Rhythm Pharmaceuticals, Inc.
RYTM- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001649904
In the last 90 days, Rhythm Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 304 institutions reported holding it in 13F filings for Q2 2026, worth $8.57B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q2 2025
Institutional positions in Rhythm Pharmaceuticals, Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 227
- 0 vs. Q1 2025
- Shares held
- 66.5M
- +1.72M (+2.7%) vs. Q1 2025
- Total value
- $4.20B
- +$767.9M (+22.3%) vs. Q1 2025
- New holders
- 33
- 93 more added
- Sold out
- 33
- 74 more reduced
1 institution that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting RYTM on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 304 | $8.57B |
| Q1 2026 | 285 | $6.42B |
| Q4 2025 | 281 | $7.80B |
| Q3 2025 | 264 | $7.32B |
| Q2 2025 | 227 | $4.22B |
| Q1 2025 | 228 | $3.44B |
| Q4 2024 | 203 | $3.63B |
| Q3 2024 | 176 | $3.55B |
| Q2 2024 | 165 | $2.86B |
| Q1 2024 | 167 | $2.98B |
| Q4 2023 | 169 | $3.09B |
| Q3 2023 | 144 | $1.57B |
| Q2 2023 | 116 | $1.09B |
| Q1 2023 | 126 | $1.09B |
| Q4 2022 | 115 | $1.81B |
| Q3 2022 | 101 | $1.48B |
| Q2 2022 | 90 | $190.8M |
| Q1 2022 | 111 | $562.7M |
| Q4 2021 | 98 | $484.7M |
| Q3 2021 | 97 | $626.3M |
| Q2 2021 | 105 | $905.6M |
| Q1 2021 | 124 | $1.01B |
Institutions, Q2 2025
Shares, value and share of portfolio for each institution holding Rhythm Pharmaceuticals, Inc.; share changes are against Q1 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BlackRock, Inc. | 6,267,538 | $396.0M | 0.01% | −587,217−8.6% | Reduced |
| Baker Bros. Advisors LP | 5,604,483 | $354.1M | 3.44% | 00.0% | Unchanged |
| Ra Capital Management, L.P. | 5,561,359 | $351.4M | 5.92% | −523,053−8.6% | Reduced |
| Primecap Management Co | 4,878,037 | $308.2M | 0.24% | −909,285−15.7% | Reduced |
| Vanguard Group Inc | 3,589,114 | $226.8M | 0.00% | +144,188+4.2% | Added |
| NEA Management Company, LLC | 2,909,956 | $183.9M | 13.84% | 00.0% | Unchanged |
| Perceptive Advisors LLC | 2,418,299 | $152.8M | 5.73% | −130,146−5.1% | Reduced |
| FMR LLC | 1,953,441 | $123.4M | 0.01% | +265,066+15.7% | Added |
| State Street Corp | 1,907,601 | $120.5M | 0.00% | −63,132−3.2% | Reduced |
| Goldman Sachs Group Inc | 1,733,722 | $109.6M | 0.02% | +95,814+5.8% | Added |
| Federated Hermes, Inc. | 1,686,494 | $106.6M | 0.20% | +94,623+5.9% | Added |
| Westfield Capital Management Co LP | 1,629,468 | $103.0M | 0.43% | +288,376+21.5% | Added |
| Janus Henderson Group PLC | 1,411,902 | $89.3M | 0.04% | −243,448−14.7% | Reduced |
| Price T Rowe Associates Inc | 1,341,392 | $84.8M | 0.01% | +142,339+11.9% | Added |
| Geode Capital Management, LLC | 1,311,253 | $82.9M | 0.01% | +24,085+1.9% | Added |
| Driehaus Capital Management LLC | 1,269,952 | $80.2M | 0.64% | −188,070−12.9% | Reduced |
| Polar Capital Holdings Plc | 1,250,870 | $79.0M | 0.41% | +750,870+150.2% | Added |
| Checkpoint Capital L.P. | 1,060,000 | $67.0M | 31.21% | +152,760+16.8% | Added |
| Alkeon Capital Management LLC | 1,017,700 | $64.3M | 0.31% | +200,000+24.5% | Added |
| Rock Springs Capital Management LP | 861,153 | $54.4M | 3.39% | +26,965+3.2% | Added |
| JPMorgan Chase & Co | 783,559 | $49.5M | 0.00% | +639,919+445.5% | Added |
