Rhythm Pharmaceuticals, Inc.
RYTM- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001649904
In the last 90 days, Rhythm Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 304 institutions reported holding it in 13F filings for Q2 2026, worth $8.55B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q3 2025
Institutional positions in Rhythm Pharmaceuticals, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 264
- +41 vs. Q2 2025
- Shares held
- 70.9M
- +4.57M (+6.9%) vs. Q2 2025
- Total value
- $7.20B
- +$3.01B (+71.8%) vs. Q2 2025
- New holders
- 57
- 99 more added
- Sold out
- 16
- 82 more reduced
4 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting RYTM on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 304 | $8.55B |
| Q1 2026 | 285 | $6.42B |
| Q4 2025 | 281 | $7.80B |
| Q3 2025 | 264 | $7.20B |
| Q2 2025 | 227 | $4.20B |
| Q1 2025 | 228 | $3.44B |
| Q4 2024 | 203 | $3.63B |
| Q3 2024 | 176 | $3.55B |
| Q2 2024 | 165 | $2.85B |
| Q1 2024 | 167 | $2.95B |
| Q4 2023 | 169 | $3.07B |
| Q3 2023 | 144 | $1.56B |
| Q2 2023 | 116 | $1.09B |
| Q1 2023 | 126 | $1.08B |
| Q4 2022 | 115 | $1.81B |
| Q3 2022 | 101 | $1.45B |
| Q2 2022 | 90 | $190.8M |
| Q1 2022 | 111 | $562.7M |
| Q4 2021 | 98 | $483.6M |
| Q3 2021 | 97 | $626.3M |
| Q2 2021 | 105 | $905.6M |
| Q1 2021 | 124 | $1.01B |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Rhythm Pharmaceuticals, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BlackRock, Inc. | 6,302,215 | $636.5M | 0.01% | +34,677+0.6% | Added |
| Ra Capital Management, L.P. | 5,681,359 | $573.8M | 7.07% | +120,000+2.2% | Added |
| Baker Bros. Advisors LP | 5,604,483 | $566.0M | 4.09% | 00.0% | Unchanged |
| Vanguard Group Inc | 4,996,427 | $504.6M | 0.01% | +1,407,313+39.2% | Added |
| Primecap Management Co | 4,262,859 | $430.5M | 0.33% | −615,178−12.6% | Reduced |
| NEA Management Company, LLC | 2,909,956 | $293.9M | 16.13% | 00.0% | Unchanged |
| Perceptive Advisors LLC | 2,438,969 | $288.4M | 8.33% | +20,670+0.9% | Added |
| FMR LLC | 2,145,183 | $216.6M | 0.01% | +191,742+9.8% | Added |
| State Street Corp | 2,028,651 | $204.9M | 0.01% | +121,050+6.3% | Added |
| Goldman Sachs Group Inc | 1,893,663 | $191.2M | 0.03% | +159,941+9.2% | Added |
| Federated Hermes, Inc. | 1,727,885 | $174.5M | 0.31% | +41,391+2.5% | Added |
| Price T Rowe Associates Inc | 1,399,897 | $141.4M | 0.02% | +58,505+4.4% | Added |
| Driehaus Capital Management LLC | 1,383,775 | $139.7M | 1.00% | +113,823+9.0% | Added |
| Geode Capital Management, LLC | 1,362,829 | $137.7M | 0.01% | +51,576+3.9% | Added |
| Polar Capital Holdings Plc | 1,244,932 | $125.7M | 0.61% | −5,938−0.5% | Reduced |
| JPMorgan Chase & Co | 1,188,069 | $120.0M | 0.01% | +404,510+51.6% | Added |
| Janus Henderson Group PLC | 1,160,887 | $117.2M | 0.05% | −251,015−17.8% | Reduced |
| Westfield Capital Management Co LP | 1,069,004 | $108.0M | 0.45% | −560,464−34.4% | Reduced |
| Alkeon Capital Management LLC | 1,017,700 | $102.8M | 0.46% | 00.0% | Unchanged |
| Alliancebernstein L.P. | 979,682 | $98.9M | 0.03% | +918,212+1,493.8% | Added |
| Checkpoint Capital L.P. | 763,707 | $77.1M | 25.84% | −296,293−28.0% | Reduced |
