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Rhythm Pharmaceuticals, Inc.

RYTM
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001649904

In the last 90 days, Rhythm Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 304 institutions reported holding it in 13F filings for Q2 2026, worth $8.57B in total; Duquesne Family Office is the only superinvestor holding it.

13F holders, Q2 2021

Institutional positions in Rhythm Pharmaceuticals, Inc. as of Jun 30, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
105
−19 vs. Q1 2021
Shares held
47.5M
−91.7K (−0.2%) vs. Q1 2021
Total value
$905.6M
−$106.4M (−10.5%) vs. Q1 2021
New holders
7
42 more added
Sold out
26
33 more reduced

Compare with Q1 2021: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting RYTM on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ2 2021: 105 institutions
Q1 2021: 124 institutionsQ2 2021: 105 institutionsQ3 2021: 97 institutionsQ4 2021: 98 institutionsQ1 2022: 111 institutionsQ2 2022: 90 institutionsQ3 2022: 101 institutionsQ4 2022: 115 institutionsQ1 2023: 126 institutionsQ2 2023: 116 institutionsQ3 2023: 144 institutionsQ4 2023: 169 institutionsQ1 2024: 167 institutionsQ2 2024: 165 institutionsQ3 2024: 176 institutionsQ4 2024: 203 institutionsQ1 2025: 228 institutionsQ2 2025: 227 institutionsQ3 2025: 264 institutionsQ4 2025: 281 institutionsQ1 2026: 285 institutionsQ2 2026: 304 institutions
Value heldQ2 2021: $905.6M
Q1 2021: $1.01BQ2 2021: $905.6MQ3 2021: $626.3MQ4 2021: $484.7MQ1 2022: $562.7MQ2 2022: $190.8MQ3 2022: $1.48BQ4 2022: $1.81BQ1 2023: $1.09BQ2 2023: $1.09BQ3 2023: $1.57BQ4 2023: $3.09BQ1 2024: $2.98BQ2 2024: $2.86BQ3 2024: $3.55BQ4 2024: $3.63BQ1 2025: $3.44BQ2 2025: $4.22BQ3 2025: $7.32BQ4 2025: $7.80BQ1 2026: $6.42BQ2 2026: $8.57B
Institutions holding RYTM and their total value by quarter
QuarterHoldersValue
Q2 2026304$8.57B
Q1 2026285$6.42B
Q4 2025281$7.80B
Q3 2025264$7.32B
Q2 2025227$4.22B
Q1 2025228$3.44B
Q4 2024203$3.63B
Q3 2024176$3.55B
Q2 2024165$2.86B
Q1 2024167$2.98B
Q4 2023169$3.09B
Q3 2023144$1.57B
Q2 2023116$1.09B
Q1 2023126$1.09B
Q4 2022115$1.81B
Q3 2022101$1.48B
Q2 202290$190.8M
Q1 2022111$562.7M
Q4 202198$484.7M
Q3 202197$626.3M
Q2 2021105$905.6M
Q1 2021124$1.01B

Institutions, Q2 2021

Shares, value and share of portfolio for each institution holding Rhythm Pharmaceuticals, Inc.; share changes are against Q1 2021.

