Rhythm Pharmaceuticals, Inc.
RYTM- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001649904
In the last 90 days, Rhythm Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 305 institutions reported holding it in 13F filings for Q2 2026, worth $8.55B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Rhythm Pharmaceuticals, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 281
- +19 vs. Q3 2025
- Shares held
- 72.9M
- +2.01M (+2.8%) vs. Q3 2025
- Total value
- $7.80B
- +$602.5M (+8.4%) vs. Q3 2025
- New holders
- 58
- 107 more added
- Sold out
- 39
- 89 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting RYTM on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 305 | $8.55B |
| Q1 2026 | 285 | $6.42B |
| Q4 2025 | 281 | $7.80B |
| Q3 2025 | 264 | $7.20B |
| Q2 2025 | 227 | $4.20B |
| Q1 2025 | 228 | $3.44B |
| Q4 2024 | 203 | $3.63B |
| Q3 2024 | 176 | $3.55B |
| Q2 2024 | 165 | $2.85B |
| Q1 2024 | 167 | $2.95B |
| Q4 2023 | 169 | $3.07B |
| Q3 2023 | 144 | $1.56B |
| Q2 2023 | 116 | $1.09B |
| Q1 2023 | 126 | $1.08B |
| Q4 2022 | 115 | $1.81B |
| Q3 2022 | 101 | $1.45B |
| Q2 2022 | 90 | $190.8M |
| Q1 2022 | 111 | $562.7M |
| Q4 2021 | 98 | $483.6M |
| Q3 2021 | 97 | $626.3M |
| Q2 2021 | 105 | $905.6M |
| Q1 2021 | 124 | $1.01B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Rhythm Pharmaceuticals, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Hillsdale Investment Management Inc. | 42,300 | $4.53M | 0.12% | −300−0.7% | Reduced |
| Raymond James Financial Inc | 41,115 | $4.40M | 0.00% | −2,978−6.8% | Reduced |
| Harbor Capital Advisors, Inc. | 40,896 | $4.38M | 0.34% | +3,691+9.9% | Added |
| PFM Health Sciences, LP | 40,210 | $4.30M | 0.44% | −7,952−16.5% | Reduced |
| Kennedy Capital Management, Inc. | 39,887 | $4.27M | 0.09% | +312+0.8% | Added |
| SEI Investments Co | 37,432 | $4.01M | 0.00% | +5,774+18.2% | Added |
| State of Wisconsin Investment Board | 36,079 | $3.86M | 0.01% | −4,697−11.5% | Reduced |
| Rhenman & Partners Asset Management AB | 35,000 | $3.75M | 0.35% | 00.0% | Unchanged |
| Mirae Asset Global ETFs Holdings Ltd. | 34,901 | $3.73M | 0.01% | +7,779+28.7% | Added |
| Nicholas Investment Partners, LP | 34,710 | $3.72M | 0.27% | +34,710 | New |
| Silvercrest Asset Management Group LLC | 34,127 | $3.65M | 0.03% | +43+0.1% | Added |
| Squarepoint Ops LLC | 32,829 | $3.51M | 0.01% | +32,829 | New |
| Dimensional Fund Advisors LP | 32,018 | $3.43M | 0.00% | +3,640+12.8% | Added |
| D. E. Shaw & Co., Inc. | 31,356 | $3.36M | 0.00% | +27,771+774.6% | Added |
| Magnetar Financial LLC | 29,598 | $3.17M | 0.03% | +29,598 | New |
| EFG International AG | 29,291 | $3.14M | 0.06% | +29,291 | New |
| MetLife Investment Management | 29,174 | $3.12M | 0.02% | −1,188−3.9% | Reduced |
| Lazard Asset Management LLC | 25,571 | $2.74M | 0.00% | −4,668−15.4% | Reduced |
| Los Angeles Capital Management LLC | 24,334 | $2.72M | 0.01% | +7,613+45.5% | Added |
| Creative Planning | 25,206 | $2.70M | 0.00% | +261+1.0% | Added |
| Atom Investors LP | 22,929 | $2.45M | 0.19% | +22,929 | New |
| Penserra Capital Management LLC | 21,514 | $2.30M | 0.03% | −8,922−29.3% | Reduced |
