Rhythm Pharmaceuticals, Inc.
RYTM- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001649904
In the last 90 days, Rhythm Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 304 institutions reported holding it in 13F filings for Q2 2026, worth $8.55B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q1 2025
Institutional positions in Rhythm Pharmaceuticals, Inc. as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 228
- +26 vs. Q4 2024
- Shares held
- 64.8M
- +48.3K (+0.1%) vs. Q4 2024
- Total value
- $3.44B
- −$189.2M (−5.2%) vs. Q4 2024
- New holders
- 45
- 86 more added
- Sold out
- 19
- 69 more reduced
1 institution that held it in Q4 2024 haven't filed for Q1 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting RYTM on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 304 | $8.55B |
| Q1 2026 | 285 | $6.42B |
| Q4 2025 | 281 | $7.80B |
| Q3 2025 | 264 | $7.20B |
| Q2 2025 | 227 | $4.20B |
| Q1 2025 | 228 | $3.44B |
| Q4 2024 | 203 | $3.63B |
| Q3 2024 | 176 | $3.55B |
| Q2 2024 | 165 | $2.85B |
| Q1 2024 | 167 | $2.95B |
| Q4 2023 | 169 | $3.07B |
| Q3 2023 | 144 | $1.56B |
| Q2 2023 | 116 | $1.09B |
| Q1 2023 | 126 | $1.08B |
| Q4 2022 | 115 | $1.81B |
| Q3 2022 | 101 | $1.45B |
| Q2 2022 | 90 | $190.8M |
| Q1 2022 | 111 | $562.7M |
| Q4 2021 | 98 | $483.6M |
| Q3 2021 | 97 | $626.3M |
| Q2 2021 | 105 | $905.6M |
| Q1 2021 | 124 | $1.01B |
Institutions, Q1 2025
Shares, value and share of portfolio for each institution holding Rhythm Pharmaceuticals, Inc.; share changes are against Q4 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BlackRock, Inc. | 6,854,755 | $363.1M | 0.01% | −95,960−1.4% | Reduced |
| Ra Capital Management, L.P. | 6,084,412 | $322.3M | 5.38% | 00.0% | Unchanged |
| Primecap Management Co | 5,787,322 | $306.6M | 0.25% | −783,868−11.9% | Reduced |
| Baker Bros. Advisors LP | 5,604,483 | $296.9M | 3.29% | −479,766−7.9% | Reduced |
| Vanguard Group Inc | 3,444,926 | $182.5M | 0.00% | +2,326+0.1% | Added |
| NEA Management Company, LLC | 2,909,956 | $154.1M | 11.87% | 00.0% | Unchanged |
| Perceptive Advisors LLC | 2,548,445 | $135.0M | 4.79% | −1,132,028−30.8% | Reduced |
| State Street Corp | 1,970,733 | $104.4M | 0.00% | +129,863+7.1% | Added |
| Janus Henderson Group PLC | 1,655,350 | $90.7M | 0.05% | +435,796+35.7% | Added |
| FMR LLC | 1,688,375 | $89.4M | 0.01% | +1,575,266+1,392.7% | Added |
| Goldman Sachs Group Inc | 1,637,908 | $86.8M | 0.02% | −174,298−9.6% | Reduced |
| Federated Hermes, Inc. | 1,591,871 | $84.3M | 0.18% | +42,236+2.7% | Added |
| Driehaus Capital Management LLC | 1,458,022 | $77.2M | 0.74% | +167,047+12.9% | Added |
| Westfield Capital Management Co LP | 1,341,092 | $71.0M | 0.35% | +1,341,092 | New |
| Geode Capital Management, LLC | 1,287,168 | $68.2M | 0.01% | +31,369+2.5% | Added |
| Price T Rowe Associates Inc | 1,199,053 | $63.5M | 0.01% | +513,901+75.0% | Added |
| Checkpoint Capital L.P. | 907,240 | $48.1M | 26.37% | +179,258+24.6% | Added |
| Rock Springs Capital Management LP | 834,188 | $44.2M | 2.53% | −328,530−28.3% | Reduced |
| Alkeon Capital Management LLC | 817,700 | $43.3M | 0.26% | −350,000−30.0% | Reduced |
| Frazier Life Sciences Management, L.P. | 678,760 | $36.0M | 1.64% | −1,191,048−63.7% | Reduced |