| Loomis Sayles & Co L P | 591,454 | $37.4M | 0.05% | −14,310−2.4% | Reduced |
| Sofinnova Investments, Inc. | 586,010 | $37.0M | 2.52% | +139,171+31.1% | Added |
| Franklin Resources Inc | 543,802 | $34.4M | 0.01% | +217,642+66.7% | Added |
| Hood River Capital Management LLC | 543,688 | $34.4M | 0.48% | −115,743−17.6% | Reduced |
| Morgan Stanley | 524,480 | $33.1M | 0.00% | +20,431+4.1% | Added |
| Woodline Partners LP | 514,381 | $32.5M | 0.17% | +514,381 | New |
| Northern Trust Corp | 510,246 | $32.2M | 0.00% | −25,960−4.8% | Reduced |
| Opaleye Management Inc. | 475,000 | $30.0M | 6.07% | −15,000−3.1% | Reduced |
| Charles Schwab Investment Management Inc | 461,438 | $29.2M | 0.01% | +16,009+3.6% | Added |
| Pictet Asset Management Holding SA | 416,115 | $26.3M | 0.03% | +156,769+60.4% | Added |
| Siren, L.L.C. | 409,742 | $25.9M | 1.34% | +132,209+47.6% | Added |
| Silverarc Capital Management, LLC | 400,772 | $25.3M | 5.18% | +63,167+18.7% | Added |
| Marshall Wace, LLP | 376,242 | $23.8M | 0.03% | −158,861−29.7% | Reduced |
| Barclays PLC | 351,198 | $22.2M | 0.01% | +249,981+247.0% | Added |
| Adage Capital Partners GP, L.L.C. | 341,000 | $21.5M | 0.04% | +341,000 | New |
| Voloridge Investment Management, LLC | 338,804 | $21.4M | 0.08% | −84,064−19.9% | Reduced |
| Renaissance Technologies LLC | 314,893 | $19.9M | 0.03% | +300,781+2,131.4% | Added |
| Candriam Luxembourg S.C.A. | 312,452 | $19.7M | 0.11% | +20,983+7.2% | Added |
| Clearbridge Investments, LLC | 312,445 | $19.7M | 0.02% | +312,445 | New |
| Comerica Bank | 301,661 | $19.1M | 0.07% | +56,907+23.3% | Added |
| UBS Group AG | 252,582 | $16.0M | 0.00% | −19,526−7.2% | Reduced |
| OrbiMed Advisors LLC | 248,512 | $15.7M | 0.39% | −131,488−34.6% | Reduced |
| Voya Investment Management LLC | 244,003 | $15.4M | 0.02% | +158,154+184.2% | Added |
| Qube Research & Technologies Ltd | 240,345 | $15.2M | 0.02% | +24,152+11.2% | Added |
| Assenagon Asset Management S.A. | 237,998 | $15.0M | 0.02% | +215,806+972.4% | Added |
| UBS Asset Management Americas Inc | 227,627 | $14.4M | 0.00% | +101,845+81.0% | Added |
| Bank of America Corp | 222,152 | $14.0M | 0.00% | +110,400+98.8% | Added |
| Norges Bank | 207,389 | $13.1M | 0.00% | −16,095−7.2% | Reduced |
| Lord, Abbett & Co. LLC | 204,275 | $12.9M | 0.04% | +68,915+50.9% | Added |
| Millennium Management LLC | 198,110 | $12.5M | 0.01% | −19,269−8.9% | Reduced |
| Royal Bank of Canada | 196,236 | $12.4M | 0.00% | +196,105+149,698.5% | Added |
| Bank of New York Mellon Corp | 184,109 | $11.6M | 0.00% | +37,524+25.6% | Added |
| StemPoint Capital LP | 176,752 | $11.2M | 3.60% | +142,936+422.7% | Added |
| Artisan Partners Limited Partnership | 174,479 | $11.0M | 0.02% | +174,479 | New |
| Ameriprise Financial Inc | 173,069 | $10.9M | 0.00% | +74,788+76.1% | Added |
| Point72 Asset Management, L.P. | 170,832 | $10.8M | 0.03% | +106,990+167.6% | Added |
| Russell Investments Group, Ltd. | 130,998 | $8.28M | 0.01% | +16,220+14.1% | Added |
| Logos Global Management LP | 130,000 | $8.21M | 1.10% | +130,000 | New |
| Nuveen, LLC | 121,855 | $7.70M | 0.00% | −25,446−17.3% | Reduced |
| Integral Health Asset Management, LLC | 120,000 | $7.58M | 0.71% | +120,000 | New |