| Intech Investment Management LLC | 21,350 | $2.29M | 0.02% | −2,962−12.2% | Reduced |
| Profund Advisors LLC | 21,046 | $2.25M | 0.07% | +8,589+68.9% | Added |
| State of New Jersey Common Pension Fund D | 19,270 | $2.06M | 0.01% | −1,649−7.9% | Reduced |
| Wedge Capital Management L L P | 19,247 | $2.06M | 0.04% | −2,997−13.5% | Reduced |
| Advisors Asset Management, Inc. | 18,524 | $1.98M | 0.03% | +4,346+30.7% | Added |
| Captrust Financial Advisors | 18,325 | $1.96M | 0.00% | +67+0.4% | Added |
| Handelsbanken Fonder AB | 17,521 | $1.88M | 0.01% | +2,000+12.9% | Added |
| Arizona State Retirement System | 15,762 | $1.69M | 0.01% | +148+0.9% | Added |
| State Board of Administration of Florida Retirement System | 14,650 | $1.57M | 0.00% | 00.0% | Unchanged |
| Police & Firemen's Retirement System of New Jersey | 14,183 | $1.52M | 0.01% | −423−2.9% | Reduced |
| Stifel Financial Corp | 13,247 | $1.42M | 0.00% | −1,208−8.4% | Reduced |
| Nisa Investment Advisors, LLC | 13,139 | $1.41M | 0.00% | −115−0.9% | Reduced |
| Citigroup Inc | 12,720 | $1.36M | 0.00% | −360−2.8% | Reduced |
| ProShare Advisors LLC | 12,622 | $1.35M | 0.00% | +1,323+11.7% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 12,435 | $1.33M | 0.00% | +1,709+15.9% | Added |
| Guggenheim Capital LLC | 12,401 | $1.33M | 0.01% | +10,116+442.7% | Added |
| STRS Ohio | 12,000 | $1.28M | 0.00% | −2,800−18.9% | Reduced |
| KLP Kapitalforvaltning AS | 12,000 | $1.28M | 0.00% | +1,000+9.1% | Added |
| Rockefeller Capital Management L.P. | 11,771 | $1.26M | 0.00% | +2,903+32.7% | Added |
| SG Americas Securities, LLC | 11,741 | $1.26M | 0.00% | −7,813−40.0% | Reduced |
| DnB Asset Management AS | 11,163 | $1.19M | 0.00% | +5,635+101.9% | Added |
| Hennion & Walsh Asset Management, Inc. | 10,908 | $1.17M | 0.04% | −33,823−75.6% | Reduced |
| China Universal Asset Management Co., Ltd. | 10,875 | $1.16M | 0.09% | −767−6.6% | Reduced |
| XTX Topco Ltd | 10,433 | $1.12M | 0.03% | +10,433 | New |
| Knights of Columbus Asset Advisors LLC | 10,314 | $1.10M | 0.06% | +10,314 | New |
| Toth Financial Advisory Corp | 10,000 | $1.07M | 0.12% | 00.0% | Unchanged |
| Cannon Financial Strategists, Inc. | 10,000 | $1.07M | 0.15% | 00.0% | Unchanged |
| Man Group plc | 9,558 | $1.02M | 0.00% | −119,772−92.6% | Reduced |
| Fred Alger Management, LLC | 9,301 | $995.6K | 0.00% | −3,034−24.6% | Reduced |
| Virginia Retirement Systems Et Al | 9,200 | $984.8K | 0.01% | +2,500+37.3% | Added |
| Headlands Technologies LLC | 8,632 | $924.0K | 0.08% | +8,632 | New |
| Teacher Retirement System of Texas | 8,359 | $894.7K | 0.00% | −4,601−35.5% | Reduced |
| Allianz Asset Management GmbH | 8,000 | $856.3K | 0.00% | −4,100−33.9% | Reduced |
| Bellevue Group AG | 7,504 | $803.2K | 0.02% | −1,549−17.1% | Reduced |
| Leo Wealth, LLC | 6,952 | $744.1K | 0.05% | −915−11.6% | Reduced |
| Jump Financial, LLC | 6,759 | $723.5K | 0.01% | +6,759 | New |
| E. Ohman J:or Asset Management AB | 6,589 | $705.3K | 0.02% | −1,624−19.8% | Reduced |
| Principal Financial Group Inc | 6,198 | $663.4K | 0.00% | −6,400−50.8% | Reduced |
