Rhythm Pharmaceuticals, Inc.

RYTM

Exchange: Nasdaq
Industry: Pharmaceutical Preparations
SEC CIK: 0001649904

SEC filings (opens in a new tab)

In the last 90 days, Rhythm Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 305 institutions reported holding it in 13F filings for Q2 2026, worth $8.55B in total; Duquesne Family Office is the only superinvestor holding it.

Q3 2025 vs. Q2 2025

How the institutions holding Rhythm Pharmaceuticals, Inc. changed between Q2 2025 and Q3 2025.

All holders in Q3 2025 All holders in Q2 2025

13F holders of RYTM: Q2 2025 compared with Q3 2025
Measure	Q2 2025	Of which not filed for Q3 2025	Q3 2025	Change
Holders	227	4	264	+41
Shares	66.5M	220.1K	70.9M	+4.57M (+6.9%)
Value	$4.20B	$13.9M	$7.20B	+$3.01B (+71.8%)

4 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so the changes leave them out.

New holders (57)

Institutions that held Rhythm Pharmaceuticals, Inc. at the end of Q3 2025 but not at the end of Q2 2025.

Institutions new to RYTM in Q3 2025
Institution	Shares	Value	% of portfolio
Capital Research Global Investors	598,247	$60.4M	0.01%
Jennison Associates LLC	411,550	$41.6M	0.02%
First Light Asset Management, LLC	180,484	$18.2M	1.72%
Citadel Advisors LLC	132,626	$13.4M	0.01%
Man Group plc	129,330	$13.1M	0.03%
EAM Investors, LLC	58,480	$5.81M	0.67%
Walleye Capital LLC	50,181	$5.07M	0.04%
PFM Health Sciences, LP	48,162	$4.86M	0.41%
WCM Investment Management, LLC	47,733	$4.80M	0.01%
Hillsdale Investment Management Inc.	42,600	$4.30M	0.13%
Castleark Management LLC	42,539	$4.30M	0.12%
Canada Pension Plan Investment Board	37,000	$3.74M	0.00%
Rhenman & Partners Asset Management AB	35,000	$3.53M	0.39%
Penserra Capital Management LLC	30,436	$3.07M	0.04%
Dimensional Fund Advisors LP	28,378	$2.87M	0.00%
Voleon Capital Management LP	26,897	$2.72M	0.07%
EFG Asset Management (North America) Corp.	20,269	$2.05M	0.26%
Burkehill Global Management, LP	20,000	$2.02M	0.11%
Quantedge Capital Pte Ltd	17,800	$1.80M	0.98%
Fred Alger Management, LLC	12,335	$1.25M	0.00%
Rockefeller Capital Management L.P.	8,868	$895.6K	0.00%
Entropy Technologies, LP	8,502	$858.6K	0.06%
Inceptionr LLC	7,482	$755.6K	0.18%
Virginia Retirement Systems Et Al	6,700	$676.6K	0.00%
Exchange Traded Concepts, LLC	6,386	$644.9K	0.01%
Arrowstreet Capital, Limited Partnership	6,307	$636.9K	0.00%
CIBC Bancorp USA Inc.	5,569	$562.4K	0.00%
Oxford Asset Management LLP	5,538	$559.3K	0.18%
DnB Asset Management AS	5,528	$558.3K	0.00%
Quantbot Technologies LP	4,981	$503.0K	0.01%
FORA Capital, LLC	3,599	$363.5K	0.06%
Capstone Investment Advisors, LLC	3,497	$353.2K	0.00%
Cim Investment Mangement Inc	2,993	$302.3K	0.08%
Jane Street Group, LLC	2,968	$299.7K	0.00%
Cerity Partners LLC	2,964	$299.3K	0.00%
National Asset Management, Inc.	2,675	$270.1K	0.01%
Toroso Investments, LLC	2,664	$269.0K	0.00%
Quantinno Capital Management LP	2,558	$258.3K	0.00%
Fox Run Management, L.L.C.	2,517	$254.2K	0.04%
Integrated Wealth Concepts LLC	2,491	$251.6K	0.00%
Swiss Life Asset Management Ltd	2,461	$248.5K	0.00%
Centaurus Financial, Inc.	2,389	$241.0K	0.01%
Guggenheim Capital LLC	2,285	$230.8K	0.00%
Empowered Funds, LLC	2,145	$216.6K	0.00%
American Century Companies Inc	2,077	$209.8K	0.00%
JustInvest LLC	2,068	$208.8K	0.00%
EntryPoint Capital, LLC	1,993	$201.3K	0.08%
RWC Asset Management LLP	1,988	$200.8K	0.01%
MAI Capital Management	1,857	$187.5K	0.00%
Bank of Montreal	715	$72.2K	0.00%
AdvisorNet Financial, Inc	105	$10.6K	0.00%
Quadrant Capital Group LLC	42	$4.24K	0.00%
Aster Capital Management (DIFC) Ltd	40	$4.04K	0.00%
Larson Financial Group LLC	28	$2.83K	0.00%
J.Safra Asset Management Corp	20	$2.02K	0.00%
Advisory Services Network, LLC	19	$1.92K	0.00%
Wealthspire Advisors, LLC	1	$101	0.00%

Sold out (16)

Institutions that held Rhythm Pharmaceuticals, Inc. at the end of Q2 2025 and filed for Q3 2025 without it.

Institutions that sold out of RYTM in Q3 2025
Institution	Shares, Q2 2025	Value, Q2 2025
Point72 Asset Management, L.P.	170,832	$10.8M
Schonfeld Strategic Advisors LLC	77,983	$4.93M
Cubist Systematic Strategies, LLC	64,577	$4.08M
Jump Financial, LLC	17,671	$1.12M
Atom Investors LP	14,866	$939.4K
Point72 (DIFC) Ltd	13,149	$830.9K
Caption Management, LLC	7,540	$476.5K
Axq Capital, LP	4,560	$288.1K
Tudor Investment Corp Et Al	4,272	$269.9K
Ameriflex Group, Inc.	360	$22.1K
Compagnie Lombard Odier SCmA	250	$15.8K
South State Corp.	71	$4.49K
Caitong International Asset Management Co., Ltd	58	$3.67K
Skopos Labs, Inc.	21	$1.33K
Whipplewood Advisors, LLC	11	$695
Twin Peaks Wealth Advisors, LLC	5	$482

Not filed for Q3 2025 yet (4)

Institutions that held Rhythm Pharmaceuticals, Inc. at the end of Q2 2025 and haven't filed a 13F for Q3 2025. Not filing isn't selling, so they aren't counted as sold out.

Institutions holding RYTM in Q2 2025 that haven't filed for Q3 2025
Institution	Shares, Q2 2025	Value, Q2 2025
Norges Bank	207,389	$13.1M
CIBC World Markets Corp	6,706	$423.8K
E Fund Management Co., Ltd.	5,761	$364.0K
First Horizon Advisors, Inc.	200	$12.6K