Amylyx Pharmaceuticals, Inc.
AMLX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001658551
In the last 90 days, Amylyx Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 206 institutions reported holding it in 13F filings for Q2 2026, worth $2.07B in total; no superinvestor holds it.
13F holders, Q1 2026
Institutional positions in Amylyx Pharmaceuticals, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 171
- −8 vs. Q4 2025
- Shares held
- 114.1M
- +7.64M (+7.2%) vs. Q4 2025
- Total value
- $1.59B
- +$299.6M (+23.3%) vs. Q4 2025
- New holders
- 28
- 63 more added
- Sold out
- 36
- 53 more reduced
1 institution that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting AMLX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 206 | $2.07B |
| Q1 2026 | 171 | $1.59B |
| Q4 2025 | 180 | $1.36B |
| Q3 2025 | 169 | $1.49B |
| Q2 2025 | 131 | $523.6M |
| Q1 2025 | 136 | $261.6M |
| Q4 2024 | 122 | $188.3M |
| Q3 2024 | 110 | $140.8M |
| Q2 2024 | 119 | $82.9M |
| Q1 2024 | 143 | $141.5M |
| Q4 2023 | 178 | $887.4M |
| Q3 2023 | 170 | $1.08B |
| Q2 2023 | 154 | $1.18B |
| Q1 2023 | 147 | $1.51B |
| Q4 2022 | 133 | $1.79B |
| Q3 2022 | 95 | $1.05B |
| Q2 2022 | 78 | $512.9M |
| Q1 2022 | 72 | $299.9M |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Amylyx Pharmaceuticals, Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Wells Fargo & Company | 75,083 | $1.04M | 0.00% | −71,226−48.7% | Reduced |
| Schonfeld Strategic Advisors LLC | 77,794 | $1.08M | 0.01% | +56,742+269.5% | Added |
| SEI Investments Co | 85,279 | $1.19M | 0.00% | +32,423+61.3% | Added |
| Alps Advisors Inc | 89,983 | $1.25M | 0.01% | −189−0.2% | Reduced |
| Point72 Asset Management, L.P. | 106,535 | $1.48M | 0.00% | −228,465−68.2% | Reduced |
| Rhumbline Advisers | 108,467 | $1.51M | 0.00% | +9,193+9.3% | Added |
| Elmind Capital, LP | 112,000 | $1.56M | 0.44% | 00.0% | Unchanged |
| Squarepoint Ops LLC | 114,877 | $1.60M | 0.00% | +38,315+50.0% | Added |
| Price T Rowe Associates Inc | 121,439 | $1.69M | 0.00% | +13,891+12.9% | Added |
| Swiss National Bank | 130,300 | $1.81M | 0.00% | −31,400−19.4% | Reduced |
| Falcon Edge Capital, LP | 142,336 | $1.98M | 0.25% | −175,342−55.2% | Reduced |
| PFM Health Sciences, LP | 145,275 | $2.02M | 0.21% | +10,726+8.0% | Added |
| JPMorgan Chase & Co | 159,663 | $2.04M | 0.00% | +93,116+139.9% | Added |
| Acuta Capital Partners, LLC | 151,067 | $2.10M | 1.49% | −182,191−54.7% | Reduced |
| UBS Asset Management Americas Inc | 157,089 | $2.18M | 0.00% | +58,251+58.9% | Added |
| Two Sigma Investments, LP | 161,945 | $2.25M | 0.00% | −182,456−53.0% | Reduced |
| Invesco Ltd. | 171,620 | $2.39M | 0.00% | −4,294−2.4% | Reduced |
| Aldebaran Capital, LLC | 197,892 | $2.75M | 2.10% | −616−0.3% | Reduced |
| SummitTX Capital, L.P. | 227,010 | $3.16M | 0.10% | +8,611+3.9% | Added |
| Wellington Management Group LLP | 241,552 | $3.36M | 0.00% | +15,770+7.0% | Added |
| Bank of New York Mellon Corp | 251,104 | $3.49M | 0.00% | +33,757+15.5% | Added |
| Nuveen, LLC | 264,897 | $3.68M | 0.00% | −19,051−6.7% | Reduced |
