Rhythm Pharmaceuticals, Inc.
RYTM- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001649904
In the last 90 days, Rhythm Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 304 institutions reported holding it in 13F filings for Q2 2026, worth $8.55B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Rhythm Pharmaceuticals, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 281
- +19 vs. Q3 2025
- Shares held
- 72.9M
- +2.01M (+2.8%) vs. Q3 2025
- Total value
- $7.80B
- +$602.5M (+8.4%) vs. Q3 2025
- New holders
- 58
- 107 more added
- Sold out
- 39
- 89 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting RYTM on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 304 | $8.55B |
| Q1 2026 | 285 | $6.42B |
| Q4 2025 | 281 | $7.80B |
| Q3 2025 | 264 | $7.20B |
| Q2 2025 | 227 | $4.20B |
| Q1 2025 | 228 | $3.44B |
| Q4 2024 | 203 | $3.63B |
| Q3 2024 | 176 | $3.55B |
| Q2 2024 | 165 | $2.85B |
| Q1 2024 | 167 | $2.95B |
| Q4 2023 | 169 | $3.07B |
| Q3 2023 | 144 | $1.56B |
| Q2 2023 | 116 | $1.09B |
| Q1 2023 | 126 | $1.08B |
| Q4 2022 | 115 | $1.81B |
| Q3 2022 | 101 | $1.45B |
| Q2 2022 | 90 | $190.8M |
| Q1 2022 | 111 | $562.7M |
| Q4 2021 | 98 | $483.6M |
| Q3 2021 | 97 | $626.3M |
| Q2 2021 | 105 | $905.6M |
| Q1 2021 | 124 | $1.01B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Rhythm Pharmaceuticals, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Ra Capital Management, L.P. | 6,666,837 | $713.6M | 7.31% | +985,478+17.3% | Added |
| BlackRock, Inc. | 6,297,334 | $674.1M | 0.01% | −4,881−0.1% | Reduced |
| Vanguard Group Inc | 6,210,916 | $664.8M | 0.01% | +1,214,489+24.3% | Added |
| Baker Bros. Advisors LP | 5,604,483 | $599.9M | 3.51% | 00.0% | Unchanged |
| Primecap Management Co | 3,478,669 | $372.4M | 0.28% | −784,190−18.4% | Reduced |
| NEA Management Company, LLC | 2,909,956 | $311.5M | 15.88% | 00.0% | Unchanged |
| Perceptive Advisors LLC | 2,546,391 | $272.6M | 4.99% | +107,422+4.4% | Added |
| State Street Corp | 2,198,615 | $235.3M | 0.01% | +169,964+8.4% | Added |
| Goldman Sachs Group Inc | 1,830,866 | $196.0M | 0.03% | −62,797−3.3% | Reduced |
| FMR LLC | 1,706,317 | $182.6M | 0.01% | −438,866−20.5% | Reduced |
| Federated Hermes, Inc. | 1,623,841 | $173.8M | 0.29% | −104,044−6.0% | Reduced |
| Price T Rowe Associates Inc | 1,560,847 | $167.1M | 0.02% | +160,950+11.5% | Added |
| JPMorgan Chase & Co | 1,423,989 | $152.4M | 0.01% | +235,920+19.9% | Added |
| Geode Capital Management, LLC | 1,375,729 | $147.3M | 0.01% | +12,900+0.9% | Added |
| Driehaus Capital Management LLC | 1,285,222 | $137.6M | 0.93% | −98,553−7.1% | Reduced |
| Westfield Capital Management Co LP | 1,267,158 | $135.6M | 0.57% | +198,154+18.5% | Added |
| Polar Capital Holdings Plc | 1,185,392 | $126.9M | 0.58% | −59,540−4.8% | Reduced |
| Janus Henderson Group PLC | 1,126,125 | $120.6M | 0.05% | −34,762−3.0% | Reduced |
| Checkpoint Capital L.P. | 992,200 | $106.2M | 33.65% | +228,493+29.9% | Added |
| Capital Research Global Investors | 985,086 | $105.4M | 0.02% | +386,839+64.7% | Added |
| Alliancebernstein L.P. | 930,233 | $99.6M | 0.03% | −49,449−5.0% | Reduced |
