Rhythm Pharmaceuticals, Inc.

RYTM

Exchange: Nasdaq
Industry: Pharmaceutical Preparations
SEC CIK: 0001649904

SEC filings (opens in a new tab)

In the last 90 days, Rhythm Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 305 institutions reported holding it in 13F filings for Q2 2026, worth $8.55B in total; Duquesne Family Office is the only superinvestor holding it.

Q4 2025 vs. Q3 2025

How the institutions holding Rhythm Pharmaceuticals, Inc. changed between Q3 2025 and Q4 2025.

All holders in Q4 2025 All holders in Q3 2025

13F holders of RYTM: Q3 2025 compared with Q4 2025
Measure	Q3 2025	Of which not filed for Q4 2025	Q4 2025	Change
Holders	264	2	281	+19
Shares	70.9M	25.8K	72.9M	+2.01M (+2.8%)
Value	$7.20B	$2.61M	$7.80B	+$602.5M (+8.4%)

2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so the changes leave them out.

New holders (58)

Institutions that held Rhythm Pharmaceuticals, Inc. at the end of Q4 2025 but not at the end of Q3 2025.

Institutions new to RYTM in Q4 2025
Institution	Shares	Value	% of portfolio
Point72 Asset Management, L.P.	429,420	$46.0M	0.07%
First Turn Management, LLC	146,303	$15.7M	1.79%
M&G Plc	137,074	$14.7M	0.08%
Capital World Investors	115,693	$12.4M	0.00%
Zweig-DiMenna Associates LLC	81,600	$8.73M	0.62%
ExodusPoint Capital Management, LP	75,141	$8.04M	0.09%
NEXTBio Capital Management LP	67,586	$7.23M	4.24%
Norges Bank	66,213	$7.09M	0.00%
Nicholas Investment Partners, LP	34,710	$3.72M	0.27%
Squarepoint Ops LLC	32,829	$3.51M	0.01%
Magnetar Financial LLC	29,598	$3.17M	0.03%
EFG International AG	29,291	$3.14M	0.06%
Atom Investors LP	22,929	$2.45M	0.19%
XTX Topco Ltd	10,433	$1.12M	0.03%
Knights of Columbus Asset Advisors LLC	10,314	$1.10M	0.06%
Headlands Technologies LLC	8,632	$924.0K	0.08%
Jump Financial, LLC	6,759	$723.5K	0.01%
Acadian Asset Management LLC	6,105	$652.0K	0.00%
Legato Capital Management LLC	5,723	$612.6K	0.05%
AlphaCentric Advisors LLC	5,052	$540.8K	0.54%
Two Sigma Securities, LLC	4,943	$529.1K	0.07%
PSP Research LLC	4,738	$507.2K	0.44%
Caption Management, LLC	4,614	$493.9K	0.02%
Vestmark Advisory Solutions, Inc.	4,560	$488.1K	0.01%
Verition Fund Management LLC	4,504	$482.1K	0.00%
CIBC World Markets Corp	3,502	$374.9K	0.00%
Keybank National Association	3,271	$350.1K	0.00%
Yorktown Management & Research Co Inc	3,050	$326.5K	0.26%
Blueshift Asset Management, LLC	2,881	$308.4K	0.09%
CIBC Asset Management Inc	2,848	$304.9K	0.00%
AlphaGrep UK Ltd	2,509	$268.6K	0.09%
Abel Hall, LLC	2,140	$229.1K	0.05%
M&T Bank Corp	2,101	$224.9K	0.00%
Cambria Investment Management, L.P.	1,997	$213.8K	0.01%
Persistent Asset Partners Ltd	1,446	$154.8K	0.07%
Danske Bank A/S	1,100	$117.7K	0.00%
CFG Wealth Management Services, Inc.	800	$85.6K	0.08%
Kemnay Advisory Services Inc.	207	$22.2K	0.00%
Basecamp Wealth Advisors LLC	125	$13.4K	0.00%
Quarry LP	77	$8.24K	0.00%
Harbour Investments, Inc.	60	$6.42K	0.00%
Eastern Bank	59	$6.32K	0.00%
Root Financial Partners, LLC	43	$4.60K	0.00%
SageView Advisory Group, LLC	30	$3.21K	0.00%
First Horizon Corp	30	$3.21K	0.00%
Rakuten Securities, Inc.	15	$1.61K	0.00%
JFS Wealth Advisors, LLC	10	$1.07K	0.00%
Keating Financial Advisory Services, Inc.	9	$963	0.00%
Toronto Dominion Bank	6	$642	0.00%
Fortitude Family Office, LLC	6	$642	0.00%
DiNuzzo Private Wealth, Inc.	3	$322	0.00%
SJS Investment Consulting Inc.	2	$215	0.00%
HFM Investment Advisors, LLC	2	$215	0.00%
Rialto Wealth Management, LLC	1	$108	0.00%
TD Private Client Wealth LLC	1	$107	0.00%
Bay Harbor Wealth Management, LLC	1	$107	0.00%
Dunhill Financial, LLC	1	$65	0.00%
Avion Wealth	4	$0	0.00%