| iA Global Asset Management Inc. | 304,786 | $4.24M | 0.06% | +304,786 | New |
| Polygon Management Ltd. | 317,877 | $4.42M | 0.87% | +45,049+16.5% | Added |
| UBS Group AG | 324,319 | $4.51M | 0.00% | −219,004−40.3% | Reduced |
| Cormorant Asset Management, LP | 350,000 | $4.87M | 0.25% | −50,000−12.5% | Reduced |
| HighVista Strategies LLC | 352,085 | $4.89M | 1.35% | +113,273+47.4% | Added |
| Federated Hermes, Inc. | 363,546 | $5.05M | 0.01% | −93,866−20.5% | Reduced |
| Citadel Advisors LLC | 411,532 | $5.72M | 0.00% | +66,564+19.3% | Added |
| Rock Springs Capital Management LP | 499,764 | $6.95M | 0.41% | 00.0% | Unchanged |
| Nantahala Capital Management, LLC | 535,684 | $7.45M | 0.46% | −300,000−35.9% | Reduced |
| Vanguard Fiduciary Trust Co | 586,152 | $8.15M | 0.00% | +586,152 | New |
| Jupiter Asset Management Ltd | 592,654 | $8.24M | 0.04% | +577,080+3,705.4% | Added |
| Parkman Healthcare Partners LLC | 621,458 | $8.64M | 0.90% | +239,698+62.8% | Added |
| StemPoint Capital LP | 669,685 | $9.31M | 1.79% | +104,545+18.5% | Added |
| Logos Global Management LP | 700,000 | $9.73M | 0.50% | −250,000−26.3% | Reduced |
| Qube Research & Technologies Ltd | 702,236 | $9.76M | 0.01% | +289,363+70.1% | Added |
| Charles Schwab Investment Management Inc | 716,225 | $9.96M | 0.00% | +3,235+0.5% | Added |
| Northern Trust Corp | 779,908 | $10.8M | 0.00% | −157,856−16.8% | Reduced |
| Boxer Capital Management, LLC | 800,000 | $11.1M | 1.46% | 00.0% | Unchanged |
| Woodline Partners LP | 845,800 | $11.8M | 0.04% | +3920.0% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 868,325 | $12.1M | 0.03% | −135,696−13.5% | Reduced |
| Dimensional Fund Advisors LP | 903,192 | $12.5M | 0.00% | +131,944+17.1% | Added |
| Vanguard Portfolio Management LLC | 944,781 | $13.1M | 0.00% | +944,781 | New |
| Barclays PLC | 971,854 | $13.5M | 0.00% | +676,677+229.2% | Added |
| ADAR1 Capital Management, LLC | 1,000,604 | $13.9M | 0.84% | +110,248+12.4% | Added |
| Balyasny Asset Management LLC | 1,107,271 | $15.4M | 0.03% | +248,587+28.9% | Added |
| Siren, L.L.C. | 1,230,000 | $17.1M | 0.47% | +1,230,000 | New |
| Deutsche Bank AG | 1,267,785 | $17.6M | 0.01% | −65,451−4.9% | Reduced |
| Bank of America Corp | 1,330,689 | $18.5M | 0.00% | −5,321−0.4% | Reduced |
| Eventide Asset Management, LLC | 1,513,958 | $21.0M | 0.35% | +810+0.1% | Added |
| 683 Capital Management, LLC | 1,530,000 | $21.3M | 1.97% | −120,000−7.3% | Reduced |
| Jones Hill Capital LP | 1,598,794 | $22.2M | 4.76% | +1,598,794 | New |
| Great Point Partners LLC | 1,750,000 | $24.3M | 5.96% | 00.0% | Unchanged |
| Almitas Capital LLC | 2,122,597 | $29.5M | 6.67% | 00.0% | Unchanged |
| Morgan Stanley | 2,175,547 | $30.2M | 0.00% | −184,277−7.8% | Reduced |
| Geode Capital Management, LLC | 2,210,932 | $30.7M | 0.00% | +45,398+2.1% | Added |
| Franklin Resources Inc | 2,261,569 | $31.4M | 0.01% | +1,061,473+88.4% | Added |
| State Street Corp | 2,363,161 | $32.8M | 0.00% | +293,277+14.2% | Added |
| Goldman Sachs Group Inc | 2,625,991 | $36.5M | 0.00% | +12,770+0.5% | Added |
