Rhythm Pharmaceuticals, Inc.
RYTM- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001649904
In the last 90 days, Rhythm Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 305 institutions reported holding it in 13F filings for Q2 2026, worth $8.55B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Rhythm Pharmaceuticals, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 281
- +19 vs. Q3 2025
- Shares held
- 72.9M
- +2.01M (+2.8%) vs. Q3 2025
- Total value
- $7.80B
- +$602.5M (+8.4%) vs. Q3 2025
- New holders
- 58
- 107 more added
- Sold out
- 39
- 89 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting RYTM on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 305 | $8.55B |
| Q1 2026 | 285 | $6.42B |
| Q4 2025 | 281 | $7.80B |
| Q3 2025 | 264 | $7.20B |
| Q2 2025 | 227 | $4.20B |
| Q1 2025 | 228 | $3.44B |
| Q4 2024 | 203 | $3.63B |
| Q3 2024 | 176 | $3.55B |
| Q2 2024 | 165 | $2.85B |
| Q1 2024 | 167 | $2.95B |
| Q4 2023 | 169 | $3.07B |
| Q3 2023 | 144 | $1.56B |
| Q2 2023 | 116 | $1.09B |
| Q1 2023 | 126 | $1.08B |
| Q4 2022 | 115 | $1.81B |
| Q3 2022 | 101 | $1.45B |
| Q2 2022 | 90 | $190.8M |
| Q1 2022 | 111 | $562.7M |
| Q4 2021 | 98 | $483.6M |
| Q3 2021 | 97 | $626.3M |
| Q2 2021 | 105 | $905.6M |
| Q1 2021 | 124 | $1.01B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Rhythm Pharmaceuticals, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| JGP Global Gestao de Recursos Ltda. | 2,866 | $306.8K | 0.18% | −387−11.9% | Reduced |
| CIBC Asset Management Inc | 2,848 | $304.9K | 0.00% | +2,848 | New |
| CWM, LLC | 2,767 | $296.0K | 0.00% | −125−4.3% | Reduced |
| Swiss Life Asset Management Ltd | 2,653 | $284.0K | 0.00% | +192+7.8% | Added |
| Chicago Partners Investment Group LLC | 2,739 | $281.8K | 0.01% | +284+11.6% | Added |
| AlphaGrep UK Ltd | 2,509 | $268.6K | 0.09% | +2,509 | New |
| Entropy Technologies, LP | 2,492 | $266.7K | 0.01% | −6,010−70.7% | Reduced |
| State of Wyoming | 2,441 | $261.3K | 0.03% | +1,487+155.9% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 2,415 | $259.0K | 0.00% | +1,918+385.9% | Added |
| Centaurus Financial, Inc. | 2,389 | $256.0K | 0.01% | 00.0% | Unchanged |
| JustInvest LLC | 2,379 | $254.6K | 0.00% | +311+15.0% | Added |
| Abel Hall, LLC | 2,140 | $229.1K | 0.05% | +2,140 | New |
| M&T Bank Corp | 2,101 | $224.9K | 0.00% | +2,101 | New |
| Cambria Investment Management, L.P. | 1,997 | $213.8K | 0.01% | +1,997 | New |
| ZRC Wealth Management, LLC | 1,971 | $211.0K | 0.07% | 00.0% | Unchanged |
| Jane Street Group, LLC | 1,960 | $209.8K | 0.00% | −1,008−34.0% | Reduced |
| KBC Group NV | 1,707 | $183.0K | 0.00% | 00.0% | Unchanged |
| Whittier Trust Co | 1,811 | $180.1K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 1,676 | $180.0K | 0.00% | −124,110−98.7% | Reduced |
| Amalgamated Bank | 1,663 | $178.0K | 0.00% | −30−1.8% | Reduced |