| Hood River Capital Management LLC | 659,431 | $34.9M | 0.60% | +15,740+2.4% | Added |
| Loomis Sayles & Co L P | 605,764 | $32.1M | 0.05% | −12,721−2.1% | Reduced |
| Northern Trust Corp | 536,206 | $28.4M | 0.00% | −9,108−1.7% | Reduced |
| Marshall Wace, LLP | 535,103 | $28.3M | 0.04% | −157,700−22.8% | Reduced |
| Morgan Stanley | 504,049 | $26.7M | 0.00% | −56,038−10.0% | Reduced |
| Polar Capital Holdings Plc | 500,000 | $26.5M | 0.16% | −1,000,000−66.7% | Reduced |
| Opaleye Management Inc. | 490,000 | $26.0M | 5.78% | −10,000−2.0% | Reduced |
| Sofinnova Investments, Inc. | 446,839 | $23.7M | 1.78% | +49,411+12.4% | Added |
| Charles Schwab Investment Management Inc | 445,429 | $23.6M | 0.00% | +5,179+1.2% | Added |
| Voloridge Investment Management, LLC | 422,868 | $22.4M | 0.08% | +42,331+11.1% | Added |
| OrbiMed Advisors LLC | 380,000 | $20.1M | 0.48% | −20,000−5.0% | Reduced |
| Balyasny Asset Management LLC | 355,712 | $18.8M | 0.05% | +217,349+157.1% | Added |
| Silverarc Capital Management, LLC | 337,605 | $17.9M | 3.74% | +63,709+23.3% | Added |
| Franklin Resources Inc | 326,160 | $17.3M | 0.01% | +57,955+21.6% | Added |
| Candriam Luxembourg S.C.A. | 291,469 | $15.4M | 0.10% | −40,923−12.3% | Reduced |
| Siren, L.L.C. | 277,533 | $14.7M | 0.83% | +277,533 | New |
| UBS Group AG | 272,108 | $14.4M | 0.00% | +17,844+7.0% | Added |
| Invesco Ltd. | 261,902 | $13.9M | 0.00% | −40,944−13.5% | Reduced |
| Pictet Asset Management Holding SA | 259,346 | $13.9M | 0.02% | −116,003−30.9% | Reduced |
| Comerica Bank | 244,754 | $13.0M | 0.05% | +227,641+1,330.2% | Added |
| Norges Bank | 223,484 | $11.8M | 0.00% | +17,835+8.7% | Added |
| Millennium Management LLC | 217,379 | $11.5M | 0.01% | +202,120+1,324.6% | Added |
| Qube Research & Technologies Ltd | 216,193 | $11.5M | 0.02% | +120,958+127.0% | Added |
| Cubist Systematic Strategies, LLC | 173,822 | $9.21M | 0.12% | +173,822 | New |
| Cormorant Asset Management, LP | 150,000 | $7.95M | 0.60% | −250,000−62.5% | Reduced |
| Nuveen, LLC | 147,301 | $7.80M | 0.00% | +147,301 | New |
| Bank of New York Mellon Corp | 146,585 | $7.76M | 0.00% | −1,661−1.1% | Reduced |
| JPMorgan Chase & Co | 143,640 | $7.61M | 0.00% | −120,945−45.7% | Reduced |
| Panagora Asset Management Inc | 141,162 | $7.48M | 0.04% | +141,162 | New |
| Samsara BioCapital, LLC | 138,118 | $7.32M | 1.30% | −34,529−20.0% | Reduced |
| Lord, Abbett & Co. LLC | 135,360 | $7.17M | 0.03% | −25,291−15.7% | Reduced |
| UBS Asset Management Americas Inc | 125,782 | $6.66M | 0.00% | −92,762−42.4% | Reduced |
| Russell Investments Group, Ltd. | 114,778 | $6.08M | 0.01% | +113,781+11,412.3% | Added |
| Bank of America Corp | 111,752 | $5.92M | 0.00% | +7,264+7.0% | Added |
| Standard Life Aberdeen plc | 108,129 | $5.73M | 0.01% | +27,612+34.3% | Added |
| Lazard Asset Management LLC | 103,202 | $5.46M | 0.01% | −3,059−2.9% | Reduced |
| PDT Partners, LLC | 102,195 | $5.41M | 0.38% | +58,612+134.5% | Added |
| Barclays PLC | 101,217 | $5.36M | 0.00% | −34,180−25.2% | Reduced |
| Ameriprise Financial Inc | 98,281 | $5.21M | 0.00% | +44,914+84.2% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 93,105 | $4.93M | 0.01% | +17,021+22.4% | Added |