| Rock Springs Capital Management LP | 717,102 | $72.4M | 4.23% | −144,051−16.7% | Reduced |
| Pictet Asset Management Holding SA | 683,017 | $69.0M | 0.07% | +266,902+64.1% | Added |
| Capital Research Global Investors | 598,247 | $60.4M | 0.01% | +598,247 | New |
| Woodline Partners LP | 580,183 | $58.6M | 0.28% | +65,802+12.8% | Added |
| Lord, Abbett & Co. LLC | 575,984 | $58.2M | 0.17% | +371,709+182.0% | Added |
| Franklin Resources Inc | 567,782 | $57.3M | 0.01% | +23,980+4.4% | Added |
| Renaissance Technologies LLC | 546,593 | $55.2M | 0.07% | +231,700+73.6% | Added |
| Adage Capital Partners GP, L.L.C. | 544,000 | $54.9M | 0.09% | +203,000+59.5% | Added |
| Charles Schwab Investment Management Inc | 527,922 | $53.3M | 0.01% | +66,484+14.4% | Added |
| Loomis Sayles & Co L P | 527,439 | $53.3M | 0.06% | −64,015−10.8% | Reduced |
| Northern Trust Corp | 510,906 | $51.6M | 0.01% | +660+0.1% | Added |
| Siren, L.L.C. | 499,975 | $50.5M | 1.98% | +90,233+22.0% | Added |
| Clearbridge Investments, LLC | 484,732 | $49.0M | 0.04% | +172,287+55.1% | Added |
| Morgan Stanley | 465,190 | $47.0M | 0.00% | −59,290−11.3% | Reduced |
| Opaleye Management Inc. | 461,700 | $46.6M | 6.59% | −13,300−2.8% | Reduced |
| UBS Asset Management Americas Inc | 437,472 | $44.2M | 0.01% | +209,845+92.2% | Added |
| UBS Group AG | 420,336 | $42.4M | 0.01% | +167,754+66.4% | Added |
| Jennison Associates LLC | 411,550 | $41.6M | 0.02% | +411,550 | New |
| Silverarc Capital Management, LLC | 369,996 | $37.4M | 5.41% | −30,776−7.7% | Reduced |
| Voloridge Investment Management, LLC | 368,263 | $37.2M | 0.12% | +29,459+8.7% | Added |
| Balyasny Asset Management LLC | 350,008 | $35.3M | 0.07% | +295,920+547.1% | Added |
| Sofinnova Investments, Inc. | 246,966 | $24.9M | 1.53% | −339,044−57.9% | Reduced |
| Qube Research & Technologies Ltd | 238,819 | $24.1M | 0.03% | −1,526−0.6% | Reduced |
| Artisan Partners Limited Partnership | 236,841 | $23.9M | 0.03% | +62,362+35.7% | Added |
| Hood River Capital Management LLC | 235,836 | $23.8M | 0.28% | −307,852−56.6% | Reduced |
| Bank of America Corp | 233,150 | $23.5M | 0.00% | +10,998+5.0% | Added |
| Assenagon Asset Management S.A. | 224,128 | $22.6M | 0.03% | −13,870−5.8% | Reduced |
| BNP Paribas Arbitrage, SA | 223,681 | $22.6M | 0.02% | +121,442+118.8% | Added |
| Candriam Luxembourg S.C.A. | 221,863 | $22.4M | 0.12% | −90,589−29.0% | Reduced |
| Voya Investment Management LLC | 221,593 | $22.4M | 0.02% | −22,410−9.2% | Reduced |
| Integral Health Asset Management, LLC | 220,000 | $22.2M | 1.62% | +100,000+83.3% | Added |
| OrbiMed Advisors LLC | 215,152 | $21.7M | 0.52% | −33,360−13.4% | Reduced |
| Comerica Bank | 209,325 | $21.1M | 0.08% | −92,336−30.6% | Reduced |
| Logos Global Management LP | 200,000 | $20.2M | 2.00% | +70,000+53.8% | Added |
| Bank of New York Mellon Corp | 182,365 | $18.4M | 0.00% | −1,744−0.9% | Reduced |
| First Light Asset Management, LLC | 180,484 | $18.2M | 1.72% | +180,484 | New |
| Marshall Wace, LLP | 171,834 | $17.4M | 0.02% | −204,408−54.3% | Reduced |
| Russell Investments Group, Ltd. | 157,678 | $15.9M | 0.02% | +26,680+20.4% | Added |
| Invesco Ltd. | 143,555 | $14.5M | 0.00% | +74,631+108.3% | Added |
