaturefd, LLC | 2 | $24 | 0.00% | 00.0% | Unchanged |
| Essential Partners LLC | 4 | $47 | 0.00% | 00.0% | Unchanged |
| CoreCap Advisors, LLC | 5 | $59 | 0.00% | 00.0% | Unchanged |
| NBT Bank N A | 6 | $71 | 0.00% | 00.0% | Unchanged |
| Strategic Investment Solutions, Inc. | 6 | $71 | 0.00% | 00.0% | Unchanged |
| Grey Fox Wealth Advisors, LLC | 6 | $71 | 0.00% | +6 | New |
| MAI Capital Management | 10 | $118 | 0.00% | 00.0% | Unchanged |
| CNB Bank | 10 | $118 | 0.00% | 00.0% | Unchanged |
| Robbins Farley LLC | 28 | $331 | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 29 | $342 | 0.00% | +12+70.6% | Added |
| Chesapeake Asset Management LLC | 33 | $389 | 0.00% | 00.0% | Unchanged |
| Plante Moran Financial Advisors, LLC | 36 | $424 | 0.00% | 00.0% | Unchanged |
| Anfield Capital Management, LLC | 36 | $424 | 0.00% | 00.0% | Unchanged |
| Sunbelt Securities, Inc. | 44 | $519 | 0.00% | +44 | New |
| Sofos Investments, Inc. | 48 | $566 | 0.00% | +48 | New |
| Louisbourg Investments Inc. | 52 | $613 | 0.00% | 00.0% | Unchanged |
| Tradewinds Capital Management, LLC | 53 | $625 | 0.00% | 00.0% | Unchanged |
| Principal Securities, Inc. | 58 | $684 | 0.00% | 00.0% | Unchanged |
| Activest Wealth Management | 66 | $778 | 0.00% | 00.0% | Unchanged |
| Guerra Advisors Inc | 66 | $778 | 0.00% | +66 | New |
| Allworth Financial LP | 85 | $1.00K | 0.00% | 00.0% | Unchanged |
| NBC Securities, Inc. | 100 | $1.18K | 0.00% | −500−83.3% | Reduced |
| HighMark Wealth Management LLC | 100 | $1.18K | 0.00% | 00.0% | Unchanged |
| EverSource Wealth Advisors, LLC | 104 | $1.23K | 0.00% | +14+15.6% | Added |
| SBI Securities Co., Ltd. | 105 | $1.24K | 0.00% | −277−72.5% | Reduced |
| GWM Advisors LLC | 142 | $1.67K | 0.00% | 00.0% | Unchanged |
| CIBC Private Wealth Group, LLC | 151 | $1.78K | 0.00% | −333−68.8% | Reduced |
| Northwestern Mutual Wealth Management Co | 166 | $1.96K | 0.00% | −467−73.8% | Reduced |
| Atlantic Edge Private Wealth Management, LLC | 193 | $2.28K | 0.00% | 00.0% | Unchanged |
| Optiver Holding B.V. | 218 | $2.57K | 0.00% | +218 | New |
| Parallel Advisors, LLC | 232 | $2.74K | 0.00% | −20−7.9% | Reduced |
| Daiwa Securities Group Inc. | 242 | $3.00K | 0.00% | 00.0% | Unchanged |
| Rothschild Investment LLC | 273 | $3.22K | 0.00% | 00.0% | Unchanged |
| Rockefeller Capital Management L.P. | 351 | $4.14K | 0.00% | +351 | New |
| Tortoise Investment Management, LLC | 400 | $4.72K | 0.00% | 00.0% | Unchanged |
| NVWM, LLC | 416 | $4.91K | 0.00% | 00.0% | Unchanged |
| Massmutual Trust Co FSB | 432 | $5.09K | 0.00% | 00.0% | Unchanged |
| Farther Finance Advisors, LLC | 457 | $5.39K | 0.00% | 00.0% | Unchanged |
| Global Retirement Partners, LLC | 500 | $5.89K | 0.00% | +500 | New |
| Harbour Investments, Inc. | 556 | $6.55K | 0.00% | 00.0% | Unchanged |
| Walleye Trading LLC | 562 | $6.63K | 0.00% | +562 | New |
| Advisory Services Network, LLC | 656 | $7.74K | 0.00% | +656 | New |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 792 | $9.00K | 0.00% | +114+16.8% | Added |
| Point72 Europe (London) LLP | 815 | $9.61K | 0.00% | +815 | New |
| GAMMA Investing LLC | 919 | $10.8K | 0.00% | −189−17.1% | Reduced |
| Stone House Investment Management, LLC | 1,000 | $11.8K | 0.00% | 00.0% | Unchanged |
| Steward Partners Investment Advisory, LLC | 1,000 | $11.8K | 0.00% | 00.0% | Unchanged |
| Bullock Wealth Management Group | 1,194 | $14.7K | 0.01% | 00.0% | Unchanged |
| National Bank of Canada | 1,591 | $18.7K | 0.00% | +170+12.0% | Added |
| GF Fund Management Co. Ltd. | 1,637 | $19.3K | 0.00% | −240−12.8% | Reduced |
| Crewe Advisors LLC | 1,999 | $23.6K | 0.00% | 00.0% | Unchanged |