| Quest Partners LLC | 1,508 | $161.4K | 0.01% | +117+8.4% | Added |
| Persistent Asset Partners Ltd | 1,446 | $154.8K | 0.07% | +1,446 | New |
| GF Fund Management Co. Ltd. | 1,310 | $140.2K | 0.00% | −119−8.3% | Reduced |
| Clearstead Advisors, LLC | 1,246 | $133.4K | 0.00% | +847+212.3% | Added |
| Danske Bank A/S | 1,100 | $117.7K | 0.00% | +1,100 | New |
| Advisor Group Holdings, Inc. | 1,039 | $111.2K | 0.00% | +59+6.0% | Added |
| US Bancorp | 953 | $102.0K | 0.00% | +807+552.7% | Added |
| Global Retirement Partners, LLC | 857 | $91.7K | 0.00% | +457+114.3% | Added |
| CFG Wealth Management Services, Inc. | 800 | $85.6K | 0.08% | +800 | New |
| Farther Finance Advisors, LLC | 642 | $68.7K | 0.00% | +291+82.9% | Added |
| Covestor Ltd | 579 | $62.0K | 0.03% | +444+328.9% | Added |
| Smartleaf Asset Management LLC | 399 | $42.6K | 0.00% | +113+39.5% | Added |
| SRS Capital Advisors, Inc. | 381 | $40.8K | 0.00% | −400−51.2% | Reduced |
| GAMMA Investing LLC | 361 | $38.6K | 0.00% | +118+48.6% | Added |
| Sterling Capital Management LLC | 344 | $36.8K | 0.00% | +217+170.9% | Added |
| SBI Securities Co., Ltd. | 343 | $36.7K | 0.00% | +145+73.2% | Added |
| EverSource Wealth Advisors, LLC | 266 | $28.5K | 0.00% | +200+303.0% | Added |
| Signaturefd, LLC | 232 | $24.8K | 0.00% | 00.0% | Unchanged |
| Jones Financial Companies LLLP | 231 | $24.7K | 0.00% | −3−1.3% | Reduced |
| Essential Partners LLC | 223 | $23.9K | 0.01% | +25+12.6% | Added |
| Kemnay Advisory Services Inc. | 207 | $22.2K | 0.00% | +207 | New |
| Daiwa Securities Group Inc. | 201 | $22.0K | 0.00% | −12−5.6% | Reduced |
| True Wealth Design, LLC | 147 | $15.7K | 0.00% | 00.0% | Unchanged |
| Truvestments Capital LLC | 138 | $14.8K | 0.00% | 00.0% | Unchanged |
| AdvisorNet Financial, Inc | 137 | $14.7K | 0.00% | +32+30.5% | Added |
| Bayforest Capital Ltd | 134 | $14.3K | 0.01% | −1,037−88.6% | Reduced |
| Basecamp Wealth Advisors LLC | 125 | $13.4K | 0.00% | +125 | New |
| Allworth Financial LP | 109 | $11.7K | 0.00% | −22−16.8% | Reduced |
| Optiver Holding B.V. | 92 | $9.85K | 0.00% | −273−74.8% | Reduced |
| Rothschild Investment LLC | 91 | $9.74K | 0.00% | +6+7.1% | Added |
| Larson Financial Group LLC | 77 | $8.24K | 0.00% | +49+175.0% | Added |
| Quarry LP | 77 | $8.24K | 0.00% | +77 | New |
| Bessemer Group Inc | 66 | $7.00K | 0.00% | 00.0% | Unchanged |
| WPG Advisers, LLC | 60 | $6.42K | 0.00% | +3+5.3% | Added |
| Harbour Investments, Inc. | 60 | $6.42K | 0.00% | +60 | New |
| Eastern Bank | 59 | $6.32K | 0.00% | +59 | New |
| Root Financial Partners, LLC | 43 | $4.60K | 0.00% | +43 | New |
| ORG Partners LLC | 37 | $3.96K | 0.00% | +5+15.6% | Added |
| Versant Capital Management, Inc | 36 | $3.85K | 0.00% | 00.0% | Unchanged |
| IFP Advisors, Inc | 36 | $3.85K | 0.00% | +17+89.5% | Added |