| Jane Street Group, LLC | 91,118 | $4.83M | 0.01% | +32,703+56.0% | Added |
| First Trust Advisors LP | 89,779 | $4.76M | 0.00% | −28,558−24.1% | Reduced |
| Hennion & Walsh Asset Management, Inc. | 89,622 | $4.75M | 0.21% | −9,825−9.9% | Reduced |
| Swiss National Bank | 89,300 | $4.73M | 0.00% | −900−1.0% | Reduced |
| Citigroup Inc | 86,206 | $4.57M | 0.00% | +16,429+23.5% | Added |
| BNP Paribas Arbitrage, SA | 86,066 | $4.56M | 0.00% | +817+1.0% | Added |
| Voya Investment Management LLC | 85,849 | $4.55M | 0.01% | −11,320−11.6% | Reduced |
| Rhumbline Advisers | 85,719 | $4.54M | 0.00% | +2,988+3.6% | Added |
| D. E. Shaw & Co., Inc. | 83,869 | $4.44M | 0.01% | +35,671+74.0% | Added |
| Susquehanna International Group, LLP | 82,980 | $4.40M | 0.01% | +32,316+63.8% | Added |
| Harbor Capital Advisors, Inc. | 77,297 | $4.09M | 0.19% | +47,045+155.5% | Added |
| Wells Fargo & Company | 70,638 | $3.74M | 0.00% | +33,314+89.3% | Added |
| Citadel Advisors LLC | 70,068 | $3.71M | 0.00% | +29,649+73.4% | Added |
| Neuberger Berman Group LLC | 67,939 | $3.60M | 0.00% | +67,939 | New |
| Manufacturers Life Insurance Company, The | 64,386 | $3.41M | 0.00% | +4,417+7.4% | Added |
| Point72 Asset Management, L.P. | 63,842 | $3.38M | 0.01% | +63,842 | New |
| Alliancebernstein L.P. | 61,470 | $3.26M | 0.00% | 00.0% | Unchanged |
| Algert Global LLC | 61,461 | $3.26M | 0.08% | +19,910+47.9% | Added |
| Rafferty Asset Management, LLC | 57,732 | $3.06M | 0.01% | +7,338+14.6% | Added |
| Schonfeld Strategic Advisors LLC | 57,150 | $3.03M | 0.02% | −2,550−4.3% | Reduced |
| Kennedy Capital Management, Inc. | 54,930 | $2.91M | 0.07% | +54,930 | New |
| Legal & General Group Plc | 51,158 | $2.71M | 0.00% | −645−1.2% | Reduced |
| Connor, Clark & Lunn Investment Management Ltd. | 50,557 | $2.68M | 0.01% | +44,468+730.3% | Added |
| TD Asset Management Inc | 50,200 | $2.66M | 0.00% | +2,400+5.0% | Added |
| Diadema Partners LP | 50,000 | $2.65M | 2.12% | −25,000−33.3% | Reduced |
| Artia Global Partners LP | 50,000 | $2.65M | 0.78% | 00.0% | Unchanged |
| Nan Fung Group Holdings Ltd | 49,120 | $2.60M | 2.12% | 00.0% | Unchanged |
| Alps Advisors Inc | 46,207 | $2.45M | 0.01% | −3,493−7.0% | Reduced |
| EAM Investors, LLC | 45,108 | $2.39M | 0.41% | −17,970−28.5% | Reduced |
| Deutsche Bank AG | 43,779 | $2.32M | 0.00% | −4,966−10.2% | Reduced |
| California State Teachers Retirement System | 42,721 | $2.26M | 0.00% | −812−1.9% | Reduced |
| Jump Financial, LLC | 41,760 | $2.21M | 0.03% | +41,760 | New |
| Aquatic Capital Management LLC | 41,476 | $2.20M | 0.06% | +32,253+349.7% | Added |
| AQR Capital Management LLC | 39,363 | $2.09M | 0.00% | +23,506+148.2% | Added |
| Trexquant Investment LP | 38,724 | $2.05M | 0.02% | +30,926+396.6% | Added |
| Principal Financial Group Inc | 37,156 | $1.97M | 0.00% | +272+0.7% | Added |
| Wedge Capital Management L L P | 36,984 | $1.96M | 0.04% | −11,427−23.6% | Reduced |
| ADAR1 Capital Management, LLC | 36,890 | $1.95M | 0.38% | +5,949+19.2% | Added |
| Walleye Capital LLC | 35,828 | $1.90M | 0.02% | −108,514−75.2% | Reduced |
| State of New Jersey Common Pension Fund D | 35,392 | $1.87M | 0.01% | +388+1.1% | Added |