| BIT Capital GmbH | 2,245 | $26.5K | 0.00% | +2,245 | New |
| Tower Research Capital LLC (TRC) | 2,450 | $28.9K | 0.00% | −6,406−72.3% | Reduced |
| Amalgamated Bank | 2,781 | $33.0K | 0.00% | 00.0% | Unchanged |
| Mirae Asset Global Investments Co., Ltd. | 2,942 | $34.7K | 0.00% | +23+0.8% | Added |
| Ameritas Advisory Services, LLC | 3,250 | $38.3K | 0.00% | 00.0% | Unchanged |
| Fifth Third Bancorp | 3,359 | $39.6K | 0.00% | +3,300+5,593.2% | Added |
| Sterling Capital Management LLC | 3,631 | $42.8K | 0.00% | +2,175+149.4% | Added |
| Sound Income Strategies, LLC | 3,681 | $46.0K | 0.00% | +3,681 | New |
| CWM, LLC | 4,532 | $53.0K | 0.00% | +73+1.6% | Added |
| Point72 (DIFC) Ltd | 4,578 | $54.0K | 0.00% | +4,578 | New |
| Walleye Capital LLC | 5,737 | $67.6K | 0.00% | +5,737 | New |
| TD Waterhouse Canada Inc. | 5,594 | $69.1K | 0.00% | −63−1.1% | Reduced |
| North Star Investment Management Corp. | 6,701 | $79.0K | 0.01% | 00.0% | Unchanged |
| Ameritas Investment Partners, Inc. | 7,053 | $83.2K | 0.00% | 00.0% | Unchanged |
| Hollencrest Capital Management | 7,516 | $88.6K | 0.00% | +300+4.2% | Added |
| FNY Investment Advisers, LLC | 9,094 | $107.0K | 0.03% | +9,094 | New |
| King Wealth | 10,000 | $118.0K | 0.01% | 00.0% | Unchanged |
| Point72 Asia (Singapore) Pte. Ltd. | 10,222 | $120.5K | 0.02% | +10,222 | New |
| Dynamic Technology Lab Private Ltd | 10,352 | $122.0K | 0.02% | −4,271−29.2% | Reduced |
| KLP Kapitalforvaltning AS | 10,400 | $122.6K | 0.00% | 00.0% | Unchanged |
| SEI Investments Co | 10,415 | $122.8K | 0.00% | 00.0% | Unchanged |
| Diversify Wealth Management, LLC | 10,000 | $122.9K | 0.01% | 00.0% | Unchanged |
| Caxton Associates LLP | 10,645 | $125.5K | 0.00% | +10,645 | New |
| Advisor Group Holdings, Inc. | 11,602 | $126.5K | 0.00% | −5,849−33.5% | Reduced |
| Bank of Montreal | 11,397 | $134.4K | 0.00% | −522−4.4% | Reduced |
| Stoneridge Investment Partners LLC | 11,563 | $136.0K | 0.09% | +804+7.5% | Added |
| Sanctuary Advisors, LLC | 11,665 | $137.5K | 0.00% | +40.0% | Added |
| Creative Planning | 11,909 | $140.4K | 0.00% | −54,188−82.0% | Reduced |
| HighTower Advisors, LLC | 12,643 | $149.1K | 0.00% | −32−0.3% | Reduced |
| Rafferty Asset Management, LLC | 12,675 | $149.4K | 0.00% | +12,675 | New |
| Money Concepts Capital Corp | 13,000 | $153.3K | 0.01% | +13,000 | New |
| China Universal Asset Management Co., Ltd. | 13,337 | $157.2K | 0.01% | −1,838−12.1% | Reduced |
| Wealth Enhancement Advisory Services, LLC | 13,352 | $159.8K | 0.00% | −84−0.6% | Reduced |
| Russell Investments Group, Ltd. | 13,703 | $161.6K | 0.00% | +9,886+259.0% | Added |
| Bay Rivers Group | 14,001 | $165.1K | 0.07% | +2,383+20.5% | Added |
| Voya Investment Management LLC | 14,282 | $168.4K | 0.00% | −6,979−32.8% | Reduced |
| Commonwealth Equity Services, LLC | 14,550 | $172.0K | 0.00% | −1,905−11.6% | Reduced |
| Teacher Retirement System of Texas | 14,694 | $173.2K | 0.00% | −1,566−9.6% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 15,117 | $178.2K | 0.00% | −485−3.1% | Reduced |
| BNP Paribas Arbitrage, SA | 15,320 | $180.6K | 0.00% | +6,903+82.0% | Added |
| FMR LLC | 15,558 | $183.4K | 0.00% | +1,771+12.8% | Added |
| Axq Capital, LP | 15,585 | $183.7K | 0.07% | +15,585 | New |
| Virtus Investment Advisers, Inc. | 15,587 | $183.8K | 0.05% | +2,706+21.0% | Added |
| ProShare Advisors LLC | 15,592 | $183.8K | 0.00% | −2,676−14.6% | Reduced |
| Cetera Investment Advisers | 16,242 | $191.5K | 0.00% | +16,242 | New |
| Omers Administration Corp | 16,600 | $195.7K | 0.00% | +16,600 | New |
| Gotham Asset Management, LLC | 17,002 | $200.5K | 0.00% | +2,924+20.8% | Added |