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Rhythm Pharmaceuticals, Inc.

RYTM
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001649904

In the last 90 days, Rhythm Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 305 institutions reported holding it in 13F filings for Q2 2026, worth $8.55B in total; Duquesne Family Office is the only superinvestor holding it.

Q1 2026 vs. Q4 2025

How the institutions holding Rhythm Pharmaceuticals, Inc. changed between Q4 2025 and Q1 2026.

All holders in Q1 2026All holders in Q4 2025

13F holders of RYTM: Q4 2025 compared with Q1 2026
MeasureQ4 2025Of which not filed for Q1 2026Q1 2026Change
Holders2816285+10
Shares72.9M6.29M73.6M+6.99M (+10.5%)
Value$7.80B$672.8M$6.42B−$704.3M (−9.9%)

6 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so the changes leave them out.

New holders (63)

Institutions that held Rhythm Pharmaceuticals, Inc. at the end of Q1 2026 but not at the end of Q4 2025.

Institutions new to RYTM in Q1 2026
InstitutionSharesValue% of portfolio
Vanguard Portfolio Management LLC3,040,718$264.5M0.01%
Vanguard Capital Management LLC2,967,825$258.1M0.01%
Vanguard Fiduciary Trust Co421,911$36.7M0.01%
Braidwell LP310,628$27.0M0.90%
Schroder Investment Management Group131,674$10.2M0.01%
Standard Life Aberdeen plc79,357$6.90M0.01%
Blue Owl Capital Holdings LP61,455$5.34M1.44%
Picton Mahoney Asset Management50,372$4.38M0.05%
Vanguard Asset Management, Ltd49,689$4.32M0.00%
Utah Retirement Systems42,177$3.67M0.04%
Exome Asset Management LLC40,581$3.53M2.08%
Aspiriant, LLC33,007$2.87M0.08%
Alyeska Investment Group, L.P.32,589$2.83M0.01%
Vanguard Global Advisers, LLC29,700$2.58M0.00%
Aquatic Capital Management LLC29,671$2.58M0.07%
Mutual of America Capital Management LLC22,529$1.96M0.02%
Liberty Mutual Group Asset Management Inc.20,514$1.78M0.14%
Tudor Investment Corp Et Al19,646$1.71M0.01%
HSBC Holdings PLC14,307$1.22M0.00%
Vanguard Investments Australia, Ltd.13,927$1.21M0.00%
Bridgefront Capital, LLC12,495$1.09M0.27%
Marshall Wace, LLP9,628$837.3K0.00%
Hudson Bay Capital Management LP9,120$793.2K0.00%
HighTower Advisors, LLC9,058$787.8K0.00%
CenterBook Partners LP9,026$785.0K0.04%
Prelude Capital Management, LLC8,372$728.1K0.06%
IMC-Chicago, LLC6,697$582.4K0.01%
E Fund Management Co., Ltd.6,453$561.2K0.02%
Texas Treasury Safekeeping Trust Co6,154$535.0K0.09%
Campbell & CO Investment Adviser LLC5,958$518.2K0.03%
Fifth Third Bancorp5,260$457.5K0.00%
Inceptionr LLC4,379$380.8K0.09%
Two Sigma Investments, LP4,300$374.0K0.00%
Amundi4,017$349.4K0.00%
Centiva Capital, LP4,000$347.9K0.02%
Fox Run Management, L.L.C.4,499$347.5K0.06%
Bank of Montreal3,801$330.6K0.00%
Brevan Howard Capital Management LP3,777$328.5K0.00%
Marex Group plc3,288$286.0K0.00%
Ethic Inc.3,003$261.2K0.00%
CIBC Bancorp USA Inc.2,663$231.6K0.00%
Blackstone Group Inc.2,600$226.1K0.00%
DRW Securities, LLC2,562$222.8K0.01%
Northwest & Ethical Investments L.P.2,491$216.6K0.01%
Integrated Wealth Concepts LLC2,480$215.7K0.00%
Cornerstone Partners Capital Management, LLC2,462$214.1K0.53%
Verdad Advisers, LP2,445$212.6K0.24%
Quantbot Technologies LP1,363$118.5K0.00%
Mitsubishi UFJ Asset Management (UK) Ltd.1,000$87.0K0.04%
E Fund Management (Hong Kong) Co., Ltd.154$13.4K0.01%
Sound Income Strategies, LLC114$10.0K0.00%
Cassaday & Co Wealth Management LLC93$8.09K0.00%
Cedar Mountain Advisors, LLC51$4.43K0.00%
Advisory Services Network, LLC37$3.22K0.00%
Golden State Equity Partners37$3.22K0.00%
Whipplewood Advisors, LLC11$9570.00%
Dogwood Wealth Management LLC11$9570.00%
Twin Peaks Wealth Advisors, LLC6$5220.00%
LRI Investments, LLC6$5220.00%
Huntington National Bank5$4350.00%
GHP Investment Advisors, Inc.3$2610.00%
Godfrey Financial Associates, Inc.3$2610.00%
Pinnacle Wealth Planning Services, Inc.2$1740.00%