| Panagora Asset Management Inc | 119,466 | $7.55M | 0.03% | −21,696−15.4% | Reduced |
| Connor, Clark & Lunn Investment Management Ltd. | 115,118 | $7.27M | 0.03% | +64,561+127.7% | Added |
| BNP Paribas Arbitrage, SA | 102,239 | $6.46M | 0.01% | +16,173+18.8% | Added |
| Lazard Asset Management LLC | 99,445 | $6.28M | 0.01% | −3,757−3.6% | Reduced |
| PDT Partners, LLC | 97,638 | $6.17M | 0.35% | −4,557−4.5% | Reduced |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 95,517 | $6.04M | 0.01% | +2,412+2.6% | Added |
| Swiss National Bank | 90,600 | $5.73M | 0.00% | +1,300+1.5% | Added |
| Rhumbline Advisers | 87,526 | $5.53M | 0.00% | +1,807+2.1% | Added |
| Harbor Capital Advisors, Inc. | 86,546 | $5.47M | 0.23% | +9,249+12.0% | Added |
| Neuberger Berman Group LLC | 86,139 | $5.44M | 0.00% | +18,200+26.8% | Added |
| Schonfeld Strategic Advisors LLC | 77,983 | $4.93M | 0.04% | +20,833+36.5% | Added |
| Susquehanna International Group, LLP | 77,262 | $4.88M | 0.01% | −5,718−6.9% | Reduced |
| First Trust Advisors LP | 73,714 | $4.66M | 0.00% | −16,065−17.9% | Reduced |
| Cinctive Capital Management LP | 70,937 | $4.48M | 0.25% | +66,581+1,528.5% | Added |
| Invesco Ltd. | 68,924 | $4.36M | 0.00% | −192,978−73.7% | Reduced |
| Manufacturers Life Insurance Company, The | 68,132 | $4.31M | 0.00% | +3,746+5.8% | Added |
| Standard Life Aberdeen plc | 67,657 | $4.28M | 0.01% | −40,472−37.4% | Reduced |
| Cubist Systematic Strategies, LLC | 64,577 | $4.08M | 0.04% | −109,245−62.8% | Reduced |
| Alliancebernstein L.P. | 61,470 | $3.88M | 0.00% | 00.0% | Unchanged |
| Algert Global LLC | 60,219 | $3.81M | 0.08% | −1,242−2.0% | Reduced |
| New York State Common Retirement Fund | 58,618 | $3.70M | 0.00% | +41,768+247.9% | Added |
| Kennedy Capital Management, Inc. | 57,217 | $3.62M | 0.09% | +2,287+4.2% | Added |
| TD Asset Management Inc | 56,000 | $3.54M | 0.00% | +5,800+11.6% | Added |
| Balyasny Asset Management LLC | 54,088 | $3.42M | 0.01% | −301,624−84.8% | Reduced |
| Legal & General Group Plc | 52,681 | $3.33M | 0.00% | +1,523+3.0% | Added |
| Axiom Investors LLC | 52,460 | $3.31M | 0.03% | +52,460 | New |
| Rafferty Asset Management, LLC | 51,611 | $3.26M | 0.01% | −6,121−10.6% | Reduced |
| Hennion & Walsh Asset Management, Inc. | 51,079 | $3.23M | 0.13% | −38,543−43.0% | Reduced |
| Samsara BioCapital, LLC | 50,476 | $3.19M | 0.65% | −87,642−63.5% | Reduced |
| Nan Fung Group Holdings Ltd | 49,120 | $3.10M | 4.89% | 00.0% | Unchanged |
| AQR Capital Management LLC | 49,040 | $3.10M | 0.00% | +9,677+24.6% | Added |
| Silvercrest Asset Management Group LLC | 48,775 | $3.08M | 0.02% | +48,775 | New |
| ADAR1 Capital Management, LLC | 45,390 | $2.87M | 0.47% | +8,500+23.0% | Added |
| California State Teachers Retirement System | 42,917 | $2.71M | 0.00% | +196+0.5% | Added |
| Wells Fargo & Company | 42,368 | $2.68M | 0.00% | −28,270−40.0% | Reduced |
| Granahan Investment Management Inc | 41,172 | $2.60M | 0.11% | +41,172 | New |
| Deutsche Bank AG | 36,779 | $2.32M | 0.00% | −7,000−16.0% | Reduced |
| State of Wisconsin Investment Board | 35,708 | $2.26M | 0.01% | +2,683+8.1% | Added |
| Dark Forest Capital Management LP | 34,829 | $2.20M | 0.09% | +9,420+37.1% | Added |