Institutions holding RYTM in Q2 2021
InstitutionSharesValue% of portfolioChange in sharesAction
Primecap Management Co6,153,691$120.5M0.08%+148,098+2.5%Added
NEA Management Company, LLC4,912,306$96.2M1.25%00.0%Unchanged
Janus Henderson Group PLC3,926,050$76.9M0.03%−161,973−4.0%Reduced
Baker Bros. Advisors LP3,863,239$75.6M0.33%+383,366+11.0%Added
Ra Capital Management, L.P.4,871,067$71.1M1.14%00.0%Unchanged
BlackRock Inc.3,335,661$65.3M0.00%+190,301+6.1%Added
Federated Hermes, Inc.3,015,211$59.0M0.11%−95,642−3.1%Reduced
Vanguard Group Inc2,257,422$44.2M0.00%+5,027+0.2%Added
State Street Corp2,179,087$42.7M0.00%−262,293−10.7%Reduced
Deerfield Management Company, L.P. (Series C)1,989,625$39.0M0.69%00.0%Unchanged
Gilder Gagnon Howe & Co LLC1,489,123$29.2M0.14%−34,111−2.2%Reduced
Wellington Management Group LLP1,296,081$25.4M0.00%+280,779+27.7%Added
Goldman Sachs Group Inc1,068,211$20.9M0.01%+409,057+62.1%Added
MPM Asset Management LLC909,258$17.8M3.31%00.0%Unchanged
Geode Capital Management, LLC684,903$13.4M0.00%+61,341+9.8%Added
Rock Springs Capital Management LP606,280$11.9M0.24%+7,000+1.2%Added
Morgan Stanley446,606$8.74M0.00%+345,757+342.8%Added
Northern Trust Corp440,686$8.63M0.00%+5,726+1.3%Added
Samsara BioCapital, LLC300,293$5.88M0.77%+99,247+49.4%Added
Dimensional Fund Advisors LP290,270$5.68M0.00%−18,303−5.9%Reduced
Charles Schwab Investment Management Inc267,631$5.24M0.00%+15,409+6.1%Added
Nuveen Asset Management, LLC250,256$4.90M0.00%+96,987+63.3%Added
Stifel Financial Corp181,414$3.55M0.01%+64,181+54.7%Added
Bank of Montreal151,446$3.09M0.00%+148,982+6,046.3%Added
Millennium Management LLC156,816$3.07M0.00%−13,711−8.0%Reduced
Rice Hall James & Associates, LLC143,994$2.82M0.10%+79,733+124.1%Added
Assenagon Asset Management S.A.142,472$2.79M0.01%+142,472New
Bank of New York Mellon Corp140,032$2.74M0.00%+3,878+2.8%Added
Citigroup Inc131,899$2.58M0.00%−20,529−13.5%Reduced
Bank of America Corp119,678$2.34M0.00%+13,236+12.4%Added
Altium Capital Management LP104,840$2.05M0.48%−118,160−53.0%Reduced
Caas Capital Management LP84,044$1.65M0.09%−533,551−86.4%Reduced
FMR LLC83,278$1.63M0.00%00.0%Unchanged
Rafferty Asset Management, LLC83,021$1.63M0.01%−38,646−31.8%Reduced
SG Americas Securities, LLC81,868$1.60M0.01%−4,916−5.7%Reduced
UBS Group AG80,119$1.57M0.00%−46,731−36.8%Reduced
Swiss National Bank76,000$1.49M0.00%−2,700−3.4%Reduced
Rhumbline Advisers61,012$1.20M0.00%+20,857+51.9%Added
California State Teachers Retirement System60,739$1.19M0.00%+3,254+5.7%Added
Two Sigma Investments, LP57,078$1.12M0.00%−237,582−80.6%Reduced
Renaissance Technologies LLC52,200$1.02M0.00%+3,200+6.5%Added
Norges Bank51,161$1.00M0.00%−13,947−21.4%Reduced
State of Wisconsin Investment Board48,400$948.0K0.00%00.0%Unchanged
Susquehanna International Group, LLP43,535$852.0K0.00%−80,202−64.8%Reduced
Alliancebernstein L.P.41,600$815.0K0.00%00.0%Unchanged
Ensign Peak Advisors, Inc40,891$801.0K0.00%00.0%Unchanged
Brandywine Global Investment Management, LLC40,663$796.0K0.01%−2,600−6.0%Reduced
New York State Common Retirement Fund40,107$785.0K0.00%+5,102+14.6%Added
