Definium Therapeutics, Inc.
DFTX- Exchange
- Nasdaq
- Industry
- Medicinal Chemicals & Botanical Products
- SEC CIK
- 0001813814
In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 1 sale; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q4 2024
Institutional positions in Definium Therapeutics, Inc. as of Dec 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 174
- +18 vs. Q3 2024
- Shares held
- 41.5M
- −7.96M (−16.1%) vs. Q3 2024
- Total value
- $288.9M
- +$7.36M (+2.6%) vs. Q3 2024
- New holders
- 37
- 60 more added
- Sold out
- 19
- 33 more reduced
2 institutions that held it in Q3 2024 haven't filed for Q4 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DFTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 362 | $5.35B |
| Q1 2026 | 248 | $1.47B |
| Q4 2025 | 209 | $908.7M |
| Q3 2025 | 196 | $468.6M |
| Q2 2025 | 183 | $271.0M |
| Q1 2025 | 191 | $240.5M |
| Q4 2024 | 174 | $288.9M |
| Q3 2024 | 158 | $281.6M |
| Q2 2024 | 152 | $299.3M |
| Q1 2024 | 135 | $327.2M |
| Q4 2023 | 104 | $17.9M |
| Q3 2023 | 93 | $12.1M |
| Q2 2023 | 84 | $13.9M |
| Q1 2023 | 89 | $12.6M |
| Q4 2022 | 104 | $11.1M |
| Q3 2022 | 101 | $20.5M |
| Q2 2022 | 156 | $15.1M |
| Q1 2022 | 159 | $53.6M |
| Q4 2021 | 176 | $72.0M |
| Q3 2021 | 175 | $104.8M |
| Q2 2021 | 156 | $131.0M |
| Q1 2021 | 8 | $932.0K |
Institutions, Q4 2024
Shares, value and share of portfolio for each institution holding Definium Therapeutics, Inc.; share changes are against Q3 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Wolverine Trading, LLC | 21,406 | $143.4K | 0.00% | +4,055+23.4% | Added |
| Federation des caisses Desjardins du Quebec | 21,422 | $149.1K | 0.00% | +1,500+7.5% | Added |
| Commonwealth Equity Services, LLC | 21,492 | $150.0K | 0.00% | +1,928+9.9% | Added |
| Voya Investment Management LLC | 23,666 | $164.7K | 0.00% | −637−2.6% | Reduced |
| SG Americas Securities, LLC | 24,406 | $170.0K | 0.00% | +8,004+48.8% | Added |
| Two Sigma Advisers, LP | 24,650 | $171.6K | 0.00% | +5,400+28.1% | Added |
| FMR LLC | 24,909 | $173.4K | 0.00% | +12,767+105.1% | Added |
| ADAR1 Capital Management, LLC | 25,000 | $174.0K | 0.04% | +25,000 | New |
| AQR Capital Management LLC | 25,137 | $175.0K | 0.00% | +2,364+10.4% | Added |
| ProShare Advisors LLC | 26,167 | $182.1K | 0.00% | +12,562+92.3% | Added |
| Manufacturers Life Insurance Company, The | 27,108 | $188.7K | 0.00% | +503+1.9% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 27,198 | $189.3K | 0.00% | +4,972+22.4% | Added |
| Janus Henderson Group PLC | 28,000 | $194.6K | 0.00% | 00.0% | Unchanged |
| Intech Investment Management LLC | 29,562 | $205.8K | 0.00% | +6,089+25.9% | Added |
| Price T Rowe Associates Inc | 31,313 | $218.0K | 0.00% | +8,361+36.4% | Added |
| Clough Capital Partners L P | 33,900 | $235.9K | 0.03% | +33,900 | New |
| Caxton Corp | 34,073 | $237.1K | 1.43% | 00.0% | Unchanged |
| XTX Topco Ltd | 36,139 | $251.5K | 0.02% | −23,083−39.0% | Reduced |
