Amylyx Pharmaceuticals, Inc.
AMLX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001658551
In the last 90 days, Amylyx Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 206 institutions reported holding it in 13F filings for Q2 2026, worth $2.07B in total; no superinvestor holds it.
13F holders, Q2 2025
Institutional positions in Amylyx Pharmaceuticals, Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 131
- −5 vs. Q1 2025
- Shares held
- 81.7M
- +7.79M (+10.5%) vs. Q1 2025
- Total value
- $523.6M
- +$262.0M (+100.2%) vs. Q1 2025
- New holders
- 31
- 37 more added
- Sold out
- 36
- 37 more reduced
Compare with Q1 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting AMLX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 206 | $2.07B |
| Q1 2026 | 171 | $1.59B |
| Q4 2025 | 180 | $1.36B |
| Q3 2025 | 169 | $1.49B |
| Q2 2025 | 131 | $523.6M |
| Q1 2025 | 136 | $261.6M |
| Q4 2024 | 122 | $188.3M |
| Q3 2024 | 110 | $140.8M |
| Q2 2024 | 119 | $82.9M |
| Q1 2024 | 143 | $141.5M |
| Q4 2023 | 178 | $887.4M |
| Q3 2023 | 170 | $1.08B |
| Q2 2023 | 154 | $1.18B |
| Q1 2023 | 147 | $1.51B |
| Q4 2022 | 133 | $1.79B |
| Q3 2022 | 95 | $1.05B |
| Q2 2022 | 78 | $512.9M |
| Q1 2022 | 72 | $299.9M |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q2 2025
Shares, value and share of portfolio for each institution holding Amylyx Pharmaceuticals, Inc.; share changes are against Q1 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Invesco Ltd. | 586,883 | $3.76M | 0.00% | +541,189+1,184.4% | Added |
| Charles Schwab Investment Management Inc | 588,411 | $3.77M | 0.00% | +215,558+57.8% | Added |
| Deutsche Bank AG | 616,919 | $3.95M | 0.00% | +46,062+8.1% | Added |
| Schonfeld Strategic Advisors LLC | 646,443 | $4.14M | 0.03% | +529,303+451.9% | Added |
| Parkman Healthcare Partners LLC | 650,000 | $4.17M | 0.48% | +650,000 | New |
| PFM Health Sciences, LP | 732,256 | $4.69M | 0.41% | −101,879−12.2% | Reduced |
| Standard Life Aberdeen plc | 738,657 | $4.73M | 0.01% | −1,691,701−69.6% | Reduced |
| Northern Trust Corp | 820,164 | $5.26M | 0.00% | +680,832+488.6% | Added |
| State Street Corp | 1,008,909 | $6.47M | 0.00% | +747,126+285.4% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 1,154,485 | $7.40M | 0.03% | −45,206−3.8% | Reduced |
| Woodline Partners LP | 1,200,290 | $7.69M | 0.04% | −409,157−25.4% | Reduced |
| ADAR1 Capital Management, LLC | 1,205,101 | $7.72M | 1.25% | −266,486−18.1% | Reduced |
| Boxer Capital Management, LLC | 1,225,000 | $7.85M | 3.95% | −525,000−30.0% | Reduced |
| Citadel Advisors LLC | 1,242,927 | $7.97M | 0.01% | −1,514,849−54.9% | Reduced |
| UBS Group AG | 1,253,344 | $8.03M | 0.00% | −135,083−9.7% | Reduced |
| Driehaus Capital Management LLC | 1,264,997 | $8.11M | 0.06% | +1,264,997 | New |
| Goldman Sachs Group Inc | 1,297,982 | $8.32M | 0.00% | −704,979−35.2% | Reduced |
| Millennium Management LLC | 1,512,058 | $9.69M | 0.01% | −1,569,795−50.9% | Reduced |
| Geode Capital Management, LLC | 1,692,413 | $10.9M | 0.00% | +886,252+109.9% | Added |
| Great Point Partners LLC | 2,000,000 | $12.8M | 8.34% | +188,004+10.4% | Added |
| Almitas Capital LLC | 2,122,597 | $13.6M | 3.43% | 00.0% | Unchanged |
| 683 Capital Management, LLC | 2,160,000 | $13.8M | 1.40% | −251,400−10.4% | Reduced |
| Nantahala Capital Management, LLC | 2,934,405 | $18.8M | 1.33% | 00.0% | Unchanged |