| Jennison Associates LLC | 918,567 | $98.3M | 0.06% | +507,017+123.2% | Added |
| Franklin Resources Inc | 695,735 | $74.5M | 0.02% | +127,953+22.5% | Added |
| Rock Springs Capital Management LP | 695,010 | $74.4M | 3.82% | −22,092−3.1% | Reduced |
| Woodline Partners LP | 688,779 | $73.7M | 0.29% | +108,596+18.7% | Added |
| Morgan Stanley | 651,402 | $69.7M | 0.00% | +186,212+40.0% | Added |
| Adage Capital Partners GP, L.L.C. | 621,585 | $66.5M | 0.10% | +77,585+14.3% | Added |
| Lord, Abbett & Co. LLC | 619,542 | $66.3M | 0.20% | +43,558+7.6% | Added |
| Pictet Asset Management Holding SA | 614,663 | $66.2M | 0.06% | −68,354−10.0% | Reduced |
| UBS Asset Management Americas Inc | 549,020 | $58.8M | 0.01% | +111,548+25.5% | Added |
| Charles Schwab Investment Management Inc | 532,447 | $57.0M | 0.01% | +4,525+0.9% | Added |
| Clearbridge Investments, LLC | 506,109 | $54.2M | 0.04% | +21,377+4.4% | Added |
| Loomis Sayles & Co L P | 503,901 | $53.9M | 0.07% | −23,538−4.5% | Reduced |
| Siren, L.L.C. | 499,975 | $53.5M | 1.60% | 00.0% | Unchanged |
| Northern Trust Corp | 488,216 | $52.3M | 0.01% | −22,690−4.4% | Reduced |
| Integral Health Asset Management, LLC | 475,000 | $50.8M | 2.58% | +255,000+115.9% | Added |
| Point72 Asset Management, L.P. | 429,420 | $46.0M | 0.07% | +429,420 | New |
| UBS Group AG | 427,236 | $45.7M | 0.01% | +6,900+1.6% | Added |
| Renaissance Technologies LLC | 341,193 | $36.5M | 0.06% | −205,400−37.6% | Reduced |
| Opaleye Management Inc. | 330,000 | $35.3M | 4.66% | −131,700−28.5% | Reduced |
| Qube Research & Technologies Ltd | 310,919 | $33.3M | 0.05% | +72,100+30.2% | Added |
| Bank of New York Mellon Corp | 301,080 | $32.2M | 0.01% | +118,715+65.1% | Added |
| First Light Asset Management, LLC | 295,844 | $31.7M | 2.42% | +115,360+63.9% | Added |
| Invesco Ltd. | 291,150 | $31.2M | 0.00% | +147,595+102.8% | Added |
| Candriam Luxembourg S.C.A. | 287,907 | $30.8M | 0.15% | +66,044+29.8% | Added |
| Sofinnova Investments, Inc. | 271,394 | $29.1M | 1.25% | +24,428+9.9% | Added |
| Artisan Partners Limited Partnership | 263,591 | $28.2M | 0.04% | +26,750+11.3% | Added |
| Ameriprise Financial Inc | 261,160 | $28.0M | 0.01% | +123,193+89.3% | Added |
| Wellington Management Group LLP | 250,156 | $26.8M | 0.00% | +225,679+922.0% | Added |
| Voya Investment Management LLC | 249,874 | $26.7M | 0.03% | +28,281+12.8% | Added |
| OrbiMed Advisors LLC | 239,800 | $25.7M | 0.53% | +24,648+11.5% | Added |
| Hood River Capital Management LLC | 237,043 | $25.4M | 0.28% | +1,207+0.5% | Added |
| Bank of America Corp | 224,484 | $24.0M | 0.00% | −8,666−3.7% | Reduced |
| Logos Global Management LP | 190,000 | $20.3M | 1.36% | −10,000−5.0% | Reduced |
| Millennium Management LLC | 186,709 | $20.0M | 0.01% | +53,548+40.2% | Added |
| BNP Paribas Arbitrage, SA | 164,563 | $17.6M | 0.01% | −59,118−26.4% | Reduced |
| Citadel Advisors LLC | 153,322 | $16.4M | 0.01% | +20,696+15.6% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 149,373 | $16.0M | 0.04% | +28,113+23.2% | Added |
| First Turn Management, LLC | 146,303 | $15.7M | 1.79% | +146,303 | New |
| M&G Plc | 137,074 | $14.7M | 0.08% | +137,074 | New |
