Rhythm Pharmaceuticals, Inc.
RYTM- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001649904
In the last 90 days, Rhythm Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 304 institutions reported holding it in 13F filings for Q2 2026, worth $8.55B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q1 2026
Institutional positions in Rhythm Pharmaceuticals, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 285
- +10 vs. Q4 2025
- Shares held
- 73.6M
- +6.99M (+10.5%) vs. Q4 2025
- Total value
- $6.42B
- −$704.3M (−9.9%) vs. Q4 2025
- New holders
- 63
- 102 more added
- Sold out
- 53
- 89 more reduced
6 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting RYTM on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 304 | $8.55B |
| Q1 2026 | 285 | $6.42B |
| Q4 2025 | 281 | $7.80B |
| Q3 2025 | 264 | $7.20B |
| Q2 2025 | 227 | $4.20B |
| Q1 2025 | 228 | $3.44B |
| Q4 2024 | 203 | $3.63B |
| Q3 2024 | 176 | $3.55B |
| Q2 2024 | 165 | $2.85B |
| Q1 2024 | 167 | $2.95B |
| Q4 2023 | 169 | $3.07B |
| Q3 2023 | 144 | $1.56B |
| Q2 2023 | 116 | $1.09B |
| Q1 2023 | 126 | $1.08B |
| Q4 2022 | 115 | $1.81B |
| Q3 2022 | 101 | $1.45B |
| Q2 2022 | 90 | $190.8M |
| Q1 2022 | 111 | $562.7M |
| Q4 2021 | 98 | $483.6M |
| Q3 2021 | 97 | $626.3M |
| Q2 2021 | 105 | $905.6M |
| Q1 2021 | 124 | $1.01B |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Rhythm Pharmaceuticals, Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Ra Capital Management, L.P. | 6,666,837 | $579.8M | 6.14% | 00.0% | Unchanged |
| BlackRock, Inc. | 6,237,151 | $542.4M | 0.01% | −60,183−1.0% | Reduced |
| Baker Bros. Advisors LP | 5,604,483 | $487.4M | 2.80% | 00.0% | Unchanged |
| Primecap Management Co | 3,417,509 | $297.2M | 0.23% | −61,160−1.8% | Reduced |
| Vanguard Portfolio Management LLC | 3,040,718 | $264.5M | 0.01% | +3,040,718 | New |
| Vanguard Capital Management LLC | 2,967,825 | $258.1M | 0.01% | +2,967,825 | New |
| Perceptive Advisors LLC | 2,373,795 | $206.4M | 4.08% | −172,596−6.8% | Reduced |
| State Street Corp | 2,271,851 | $197.6M | 0.01% | +73,236+3.3% | Added |
| Goldman Sachs Group Inc | 1,965,432 | $170.9M | 0.02% | +134,566+7.3% | Added |
| Westfield Capital Management Co LP | 1,929,123 | $167.8M | 0.70% | +661,965+52.2% | Added |
| FMR LLC | 1,689,671 | $147.0M | 0.01% | −16,646−1.0% | Reduced |
| Price T Rowe Associates Inc | 1,654,876 | $143.9M | 0.02% | +94,029+6.0% | Added |
| Polar Capital Holdings Plc | 1,615,586 | $140.5M | 0.61% | +430,194+36.3% | Added |
| Citadel Advisors LLC | 1,418,619 | $123.4M | 0.09% | +1,265,297+825.3% | Added |
| Geode Capital Management, LLC | 1,416,269 | $123.2M | 0.01% | +40,540+2.9% | Added |
| JPMorgan Chase & Co | 1,553,644 | $120.0M | 0.01% | +129,655+9.1% | Added |
| Federated Hermes, Inc. | 1,286,303 | $111.9M | 0.18% | −337,538−20.8% | Reduced |
| Checkpoint Capital L.P. | 1,227,200 | $106.7M | 38.30% | +235,000+23.7% | Added |
| Alliancebernstein L.P. | 910,413 | $97.5M | 0.03% | −19,820−2.1% | Reduced |
| Capital Research Global Investors | 1,115,460 | $97.0M | 0.02% | +130,374+13.2% | Added |
| Janus Henderson Group PLC | 918,153 | $79.9M | 0.04% | −207,972−18.5% | Reduced |