Citadel Advisors LLC32,574$638.0K0.00%−86,134−72.6%Reduced
Hennion & Walsh Asset Management, Inc.32,193$630.0K0.03%+505+1.6%Added
Prudential Financial Inc30,973$607.0K0.00%+30,973New
ACT Capital Management, LLC31,000$607.0K0.31%+31,000New
Deutsche Bank AG29,876$585.0K0.00%−9,353−23.8%Reduced
Manufacturers Life Insurance Company, The25,708$503.0K0.00%+3,686+16.7%Added
Invesco Ltd.25,308$495.0K0.00%+8,101+47.1%Added
Parametric Portfolio Associates LLC25,255$494.0K0.00%−17,300−40.7%Reduced
UBS Asset Management Americas Inc25,215$493.7K0.00%+14,719+140.2%Added
American International Group, Inc.24,684$483.0K0.00%+2,472+11.1%Added
Credit Suisse AG23,802$467.0K0.00%−1,654−6.5%Reduced
Qube Research & Technologies Ltd23,224$455.0K0.01%−3,452−12.9%Reduced
JPMorgan Chase & Co22,169$434.0K0.00%−57,656−72.2%Reduced
Squarepoint Ops LLC20,611$404.0K0.00%−50,933−71.2%Reduced
ProShare Advisors LLC20,450$400.0K0.00%+3,454+20.3%Added
Barclays PLC18,488$363.0K0.00%−55,795−75.1%Reduced
Voya Investment Management LLC17,259$338.0K0.00%+1,228+7.7%Added
Winton Group Ltd16,863$330.0K0.02%+16,863New
Price T Rowe Associates Inc16,712$327.0K0.00%+1,247+8.1%Added
MetLife Investment Management15,372$301.0K0.00%00.0%Unchanged
ExodusPoint Capital Management, LP14,944$293.0K0.00%+14,944New
State Board of Administration of Florida Retirement System13,844$271.0K0.00%+13,844New
Metropolitan Life Insurance Co12,450$243.8K0.00%+2,835+29.5%Added
DekaBank Deutsche Girozentrale12,000$239.0K0.00%00.0%Unchanged
Principal Financial Group Inc11,364$223.0K0.00%+1,562+15.9%Added
Virtus ETF Advisers LLC10,765$211.0K0.09%+826+8.3%Added
Wells Fargo & Company9,771$191.0K0.00%−11,292−53.6%Reduced
Cutler Group LP7,418$145.0K0.01%−784−9.6%Reduced
Legal & General Group Plc6,452$127.0K0.00%−4−0.1%Reduced
Meeder Asset Management Inc6,078$119.0K0.01%+6,078New
Zurcher Kantonalbank (Zurich Cantonalbank)5,571$109.0K0.00%+69+1.3%Added
BNP Paribas Arbitrage, SA5,297$103.7K0.00%−9,437−64.0%Reduced
Simplex Trading, LLC5,204$101.0K0.00%+488+10.3%Added
Exane Derivatives5,167$100.1K0.02%00.0%Unchanged
Royal Bank of Canada4,217$83.0K0.00%+402+10.5%Added
Retirement Group, LLC3,812$75.0K0.04%00.0%Unchanged
Tower Research Capital LLC (TRC)3,735$73.0K0.00%+1,461+64.2%Added
Sierra Capital LLC3,600$70.0K0.01%00.0%Unchanged
Ameritas Investment Partners, Inc.3,454$68.0K0.00%+484+16.3%Added
Great West Life Assurance Co2,363$46.0K0.00%00.0%Unchanged
Macquarie Group Ltd1,930$38.0K0.00%+1,463+313.3%Added
Penserra Capital Management LLC1,145$22.0K0.00%+35+3.2%Added
FORA Capital, LLC1,085$21.0K0.00%+6+0.6%Added
Group One Trading, L.P.974$19.0K0.00%−2,022−67.5%Reduced
Advisor Group Holdings, Inc.915$18.0K0.00%−80−8.0%Reduced
Nisa Investment Advisors, LLC550$11.0K0.00%00.0%Unchanged
Evolution Wealth Advisors, LLC538$11.0K0.00%00.0%Unchanged
Signaturefd, LLC500$10.0K0.00%−168−25.1%Reduced
The PNC Financial Services Group, Inc.359$7.00K0.00%00.0%Unchanged
State of Wyoming292$6.00K0.00%+201+220.9%Added
Bessemer Group Inc251$5.00K0.00%00.0%Unchanged
Geneos Wealth Management Inc.200$4.00K0.00%00.0%Unchanged