| Fore Capital, LLC | 37,539 | $261.3K | 0.32% | +7,539+25.1% | Added |
| Wells Fargo & Company | 39,974 | $278.2K | 0.00% | +15,269+61.8% | Added |
| Corebridge Financial, Inc. | 40,064 | $278.8K | 0.00% | +1,569+4.1% | Added |
| Invesco Ltd. | 41,400 | $288.1K | 0.00% | +4,564+12.4% | Added |
| Squarepoint Ops LLC | 41,968 | $292.1K | 0.00% | −38,153−47.6% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 45,690 | $318.0K | 0.00% | +6,182+15.6% | Added |
| JPMorgan Chase & Co | 48,158 | $335.2K | 0.00% | +11,163+30.2% | Added |
| MetLife Investment Management | 49,662 | $345.6K | 0.00% | +7,113+16.7% | Added |
| Kestra Private Wealth Services, LLC | 51,206 | $356.4K | 0.01% | −133−0.3% | Reduced |
| Scotia Capital Inc. | 53,955 | $375.6K | 0.00% | +40.0% | Added |
| Legal & General Group Plc | 58,437 | $406.7K | 0.00% | +762+1.3% | Added |
| California State Teachers Retirement System | 58,498 | $407.1K | 0.00% | +140.0% | Added |
| Royal Bank of Canada | 59,089 | $410.0K | 0.00% | +2,401+4.2% | Added |
| LPL Financial LLC | 62,334 | $433.8K | 0.00% | +14,439+30.1% | Added |
| Ikarian Capital, LLC | 62,691 | $436.3K | 0.12% | +210+0.3% | Added |
| BIT Capital GmbH | 63,405 | $441.3K | 0.04% | +63,405 | New |
| Oppenheimer & Co Inc | 65,541 | $456.2K | 0.01% | +13,160+25.1% | Added |
| Alliancebernstein L.P. | 67,930 | $472.8K | 0.00% | −7,400−9.8% | Reduced |
| Deutsche Bank AG | 71,595 | $498.3K | 0.00% | +24,716+52.7% | Added |
| Citigroup Inc | 76,908 | $535.3K | 0.00% | −7,588−9.0% | Reduced |
| UBS Asset Management Americas Inc | 85,044 | $591.9K | 0.00% | +14,691+20.9% | Added |
| Data Collective IV GP, LLC | 100,350 | $698.4K | 0.31% | 00.0% | Unchanged |
| Rhumbline Advisers | 100,695 | $700.8K | 0.00% | +4,868+5.1% | Added |
| AdvisorShares Investments LLC | 103,709 | $721.8K | 0.14% | −5,457−5.0% | Reduced |
| UBS Group AG | 114,438 | $796.5K | 0.00% | −13,860−10.8% | Reduced |
| Moloney Securities Asset Management, LLC | 116,511 | $810.9K | 0.11% | +1,000+0.9% | Added |
| Swiss National Bank | 119,900 | $834.5K | 0.00% | 00.0% | Unchanged |
| Citadel Advisors LLC | 121,760 | $847.5K | 0.00% | +78,917+184.2% | Added |
| Allostery Investments LP | 130,000 | $904.8K | 1.78% | +130,000 | New |
| Barclays PLC | 155,434 | $1.08M | 0.00% | +19,336+14.2% | Added |
| Two Sigma Investments, LP | 180,293 | $1.25M | 0.00% | −98,746−35.4% | Reduced |
| Millennium Management LLC | 185,721 | $1.29M | 0.00% | +106,511+134.5% | Added |
| Wellington Management Group LLP | 194,491 | $1.35M | 0.00% | +8,769+4.7% | Added |
| Susquehanna International Group, LLP | 198,420 | $1.38M | 0.00% | +198,420 | New |
| Tang Capital Management LLC | 200,000 | $1.39M | 0.09% | +200,000 | New |
| Bank of New York Mellon Corp | 200,121 | $1.39M | 0.00% | +10,338+5.4% | Added |
| Bank of America Corp | 272,929 | $1.90M | 0.00% | −39,662−12.7% | Reduced |
| Nuveen Asset Management, LLC | 286,334 | $1.99M | 0.00% | +8,856+3.2% | Added |