| Point72 Asset Management, L.P. | 846,801 | $73.6M | 0.13% | +417,381+97.2% | Added |
| Woodline Partners LP | 758,891 | $66.0M | 0.25% | +70,112+10.2% | Added |
| Adage Capital Partners GP, L.L.C. | 725,744 | $63.1M | 0.10% | +104,159+16.8% | Added |
| Siren, L.L.C. | 725,511 | $63.1M | 1.75% | +225,536+45.1% | Added |
| Morgan Stanley | 703,978 | $61.2M | 0.00% | +52,576+8.1% | Added |
| Rock Springs Capital Management LP | 689,748 | $60.0M | 3.54% | −5,262−0.8% | Reduced |
| Pictet Asset Management Holding SA | 667,046 | $57.3M | 0.06% | +52,383+8.5% | Added |
| Bank of America Corp | 628,667 | $54.7M | 0.00% | +404,183+180.0% | Added |
| Franklin Resources Inc | 626,845 | $54.5M | 0.01% | −68,890−9.9% | Reduced |
| Clearbridge Investments, LLC | 609,437 | $53.0M | 0.05% | +103,328+20.4% | Added |
| Integral Health Asset Management, LLC | 600,000 | $52.2M | 2.76% | +125,000+26.3% | Added |
| UBS Asset Management Americas Inc | 541,450 | $47.1M | 0.01% | −7,570−1.4% | Reduced |
| Charles Schwab Investment Management Inc | 526,459 | $45.8M | 0.01% | −5,988−1.1% | Reduced |
| Northern Trust Corp | 498,514 | $43.4M | 0.01% | +10,298+2.1% | Added |
| Loomis Sayles & Co L P | 465,102 | $40.4M | 0.05% | −38,799−7.7% | Reduced |
| Candriam Luxembourg S.C.A. | 464,340 | $40.4M | 0.21% | +176,433+61.3% | Added |
| Millennium Management LLC | 451,825 | $39.3M | 0.03% | +265,116+142.0% | Added |
| Sofinnova Investments, Inc. | 450,096 | $39.1M | 1.96% | +178,702+65.8% | Added |
| Logos Global Management LP | 450,000 | $39.1M | 2.02% | +260,000+136.8% | Added |
| Driehaus Capital Management LLC | 436,546 | $38.0M | 0.28% | −848,676−66.0% | Reduced |
| Vanguard Fiduciary Trust Co | 421,911 | $36.7M | 0.01% | +421,911 | New |
| Opaleye Management Inc. | 123,000 | $35.3M | 4.65% | −207,000−62.7% | Reduced |
| Artisan Partners Limited Partnership | 390,669 | $34.0M | 0.06% | +127,078+48.2% | Added |
| Ameriprise Financial Inc | 383,957 | $33.4M | 0.01% | +122,797+47.0% | Added |
| Invesco Ltd. | 364,306 | $31.7M | 0.00% | +73,156+25.1% | Added |
| Lord, Abbett & Co. LLC | 348,953 | $30.3M | 0.10% | −270,589−43.7% | Reduced |
| OrbiMed Advisors LLC | 314,100 | $27.3M | 0.62% | +74,300+31.0% | Added |
| Braidwell LP | 310,628 | $27.0M | 0.90% | +310,628 | New |
| Silverarc Capital Management, LLC | 306,000 | $26.6M | 3.14% | +170,050+125.1% | Added |
| Bank of New York Mellon Corp | 293,298 | $25.5M | 0.00% | −7,782−2.6% | Reduced |
| Qube Research & Technologies Ltd | 277,943 | $24.2M | 0.03% | −32,976−10.6% | Reduced |
| Wellington Management Group LLP | 273,757 | $23.8M | 0.00% | +23,601+9.4% | Added |
| Squarepoint Ops LLC | 262,968 | $22.9M | 0.05% | +230,139+701.0% | Added |
| Renaissance Technologies LLC | 258,011 | $22.4M | 0.04% | −83,182−24.4% | Reduced |
| BNP Paribas Arbitrage, SA | 247,876 | $21.6M | 0.01% | +83,313+50.6% | Added |
| Hood River Capital Management LLC | 239,912 | $20.9M | 0.21% | +2,869+1.2% | Added |
| Voya Investment Management LLC | 233,810 | $20.3M | 0.02% | −16,064−6.4% | Reduced |
| UBS Group AG | 231,650 | $20.1M | 0.00% | −195,586−45.8% | Reduced |
| ADAR1 Capital Management, LLC | 211,450 | $18.4M | 1.11% | +160,101+311.8% | Added |
