Amylyx Pharmaceuticals, Inc.
AMLX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001658551
In the last 90 days, Amylyx Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 206 institutions reported holding it in 13F filings for Q2 2026, worth $2.07B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Amylyx Pharmaceuticals, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 180
- +13 vs. Q3 2025
- Shares held
- 112.3M
- +2.61M (+2.4%) vs. Q3 2025
- Total value
- $1.36B
- −$134.1M (−9.0%) vs. Q3 2025
- New holders
- 40
- 72 more added
- Sold out
- 27
- 44 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting AMLX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 206 | $2.07B |
| Q1 2026 | 171 | $1.59B |
| Q4 2025 | 180 | $1.36B |
| Q3 2025 | 169 | $1.49B |
| Q2 2025 | 131 | $523.6M |
| Q1 2025 | 136 | $261.6M |
| Q4 2024 | 122 | $188.3M |
| Q3 2024 | 110 | $140.8M |
| Q2 2024 | 119 | $82.9M |
| Q1 2024 | 143 | $141.5M |
| Q4 2023 | 178 | $887.4M |
| Q3 2023 | 170 | $1.08B |
| Q2 2023 | 154 | $1.18B |
| Q1 2023 | 147 | $1.51B |
| Q4 2022 | 133 | $1.79B |
| Q3 2022 | 95 | $1.05B |
| Q2 2022 | 78 | $512.9M |
| Q1 2022 | 72 | $299.9M |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Amylyx Pharmaceuticals, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Legal & General Group Plc | 72,612 | $877.2K | 0.00% | +5,400+8.0% | Added |
| D. E. Shaw & Co., Inc. | 73,224 | $884.5K | 0.00% | +4,347+6.3% | Added |
| Squarepoint Ops LLC | 76,562 | $924.9K | 0.00% | +76,562 | New |
| Campbell & CO Investment Adviser LLC | 78,763 | $951.5K | 0.05% | +54,281+221.7% | Added |
| California State Teachers Retirement System | 79,090 | $955.4K | 0.00% | +74,759+1,726.1% | Added |
| State of Wisconsin Investment Board | 84,144 | $1.02M | 0.00% | +70,269+506.4% | Added |
| Alps Advisors Inc | 90,172 | $1.09M | 0.01% | +90,172 | New |
| UBS Asset Management Americas Inc | 98,838 | $1.19M | 0.00% | +98,838 | New |
| Rhumbline Advisers | 99,274 | $1.20M | 0.00% | +617+0.6% | Added |
| Price T Rowe Associates Inc | 107,548 | $1.30M | 0.00% | +7,103+7.1% | Added |
| Elmind Capital, LP | 112,000 | $1.35M | 0.40% | +112,000 | New |
| Numerai GP LLC | 112,648 | $1.36M | 0.16% | +45,495+67.7% | Added |
| PFM Health Sciences, LP | 134,549 | $1.63M | 0.16% | −301,607−69.2% | Reduced |
| Bank of Montreal | 138,525 | $1.67M | 0.00% | −5,227−3.6% | Reduced |
| Atom Investors LP | 139,422 | $1.68M | 0.13% | +139,422 | New |
| Wells Fargo & Company | 146,309 | $1.77M | 0.00% | +52,618+56.2% | Added |
| Voloridge Investment Management, LLC | 153,363 | $1.85M | 0.01% | +153,363 | New |
| Swiss National Bank | 161,700 | $1.95M | 0.00% | +161,700 | New |
| Invesco Ltd. | 175,914 | $2.13M | 0.00% | −634,726−78.3% | Reduced |
| XTX Topco Ltd | 189,673 | $2.29M | 0.06% | +189,673 | New |
| Renaissance Technologies LLC | 192,500 | $2.33M | 0.00% | +172,600+867.3% | Added |
| Aldebaran Capital, LLC | 198,508 | $2.40M | 2.15% | −5,966−2.9% | Reduced |
| Bank of New York Mellon Corp | 217,347 | $2.63M | 0.00% | +34,391+18.8% | Added |
