Spruce Biosciences, Inc.
SPRB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001683553
No open-market purchases or sales by Spruce Biosciences, Inc. insiders were filed in the last 90 days; 65 institutions reported holding it in 13F filings for Q2 2026, worth $116.3M in total; no superinvestor holds it.
13F holders, Q4 2021
Institutional positions in Spruce Biosciences, Inc. as of Dec 31, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 50
- +6 vs. Q3 2021
- Shares held
- 17.7M
- −1.93M (−9.8%) vs. Q3 2021
- Total value
- $79.0M
- −$39.1M (−33.1%) vs. Q3 2021
- New holders
- 16
- 14 more added
- Sold out
- 10
- 9 more reduced
Compare with Q3 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 65 | $116.3M |
| Q1 2026 | 32 | $48.3M |
| Q4 2025 | 32 | $65.6M |
| Q3 2025 | 9 | $25.1M |
| Q2 2025 | 3 | $146.6K |
| Q1 2025 | 31 | $3.03M |
| Q4 2024 | 31 | $4.69M |
| Q3 2024 | 30 | $6.41M |
| Q2 2024 | 38 | $8.61M |
| Q1 2024 | 50 | $14.1M |
| Q4 2023 | 40 | $94.4M |
| Q3 2023 | 41 | $72.0M |
| Q2 2023 | 39 | $68.7M |
| Q1 2023 | 44 | $74.5M |
| Q4 2022 | 31 | $20.0M |
| Q3 2022 | 36 | $24.7M |
| Q2 2022 | 38 | $28.5M |
| Q1 2022 | 43 | $34.4M |
| Q4 2021 | 50 | $79.0M |
| Q3 2021 | 44 | $118.1M |
| Q2 2021 | 41 | $225.3M |
| Q1 2021 | 40 | $313.2M |
Institutions, Q4 2021
Shares, value and share of portfolio for each institution holding Spruce Biosciences, Inc.; share changes are against Q3 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Ellevest, Inc. | 114 | $1.00K | 0.00% | +83+267.7% | Added |
| TCI Wealth Advisors, Inc. | 250 | $1.00K | 0.00% | +250 | New |
| Capital Advisors, Ltd. LLC | 242 | $1.00K | 0.00% | +242 | New |
| Legal & General Group Plc | 782 | $3.00K | 0.00% | 00.0% | Unchanged |
| Ameritas Investment Partners, Inc. | 584 | $3.00K | 0.00% | 00.0% | Unchanged |
| Captrust Financial Advisors | 1,477 | $7.00K | 0.00% | +1,477 | New |
| Royal Bank of Canada | 1,776 | $8.00K | 0.00% | +870+96.0% | Added |
| Citigroup Inc | 2,207 | $10.0K | 0.00% | +827+59.9% | Added |
| California State Teachers Retirement System | 3,712 | $17.0K | 0.00% | −928−20.0% | Reduced |
| American International Group, Inc. | 4,615 | $21.0K | 0.00% | −138−2.9% | Reduced |
| Tower Research Capital LLC (TRC) | 4,948 | $22.0K | 0.00% | +1,687+51.7% | Added |
| Deutsche Bank AG | 5,278 | $24.0K | 0.00% | +280+5.6% | Added |
| UBS Group AG | 5,349 | $24.0K | 0.00% | +5,349 | New |
| New York State Common Retirement Fund | 6,091 | $27.0K | 0.00% | 00.0% | Unchanged |
| Nuveen Asset Management, LLC | 11,643 | $29.0K | 0.00% | −11,375−49.4% | Reduced |
| Wells Fargo & Company | 9,475 | $43.0K | 0.00% | −1,444−13.2% | Reduced |
| Laurion Capital Management LP | 11,337 | $51.0K | 0.00% | 00.0% | Unchanged |
| Morgan Stanley | 12,391 | $55.0K | 0.00% | −63,520−83.7% | Reduced |
| Squarepoint Ops LLC | 13,593 | $61.0K | 0.00% | +13,593 | New |
| Prelude Capital Management, LLC | 16,718 | $75.0K | 0.00% | +16,718 | New |
| State Board of Administration of Florida Retirement System | 17,440 | $78.0K | 0.00% | 00.0% | Unchanged |
