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Rhythm Pharmaceuticals, Inc.

RYTM
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001649904

In the last 90 days, Rhythm Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 304 institutions reported holding it in 13F filings for Q2 2026, worth $8.55B in total; Duquesne Family Office is the only superinvestor holding it.

13F holders, Q1 2023

Institutional positions in Rhythm Pharmaceuticals, Inc. as of Mar 31, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
126
+11 vs. Q4 2022
Shares held
60.3M
−1.98M (−3.2%) vs. Q4 2022
Total value
$1.08B
−$738.2M (−40.7%) vs. Q4 2022
New holders
29
46 more added
Sold out
18
24 more reduced

Compare with Q4 2022: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting RYTM on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ1 2023: 126 institutions
Q1 2021: 124 institutionsQ2 2021: 105 institutionsQ3 2021: 97 institutionsQ4 2021: 98 institutionsQ1 2022: 111 institutionsQ2 2022: 90 institutionsQ3 2022: 101 institutionsQ4 2022: 115 institutionsQ1 2023: 126 institutionsQ2 2023: 116 institutionsQ3 2023: 144 institutionsQ4 2023: 169 institutionsQ1 2024: 167 institutionsQ2 2024: 165 institutionsQ3 2024: 176 institutionsQ4 2024: 203 institutionsQ1 2025: 228 institutionsQ2 2025: 227 institutionsQ3 2025: 264 institutionsQ4 2025: 281 institutionsQ1 2026: 285 institutionsQ2 2026: 304 institutions
Value heldQ1 2023: $1.08B
Q1 2021: $1.01BQ2 2021: $905.6MQ3 2021: $626.3MQ4 2021: $483.6MQ1 2022: $562.7MQ2 2022: $190.8MQ3 2022: $1.45BQ4 2022: $1.81BQ1 2023: $1.08BQ2 2023: $1.09BQ3 2023: $1.56BQ4 2023: $3.07BQ1 2024: $2.95BQ2 2024: $2.85BQ3 2024: $3.55BQ4 2024: $3.63BQ1 2025: $3.44BQ2 2025: $4.20BQ3 2025: $7.20BQ4 2025: $7.80BQ1 2026: $6.42BQ2 2026: $8.55B
Institutions holding RYTM and their total value by quarter
QuarterHoldersValue
Q2 2026304$8.55B
Q1 2026285$6.42B
Q4 2025281$7.80B
Q3 2025264$7.20B
Q2 2025227$4.20B
Q1 2025228$3.44B
Q4 2024203$3.63B
Q3 2024176$3.55B
Q2 2024165$2.85B
Q1 2024167$2.95B
Q4 2023169$3.07B
Q3 2023144$1.56B
Q2 2023116$1.09B
Q1 2023126$1.08B
Q4 2022115$1.81B
Q3 2022101$1.45B
Q2 202290$190.8M
Q1 2022111$562.7M
Q4 202198$483.6M
Q3 202197$626.3M
Q2 2021105$905.6M
Q1 2021124$1.01B

Institutions, Q1 2023

Shares, value and share of portfolio for each institution holding Rhythm Pharmaceuticals, Inc.; share changes are against Q4 2022.