| SummitTX Capital, L.P. | 218,399 | $2.64M | 0.08% | +50,399+30.0% | Added |
| Wellington Management Group LLP | 225,782 | $2.73M | 0.00% | −10,415−4.4% | Reduced |
| HighVista Strategies LLC | 238,812 | $2.88M | 0.74% | +238,812 | New |
| Acadian Asset Management LLC | 254,328 | $3.07M | 0.01% | −113,003−30.8% | Reduced |
| Jane Street Group, LLC | 263,235 | $3.18M | 0.00% | +263,235 | New |
| Polygon Management Ltd. | 272,828 | $3.30M | 0.69% | +14,586+5.6% | Added |
| Nuveen, LLC | 283,948 | $3.43M | 0.00% | +123,529+77.0% | Added |
| Barclays PLC | 295,177 | $3.57M | 0.00% | −118,935−28.7% | Reduced |
| Falcon Edge Capital, LP | 317,678 | $3.84M | 0.47% | −9,634−2.9% | Reduced |
| Two Sigma Advisers, LP | 328,401 | $3.97M | 0.01% | +185,401+129.7% | Added |
| Acuta Capital Partners, LLC | 333,258 | $4.03M | 2.73% | 00.0% | Unchanged |
| Point72 Asset Management, L.P. | 335,000 | $4.05M | 0.01% | −2,455,066−88.0% | Reduced |
| Two Sigma Investments, LP | 344,401 | $4.16M | 0.01% | +245,985+249.9% | Added |
| Citadel Advisors LLC | 344,968 | $4.17M | 0.00% | +110,295+47.0% | Added |
| Patient Square Capital LP | 350,000 | $4.23M | 0.91% | +33,688+10.7% | Added |
| Parkman Healthcare Partners LLC | 381,760 | $4.61M | 0.44% | −197,414−34.1% | Reduced |
| Cormorant Asset Management, LP | 400,000 | $4.83M | 0.27% | −100,000−20.0% | Reduced |
| Qube Research & Technologies Ltd | 412,873 | $4.99M | 0.01% | +245,767+147.1% | Added |
| Federated Hermes, Inc. | 457,412 | $5.53M | 0.01% | +245,033+115.4% | Added |
| Rock Springs Capital Management LP | 499,764 | $6.04M | 0.31% | 00.0% | Unchanged |
| Ameriprise Financial Inc | 502,366 | $6.07M | 0.00% | +368,858+276.3% | Added |
| Silverarc Capital Management, LLC | 506,242 | $6.12M | 0.88% | −193,758−27.7% | Reduced |
| Sofinnova Investments, Inc. | 527,099 | $6.37M | 0.27% | +527,099 | New |
| UBS Group AG | 543,323 | $6.56M | 0.00% | −861,148−61.3% | Reduced |
| StemPoint Capital LP | 565,140 | $6.83M | 1.17% | +288,256+104.1% | Added |
| Charles Schwab Investment Management Inc | 712,990 | $8.61M | 0.00% | +67,805+10.5% | Added |
| Dimensional Fund Advisors LP | 771,248 | $9.32M | 0.00% | +261,468+51.3% | Added |
| Boxer Capital Management, LLC | 800,000 | $9.66M | 2.12% | −100,000−11.1% | Reduced |
| Nantahala Capital Management, LLC | 835,684 | $10.1M | 0.60% | −100,000−10.7% | Reduced |
| Woodline Partners LP | 845,408 | $10.2M | 0.04% | +1180.0% | Added |
| Balyasny Asset Management LLC | 858,684 | $10.4M | 0.02% | −617,618−41.8% | Reduced |
| ADAR1 Capital Management, LLC | 890,356 | $10.8M | 0.80% | +24,154+2.8% | Added |
| Northern Trust Corp | 937,764 | $11.3M | 0.00% | +115,527+14.1% | Added |
| Logos Global Management LP | 950,000 | $11.5M | 0.76% | −500,000−34.5% | Reduced |
| Connor, Clark & Lunn Investment Management Ltd. | 1,004,021 | $12.1M | 0.03% | −102,987−9.3% | Reduced |
| Franklin Resources Inc | 1,200,096 | $14.5M | 0.00% | +1,200,096 | New |
| Deutsche Bank AG | 1,333,236 | $16.1M | 0.01% | −32,285−2.4% | Reduced |
| Bank of America Corp | 1,336,010 | $16.1M | 0.00% | +906,494+211.1% | Added |