| Acadian Asset Management LLC | 6,105 | $652.0K | 0.00% | +6,105 | New |
| Exchange Traded Concepts, LLC | 6,080 | $650.8K | 0.01% | −306−4.8% | Reduced |
| Virtus Investment Advisers, Inc. | 6,017 | $644.1K | 0.18% | −1,035−14.7% | Reduced |
| Great West Life Assurance Co | 5,797 | $621.0K | 0.00% | −8,598−59.7% | Reduced |
| Legato Capital Management LLC | 5,723 | $612.6K | 0.05% | +5,723 | New |
| Jasper Ridge Partners, L.P. | 5,639 | $603.6K | 0.01% | 00.0% | Unchanged |
| Quantedge Capital Pte Ltd | 5,600 | $599.4K | 0.29% | −12,200−68.5% | Reduced |
| Public Employees Retirement Association of Colorado | 5,463 | $585.0K | 0.00% | 00.0% | Unchanged |
| LPL Financial LLC | 5,427 | $580.9K | 0.00% | +1,437+36.0% | Added |
| AlphaCentric Advisors LLC | 5,052 | $540.8K | 0.54% | +5,052 | New |
| Voleon Capital Management LP | 5,025 | $537.9K | 0.01% | −21,872−81.3% | Reduced |
| Two Sigma Securities, LLC | 4,943 | $529.1K | 0.07% | +4,943 | New |
| Gotham Asset Management, LLC | 4,851 | $519.3K | 0.00% | −4−0.1% | Reduced |
| PSP Research LLC | 4,738 | $507.2K | 0.44% | +4,738 | New |
| The PNC Financial Services Group, Inc. | 4,659 | $498.7K | 0.00% | +442+10.5% | Added |
| Caption Management, LLC | 4,614 | $493.9K | 0.02% | +4,614 | New |
| Vestmark Advisory Solutions, Inc. | 4,560 | $488.1K | 0.01% | +4,560 | New |
| Verition Fund Management LLC | 4,504 | $482.1K | 0.00% | +4,504 | New |
| Mackenzie Financial Corp | 4,398 | $468.6K | 0.00% | 00.0% | Unchanged |
| Ameritas Investment Partners, Inc. | 4,365 | $467.2K | 0.01% | 00.0% | Unchanged |
| Xponance, Inc. | 4,269 | $457.0K | 0.00% | +107+2.6% | Added |
| Empowered Funds, LLC | 4,164 | $445.7K | 0.01% | +2,019+94.1% | Added |
| Susquehanna International Group, LLP | 4,097 | $438.5K | 0.00% | +993+32.0% | Added |
| Comerica Bank | 4,014 | $429.6K | 0.00% | −205,311−98.1% | Reduced |
| Ensign Peak Advisors, Inc | 3,859 | $413.1K | 0.00% | −107,685−96.5% | Reduced |
| Quantinno Capital Management LP | 3,831 | $410.1K | 0.00% | +1,273+49.8% | Added |
| Freestone Capital Holdings, LLC | 3,700 | $396.0K | 0.01% | 00.0% | Unchanged |
| Cerity Partners LLC | 3,664 | $392.2K | 0.00% | +700+23.6% | Added |
| O'Shaughnessy Asset Management, LLC | 3,580 | $383.2K | 0.00% | −1,256−26.0% | Reduced |
| Nelson, Van Denburg & Campbell Wealth Management Group, LLC | 3,572 | $382.3K | 0.01% | +31+0.9% | Added |
| CIBC World Markets Corp | 3,502 | $374.9K | 0.00% | +3,502 | New |
| Toroso Investments, LLC | 3,336 | $357.1K | 0.00% | +672+25.2% | Added |
| Keybank National Association | 3,271 | $350.1K | 0.00% | +3,271 | New |
| Mirae Asset Global Investments Co., Ltd. | 3,243 | $347.1K | 0.00% | +675+26.3% | Added |
| Cinctive Capital Management LP | 3,225 | $345.2K | 0.02% | −31,931−90.8% | Reduced |
| Yorktown Management & Research Co Inc | 3,050 | $326.5K | 0.26% | +3,050 | New |
| Cim Investment Mangement Inc | 2,993 | $320.4K | 0.08% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 2,962 | $317.1K | 0.01% | +1,209+69.0% | Added |
| Two Sigma Advisers, LP | 2,900 | $310.4K | 0.00% | −400−12.1% | Reduced |
| Blueshift Asset Management, LLC | 2,881 | $308.4K | 0.09% | +2,881 | New |