| Driehaus Capital Management LLC | 2,987,147 | $41.5M | 0.31% | −122,356−3.9% | Reduced |
| First Light Asset Management, LLC | 3,190,645 | $44.3M | 3.97% | −164,894−4.9% | Reduced |
| Adage Capital Partners GP, L.L.C. | 3,560,764 | $49.5M | 0.08% | +783,709+28.2% | Added |
| Vanguard Capital Management LLC | 4,141,575 | $57.6M | 0.00% | +4,141,575 | New |
| Saturn V Capital Management LLC | 4,349,885 | $60.5M | 10.95% | −146,602−3.3% | Reduced |
| Janus Henderson Group PLC | 4,986,073 | $69.3M | 0.03% | +520,201+11.6% | Added |
| Commodore Capital LP | 5,650,000 | $78.5M | 4.54% | 00.0% | Unchanged |
| TCG Crossover Management, LLC | 6,243,812 | $86.8M | 2.48% | 00.0% | Unchanged |
| Perceptive Advisors LLC | 8,284,882 | $115.2M | 2.27% | 00.0% | Unchanged |
| BlackRock, Inc. | 8,828,836 | $122.7M | 0.00% | −225,595−2.5% | Reduced |
| FMR LLC | 16,630,541 | $231.2M | 0.01% | +112,122+0.7% | Added |
| Sofinnova Investments, Inc. | 0 | $0 | 0.00% | −527,099−100.0% | Sold out |
| Silverarc Capital Management, LLC | 0 | $0 | 0.00% | −506,242−100.0% | Sold out |
| Ameriprise Financial Inc | 0 | $0 | 0.00% | −502,366−100.0% | Sold out |
| Patient Square Capital LP | 0 | $0 | 0.00% | −350,000−100.0% | Sold out |
| Two Sigma Advisers, LP | 0 | $0 | 0.00% | −328,401−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −263,235−100.0% | Sold out |
| Acadian Asset Management LLC | 0 | $0 | 0.00% | −254,328−100.0% | Sold out |
| Renaissance Technologies LLC | 0 | $0 | 0.00% | −192,500−100.0% | Sold out |
| XTX Topco Ltd | 0 | $0 | 0.00% | −189,673−100.0% | Sold out |
| Voloridge Investment Management, LLC | 0 | $0 | 0.00% | −153,363−100.0% | Sold out |
| Atom Investors LP | 0 | $0 | 0.00% | −139,422−100.0% | Sold out |
| Bank of Montreal | 0 | $0 | 0.00% | −138,525−100.0% | Sold out |
| Kennondale Capital Management LLC | 0 | $0 | 0.00% | −53,423−100.0% | Sold out |
| Trexquant Investment LP | 0 | $0 | 0.00% | −48,112−100.0% | Sold out |
| Millennium Management LLC | 0 | $0 | 0.00% | −46,455−100.0% | Sold out |
| Mariner, LLC | 0 | $0 | 0.00% | −46,342−100.0% | Sold out |
| Gsa Capital Partners LLP | 0 | $0 | 0.00% | −36,758−100.0% | Sold out |
| Fox Run Management, L.L.C. | 0 | $0 | 0.00% | −35,409−100.0% | Sold out |
| Persistent Asset Partners Ltd | 0 | $0 | 0.00% | −31,147−100.0% | Sold out |
| Aquatic Capital Management LLC | 0 | $0 | 0.00% | −24,352−100.0% | Sold out |
| SG Americas Securities, LLC | 0 | $0 | 0.00% | −20,846−100.0% | Sold out |
| Engineers Gate Manager LP | 0 | $0 | 0.00% | −18,358−100.0% | Sold out |
| Rafferty Asset Management, LLC | 0 | $0 | 0.00% | −17,673−100.0% | Sold out |
| Quadrature Capital Ltd | 0 | $0 | 0.00% | −15,465−100.0% | Sold out |
| Teacher Retirement System of Texas | 0 | $0 | 0.00% | −12,174−100.0% | Sold out |
| EntryPoint Capital, LLC | 0 | $0 | 0.00% | −10,487−100.0% | Sold out |
| Quest Partners LLC | 0 | $0 | 0.00% | −7,195−100.0% | Sold out |
| T. Rowe Price Investment Management, Inc. | 0 | $0 | 0.00% | −4,517−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −3,727−100.0% | Sold out |