| Eventide Asset Management, LLC | 1,513,148 | $18.3M | 0.29% | +6480.0% | Added |
| 683 Capital Management, LLC | 1,650,000 | $19.9M | 1.66% | −110,000−6.3% | Reduced |
| Great Point Partners LLC | 1,750,000 | $21.1M | 6.85% | +50,000+2.9% | Added |
| State Street Corp | 2,069,884 | $25.0M | 0.00% | +448,624+27.7% | Added |
| Almitas Capital LLC | 2,122,597 | $25.6M | 5.65% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 2,165,534 | $26.2M | 0.00% | +353,495+19.5% | Added |
| Morgan Stanley | 2,359,824 | $28.5M | 0.00% | +409,523+21.0% | Added |
| Goldman Sachs Group Inc | 2,613,221 | $31.6M | 0.00% | +602,588+30.0% | Added |
| Adage Capital Partners GP, L.L.C. | 2,777,055 | $33.5M | 0.05% | −4,039,773−59.3% | Reduced |
| Driehaus Capital Management LLC | 3,109,503 | $37.6M | 0.26% | +688,736+28.5% | Added |
| First Light Asset Management, LLC | 3,355,539 | $40.5M | 3.10% | −3430.0% | Reduced |
| Janus Henderson Group PLC | 4,465,872 | $54.0M | 0.02% | +1,929,639+76.1% | Added |
| Saturn V Capital Management LLC | 4,496,487 | $54.3M | 9.97% | −108,391−2.4% | Reduced |
| Commodore Capital LP | 5,650,000 | $68.3M | 4.54% | +1,574,522+38.6% | Added |
| Vanguard Group Inc | 5,804,912 | $70.1M | 0.00% | +531,162+10.1% | Added |
| TCG Crossover Management, LLC | 6,243,812 | $75.4M | 2.50% | 00.0% | Unchanged |
| Perceptive Advisors LLC | 8,284,882 | $100.1M | 1.83% | −667,483−7.5% | Reduced |
| BlackRock, Inc. | 9,054,431 | $109.4M | 0.00% | +1,913,739+26.8% | Added |
| FMR LLC | 16,518,419 | $199.5M | 0.01% | +5,139,212+45.2% | Added |
| Paradigm Biocapital Advisors LP | 0 | $0 | 0.00% | −1,900,000−100.0% | Sold out |
| OrbiMed Advisors LLC | 0 | $0 | 0.00% | −750,600−100.0% | Sold out |
| Braidwell LP | 0 | $0 | 0.00% | −612,841−100.0% | Sold out |
| Jennison Associates LLC | 0 | $0 | 0.00% | −578,659−100.0% | Sold out |
| Ally Bridge Group (NY) LLC | 0 | $0 | 0.00% | −437,391−100.0% | Sold out |
| Longaeva Partners L.P. | 0 | $0 | 0.00% | −200,000−100.0% | Sold out |
| Fred Alger Management, LLC | 0 | $0 | 0.00% | −164,042−100.0% | Sold out |
| Tang Capital Management LLC | 0 | $0 | 0.00% | −100,000−100.0% | Sold out |
| Diadema Partners LP | 0 | $0 | 0.00% | −100,000−100.0% | Sold out |
| Dark Forest Capital Management LP | 0 | $0 | 0.00% | −86,795−100.0% | Sold out |
| Maven Securities LTD | 0 | $0 | 0.00% | −70,000−100.0% | Sold out |
| Readystate Asset Management LP | 0 | $0 | 0.00% | −59,132−100.0% | Sold out |
| Brevan Howard Capital Management LP | 0 | $0 | 0.00% | −56,667−100.0% | Sold out |
| Hennion & Walsh Asset Management, Inc. | 0 | $0 | 0.00% | −47,898−100.0% | Sold out |
| TD Asset Management Inc | 0 | $0 | 0.00% | −40,966−100.0% | Sold out |
| Monashee Investment Management LLC | 0 | $0 | 0.00% | −30,000−100.0% | Sold out |
| HSBC Holdings PLC | 0 | $0 | 0.00% | −19,369−100.0% | Sold out |
| Oxford Asset Management LLP | 0 | $0 | 0.00% | −19,120−100.0% | Sold out |
| Quantbot Technologies LP | 0 | $0 | 0.00% | −16,653−100.0% | Sold out |
| Capstone Investment Advisors, LLC | 0 | $0 | 0.00% | −10,634−100.0% | Sold out |