| Parkside Financial Bank & Trust | 33 | $3.53K | 0.00% | 00.0% | Unchanged |
| SageView Advisory Group, LLC | 30 | $3.21K | 0.00% | +30 | New |
| First Horizon Corp | 30 | $3.21K | 0.00% | +30 | New |
| Parallel Advisors, LLC | 25 | $2.68K | 0.00% | 00.0% | Unchanged |
| Bare Financial Services, Inc | 22 | $2.35K | 0.00% | +4+22.2% | Added |
| UMA Financial Services, Inc. | 16 | $1.71K | 0.00% | 00.0% | Unchanged |
| Rakuten Securities, Inc. | 15 | $1.61K | 0.00% | +15 | New |
| CVA Family Office, LLC | 12 | $1.28K | 0.00% | 00.0% | Unchanged |
| JFS Wealth Advisors, LLC | 10 | $1.07K | 0.00% | +10 | New |
| Keating Financial Advisory Services, Inc. | 9 | $963 | 0.00% | +9 | New |
| Toronto Dominion Bank | 6 | $642 | 0.00% | +6 | New |
| Fortitude Family Office, LLC | 6 | $642 | 0.00% | +6 | New |
| DiNuzzo Private Wealth, Inc. | 3 | $322 | 0.00% | +3 | New |
| MAI Capital Management | 2 | $215 | 0.00% | −1,855−99.9% | Reduced |
| SJS Investment Consulting Inc. | 2 | $215 | 0.00% | +2 | New |
| HFM Investment Advisors, LLC | 2 | $215 | 0.00% | +2 | New |
| Rialto Wealth Management, LLC | 1 | $108 | 0.00% | +1 | New |
| TD Private Client Wealth LLC | 1 | $107 | 0.00% | +1 | New |
| Bay Harbor Wealth Management, LLC | 1 | $107 | 0.00% | +1 | New |
| Dunhill Financial, LLC | 1 | $65 | 0.00% | +1 | New |
| Avion Wealth | 4 | $0 | 0.00% | +4 | New |
| Alkeon Capital Management LLC | 0 | $0 | 0.00% | −1,017,700−100.0% | Sold out |
| Assenagon Asset Management S.A. | 0 | $0 | 0.00% | −224,128−100.0% | Sold out |
| Marshall Wace, LLP | 0 | $0 | 0.00% | −171,834−100.0% | Sold out |
| Panagora Asset Management Inc | 0 | $0 | 0.00% | −64,614−100.0% | Sold out |
| Walleye Capital LLC | 0 | $0 | 0.00% | −50,181−100.0% | Sold out |
| Aquatic Capital Management LLC | 0 | $0 | 0.00% | −42,490−100.0% | Sold out |
| Trexquant Investment LP | 0 | $0 | 0.00% | −37,161−100.0% | Sold out |
| Canada Pension Plan Investment Board | 0 | $0 | 0.00% | −37,000−100.0% | Sold out |
| Jain Global LLC | 0 | $0 | 0.00% | −35,110−100.0% | Sold out |
| Alps Advisors Inc | 0 | $0 | 0.00% | −33,000−100.0% | Sold out |
| Samsara BioCapital, LLC | 0 | $0 | 0.00% | −30,285−100.0% | Sold out |
| Dark Forest Capital Management LP | 0 | $0 | 0.00% | −28,639−100.0% | Sold out |
| Standard Life Aberdeen plc | 0 | $0 | 0.00% | −26,740−100.0% | Sold out |
| Burkehill Global Management, LP | 0 | $0 | 0.00% | −20,000−100.0% | Sold out |
| Schroder Investment Management Group | 0 | $0 | 0.00% | −18,042−100.0% | Sold out |
| Engineers Gate Manager LP | 0 | $0 | 0.00% | −13,775−100.0% | Sold out |
| Fiduciary Trust Co | 0 | $0 | 0.00% | −10,000−100.0% | Sold out |
| Readystate Asset Management LP | 0 | $0 | 0.00% | −8,365−100.0% | Sold out |
| Aigen Investment Management, LP | 0 | $0 | 0.00% | −8,225−100.0% | Sold out |