| SummitTX Capital, L.P. | 165,599 | $14.4M | 0.46% | +84,870+105.1% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 151,842 | $13.2M | 0.03% | +2,469+1.7% | Added |
| Deutsche Bank AG | 141,601 | $12.3M | 0.00% | +12,478+9.7% | Added |
| M&G Plc | 138,567 | $12.1M | 0.06% | +1,493+1.1% | Added |
| PFM Health Sciences, LP | 136,621 | $11.9M | 1.25% | +96,411+239.8% | Added |
| NEXTBio Capital Management LP | 126,078 | $11.0M | 5.09% | +58,492+86.5% | Added |
| New York State Common Retirement Fund | 125,207 | $10.9M | 0.02% | +31,530+33.7% | Added |
| Nuveen, LLC | 117,376 | $10.2M | 0.00% | +1,442+1.2% | Added |
| Schroder Investment Management Group | 131,674 | $10.2M | 0.01% | +131,674 | New |
| Russell Investments Group, Ltd. | 115,712 | $10.1M | 0.01% | −18,468−13.8% | Reduced |
| Capital World Investors | 115,693 | $10.1M | 0.00% | 00.0% | Unchanged |
| Swiss National Bank | 112,200 | $9.76M | 0.01% | +900+0.8% | Added |
| Axiom Investors LLC | 91,749 | $7.98M | 0.09% | +8,195+9.8% | Added |
| First Light Asset Management, LLC | 87,181 | $7.58M | 0.68% | −208,663−70.5% | Reduced |
| First Trust Advisors LP | 85,506 | $7.44M | 0.01% | −2,999−3.4% | Reduced |
| Standard Life Aberdeen plc | 79,357 | $6.90M | 0.01% | +79,357 | New |
| Granahan Investment Management Inc | 77,709 | $6.76M | 0.33% | +24,257+45.4% | Added |
| Neuberger Berman Group LLC | 73,434 | $6.39M | 0.00% | −138−0.2% | Reduced |
| WCM Investment Management, LLC | 80,620 | $6.23M | 0.01% | +35,815+79.9% | Added |
| Rhumbline Advisers | 69,858 | $6.08M | 0.01% | −1,354−1.9% | Reduced |
| Kennedy Capital Management, Inc. | 65,818 | $5.72M | 0.12% | +25,931+65.0% | Added |
| California State Teachers Retirement System | 65,806 | $5.72M | 0.01% | +12,269+22.9% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 62,936 | $5.47M | 0.01% | −60,601−49.1% | Reduced |
| Blue Owl Capital Holdings LP | 61,455 | $5.34M | 1.44% | +61,455 | New |
| XTX Topco Ltd | 59,502 | $5.17M | 0.09% | +49,069+470.3% | Added |
| AQR Capital Management LLC | 59,279 | $5.16M | 0.00% | −10,767−15.4% | Reduced |
| Algert Global LLC | 58,513 | $5.09M | 0.08% | −29,737−33.7% | Reduced |
| Atom Investors LP | 57,000 | $4.96M | 0.35% | +34,071+148.6% | Added |
| Balyasny Asset Management LLC | 52,967 | $4.61M | 0.01% | −19,315−26.7% | Reduced |
| Castleark Management LLC | 52,279 | $4.55M | 0.15% | −12,200−18.9% | Reduced |
| Susquehanna International Group, LLP | 50,784 | $4.42M | 0.01% | +46,687+1,139.5% | Added |
| Manufacturers Life Insurance Company, The | 50,769 | $4.42M | 0.00% | −8,840−14.8% | Reduced |
| Picton Mahoney Asset Management | 50,372 | $4.38M | 0.05% | +50,372 | New |
| Rafferty Asset Management, LLC | 50,105 | $4.36M | 0.02% | −5,421−9.8% | Reduced |
| Raymond James Financial Inc | 49,920 | $4.34M | 0.00% | +8,805+21.4% | Added |
| Vanguard Asset Management, Ltd | 49,689 | $4.32M | 0.00% | +49,689 | New |
| Nan Fung Group Holdings Ltd | 49,120 | $4.27M | 3.52% | 00.0% | Unchanged |
| Harvest Investment Services, LLC | 48,468 | $4.22M | 0.77% | +4,515+10.3% | Added |
| Legal & General Group Plc | 47,032 | $4.09M | 0.00% | −8,043−14.6% | Reduced |
| Silvercrest Asset Management Group LLC | 46,887 | $4.08M | 0.03% | +12,760+37.4% | Added |