Spruce Biosciences, Inc.
SPRB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001683553
No open-market purchases or sales by Spruce Biosciences, Inc. insiders were filed in the last 90 days; 65 institutions reported holding it in 13F filings for Q2 2026, worth $116.3M in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Spruce Biosciences, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 32
- +23 vs. Q3 2025
- Shares held
- 753.9K
- −2.18M (−74.3%) vs. Q3 2025
- Total value
- $65.6M
- +$40.5M (+161.0%) vs. Q3 2025
- New holders
- 25
- 4 more added
- Sold out
- 2
- 1 more reduced
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 65 | $116.3M |
| Q1 2026 | 32 | $48.3M |
| Q4 2025 | 32 | $65.6M |
| Q3 2025 | 9 | $25.1M |
| Q2 2025 | 3 | $146.6K |
| Q1 2025 | 31 | $3.03M |
| Q4 2024 | 31 | $4.69M |
| Q3 2024 | 30 | $6.41M |
| Q2 2024 | 38 | $8.61M |
| Q1 2024 | 50 | $14.1M |
| Q4 2023 | 40 | $94.4M |
| Q3 2023 | 41 | $72.0M |
| Q2 2023 | 39 | $68.7M |
| Q1 2023 | 44 | $74.5M |
| Q4 2022 | 31 | $20.0M |
| Q3 2022 | 36 | $24.7M |
| Q2 2022 | 38 | $28.5M |
| Q1 2022 | 43 | $34.4M |
| Q4 2021 | 50 | $79.0M |
| Q3 2021 | 44 | $118.1M |
| Q2 2021 | 41 | $225.3M |
| Q1 2021 | 40 | $313.2M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Spruce Biosciences, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Tower Research Capital LLC (TRC) | 1 | $87 | 0.00% | +1 | New |
| Caldwell Sutter Capital, Inc. | 13 | $1.13K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 40 | $3.00K | 0.00% | +40 | New |
| Jones Financial Companies LLLP | 84 | $7.32K | 0.00% | +84 | New |
| Bank of America Corp | 93 | $8.10K | 0.00% | +90+3,000.0% | Added |
| Sound Income Strategies, LLC | 200 | $14.7K | 0.00% | +200 | New |
| Morgan Stanley | 388 | $33.8K | 0.00% | +290+295.9% | Added |
| Lion Point Capital, LP | 1,000 | $87.1K | 0.45% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 2,000 | $174.2K | 0.00% | +2,000 | New |
| Northern Trust Corp | 2,422 | $211.0K | 0.00% | +2,422 | New |
| SkyView Investment Advisors, LLC | 3,000 | $261.0K | 0.03% | +3,000 | New |
| Resolute Capital Asset Partners LLC | 4,000 | $348.4K | 0.17% | +4,000 | New |
| UBS Group AG | 4,902 | $427.0K | 0.00% | +4,770+3,613.6% | Added |
| State Street Corp | 6,400 | $557.5K | 0.00% | +6,400 | New |
| Superstring Capital Management LP | 12,137 | $1.06M | 0.57% | +12,137 | New |
| Geode Capital Management, LLC | 12,732 | $1.11M | 0.00% | +12,732 | New |
| BlackRock, Inc. | 16,938 | $1.48M | 0.00% | +16,938 | New |
| Vanguard Group Inc | 17,873 | $1.56M | 0.00% | +17,873 | New |
| Stonepine Capital Management, LLC | 19,742 | $1.72M | 1.36% | +19,742 | New |
| Caligan Partners LP | 20,514 | $1.79M | 0.16% | +20,514 | New |
| Quinn Opportunity Partners LLC | 22,810 | $1.99M | 0.09% | +22,810 | New |
| Schonfeld Strategic Advisors LLC | 24,767 | $2.16M | 0.01% | +24,767 | New |
| ExodusPoint Capital Management, LP | 25,271 | $2.20M | 0.02% | +25,271 | New |
| Carlyle Group Inc. | 38,620 | $3.30M | 0.02% | −2,857,898−98.7% | Reduced |
| Balyasny Asset Management LLC | 40,000 | $3.48M | 0.01% | +40,000 | New |
| Boothbay Fund Management, LLC | 47,933 | $4.18M | 0.11% | +47,933 | New |
| Alyeska Investment Group, L.P. | 51,671 | $4.50M | 0.01% | +51,671 | New |
| ADAR1 Capital Management, LLC | 58,000 | $5.05M | 0.38% | +58,000 | New |
| Wellington Management Group LLP | 58,949 | $5.14M | 0.00% | +58,949 | New |
| Citadel Advisors LLC | 69,999 | $6.10M | 0.00% | +69,999 | New |
| Squadron Capital Management LLC | 70,000 | $6.10M | 2.72% | +70,000 | New |
| Ikarian Capital, LLC | 121,356 | $10.6M | 1.37% | +108,024+810.3% | Added |
| Cable Car Capital LLC | 0 | $0 | 0.00% | −26,666−100.0% | Sold out |
| Advisor Group Holdings, Inc. | 0 | $0 | 0.00% | −133−100.0% | Sold out |