| FMR LLC | 3,048,019 | $19.5M | 0.00% | +1,890,031+163.2% | Added |
| Saturn V Capital Management LLC | 3,260,570 | $20.9M | 8.47% | +834,134+34.4% | Added |
| Vanguard Group Inc | 4,498,028 | $28.8M | 0.00% | +381,516+9.3% | Added |
| Point72 Asset Management, L.P. | 4,536,266 | $29.1M | 0.07% | +3,619,300+394.7% | Added |
| BlackRock, Inc. | 5,510,189 | $35.3M | 0.00% | +3,122,780+130.8% | Added |
| TCG Crossover Management, LLC | 5,943,812 | $38.1M | 4.35% | 00.0% | Unchanged |
| Perceptive Advisors LLC | 7,902,365 | $50.7M | 1.90% | +28,017+0.4% | Added |
| Adage Capital Partners GP, L.L.C. | 8,800,000 | $56.4M | 0.10% | +3,102,395+54.5% | Added |
| Alyeska Investment Group, L.P. | 0 | $0 | 0.00% | −750,412−100.0% | Sold out |
| Walleye Capital LLC | 0 | $0 | 0.00% | −250,888−100.0% | Sold out |
| Marshall Wace, LLP | 0 | $0 | 0.00% | −247,275−100.0% | Sold out |
| Omers Administration Corp | 0 | $0 | 0.00% | −169,600−100.0% | Sold out |
| Balyasny Asset Management LLC | 0 | $0 | 0.00% | −148,559−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −127,998−100.0% | Sold out |
| Man Group plc | 0 | $0 | 0.00% | −87,352−100.0% | Sold out |
| Jacobs Levy Equity Management, Inc | 0 | $0 | 0.00% | −77,091−100.0% | Sold out |
| Jain Global LLC | 0 | $0 | 0.00% | −73,942−100.0% | Sold out |
| Alps Advisors Inc | 0 | $0 | 0.00% | −67,597−100.0% | Sold out |
| ExodusPoint Capital Management, LP | 0 | $0 | 0.00% | −59,491−100.0% | Sold out |
| Algert Global LLC | 0 | $0 | 0.00% | −57,133−100.0% | Sold out |
| Jefferies Financial Group Inc. | 0 | $0 | 0.00% | −46,200−100.0% | Sold out |
| LMR Partners LLP | 0 | $0 | 0.00% | −43,228−100.0% | Sold out |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | $0 | 0.00% | −43,200−100.0% | Sold out |
| Quantessence Capital LLC | 0 | $0 | 0.00% | −40,134−100.0% | Sold out |
| XTX Topco Ltd | 0 | $0 | 0.00% | −39,542−100.0% | Sold out |
| Cannon Global Investment Management, LLC | 0 | $0 | 0.00% | −25,500−100.0% | Sold out |
| SG Americas Securities, LLC | 0 | $0 | 0.00% | −25,210−100.0% | Sold out |
| Verition Fund Management LLC | 0 | $0 | 0.00% | −24,013−100.0% | Sold out |
| Paloma Partners Management Co | 0 | $0 | 0.00% | −22,242−100.0% | Sold out |
| Capstone Investment Advisors, LLC | 0 | $0 | 0.00% | −16,150−100.0% | Sold out |
| State of Wyoming | 0 | $0 | 0.00% | −15,920−100.0% | Sold out |
| Catalyst Funds Management Pty Ltd | 0 | $0 | 0.00% | −14,905−100.0% | Sold out |
| HSBC Holdings PLC | 0 | $0 | 0.00% | −14,419−100.0% | Sold out |
| Engineers Gate Manager LP | 0 | $0 | 0.00% | −13,382−100.0% | Sold out |
| Two Sigma Securities, LLC | 0 | $0 | 0.00% | −13,301−100.0% | Sold out |
| R Squared Ltd | 0 | $0 | 0.00% | −12,736−100.0% | Sold out |
| Brevan Howard Capital Management LP | 0 | $0 | 0.00% | −11,330−100.0% | Sold out |
| Capula Management Ltd | 0 | $0 | 0.00% | −10,980−100.0% | Sold out |
| EntryPoint Capital, LLC | 0 | $0 | 0.00% | −10,587−100.0% | Sold out |
| Hudson Bay Capital Management LP | 0 | $0 | 0.00% | −10,340−100.0% | Sold out |
| Point72 (DIFC) Ltd | 0 | $0 | 0.00% | −5,047−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −4,162−100.0% | Sold out |
| Advisors Asset Management, Inc. | 0 | $0 | 0.00% | −2,573−100.0% | Sold out |
| Coldstream Capital Management Inc | 0 | $0 | 0.00% | −238−100.0% | Sold out |