Institutions holding RYTM in Q1 2023
InstitutionSharesValue% of portfolioChange in sharesAction
Primecap Management Co7,607,311$135.7M0.12%+696,169+10.1%Added
Baker Bros. Advisors LP6,498,267$115.9M0.63%+143,659+2.3%Added
Ra Capital Management, L.P.5,516,067$98.4M2.23%00.0%Unchanged
Goldman Sachs Group Inc5,310,703$94.7M0.03%+108,911+2.1%Added
Federated Hermes, Inc.3,891,683$69.4M0.17%−2,412,799−38.3%Reduced
BlackRock Inc.3,780,599$67.4M0.00%+56,885+1.5%Added
NEA Management Company, LLC2,909,956$51.9M3.59%−2,000,000−40.7%Reduced
Vanguard Group Inc2,648,136$47.2M0.00%+51,822+2.0%Added
State Street Corp2,612,188$46.6M0.00%−568,510−17.9%Reduced
Frazier Life Sciences Management, L.P.2,164,739$38.6M2.80%+270,739+14.3%Added
Alkeon Capital Management LLC2,015,966$36.0M0.23%−222,296−9.9%Reduced
Polar Capital Holdings Plc1,750,000$31.2M0.23%+500,000+40.0%Added
Rock Springs Capital Management LP1,597,123$28.5M0.68%−163,742−9.3%Reduced
Janus Henderson Group PLC1,097,573$19.6M0.01%−142,580−11.5%Reduced
Susquehanna International Group, LLP784,555$14.0M0.02%+90,513+13.0%Added
Opaleye Management Inc.735,000$13.1M3.93%00.0%Unchanged
FMR LLC698,824$12.5M0.00%−74,204−9.6%Reduced
Assenagon Asset Management S.A.664,026$11.8M0.05%+200,510+43.3%Added
Millennium Management LLC546,906$9.76M0.01%+504,608+1,193.0%Added
Geode Capital Management, LLC472,761$8.43M0.00%+14,251+3.1%Added
Citadel Advisors LLC365,040$6.51M0.01%+294,342+416.3%Added
Bank of America Corp359,666$6.42M0.00%+93,513+35.1%Added
Jane Street Group, LLC349,639$6.24M0.01%+150,136+75.3%Added
Samsara BioCapital, LLC345,293$6.16M1.27%00.0%Unchanged
Citigroup Inc339,955$6.06M0.01%+64,394+23.4%Added
Qube Research & Technologies Ltd291,314$5.20M0.03%+110,757+61.3%Added
Cubist Systematic Strategies, LLC278,758$4.97M0.05%+262,250+1,588.6%Added
D. E. Shaw & Co., Inc.278,203$4.96M0.01%−77,327−21.7%Reduced
Rafferty Asset Management, LLC255,210$4.55M0.03%−50,803−16.6%Reduced
Charles Schwab Investment Management Inc228,037$4.07M0.00%−1,879−0.8%Reduced
HRT Financial LP218,445$3.90M0.05%+218,445New
Morgan Stanley216,621$3.86M0.00%−27,064−11.1%Reduced
UBS Asset Management Americas Inc206,035$3.68M0.00%+163,838+388.3%Added
Voloridge Investment Management, LLC193,590$3.45M0.02%−1,406−0.7%Reduced
Price T Rowe Associates Inc171,580$3.06M0.00%+157,380+1,108.3%Added
Rice Hall James & Associates, LLC153,786$2.74M0.16%+584+0.4%Added
Northern Trust Corp142,137$2.54M0.00%+4,036+2.9%Added
Walleye Capital LLC137,769$2.46M0.05%+137,769New
Dimensional Fund Advisors LP124,509$2.22M0.00%−12,482−9.1%Reduced
Wellington Management Group LLP111,633$1.99M0.00%+4,717+4.4%Added
Squarepoint Ops LLC105,975$1.89M0.01%+40,837+62.7%Added
Great Point Partners LLC97,544$1.74M0.34%+97,544New
Swiss National Bank97,300$1.74M0.00%−600−0.6%Reduced
Marshall Wace, LLP93,846$1.67M0.00%+72,563+340.9%Added
Kynam Capital Management, LP92,602$1.65M0.21%+92,602New
Barclays PLC87,118$1.55M0.00%−95,481−52.3%Reduced
BNP Paribas Arbitrage, SA87,042$1.55M0.00%+34,158+64.6%Added
UBS Group AG84,077$1.50M0.00%−107,188−56.0%Reduced
Verition Fund Management LLC77,228$1.38M0.02%+77,228New