| Barclays PLC | 142,385 | $14.4M | 0.01% | −208,813−59.5% | Reduced |
| Algert Global LLC | 140,284 | $14.2M | 0.24% | +80,065+133.0% | Added |
| Ameriprise Financial Inc | 137,967 | $13.9M | 0.00% | −35,102−20.3% | Reduced |
| Millennium Management LLC | 133,161 | $13.4M | 0.01% | −64,949−32.8% | Reduced |
| Citadel Advisors LLC | 132,626 | $13.4M | 0.01% | +132,626 | New |
| Man Group plc | 129,330 | $13.1M | 0.03% | +129,330 | New |
| Royal Bank of Canada | 125,786 | $12.7M | 0.00% | −70,450−35.9% | Reduced |
| Connor, Clark & Lunn Investment Management Ltd. | 121,260 | $12.2M | 0.04% | +6,142+5.3% | Added |
| Nuveen, LLC | 117,964 | $11.9M | 0.00% | −3,891−3.2% | Reduced |
| Deutsche Bank AG | 116,742 | $11.8M | 0.00% | +79,963+217.4% | Added |
| Ensign Peak Advisors, Inc | 111,544 | $11.3M | 0.02% | +93,885+531.7% | Added |
| Swiss National Bank | 102,300 | $10.3M | 0.01% | +11,700+12.9% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 101,372 | $10.2M | 0.02% | +5,855+6.1% | Added |
| StemPoint Capital LP | 91,444 | $9.23M | 1.86% | −85,308−48.3% | Reduced |
| PDT Partners, LLC | 86,136 | $8.70M | 0.55% | −11,502−11.8% | Reduced |
| Neuberger Berman Group LLC | 85,117 | $8.60M | 0.01% | −1,022−1.2% | Reduced |
| Axiom Investors LLC | 83,031 | $8.39M | 0.06% | +30,571+58.3% | Added |
| Rhumbline Advisers | 82,068 | $8.29M | 0.01% | −5,458−6.2% | Reduced |
| First Trust Advisors LP | 80,903 | $8.17M | 0.01% | +7,189+9.8% | Added |
| AQR Capital Management LLC | 79,780 | $8.06M | 0.01% | +30,740+62.7% | Added |
| New York State Common Retirement Fund | 75,131 | $7.59M | 0.01% | +16,513+28.2% | Added |
| Prudential Financial Inc | 73,010 | $7.37M | 0.01% | +65,915+929.0% | Added |
| Panagora Asset Management Inc | 64,614 | $6.53M | 0.03% | −54,852−45.9% | Reduced |
| Manufacturers Life Insurance Company, The | 60,917 | $6.15M | 0.01% | −7,215−10.6% | Reduced |
| TD Asset Management Inc | 59,564 | $6.02M | 0.00% | +3,564+6.4% | Added |
| EAM Investors, LLC | 58,480 | $5.81M | 0.67% | +58,480 | New |
| Legal & General Group Plc | 57,376 | $5.79M | 0.00% | +4,695+8.9% | Added |
| Rafferty Asset Management, LLC | 55,734 | $5.63M | 0.02% | +4,123+8.0% | Added |
| Walleye Capital LLC | 50,181 | $5.07M | 0.04% | +50,181 | New |
| Granahan Investment Management Inc | 49,728 | $5.02M | 0.21% | +8,556+20.8% | Added |
| ADAR1 Capital Management, LLC | 49,571 | $5.01M | 0.50% | +4,181+9.2% | Added |
| Nan Fung Group Holdings Ltd | 49,120 | $4.96M | 8.32% | 00.0% | Unchanged |
| California State Teachers Retirement System | 48,934 | $4.94M | 0.01% | +6,017+14.0% | Added |
| PFM Health Sciences, LP | 48,162 | $4.86M | 0.41% | +48,162 | New |
| Harvest Investment Services, LLC | 48,140 | $4.86M | 0.98% | +32,674+211.3% | Added |
| WCM Investment Management, LLC | 47,733 | $4.80M | 0.01% | +47,733 | New |
| Wells Fargo & Company | 47,134 | $4.76M | 0.00% | +4,766+11.2% | Added |
| Hennion & Walsh Asset Management, Inc. | 44,731 | $4.52M | 0.16% | −6,348−12.4% | Reduced |
| Raymond James Financial Inc | 44,093 | $4.45M | 0.00% | +33,547+318.1% | Added |
| Victory Capital Management Inc | 42,883 | $4.33M | 0.00% | +26,642+164.0% | Added |