Rhythm Pharmaceuticals, Inc.

RYTM

Exchange: Nasdaq
Industry: Pharmaceutical Preparations
SEC CIK: 0001649904

SEC filings (opens in a new tab)

In the last 90 days, Rhythm Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 305 institutions reported holding it in 13F filings for Q2 2026, worth $8.55B in total; Duquesne Family Office is the only superinvestor holding it.

Q2 2025 vs. Q1 2025

How the institutions holding Rhythm Pharmaceuticals, Inc. changed between Q1 2025 and Q2 2025.

All holders in Q2 2025 All holders in Q1 2025

13F holders of RYTM: Q1 2025 compared with Q2 2025
Measure	Q1 2025	Of which not filed for Q2 2025	Q2 2025	Change
Holders	228	1	227	0
Shares	64.8M	129	66.5M	+1.72M (+2.7%)
Value	$3.44B	$6.83K	$4.20B	+$767.9M (+22.3%)

1 institution that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so the changes leave them out.

New holders (33)

Institutions that held Rhythm Pharmaceuticals, Inc. at the end of Q2 2025 but not at the end of Q1 2025.

Institutions new to RYTM in Q2 2025
Institution	Shares	Value	% of portfolio
Woodline Partners LP	514,381	$32.5M	0.17%
Adage Capital Partners GP, L.L.C.	341,000	$21.5M	0.04%
Clearbridge Investments, LLC	312,445	$19.7M	0.02%
Artisan Partners Limited Partnership	174,479	$11.0M	0.02%
Logos Global Management LP	130,000	$8.21M	1.10%
Integral Health Asset Management, LLC	120,000	$7.58M	0.71%
Axiom Investors LLC	52,460	$3.31M	0.03%
Silvercrest Asset Management Group LLC	48,775	$3.08M	0.02%
Granahan Investment Management Inc	41,172	$2.60M	0.11%
Readystate Asset Management LP	24,666	$1.56M	0.06%
Harvest Investment Services, LLC	15,466	$977.3K	0.22%
Raymond James Financial Inc	10,546	$666.4K	0.00%
Toth Financial Advisory Corp	10,000	$631.9K	0.07%
E. Ohman J:or Asset Management AB	8,213	$519.0K	0.01%
Caption Management, LLC	7,540	$476.5K	0.04%
Axq Capital, LP	4,560	$288.1K	0.09%
Jain Global LLC	3,908	$246.9K	0.00%
Los Angeles Capital Management LLC	3,872	$244.7K	0.00%
Freestone Capital Holdings, LLC	3,700	$233.8K	0.01%
O'Shaughnessy Asset Management, LLC	3,476	$219.6K	0.00%
State of Wyoming	1,065	$67.3K	0.01%
Clearstead Advisors, LLC	590	$37.3K	0.00%
BNP PARIBAS ASSET MANAGEMENT Holding S.A.	421	$27.0K	0.00%
Global Retirement Partners, LLC	400	$25.3K	0.00%
Compagnie Lombard Odier SCmA	250	$15.8K	0.00%
First Horizon Advisors, Inc.	200	$12.6K	0.00%
Essential Partners LLC	120	$7.58K	0.00%
Caitong International Asset Management Co., Ltd	58	$3.67K	0.00%
WPG Advisers, LLC	57	$3.60K	0.00%
IFP Advisors, Inc	15	$1.20K	0.00%
UMA Financial Services, Inc.	16	$1.01K	0.00%
Bare Financial Services, Inc	10	$632	0.00%
Twin Peaks Wealth Advisors, LLC	5	$482	0.00%

Sold out (33)

Institutions that held Rhythm Pharmaceuticals, Inc. at the end of Q1 2025 and filed for Q2 2025 without it.

Institutions that sold out of RYTM in Q2 2025
Institution	Shares, Q1 2025	Value, Q1 2025
Frazier Life Sciences Management, L.P.	678,760	$36.0M
Cormorant Asset Management, LP	150,000	$7.95M
Jane Street Group, LLC	91,118	$4.83M
Citadel Advisors LLC	70,068	$3.71M
Artia Global Partners LP	50,000	$2.65M
Diadema Partners LP	50,000	$2.65M
EAM Investors, LLC	45,108	$2.39M
Walleye Capital LLC	35,828	$1.90M
XTX Topco Ltd	29,949	$1.59M
Corebridge Financial, Inc.	26,821	$1.42M
Squarepoint Ops LLC	24,413	$1.29M
Fox Run Management, L.L.C.	19,172	$1.02M
Jefferies Financial Group Inc.	17,100	$905.8K
Quantinno Capital Management LP	17,086	$905.0K
HSBC Holdings PLC	15,570	$823.3K
Voleon Capital Management LP	13,819	$732.0K
American Century Companies Inc	13,282	$703.5K
Exchange Traded Concepts, LLC	11,912	$631.0K
Persistent Asset Partners Ltd	11,501	$609.2K
Bridgefront Capital, LLC	6,414	$339.8K
Springhill Fund Asset Management (HK) Co Ltd	6,277	$332.5K
Fieldview Capital Management, LLC	6,037	$319.8K
BIT Capital GmbH	6,013	$318.5K
Y-Intercept (Hong Kong) Ltd	5,966	$316.0K
Entropy Technologies, LP	5,502	$291.4K
Quadrature Capital Ltd	5,278	$279.6K
Verition Fund Management LLC	4,424	$234.3K
SIH Partners, LLLP	3,980	$210.8K
BI Asset Management Fondsmaeglerselskab A/S	648	$34.0K
Northwestern Mutual Wealth Management Co	48	$2.54K
Coldstream Capital Management Inc	30	$1.59K
Stephens Consulting, LLC	20	$1.06K
Hexagon Capital Partners LLC	11	$583

Not filed for Q2 2025 yet (1)

Institutions that held Rhythm Pharmaceuticals, Inc. at the end of Q1 2025 and haven't filed a 13F for Q2 2025. Not filing isn't selling, so they aren't counted as sold out.

Institutions holding RYTM in Q1 2025 that haven't filed for Q2 2025
Institution	Shares, Q1 2025	Value, Q1 2025
Lindbrook Capital, LLC	129	$6.83K