Voya Investment Management LLC63,595$1.13M0.00%00.0%Unchanged
Hennion & Walsh Asset Management, Inc.57,335$1.02M0.06%−1,963−3.3%Reduced
UBS Oconnor LLC56,050$999.9K0.02%+56,050New
Credit Suisse AG55,291$986.4K0.00%+7,879+16.6%Added
Stratos Wealth Partners, LTD.54,084$964.9K0.03%−19,236−26.2%Reduced
ExodusPoint Capital Management, LP53,658$957.0K0.01%+53,658New
California State Teachers Retirement System52,422$935.2K0.00%+17,116+48.5%Added
Wells Fargo & Company50,803$906.3K0.00%+44,060+653.4%Added
Nuveen Asset Management, LLC49,404$881.0K0.00%+1,913+4.0%Added
Profund Advisors LLC46,375$827.3K0.05%+46,375New
LMR Partners LLP43,114$769.2K0.02%+18,070+72.2%Added
Twinbeech Capital LP42,130$751.6K0.02%+42,130New
State of Wisconsin Investment Board41,611$742.3K0.00%+853+2.1%Added
Fox Run Management, L.L.C.37,950$677.0K0.22%+37,950New
Alps Advisors Inc37,388$667.0K0.01%−810−2.1%Reduced
HighVista Strategies LLC35,478$632.9K0.52%00.0%Unchanged
Jupiter Asset Management Ltd34,899$622.6K0.01%+1,539+4.6%Added
Nan Fung Group Holdings Ltd32,520$580.2K0.39%00.0%Unchanged
Landscape Capital Management, L.L.C.30,810$549.6K0.07%+3,678+13.6%Added
Mirabella Financial Services LLP29,500$526.3K0.11%+18,011+156.8%Added
DekaBank Deutsche Girozentrale30,000$525.0K0.00%00.0%Unchanged
Utah Retirement Systems28,197$503.0K0.01%+28,197New
Bank of New York Mellon Corp26,726$476.8K0.00%−5,557−17.2%Reduced
Tudor Investment Corp Et Al25,874$462.0K0.01%+25,874New
Driehaus Capital Management LLC22,993$410.2K0.01%00.0%Unchanged
JPMorgan Chase & Co22,285$398.0K0.00%+2,644+13.5%Added
Stifel Financial Corp21,490$383.4K0.00%+2,110+10.9%Added
Diametric Capital, LP20,880$372.5K0.18%+20,880New
Fiduciary Trust Co20,000$356.8K0.01%00.0%Unchanged
Parkwood LLC19,147$342.0K0.06%+1,601+9.1%Added
Ameriprise Financial Inc18,140$323.6K0.00%00.0%Unchanged
Tower Research Capital LLC (TRC)17,213$307.0K0.01%+3,463+25.2%Added
Legal & General Group Plc17,119$305.4K0.00%+2,323+15.7%Added
Balyasny Asset Management LLC16,313$291.0K0.00%+15,547+2,029.6%Added
E Fund Management Co., Ltd.14,484$258.0K0.02%−1,572−9.8%Reduced
ClariVest Asset Management LLC14,360$256.0K0.01%−2,140−13.0%Reduced
STRS Ohio14,099$251.0K0.00%+14,099New
Teacher Retirement System of Texas13,887$248.0K0.00%+1,853+15.4%Added
Schonfeld Strategic Advisors LLC13,311$237.5K0.00%−107,378−89.0%Reduced
Arizona State Retirement System13,061$233.0K0.00%+1,612+14.1%Added
Point72 Asset Management, L.P.11,955$213.3K0.00%+11,955New
Allianz Asset Management GmbH11,900$212.3K0.00%00.0%Unchanged
Jump Financial, LLC11,618$207.3K0.01%+11,618New
Ergoteles LLC11,563$206.3K0.01%+11,563New
Mirae Asset Global Investments Co., Ltd.11,056$197.2K0.00%+11,056New
Jefferies Financial Group Inc.10,773$192.2K0.00%+10,773New
Boulder Hill Capital Management LP10,600$189.1K0.15%+10,600New
Virtus ETF Advisers LLC10,404$185.6K0.10%+183+1.8%Added
Point72 Middle East FZE10,339$184.4K0.01%+10,339New
Zurcher Kantonalbank (Zurich Cantonalbank)9,108$162.5K0.00%+2,229+32.4%Added
Public Employees Retirement Association of Colorado7,985$142.0K0.00%+7,985New