Sold out (53)

Institutions that held Rhythm Pharmaceuticals, Inc. at the end of Q4 2025 and filed for Q1 2026 without it.

Institutions that sold out of RYTM in Q1 2026
InstitutionShares, Q4 2025Value, Q4 2025
NEA Management Company, LLC2,909,956$311.5M
Jennison Associates LLC918,567$98.3M
First Turn Management, LLC146,303$15.7M
Zweig-DiMenna Associates LLC81,600$8.73M
Voloridge Investment Management, LLC60,575$6.48M
StemPoint Capital LP58,915$6.31M
EAM Investors, LLC57,327$6.14M
Rhenman & Partners Asset Management AB35,000$3.75M
Nicholas Investment Partners, LP34,710$3.72M
Magnetar Financial LLC29,598$3.17M
Penserra Capital Management LLC21,514$2.30M
Hennion & Walsh Asset Management, Inc.10,908$1.17M
Fred Alger Management, LLC9,301$995.6K
Virginia Retirement Systems Et Al9,200$984.8K
Headlands Technologies LLC8,632$924.0K
Jump Financial, LLC6,759$723.5K
Legato Capital Management LLC5,723$612.6K
Quantedge Capital Pte Ltd5,600$599.4K
Voleon Capital Management LP5,025$537.9K
PSP Research LLC4,738$507.2K
Caption Management, LLC4,614$493.9K
Vestmark Advisory Solutions, Inc.4,560$488.1K
Verition Fund Management LLC4,504$482.1K
Mackenzie Financial Corp4,398$468.6K
Empowered Funds, LLC4,164$445.7K
O'Shaughnessy Asset Management, LLC3,580$383.2K
Toroso Investments, LLC3,336$357.1K
Keybank National Association3,271$350.1K
Cinctive Capital Management LP3,225$345.2K
Yorktown Management & Research Co Inc3,050$326.5K
Two Sigma Advisers, LP2,900$310.4K
JGP Global Gestao de Recursos Ltda.2,866$306.8K
AlphaGrep UK Ltd2,509$268.6K
State of Wyoming2,441$261.3K
M&T Bank Corp2,101$224.9K
Cambria Investment Management, L.P.1,997$213.8K
Jane Street Group, LLC1,960$209.8K
Amalgamated Bank1,663$178.0K
Quest Partners LLC1,508$161.4K
Persistent Asset Partners Ltd1,446$154.8K
Clearstead Advisors, LLC1,246$133.4K
CFG Wealth Management Services, Inc.800$85.6K
Daiwa Securities Group Inc.201$22.0K
AdvisorNet Financial, Inc137$14.7K
Bayforest Capital Ltd134$14.3K
Quarry LP77$8.24K
SageView Advisory Group, LLC30$3.21K
Rakuten Securities, Inc.15$1.61K
SJS Investment Consulting Inc.2$215
Rialto Wealth Management, LLC1$108
TD Private Client Wealth LLC1$107
Dunhill Financial, LLC1$65
Avion Wealth4$0

Not filed for Q1 2026 yet (6)

Institutions that held Rhythm Pharmaceuticals, Inc. at the end of Q4 2025 and haven't filed a 13F for Q1 2026. Not filing isn't selling, so they aren't counted as sold out.

Institutions holding RYTM in Q4 2025 that haven't filed for Q1 2026
InstitutionShares, Q4 2025Value, Q4 2025
Vanguard Group Inc6,210,916$664.8M
Norges Bank66,213$7.09M
Comerica Bank4,014$429.6K
CIBC World Markets Corp3,502$374.9K
Global Retirement Partners, LLC857$91.7K
ORG Partners LLC37$3.96K