Sold out (39)

Institutions that held Rhythm Pharmaceuticals, Inc. at the end of Q3 2025 and filed for Q4 2025 without it.

Institutions that sold out of RYTM in Q4 2025
Institution	Shares, Q3 2025	Value, Q3 2025
Alkeon Capital Management LLC	1,017,700	$102.8M
Assenagon Asset Management S.A.	224,128	$22.6M
Marshall Wace, LLP	171,834	$17.4M
Panagora Asset Management Inc	64,614	$6.53M
Walleye Capital LLC	50,181	$5.07M
Aquatic Capital Management LLC	42,490	$4.29M
Trexquant Investment LP	37,161	$3.75M
Canada Pension Plan Investment Board	37,000	$3.74M
Jain Global LLC	35,110	$3.55M
Alps Advisors Inc	33,000	$3.33M
Samsara BioCapital, LLC	30,285	$3.06M
Dark Forest Capital Management LP	28,639	$2.89M
Standard Life Aberdeen plc	26,740	$2.70M
Burkehill Global Management, LP	20,000	$2.02M
Schroder Investment Management Group	18,042	$1.82M
Engineers Gate Manager LP	13,775	$1.39M
Fiduciary Trust Co	10,000	$1.01M
Readystate Asset Management LP	8,365	$844.8K
Aigen Investment Management, LP	8,225	$830.6K
Inceptionr LLC	7,482	$755.6K
Arrowstreet Capital, Limited Partnership	6,307	$636.9K
Oxford Asset Management LLP	5,538	$559.3K
Quantbot Technologies LP	4,981	$503.0K
Gsa Capital Partners LLP	3,897	$394.0K
FORA Capital, LLC	3,599	$363.5K
Mariner, LLC	3,597	$363.3K
Capstone Investment Advisors, LLC	3,497	$353.2K
National Asset Management, Inc.	2,675	$270.1K
Fox Run Management, L.L.C.	2,517	$254.2K
Integrated Wealth Concepts LLC	2,491	$251.6K
American Century Companies Inc	2,077	$209.8K
EntryPoint Capital, LLC	1,993	$201.3K
RWC Asset Management LLP	1,988	$200.8K
Bank of Montreal	715	$72.2K
Quadrant Capital Group LLC	42	$4.24K
Aster Capital Management (DIFC) Ltd	40	$4.04K
J.Safra Asset Management Corp	20	$2.02K
Advisory Services Network, LLC	19	$1.92K
Wealthspire Advisors, LLC	1	$101

Not filed for Q4 2025 yet (2)

Institutions that held Rhythm Pharmaceuticals, Inc. at the end of Q3 2025 and haven't filed a 13F for Q4 2025. Not filing isn't selling, so they aren't counted as sold out.

Institutions holding RYTM in Q3 2025 that haven't filed for Q4 2025
Institution	Shares, Q3 2025	Value, Q3 2025
EFG Asset Management (North America) Corp.	20,269	$2.05M
CIBC Bancorp USA Inc.	5,569	$562.4K