| Charles Schwab Investment Management Inc | 18,417 | $83.0K | 0.00% | 00.0% | Unchanged |
| Susquehanna International Group, LLP | 27,306 | $122.0K | 0.00% | +27,306 | New |
| Bank of New York Mellon Corp | 27,893 | $124.0K | 0.00% | +445+1.6% | Added |
| Two Sigma Securities, LLC | 28,691 | $128.0K | 0.02% | +28,691 | New |
| Bank of Montreal | 26,259 | $132.0K | 0.00% | +26,259 | New |
| Jane Street Group, LLC | 35,953 | $160.0K | 0.00% | +35,953 | New |
| Renaissance Technologies LLC | 39,800 | $178.0K | 0.00% | +5,800+17.1% | Added |
| Cubist Systematic Strategies, LLC | 40,589 | $181.0K | 0.00% | +40,589 | New |
| Marquette Asset Management, LLC | 40,853 | $182.0K | 0.04% | +40,853 | New |
| Parametric Portfolio Associates LLC | 64,628 | $288.0K | 0.00% | +64,628 | New |
| Acadian Asset Management LLC | 71,756 | $318.0K | 0.00% | +71,756 | New |
| Northern Trust Corp | 75,011 | $334.0K | 0.00% | +341+0.5% | Added |
| Bank of America Corp | 83,104 | $371.0K | 0.00% | +66,286+394.1% | Added |
| FMR LLC | 114,500 | $511.0K | 0.00% | −837,029−88.0% | Reduced |
| JPMorgan Chase & Co | 118,367 | $528.0K | 0.00% | −7,092−5.7% | Reduced |
| State Street Corp | 126,969 | $566.0K | 0.00% | −848−0.7% | Reduced |
| Geode Capital Management, LLC | 142,469 | $635.0K | 0.00% | +31,052+27.9% | Added |
| Bridgeway Capital Management, LLC | 209,864 | $936.0K | 0.02% | +209,864 | New |
| Goldman Sachs Group Inc | 230,801 | $1.03M | 0.00% | +217,845+1,681.4% | Added |
| Vanguard Group Inc | 372,127 | $1.66M | 0.00% | +1,277+0.3% | Added |
| BlackRock Inc. | 420,328 | $1.88M | 0.00% | −929−0.2% | Reduced |
| Sands Capital Ventures, LLC | 787,007 | $3.51M | 0.52% | 00.0% | Unchanged |
| Logos Global Management LP | 1,100,000 | $4.91M | 0.51% | +1,100,000 | New |
| Aisling Capital Management LP | 1,205,511 | $5.38M | 1.90% | 00.0% | Unchanged |
| Rock Springs Capital Management LP | 1,622,689 | $7.24M | 0.17% | +5,088+0.3% | Added |
| Citadel Advisors LLC | 1,727,101 | $7.70M | 0.01% | +26,025+1.5% | Added |
| RiverVest Venture Management LLC | 2,148,281 | $9.58M | 6.84% | 00.0% | Unchanged |
| Omega Fund Management, LLC | 2,161,022 | $9.64M | 1.36% | 00.0% | Unchanged |
| Novo Holdings A/S | 4,514,336 | $20.1M | 0.95% | 00.0% | Unchanged |
| Deerfield Management Company, L.P. (Series C) | 0 | $0 | 0.00% | −2,200,000−100.0% | Sold out |
| Sio Capital Management, LLC | 0 | $0 | 0.00% | −603,027−100.0% | Sold out |
| Granite Point Capital Management, L.P. | 0 | $0 | 0.00% | −63,614−100.0% | Sold out |
| Millennium Management LLC | 0 | $0 | 0.00% | −38,622−100.0% | Sold out |
| Two Sigma Investments, LP | 0 | $0 | 0.00% | −29,392−100.0% | Sold out |
| Alps Advisors Inc | 0 | $0 | 0.00% | −28,648−100.0% | Sold out |
| Caas Capital Management LP | 0 | $0 | 0.00% | −27,546−100.0% | Sold out |
| Jacobs Levy Equity Management, Inc | 0 | $0 | 0.00% | −24,361−100.0% | Sold out |
| Two Sigma Advisers, LP | 0 | $0 | 0.00% | −19,200−100.0% | Sold out |
| Trexquant Investment LP | 0 | $0 | 0.00% | −11,998−100.0% | Sold out |