| Goldman Sachs Group Inc | 296,806 | $2.07M | 0.00% | +126,857+74.6% | Added |
| Ally Bridge Group (NY) LLC | 330,275 | $2.30M | 1.97% | −458,233−58.1% | Reduced |
| Morgan Stanley | 496,652 | $3.46M | 0.00% | +141,033+39.7% | Added |
| Charles Schwab Investment Management Inc | 593,356 | $4.13M | 0.00% | −9,188−1.5% | Reduced |
| Northern Trust Corp | 684,836 | $4.77M | 0.00% | +76,559+12.6% | Added |
| Tri Locum Partners LP | 820,793 | $5.71M | 1.18% | −842,160−50.6% | Reduced |
| Woodline Partners LP | 1,005,198 | $7.00M | 0.05% | +2,654+0.3% | Added |
| AWM Investment Company, Inc. | 1,193,162 | $8.30M | 1.01% | +340,162+39.9% | Added |
| Geode Capital Management, LLC | 1,723,088 | $12.0M | 0.00% | +45,386+2.7% | Added |
| State Street Corp | 1,781,499 | $12.4M | 0.00% | −33,330−1.8% | Reduced |
| Vanguard Group Inc | 1,910,825 | $13.3M | 0.00% | −37,482−1.9% | Reduced |
| Marshall Wace, LLP | 2,501,391 | $17.4M | 0.02% | +213,526+9.3% | Added |
| Deep Track Capital, LP | 2,816,594 | $19.6M | 0.73% | −4,248,505−60.1% | Reduced |
| Octagon Capital Advisors LP | 3,018,000 | $21.0M | 3.58% | 00.0% | Unchanged |
| Driehaus Capital Management LLC | 3,376,207 | $23.5M | 0.19% | −517,920−13.3% | Reduced |
| Blackstone Group Inc. | 3,587,479 | $25.0M | 0.12% | −325,000−8.3% | Reduced |
| Commodore Capital LP | 4,308,425 | $30.0M | 2.20% | −3,691,575−46.1% | Reduced |
| BlackRock, Inc. | 6,070,053 | $42.2M | 0.00% | +406,020+7.2% | Added |
| Alyeska Investment Group, L.P. | 0 | $0 | 0.00% | −66,694−100.0% | Sold out |
| Balyasny Asset Management LLC | 0 | $0 | 0.00% | −26,386−100.0% | Sold out |
| GTS Securities LLC | 0 | $0 | 0.00% | −21,567−100.0% | Sold out |
| Rafferty Asset Management, LLC | 0 | $0 | 0.00% | −18,658−100.0% | Sold out |
| Sherbrooke Park Advisers LLC | 0 | $0 | 0.00% | −13,827−100.0% | Sold out |
| Change Path, LLC | 0 | $0 | 0.00% | −12,462−100.0% | Sold out |
| Voloridge Investment Management, LLC | 0 | $0 | 0.00% | −11,198−100.0% | Sold out |
| Blair William & Co | 0 | $0 | 0.00% | −11,000−100.0% | Sold out |
| Wealth Alliance | 0 | $0 | 0.00% | −11,000−100.0% | Sold out |
| Jaffetilchin Investment Partners, LLC | 0 | $0 | 0.00% | −2,389−100.0% | Sold out |
| NBC Securities, Inc. | 0 | $0 | 0.00% | −600−100.0% | Sold out |
| Albion Financial Group | 0 | $0 | 0.00% | −132−100.0% | Sold out |
| Tower View Investment Management & Research LLC | 0 | $0 | 0.00% | −100−100.0% | Sold out |
| Capital Performance Advisors LLP | 0 | $0 | 0.00% | −80−100.0% | Sold out |
| Arrow Financial Corp | 0 | $0 | 0.00% | −66−100.0% | Sold out |
| Westside Investment Management, Inc. | 0 | $0 | 0.00% | −66−100.0% | Sold out |
| True Wealth Design, LLC | 0 | $0 | 0.00% | −19−100.0% | Sold out |
| SJS Investment Consulting Inc. | 0 | $0 | 0.00% | −12−100.0% | Sold out |
| Motco | 0 | $0 | 0.00% | −10−100.0% | Sold out |
| Raymond James Financial Services Advisors, Inc. | – | – | – | – | Not filed |
| PEAK6 Investments LLC | – | – | – | – | Not filed |