| Silverarc Capital Management, LLC | 135,950 | $14.6M | 2.11% | −234,046−63.3% | Reduced |
| Russell Investments Group, Ltd. | 134,180 | $14.4M | 0.02% | −23,498−14.9% | Reduced |
| Barclays PLC | 131,436 | $14.1M | 0.01% | −10,949−7.7% | Reduced |
| Deutsche Bank AG | 129,123 | $13.8M | 0.00% | +12,381+10.6% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 123,537 | $13.2M | 0.02% | +22,165+21.9% | Added |
| Nuveen, LLC | 115,934 | $12.4M | 0.00% | −2,030−1.7% | Reduced |
| Capital World Investors | 115,693 | $12.4M | 0.00% | +115,693 | New |
| Swiss National Bank | 111,300 | $11.9M | 0.01% | +9,000+8.8% | Added |
| New York State Common Retirement Fund | 93,677 | $10.0M | 0.01% | +18,546+24.7% | Added |
| First Trust Advisors LP | 88,505 | $9.47M | 0.01% | +7,602+9.4% | Added |
| Algert Global LLC | 88,250 | $9.45M | 0.15% | −52,034−37.1% | Reduced |
| Axiom Investors LLC | 83,554 | $8.94M | 0.08% | +523+0.6% | Added |
| Zweig-DiMenna Associates LLC | 81,600 | $8.73M | 0.62% | +81,600 | New |
| SummitTX Capital, L.P. | 80,729 | $8.64M | 0.26% | +68,860+580.2% | Added |
| ExodusPoint Capital Management, LP | 75,141 | $8.04M | 0.09% | +75,141 | New |
| Neuberger Berman Group LLC | 73,572 | $7.88M | 0.01% | −11,545−13.6% | Reduced |
| Wells Fargo & Company | 72,617 | $7.77M | 0.00% | +25,483+54.1% | Added |
| Balyasny Asset Management LLC | 72,282 | $7.74M | 0.01% | −277,726−79.3% | Reduced |
| Rhumbline Advisers | 71,212 | $7.62M | 0.01% | −10,856−13.2% | Reduced |
| AQR Capital Management LLC | 70,046 | $7.50M | 0.00% | −9,734−12.2% | Reduced |
| NEXTBio Capital Management LP | 67,586 | $7.23M | 4.24% | +67,586 | New |
| Norges Bank | 66,213 | $7.09M | 0.00% | +66,213 | New |
| Castleark Management LLC | 64,479 | $6.90M | 0.20% | +21,940+51.6% | Added |
| Voloridge Investment Management, LLC | 60,575 | $6.48M | 0.02% | −307,688−83.6% | Reduced |
| Manufacturers Life Insurance Company, The | 59,609 | $6.37M | 0.01% | −1,308−2.1% | Reduced |
| PDT Partners, LLC | 59,436 | $6.36M | 0.41% | −26,700−31.0% | Reduced |
| StemPoint Capital LP | 58,915 | $6.31M | 1.08% | −32,529−35.6% | Reduced |
| EAM Investors, LLC | 57,327 | $6.14M | 0.68% | −1,153−2.0% | Reduced |
| Rafferty Asset Management, LLC | 55,526 | $5.94M | 0.02% | −208−0.4% | Reduced |
| Legal & General Group Plc | 55,075 | $5.90M | 0.00% | −2,301−4.0% | Reduced |
| TD Asset Management Inc | 55,050 | $5.89M | 0.00% | −4,514−7.6% | Reduced |
| California State Teachers Retirement System | 53,537 | $5.73M | 0.01% | +4,603+9.4% | Added |
| Granahan Investment Management Inc | 53,452 | $5.72M | 0.24% | +3,724+7.5% | Added |
| Prudential Financial Inc | 53,145 | $5.69M | 0.01% | −19,865−27.2% | Reduced |
| ADAR1 Capital Management, LLC | 51,349 | $5.50M | 0.41% | +1,778+3.6% | Added |
| Nan Fung Group Holdings Ltd | 49,120 | $5.26M | 4.71% | 00.0% | Unchanged |
| Victory Capital Management Inc | 45,381 | $4.86M | 0.00% | +2,498+5.8% | Added |
| WCM Investment Management, LLC | 44,805 | $4.78M | 0.01% | −2,928−6.1% | Reduced |
| Harvest Investment Services, LLC | 43,953 | $4.70M | 0.89% | −4,187−8.7% | Reduced |
| HighVista Strategies LLC | 42,867 | $4.59M | 1.18% | +5,385+14.4% | Added |